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R. Rickles · SciRah

Researcher profile · Semantic Scholar

R. Rickles

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R. Rickles — researcher profile on SciRah

h-index: 20
Works: 52
Citations: 3,466

Most-cited papers

Synergistic drug combinations improve therapeutic selectivity
J. Lehar, A. Krueger, W. Avery, Adrian M. Heilbut +9 more
2009Nature Biotechnology920 citations Open access
Semantic Scholar
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells.
F. Stegmeier, G. Hu, R. Rickles, G. Hannon +1 more
2005Proceedings of the National Academy of Sciences of the United States of America577 citations Open access
Semantic Scholar
Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands.
Si-Bo Feng, C. Kasahara, R. Rickles, Stuart L. Schreiber
1995Proceedings of the National Academy of Sciences of the United States of America239 citations Open access
Semantic Scholar
Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes.
J. Vassalli, J. Huarte, D. Belin, P. Gubler +5 more
1989Genes & Development239 citations Open access
Semantic Scholar
Identification of Itk/Tsk Src Homology 3 Domain Ligands*
Stephen C. Bunnell, P. Henry, Rikki Kolluri, T. Kirchhausen +2 more
1996Journal of Biological Chemistry195 citations Open access
Semantic Scholar
SH3 domains and drug design: ligands, structure, and biological function.
D. Dalgarno, M. Botfield, R. Rickles
1997Biopolymers167 citations
Semantic Scholar
Antisense RNA directed against the 3' noncoding region prevents dormant mRNA activation in mouse oocytes.
Sidney Strickland, J. Huarte, D. Belin, A. Vassalli +2 more
1988Science155 citations Open access
Semantic Scholar
Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation.
R. Rickles, A. Darrow, S. Strickland
1988Journal of Biological Chemistry148 citations Open access
Semantic Scholar
Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions
Z. Weng, R. Rickles, Si-Bo Feng, S. Richard +3 more
1995Molecular and Cellular Biology126 citations Open access
Semantic Scholar
Organization of human histone genes.
F. Sierra, A. Lichtler, F. Marashi, R. Rickles +5 more
1982Proceedings of the National Academy of Sciences of the United States of America103 citations Open access
Semantic Scholar
Differentiation-responsive elements in the 5' region of the mouse tissue plasminogen activator gene confer two-stage regulation by retinoic acid and cyclic AMP in teratocarcinoma cells
R. Rickles, A. Darrow, S. Strickland
1989Molecular and Cellular Biology84 citations Open access
Semantic Scholar
Transcription factor Sp1 is important for retinoic acid-induced expression of the tissue plasminogen activator gene during F9 teratocarcinoma cell differentiation
A. Darrow, R. Rickles, Lauren T. Pecorino, S. Strickland
1990Molecular and Cellular Biology56 citations Open access
Semantic Scholar
Genome-length copies of poliovirion RNA are synthesized in vitro by the poliovirus RNA-dependent RNA polymerase.
T. A. van Dyke, R. Rickles, J. Flanegan
1982Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Analysis of histone gene expression during the cell cycle in HeLa cells by using cloned human histone genes.
R. Rickles, F. Marashi, F. Sierra, S. J. Clark +3 more
1982Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
Semantic Scholar
Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner.
F. Marashi, L. Baumbach, R. Rickles, F. Sierra +2 more
1982Science50 citations
Semantic Scholar
Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli.
R. J. Reece, R. Rickles, M. Ptashne
1993Gene48 citations
Semantic Scholar
Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption.
S. Violette, W. Guan, C. Bartlett, Jeremy Smith +18 more
2001Bone40 citations
Semantic Scholar
Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies.
R. Rickles, Laura T. Pierce, T. Giordano, Winnie F. Tam +6 more
2010Blood38 citations Open access
Semantic Scholar
Tissue plasminogen activator mRNA in murine tissues
R. Rickles, S. Strickland
1988FEBS Letters38 citations
Semantic Scholar
Maintenance and use of F9 teratocarcinoma cells.
A. Darrow, R. Rickles, S. Strickland
1990Methods in Enzymology32 citations
Semantic Scholar
Adenosine A2A and Beta-2 Adrenergic Receptor Agonists: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening
R. Rickles, Winnie F. Tam, T. Giordano, Laura T. Pierce +14 more
2012Molecular Cancer Therapeutics17 citations Open access
Semantic Scholar
Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse
B. Rajput, A. Marshall, A. M. Killary, P. Lalley +4 more
1987Somatic Cell Genetics17 citations Open access
Semantic Scholar
Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages
Anupama Reddy, J. Growney, Nick Wilson, Caroline M. Emery +17 more
2015PLoS ONE14 citations Open access
Semantic Scholar
High throughput in vitro combination sensitivity screen in hematologic malignancies with the phosphoinositide-3 kinase (PI3K)-{delta},{gamma} inhibitor, duvelisib.
K. Faia, Kerry F White, J. Proctor, Paula Andrade +9 more
201511 citations
Semantic Scholar
A novel mechanism-based mammalian cell assay for the identification of SH2-domain-specific protein-protein inhibitors.
R. Rickles, P. Henry, W. Guan, Mihai Dumitru Azimioara +3 more
1998Chemistry and Biology10 citations Open access
Semantic Scholar
