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Brandon Nicolay · SciRah

Researcher profile · Semantic Scholar

Brandon Nicolay

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Brandon Nicolay — researcher profile on SciRah

h-index: 24
Works: 57
Citations: 3,091

Most-cited papers

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
L. Bunse, S. Pusch, T. Bunse, F. Sahm +52 more
2018Nature Medicine493 citations
Semantic Scholar
LKB1 loss links serine metabolism to DNA methylation and tumourigenesis
F. Kottakis, Brandon Nicolay, Ahlima Roumane, R. Karnik +15 more
2016Nature314 citations Open access
Semantic Scholar
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
Edouard Mullarky, N. Lucki, Reza Beheshti Zavareh, J. Anglin +14 more
2016Proceedings of the National Academy of Sciences of the United States of America303 citations Open access
Semantic Scholar
Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML.
S. Choe, Hongfang Wang, C. Dinardo, E. Stein +25 more
2020Blood Advances190 citations Open access
Semantic Scholar
Transcriptional control of the autophagy-lysosome system in pancreatic cancer
R. Perera, S. Stoykova, Brandon Nicolay, K. Ross +13 more
2015Nature180 citations Open access
Semantic Scholar
Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
Z. Konteatis, Erin Artin, Brandon Nicolay, Kimberly S. Straley +24 more
2020ACS Medicinal Chemistry Letters175 citations Open access
Semantic Scholar
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.
Pierre-Damien Denechaud, Isabel C. Lopez-Mejia, A. Giralt, Qiuwen Lai +8 more
2016Journal of Clinical Investigation125 citations Open access
Semantic Scholar
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
L. Stuani, Marie Sabatier, E. Saland, Guillaume Cognet +49 more
2021Journal of Experimental Medicine120 citations Open access
Semantic Scholar
Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
Meng-Ju Wu, Lei Shi, J. Dubrot, J. Merritt +29 more
2021Cancer Discovery117 citations Open access
Semantic Scholar
CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers
A. Heilmann, R. Perera, Veronika Ecker, Brandon Nicolay +3 more
2014Cancer Research113 citations Open access
Semantic Scholar
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
Z. Konteatis, J. Travins, S. Gross, Katya Marjon +23 more
2021Journal of Medicinal Chemistry95 citations Open access
Semantic Scholar
Loss of RBF1 changes glutamine catabolism.
Brandon Nicolay, P. Gameiro, Katrin Tschop, M. Korenjak +5 more
2013Genes & Development94 citations Open access
Semantic Scholar
Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion
Amity L. Manning, S. Yazinski, Brandon Nicolay, Alysia R. Bryll +2 more
2014Molecules and Cells88 citations Open access
Semantic Scholar
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
Brandon Nicolay, P. Danielian, F. Kottakis, John D. Lapek +12 more
2015Genes & Development87 citations Open access
Semantic Scholar
The multiple connections between pRB and cell metabolism
Brandon Nicolay, N. Dyson
2013Current Opinion in Cell Biology80 citations Open access
Semantic Scholar
Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit.
Brandon Nicolay, Battuya Bayarmagnai, A. Islam, N. López-Bigas +1 more
2011Genes & Development55 citations Open access
Semantic Scholar
Combined Inactivation of pRB and Hippo Pathways Induces Dedifferentiation in the Drosophila Retina
Brandon Nicolay, Battuya Bayarmagnai, Nam-Sung Moon, Elizaveta V. Benevolenskaya +1 more
2010PLoS Genetics48 citations Open access
Semantic Scholar
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy
