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L. Hazlehurst · SciRah

Researcher profile · Semantic Scholar

L. Hazlehurst

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L. Hazlehurst — researcher profile on SciRah

h-index: 38
Works: 121
Citations: 5,337

Most-cited papers

The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance
M. Meads, L. Hazlehurst, W. Dalton
2008Clinical Cancer Research526 citations Open access
Semantic Scholar
β1 integrin adhesion enhances IL-6 mediated STAT3 signaling in Myeloma cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation
K. Shain, D. Yarde, M. Meads, Mei-Juan Huang +3 more
2009Cancer Research200 citations Open access
Semantic Scholar
Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
N. Bewry, R. Nair, Michael F. Emmons, D. Boulware +2 more
2008Molecular Cancer Therapeutics158 citations Open access
Semantic Scholar
Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas.
T. Lwin, L. Hazlehurst, S. Dessureault, R. Lai +5 more
2006Blood115 citations Open access
Semantic Scholar
Proteomic Contributions to Personalized Cancer Care*
J. Koomen, E. Haura, G. Bepler, R. Sutphen +10 more
2008Molecular & Cellular Proteomics110 citations Open access
Semantic Scholar
The bone marrow microenvironment as a sanctuary for minimal residual disease in CML
R. Nair, J. H. Tolentino, L. Hazlehurst
2010Biochemical Pharmacology94 citations Open access
Semantic Scholar
β1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells
L. Hazlehurst, Raul F. Argilagos, W. Dalton
2007British Journal of Haematology86 citations
Semantic Scholar
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases
E. Schönbrunn, S. Betzi, Riazul Alam, Mathew P. Martin +12 more
2013Journal of Medicinal Chemistry83 citations Open access
Semantic Scholar
Human Multiple Myeloma Cells Are Sensitized to Topoisomerase II Inhibitors by CRM1 Inhibition
J. Turner, D. Marchion, J. Dawson, Michael F. Emmons +3 more
2009Cancer Research79 citations Open access
Semantic Scholar
Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-κB (RelB/p52) in non-Hodgkin's lymphoma cells
T. Lwin, L. Hazlehurst, Z. Li, S. Dessureault +4 more
2007Leukemia76 citations Open access
Semantic Scholar
Experimental Therapeutics , Molecular Targets , and Chemical Biology Targeting the Fanconi Anemia / BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma
D. Yarde, Vasco Oliveira, L. Mathews, Xing-Yu Wang +8 more
200975 citations
Semantic Scholar
The Role of TRPC1 in Modulating Cancer Progression
Osama M Elzamzamy, R. Penner, L. Hazlehurst
2020Cells64 citations Open access
Semantic Scholar
CRM1 Inhibition Sensitizes Drug Resistant Human Myeloma Cells to Topoisomerase II and Proteasome Inhibitors both In Vitro and Ex Vivo
J. Turner, J. Dawson, Michael F. Emmons, C. Cubitt +4 more
2013Journal of Cancer64 citations Open access
Semantic Scholar
Signaling networks associated with BCR-ABL-dependent transformation.
L. Hazlehurst, N. Bewry, R. Nair, J. Pinilla-Ibarz
2009Cancer Control: Journal of the Moffitt Cancer Cente63 citations Open access
Semantic Scholar
A Database of Reaction Monitoring Mass Spectrometry Assays for Elucidating Therapeutic Response in Cancer
Elizabeth R. Remily-Wood, Richard Z. Liu, Y. Xiang, Yi Chen +18 more
2011PROTEOMICS - Clinical Applications56 citations Open access
Semantic Scholar
Role of STAT3 in Transformation and Drug Resistance in CML
R. Nair, J. H. Tolentino, L. Hazlehurst
2012Frontiers in Oncology53 citations Open access
Semantic Scholar
Integrated Systems and Technologies: Mathematical Oncology APreclinical Assay for Chemosensitivity inMultiple Myeloma
Zayar P. Khin, M. Ribeiro, Timothy Jacobson, L. Hazlehurst +4 more
201349 citations
Semantic Scholar
A phase I clinical trial of ruxolitinib in combination with nilotinib in chronic myeloid leukemia patients with molecular evidence of disease
K. Sweet, L. Hazlehurst, Eva Sahakian, J. Powers +5 more
2018Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis48 citations Open access
