J. Lees

Most-cited papers

Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Jatin Roper, T. Tammela, N. Cetinbas, Adam Akkad +30 more
2017Nature Biotechnology1,849 citations Open access
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Transcription: Sibling rivalry in the E2F family
J. Trimarchi, J. Lees
2002Nature reviews. Molecular cell biology1,280 citations
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Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers.
G. Mutter, Ming-Chieh Lin, J. Fitzgerald, J. Kum +4 more
2000Journal of the National Cancer Institute863 citations
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p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
H. Reinhardt, A. Aslanian, J. Lees, M. Yaffe
2007Cancer Cell630 citations Open access
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Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish
A. Amsterdam, K. Sadler, K. Lai, S. Farrington +3 more
2004PLoS Biology451 citations Open access
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Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast.
A. Perren, L. Weng, A. Boag, U. Ziebold +7 more
1999American Journal of Pathology399 citations Open access
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E2f3 is critical for normal cellular proliferation.
P. Humbert, R. Verona, J. Trimarchi, Catherine Rogers +2 more
2000Genes & Development360 citations Open access
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Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors.
O. Gimm, A. Perren, L. Weng, D. J. Marsh +11 more
2000American Journal of Pathology351 citations Open access
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Single molecule transcript counting of stem cell markers in the mouse intestine
S. Itzkovitz, A. Lyubimova, Irene C. Blat, M. Maynard +5 more
2011Nature Cell Biology348 citations Open access
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E2Fs regulate adipocyte differentiation.
L. Fajas, R. Landsberg, Yolande Huss-Garcia, C. Sardet +2 more
2002Developmental Cell339 citations Open access
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Life and death decisions by the E2F transcription factors.
Phillip J. Iaquinta, J. Lees
2007Current Opinion in Cell Biology322 citations Open access
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Rb regulates fate choice and lineage commitment in vivo
Eliezer Calo, J. A. Quintero-Estades, P. Danielian, Simona Nedelcu +2 more
2010Nature320 citations Open access
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In vivo genome editing and organoid transplantation models of colorectal cancer
Jatin Roper, T. Tammela, N. Cetinbas, Adam Akkad +30 more
2017Nature Biotechnology303 citations Open access
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Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation.
J. Brugarolas, Ken Moberg, S. D. Boyd, Y. Taya +2 more
1999Proceedings of the National Academy of Sciences of the United States of America296 citations Open access
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The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.
J. Trimarchi, B. Fairchild, Jessica H. Wen, J. Lees
2001Proceedings of the National Academy of Sciences of the United States of America292 citations Open access
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PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.
L. Weng, W. M. Smith, P. Dahia, U. Ziebold +3 more
1999Cancer Research283 citations
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Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells.
A. Perren, P. Komminoth, P. Saremaslani, C. Matter +4 more
2000American Journal of Pathology282 citations Open access
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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
Seth D. Berman, Eliezer Calo, Allison S. Landman, P. Danielian +8 more
2008Proceedings of the National Academy of Sciences of the United States of America276 citations Open access
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E2F-6, a member of the E2F family that can behave as a transcriptional repressor.
J. Trimarchi, B. Fairchild, R. Verona, K. Moberg +2 more
1998Proceedings of the National Academy of Sciences of the United States of America250 citations Open access
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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos.
U. Ziebold, Tammi L. Reza, A. Caron, J. Lees
2001Genes & Development235 citations Open access
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E2F4 is essential for normal erythrocyte maturation and neonatal viability.
Patrick O. Humbert, Catherine Rogers, Soula Ganiatsas, R. Landsberg +7 more
2000Molecules and Cells229 citations Open access
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Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics.
A. Aslanian, Phillip J. Iaquinta, R. Verona, J. Lees
2004Genes & Development208 citations Open access
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Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
Christian J. Braun, M. Stanciu, Paul L. Boutz, J. C. Patterson +11 more
2017Cancer Cell205 citations Open access
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Emerging Mechanisms by which EMT Programs Control Stemness.
Molly M Wilson, R. Weinberg, J. Lees, Vincent J Guen
2020Trends in Cancer176 citations Open access
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Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion
J. Dovey, S. Zacharek, Carla F. Kim, J. Lees
2008Proceedings of the National Academy of Sciences of the United States of America176 citations Open access
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DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.
Christopher L Sansam, J. Shepard, K. Lai, A. Ianari +4 more
2006Genes & Development171 citations Open access
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Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.