Barbara S Nelson, Lin Lin, Daniel M. Kremer, Cristovao Sousa +22 more
2019Cancer & Metabolism42 citations Open access
Semantic Scholar
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma
P. Chuntova, A. Yamamichi, Tiffany Chen, R. Narayanaswamy +12 more
2022Journal for ImmunoTherapy of Cancer31 citations Open access
Semantic Scholar
Drosophila GAGA factor is required for full activation of the dE2f1-Yki/Sd transcriptional program
Battuya Bayarmagnai, Brandon Nicolay, A. Islam, N. López-Bigas +1 more
2012Cell Cycle30 citations Open access
Semantic Scholar
A phase I, open label, perioperative study of AG-120 and AG-881 in recurrent IDH1 mutant, low-grade glioma: Results from cohort 1.
I. Mellinghoff, T. Cloughesy, P. Wen, Jennie W. Taylor +16 more
2019Journal of Clinical Oncology26 citations
Semantic Scholar
Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells
Emily Gruber, J. So, Alexander C. Lewis, Rheana L Franich +17 more
2022bioRxiv25 citations Open access
Semantic Scholar
Context-Dependent Requirement for dE2F during Oncogenic Proliferation
Brandon Nicolay, M. Frolov
2008PLoS Genetics25 citations Open access
Semantic Scholar
Combination of Enasidenib and Venetoclax Shows Superior Anti-Leukemic Activity Against IDH2 Mutated AML in Patient-Derived Xenograft Models
S. Cathelin, D. Sharon, Amit Subedi, Dan Cojocari +8 more
2018Blood24 citations Open access
Semantic Scholar
Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia
S. Cathelin, D. Sharon, Amit Subedi, Dan Cojocari +8 more
2021Leukemia23 citations
Semantic Scholar
EXTH-59. THE IDH1 MUTANT INHIBITOR AG-120 SHOWS STRONG INHIBITION OF 2-HG PRODUCTION IN AN ORTHOTOPIC IDH1 MUTANT GLIOMA MODEL IN VIVO
Brandon Nicolay, R. Narayanaswamy, E. Aguado, R. Nagaraja +3 more
201722 citations Open access
Semantic Scholar
dE2F2-Independent Rescue of Proliferation in Cells Lacking an Activator dE2F1
A. Ambrus, Brandon Nicolay, V. Rasheva, R. Suckling +1 more
2007Molecular and Cellular Biology22 citations Open access
Semantic Scholar
Discovery of M-1121 as an orally active covalent inhibitor of menin-MLL interaction capable of achieving complete and long-lasting tumor regression
Meng Zhang, A. Aguilar, Shilin Xu, Li-Yue Huang +15 more
2021Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
ACTR-66. A PHASE 1, OPEN-LABEL, PERIOPERATIVE STUDY OF IVOSIDENIB (AG-120) AND VORASIDENIB (AG-881) IN RECURRENT IDH1 MUTANT, LOW-GRADE GLIOMA: UPDATED RESULTS
I. Mellinghoff, T. Cloughesy, P. Wen, Jennie W. Taylor +17 more
2019Neuro-Oncology18 citations Open access
Semantic Scholar
Mosaic Genetic Screen for Suppressors of the de2f1 Mutant Phenotype in Drosophila
A. Ambrus, V. Rasheva, Brandon Nicolay, M. Frolov
2009Genetics16 citations Open access
Semantic Scholar
Abstract B126: AG-881, a brain penetrant, potent, pan-mutant IDH (mIDH) inhibitor for use in mIDH solid and hematologic malignancies
K. Yen, D. KonteatisZenon, Zhihua Sui, Erin Artin +16 more
201815 citations
Semantic Scholar
Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye
Sarah C. Nicholson, Brandon Nicolay, M. Frolov, K. Moberg
2011Development15 citations Open access
Semantic Scholar
Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival
T.-C. Hsieh, Brandon Nicolay, M. Frolov, Nam-Sung Moon
2010PLoS Genetics15 citations Open access
Semantic Scholar
EXTH-34. COMBINED USE OF THE PAN-IDH MUTANT INHIBITOR AG-881 WITH RADIATION THERAPY SHOWS ADDED BENEFIT IN AN ORTHOTOPIC IDH1 MUTANT GLIOMA MODEL IN VIVO
Brandon Nicolay, R. Narayanaswamy, Michael Amatangelo, E. Aguado +4 more
201713 citations Open access
Semantic Scholar
Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma
S. Sahoo, Ranjith Kumar Ravi Kumar, Brandon Nicolay, Omkar S Mohite +8 more
2018FEBS Letters11 citations Open access
Semantic Scholar
Metabolic analysis of the loss of Rb1 in vivo
Brandon Nicolay, P. Danielian, W. Haas, G. Stephanopoulos +2 more
2014Cancer & Metabolism10 citations Open access
Semantic Scholar
E2F/Dp inactivation in fat body cells triggers systemic metabolic changes
M. Zappia, A. Guarner, Nadia Kellie-Smith, A. Rogers +6 more
2021bioRxiv8 citations Open access
Semantic Scholar
RBTT-03. A PHASE 1, MULTICENTER, RANDOMIZED, OPEN-LABEL, PERIOPERATIVE STUDY OF AG-120 (IVOSIDENIB) AND AG-881 IN PATIENTS WITH RECURRENT, NONENHANCING, IDH1-MUTANT, LOW-GRADE GLIOMA
I. Mellinghoff, E. Maher, P. Wen, T. Cloughesy +18 more
2018Neuro-Oncology4 citations Open access
Semantic Scholar
Correction for Mullarky et al., Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
Edouard Mullarky, N. Lucki, R. B. Zavareh, J. Anglin +14 more
2016Proceedings of the National Academy of Sciences of the United States of America4 citations Open access
Semantic Scholar
Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
S. Rajasekaran, Jalal K. Siddiqui, Jessica B. Rakijas, Brandon Nicolay +16 more
2021Communications Biology3 citations Open access
Semantic Scholar
Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
F. Kottakis, Brandon Nicolay, Ahlima Roumane, R. Karnik +15 more
2019Nature2 citations Open access
Semantic Scholar
Abstract 1810: The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinoma
Meng-Ju Wu, Lei Shi, J. Dubrot, Christine C. Hudson +8 more
2020Experimental and Molecular Therapeutics1 citations
Semantic Scholar
Abstract 3607: Inhibition of mutant IDH enzymes reduces production of 2-HG but does not restore wild type IDH activityin vitroorin vivo
Katie Sellers, Taryn Sleger, Sébastien Ronseaux, R. Narayanaswamy +3 more
2019Molecular and Cellular Biology / Genetics1 citations
Semantic Scholar
Abstract 1339: Investigations into rational combination approaches with ivosidenib in a mutant IDH1 acute myeloid leukemia patient-derived xenograft model
Christine C. Hudson, R. Narayanaswamy, Sébastien Ronseaux, C. Bowden +1 more
2021Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Author Correction: Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
S. Rajasekaran, Jalal K. Siddiqui, Jessica B. Rakijas, Brandon Nicolay +16 more
2021Communications Biology0 citations Open access
Semantic Scholar
EXTH-15. INHIBITION OF 2-HG LEADS TO UPREGULATION OF A PRO-INFLAMMATORY GENE SIGNATURE IN A NOVEL HLA-A2/HLA-DR1 TRANSGENIC MOUSE MODEL OF IDH1R132H-EXPRESSING GLIOMA
Polly Chuntova, Brandon Nicolay, Christine C. Hudson, R. Narayanaswamy +4 more
20200 citations Open access
Semantic Scholar
2031 - DELINEATING MECHANISMS OF ACQUIRED RESISTANCE TO IDH INHIBITORS IN AML
L. Kats, Emily Gruber, R. Narayanaswamy, Sébastien Ronseaux +2 more
2019Experimental Hematology0 citations Open access
Semantic Scholar
Combinatory therapy targeting mitochondrial oxidative phosphorylation improves efficacy of IDH mutant inhibitors in acute myeloid leukemia
L. Stuani, Marie Sabatier, Feng Wang, N. Poupin +51 more
2019bioRxiv0 citations Open access
Semantic Scholar
IDH Inhibitors for the Treatment of IDH-Mutated Cancer
L. Dang, Brandon Nicolay, Zenon Konteatis
20190 citations
Semantic Scholar
Abstract 3510: IDH1-R132H tumor cells are not robustly sensitive to PARP inhibition in a 2-HG dependent manner
E. Aguado-Fraile, Christine C. Hudson, Taryn Sleger, Sébastien Ronseaux +5 more
2019Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar

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