Semantic Scholar
HYD1-induced increase in ROS leads to autophagy and necrotic cell death in multiple myeloma cells
R. Nair, Michael F. Emmons, A. Cress, Raul F. Argilagos +5 more
2009Molecular Cancer Therapeutics46 citations Open access
Semantic Scholar
Targeting PYK2 mediates microenvironment-specific cell death in multiple myeloma
M. Meads, B. Fang, L. Mathews, J. Gemmer +10 more
2015Oncogene43 citations Open access
Semantic Scholar
Potentiation of Nilotinib-mediated cell death in the context of the bone marrow microenvironment requires a promiscuous JAK inhibitor in CML
R. Nair, J. H. Tolentino, Raul F. Argilagos, Ling Zhang +2 more
2011Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis43 citations Open access
Semantic Scholar
Chloroquine reduces neutrophil extracellular trap (NET) formation through inhibition of peptidyl arginine deiminase 4 (PAD4).
Abby D. Ivey, B. M. Fagan, P. Murthy, M. Lotze +4 more
2023Clinical and Experimental Immunology42 citations Open access
Semantic Scholar
Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 a strategy for treatment of multiple myeloma
K. Hayes, Paratchata Batsomboon, Wei-Chi Chen, Brennan D. Johnson +7 more
2019Bioorganic & Medicinal Chemistry42 citations Open access
Semantic Scholar
Tipifarnib-Induced Apoptosis in Acute Myeloid Leukemia and Multiple Myeloma Cells Depends on Ca2+ Influx through Plasma Membrane Ca2+ Channels
N. Yanamandra, Robert W Buzzeo, Mark Gabriel, L. Hazlehurst +3 more
2011Journal of Pharmacology and Experimental Therapeutics42 citations Open access
Semantic Scholar
Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy
Christina A. von Roemeling, T. Caulfield, L. Marlow, Ilah Bok +10 more
2017OncoTarget41 citations Open access
Semantic Scholar
Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB/p52) in non-Hodgkin's lymphoma cells.
T. Lwin, L. Hazlehurst, Z. Li, S. Dessureault +4 more
2007Leukemia38 citations
Semantic Scholar
Dissecting the Multiple Myeloma-bone microenvironment reveals new therapeutic opportunities
G. Shay, L. Hazlehurst, C. Lynch
2015Journal of molecular medicine37 citations Open access
Semantic Scholar
Stable and potent selenomab-drug conjugates
Xiu-Ling Li, C. Nelson, R. R. Nair, L. Hazlehurst +6 more
2017Cell Chemical Biology35 citations Open access
Semantic Scholar
Role of Calcium Homeostasis in Modulating EMT in Cancer
Clark A. Jones, L. Hazlehurst
2021Biomedicines34 citations Open access
Semantic Scholar
Monitoring a Nuclear Factor-κB Signature of Drug Resistance in Multiple Myeloma*
Y. Xiang, Elizabeth R. Remily-Wood, Vasco Oliveira, D. Yarde +12 more
2011Molecular & Cellular Proteomics33 citations Open access
Semantic Scholar
Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand
W. Geldenhuys, T. Long, P. Saralkar, T. Iwasaki +8 more
2019Communications Chemistry29 citations Open access
Semantic Scholar
Acquisition of resistance towards HYD1 correlates with a reduction in cleaved alpha 4 integrin expression and a compromised CAM-DR phenotype
Michael F. Emmons, Anthony W. Gebhard, R. Nair, R. Baz +3 more
2011Molecular Cancer Therapeutics28 citations Open access
Semantic Scholar
MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma
Anthony W. Gebhard, Priyesh Jain, R. Nair, Michael F. Emmons +4 more
2013Molecular Cancer Therapeutics25 citations Open access
Semantic Scholar
Topoisomerase II beta levels are a determinant of melphalan-induced DNA crosslinks and sensitivity to cell death.
Michael F. Emmons, David R. Boulware, D. Sullivan, L. Hazlehurst
2006Biochemical Pharmacology24 citations
Semantic Scholar
Contribution of the bone marrow stromal cells in mediating drug resistance in hematopoietic tumors
Wei-Chi Chen, Gang-Qing Hu, L. Hazlehurst
2020Current opinion in pharmacology (Print)23 citations Open access
Semantic Scholar
The Role of ERO1α in Modulating Cancer Progression and Immune Escape
Brennan D. Johnson, W. Geldenhuys, L. Hazlehurst
2020Journal of cancer immunology21 citations Open access
Semantic Scholar