E. Gil, E. M. Link, L.-X. Liu, C. Johnson +1 more
1999Proceedings of the National Academy of Sciences of the United States of America157 citations Open access
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E2F4 loss suppresses tumorigenesis in Rb mutant mice.
Eunice Lee, Hieu Cam, U. Ziebold, J. Rayman +2 more
2002Cancer Cell149 citations Open access
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Cell size is a determinant of stem cell potential during aging
Jette Lengefeld, Chia-Wei Cheng, Pema Maretich, Marguerite Blair +15 more
2020bioRxiv148 citations Open access
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Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations
A. W. MacInnes, A. Amsterdam, C. Whittaker, N. Hopkins +1 more
2008Proceedings of the National Academy of Sciences of the United States of America141 citations Open access
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Pro-apoptotic function of the retinoblastoma tumor suppressor protein
A. Ianari, Tiziana Natale, Eliezer Calo, E. Ferretti +5 more
2009Cancer Cell140 citations Open access
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A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.
Christopher L Sansam, N. Cruz, P. Danielian, A. Amsterdam +3 more
2010Genes & Development132 citations Open access
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E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner
S. Gaubatz, J. Lees, G. Lindeman, D. Livingston
2001Molecular and Cellular Biology129 citations Open access
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EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling
Vincent J Guen, Tony E. Chavarria, Cornelia Kröger, Xin Ye +2 more
2017Proceedings of the National Academy of Sciences of the United States of America128 citations Open access
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The retinoblastoma protein induces apoptosis directly at the mitochondria.
Keren I. Hilgendorf, Elizaveta S. Leshchiner, Simona Nedelcu, M. Maynard +4 more
2013Genes & Development128 citations Open access
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Minor changes in expression of the mismatch repair protein MSH2 exert a major impact on glioblastoma response to temozolomide
J. McFaline-Figueroa, Christian J. Braun, M. Stanciu, Z. Nagel +11 more
2015Cancer Research116 citations Open access
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Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis
Yun Zhang, Joana Liu Donaher, Sunny Das, Xin Li +17 more
2022Nature Cell Biology115 citations Open access
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Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo
Jennifer E. Cloud, Catherine Rogers, T. Reza, U. Ziebold +5 more
2002Molecular and Cellular Biology108 citations Open access
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E2F3 Loss Has Opposing Effects on Different pRB-Deficient Tumors, Resulting in Suppression of Pituitary Tumors but Metastasis of Medullary Thyroid Carcinomas
U. Ziebold, Eunice Lee, R. Bronson, J. Lees
2003Molecular and Cellular Biology106 citations Open access
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Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.
T. Baudino, K. Maclean, Jennifer A. Brennan, E. Parganas +6 more
2003Molecules and Cells104 citations Open access
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Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
Jianfang Ning, M. Stanciu, Melissa R. Humphrey, J. Gorham +7 more
2019Nature Communications103 citations Open access
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Many Ribosomal Protein Mutations Are Associated With Growth Impairment and Tumor Predisposition in Zebrafish
K. Lai, A. Amsterdam, S. Farrington, R. Bronson +2 more
2009Developmental Dynamics88 citations Open access
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Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
Brandon Nicolay, P. Danielian, F. Kottakis, John D. Lapek +12 more
2015Genes & Development87 citations Open access
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Expression of the PTEN tumour suppressor protein during human development.
O. Gimm, T. Attié-Bitach, J. Lees, M. Vekemans +1 more
2000Human Molecular Genetics86 citations Open access
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E2f4 is required for normal development of the airway epithelium.
P. Danielian, Carla F. Bender Kim, A. Caron, E. Vasile +2 more
2007Developmental Biology79 citations Open access
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The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development
Seth D. Berman, Tina Yuan, Emily S. Miller, Eunice Lee +2 more
2008Molecular Cancer Research77 citations Open access
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Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER1
Arvind Ravi, A. Gurtan, Madhu S. Kumar, A. Bhutkar +5 more
2012Cancer Cell71 citations Open access
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Cell Cycle Genes Are the Evolutionarily Conserved Targets of the E2F4 Transcription Factor
Caitlin M. Conboy, C. Spyrou, Natalie Thorne, E. Wade +7 more
2007PLoS ONE67 citations Open access
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The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity
R. Landsberg, Julia E. Sero, P. Danielian, Tina Yuan +2 more
2003Proceedings of the National Academy of Sciences of the United States of America60 citations Open access
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E2f4 and E2f5 are essential for the development of the male reproductive system
P. Danielian, R. Hess, J. Lees
2016Cell Cycle58 citations Open access
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