Adenosine A 2 A receptor agonists and PDE inhibitors : a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies
R. Rickles, Laura T. Pierce, T. Giordano, Winnie F. Tam +6 more
20107 citations
Semantic Scholar
Anti-sense inhibition of tissue plasminogen activator production in differentiated F9 teratocarcinoma cells.
Lauren T. Pecorino, R. Rickles, Sidney Strickland
1988Developmental Biology7 citations
Semantic Scholar
Human histone genes are interspersed with members of the Alu family and with other transcribed sequences.
F. Sierra, A. Leza, F. Marashi, M. Plumb +6 more
1982Biochemical and Biophysical Research Communications - BBRC5 citations
Semantic Scholar
Identification of Combinatorial Drugs that Synergistically Kill both Eribulin-Sensitive and Eribulin- Insensitive Tumor Cells
R. Rickles, J. Matsui, Y. Funahashi, Janine L. Steiger +2 more
20154 citations
Semantic Scholar
ORGANIZATION AND CELL CYCLE REGULATION OF HUMAN HISTONE GENES *
G. Stein, J. Stein, L. Baumbach, A. Leza +6 more
1982Annals of the New York Academy of Sciences4 citations
Semantic Scholar
ATL313, A Potent, and Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma
R. Rickles, M. Padval, Thomas Giordanno, J. Rieger +1 more
20102 citations
Semantic Scholar
298 Identification of synergistic drugs using combination highthroughput screening (cHTS) and breadth of activity in diverse cancer cell networks
R. Rickles, W. Tam, G. F. Short, A. Myaskovsky +5 more
20102 citations
Semantic Scholar
Adenosine A2A and Beta-2 Adrenergic Receptor Agonism: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening
R. Rickles, Laura T. Pierce, T. Giordano, Winnie F. Tam +10 more
20082 citations
Semantic Scholar
Abstract 5509: Identification of synergistic drugs using combination high-throughput screening
R. Rickles, G. F. Short, Winnie F. Tam, T. Giordano +6 more
20101 citations
Semantic Scholar
A2A or Beta-2 Adrenergic Receptor Agonist Synergies Induce Distinct Patterns of Gene Expression Relevant to Multiple Myeloma Cell Survival.
Winnie F. Tam, R. Rickles, T. Giordano, A. Borisy +1 more
20091 citations
Semantic Scholar
Correction: Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages
Anupama Reddy, J. Growney, Nick Wilson, Caroline M. Emery +17 more
2016PLoS ONE0 citations Open access
Semantic Scholar
Abstract 4324: Predictive biomarker signatures for IAP inhibitor CUDC-427
K. Sun, Z. Tian, Qi Zhang, M. Samson +10 more
20150 citations
Semantic Scholar
511 ComboPredictor: identification of synergy biomarkers and enrichment within tumor sample populations
M. Tomilo, A. Bankhead, M. Urick, S. Eddy +3 more
20140 citations
Semantic Scholar
Abstract 4765: Drug synergies observed for antibody and toxin components of SAR3419 ADC contribute to overall conjugate efficacy and can be combination drug or tumor cell line dependent
R. Rickles, T. Giordano, S. Cotard, Jill M. Grenier +2 more
20140 citations
Semantic Scholar
Abstract 1698: Identification of drugs with eribulin combinatorial activity that kill both eribulin-sensitive and eribulin-insensitive tumor cells
T. Uenaka, R. Rickles, Y. Funahashi, P. Zhu +6 more
20140 citations
Semantic Scholar
Abstract 2215: Pharmacogenomic investigation of Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (PCI-32765): drug sensitivity in diffuse large B-cell lymphoma (DLBCL) within a tumor microenvironment-aligned high-throughput screen.
C. Davis, T. Casneuf, Willem Lightenberg, R. Rickles +7 more
20130 citations
Semantic Scholar
Therapeutic Discovery Adenosine A 2 A and Beta-2 Adrenergic Receptor Agonists : Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening
R. Rickles, Winnie F. Tam, T. Giordano, Laura T. Pierce +14 more
20120 citations
Semantic Scholar
Adenosine A2A and Beta-2 Adrenergic Receptor Agonist Synergy in B-Cell Malignancies: Selectivity, Breadth of Activity and Effects of Chronic Exposure.
R. Rickles, Winnie F. Tam, Antoaneta S. Necheva, T. Giordano +2 more
20090 citations
Semantic Scholar
Adenosine A2A Receptor Agonism and PDE Inhibition: A Synergistic Multi-Target Mechanism Discovered through Systematic Combination Screening in Multiple Myeloma
R. Rickles, Laura T. Pierce, T. Giordano, Winnie F. Tam +4 more
20080 citations
Semantic Scholar
Synergistic Activity of Adenosine A2A and Beta-2 Adrenergic Receptor Agonists in Myeloma Cells in the Context of Tumor-Stromal Interactions
Douglas W. McMillin, R. Rickles, J. Negri, Jake E. Delmore +9 more
20080 citations
Semantic Scholar
Preclinical Evaluation of CRx-501, a Potent Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma
R. Rickles, Laura T. Pierce, T. Giordano, W. Avery +9 more
20080 citations
Semantic Scholar
Multi-dimensional chemical genetics for oncology drug discovery
Margaret S. Lee, R. Rickles, G. F. Short, L. Johansen +2 more
20070 citations
Semantic Scholar
Bobrove activation Mononuclear cell tissue factor : cell of origin and requirements for
Frédérick, R. Rickles
20050 citations
Semantic Scholar
C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP12
Su Feng, K. Chiyoshi, R. Rickles, S. Schreiber
19960 citations
Semantic Scholar
The use of antisense and chimeric RNA injection to study translational regulation of mRNA in mouse oocytes
J. Huarte, D. Belin, A. Vassalli, P. Gubler +5 more
19890 citations
Semantic Scholar

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