Bone Marrow Stroma-Induced Transcriptome and Regulome Signatures of Multiple Myeloma
S. Dziadowicz, Lei Wang, Halima Akhter, Drake Aesoph +4 more
2022Cancers19 citations Open access
Semantic Scholar
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment
G. Shay, M. Tauro, F. Loiodice, P. Tortorella +3 more
2017OncoTarget17 citations Open access
Semantic Scholar
MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma
Michael F. Emmons, Nagaraju Anreddy, J. Cuevas, Kayla J. Steinberger +4 more
2017Scientific Reports15 citations Open access
Semantic Scholar
Emerging strategies for targeting cell adhesion in multiple myeloma.
R. Nair, Anthony W. Gebhard, Michael F. Emmons, L. Hazlehurst
2012Advances in Pharmacology14 citations
Semantic Scholar
Identification of Natural Product Sulfuretin Derivatives as Inhibitors for the Endoplasmic Reticulum Redox Protein ERO1α
Brennan D. Johnson, S. R. Kaulagari, Wei-Chi Chen, Karen Hayes +2 more
2022ACS Bio & Med Chem Au13 citations Open access
Semantic Scholar
Emerging combination therapies for the management of multiple myeloma: the role of elotuzumab
Wei-Chi Chen, A. Kanate, M. Craig, W. Petros +1 more
2017Cancer Management and Research13 citations Open access
Semantic Scholar
A Virtual Screening Platform Identifies Chloroethylagelastatin A as a Potential Ribosomal Inhibitor
T. Caulfield, K. Hayes, Yu-Shi Qiu, Matt Coban +6 more
2020Biomolecules11 citations Open access
Semantic Scholar
The one-two punch: combination treatment in chronic myeloid leukemia.
K. Sweet, L. Hazlehurst, J. Pinilla-Ibarz
2013Critical reviews in oncology/hematology10 citations
Semantic Scholar
Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma
Osama M Elzamzamy, Brandon E. Johnson, Wei-Chi Chen, Gang-Qing Hu +2 more
2021Cells7 citations Open access
Semantic Scholar
Comprehensive characterization of mesothelin expression in colorectal cancer.
Midhun Malla, S. Deshmukh, Sharon Wu, J. Xiu +8 more
2023Journal of Clinical Oncology6 citations
Semantic Scholar
A Phase I Study of Ruxolitinib Plus Nilotinib in Chronic Phase CML Patients with Molecular Evidence of Disease
K. Sweet, L. Hazlehurst, Eva Sahakian, J. Powers +5 more
20164 citations
Semantic Scholar
Development of a fluorescence screening assay for binding partners of the iron-sulfur mitochondrial protein mitoNEET
Ebenezer Newton, Sarah A. Starcovic, Michael A. Menze, M. Konkle +5 more
2023Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
High-content screen using Zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor
W. Geldenhuys, S. A. Bergeron, Jackie E Mullins, Rowaa Aljammal +4 more
2017Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Detection of DNA damage induced by topoisomerase II inhibitors, gamma radiation and crosslinking agents using the comet assay.
L. Hazlehurst
2009Methods in molecular biology3 citations
Semantic Scholar

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R. Nair×10
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R. Nair — researcher profile on SciRah
Michael F. Emmons×9
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Michael F. Emmons — researcher profile on SciRah
W. Dalton×8
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W. Dalton — researcher profile on SciRah
J. Pinilla-Ibarz×7
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W. Geldenhuys — researcher profile on SciRah

Wei-Chi Chen×6

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Wei-Chi Chen — researcher profile on SciRah

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K. Shain — researcher profile on SciRah

Raul F. Argilagos×4

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Raul F. Argilagos — researcher profile on SciRah

Anthony W. Gebhard×4

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Anthony W. Gebhard — researcher profile on SciRah

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M. Meads — researcher profile on SciRah

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D. Yarde — researcher profile on SciRah