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S. Betzi · SciRah

Researcher profile · Semantic Scholar

S. Betzi

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S. Betzi — researcher profile on SciRah

h-index: 24
Works: 129
Citations: 1,869

Most-cited papers

Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes
M. Bouvet, A. Lugari, C. Posthuma, Jessika C. Zevenhoven +11 more
2014Journal of Biological Chemistry192 citations Open access
Semantic Scholar
2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions
M. Basse, S. Betzi, Raphaël Bourgeas, S. Bouzidi +4 more
2012Nucleic Acids Res.141 citations Open access
Semantic Scholar
A novel approach to the discovery of small molecule ligands of CDK2
Mathew P. Martin, Riazul Alam, S. Betzi, D. Ingles +2 more
2012ChemBioChem90 citations Open access
Semantic Scholar
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases
E. Schönbrunn, S. Betzi, Riazul Alam, Mathew P. Martin +12 more
2013Journal of Medicinal Chemistry83 citations Open access
Semantic Scholar
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.
B. Raux, Yuliia V Voitovich, C. Derviaux, A. Lugari +14 more
2016Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions
M. Basse, S. Betzi, X. Morelli, P. Roche
2016Database J. Biol. Databases Curation74 citations Open access
Semantic Scholar
Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.
L. Hoffer, Yuliia V Voitovich, B. Raux, Kendall Carrasco +11 more
2018Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)*
Jin-Yi Zhu, Yan Yang, Huijong Han, S. Betzi +3 more
2012Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo
R. Leblanc, R. Kashyap, K. Barral, A. L. Egea-Jimenez +11 more
2020Journal of Extracellular Vesicles52 citations Open access
Semantic Scholar
Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions
J. Bonzi, O. Bornet, S. Betzi, B. Kasper +6 more
2015Nature Communications50 citations Open access
Semantic Scholar
Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining
Davide Normanno, Aurélie Négrel, A. J. de Melo, S. Betzi +2 more
2017eLife37 citations Open access
Semantic Scholar
Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis
A. Cartier-Michaud, Anne-Laure Bailly, S. Betzi, Xiao-Li Shi +16 more
2017PLoS Genetics35 citations Open access
Semantic Scholar
Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.
Sabine Milhas, B. Raux, S. Betzi, C. Derviaux +22 more
2016ACS Chemical Biology32 citations Open access
Semantic Scholar
Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.
Xu Zhang, S. Betzi, X. Morelli, P. Roche
2014Future Medicinal Chemistry32 citations
Semantic Scholar
Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer
Melissa Birol, R. Enchev, A. Padilla, F. Stengel +7 more
2014PLoS ONE30 citations Open access
Semantic Scholar
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
J. Ariey-Bonnet, Kendall Carrasco, M. Le Grand, L. Hoffer +8 more
2020bioRxiv28 citations Open access
Semantic Scholar
Crystal Structure of the Vaccinia Virus DNA Polymerase Holoenzyme Subunit D4 in Complex with the A20 N-Terminal Domain
Céline Contesto-Richefeu, N. Tarbouriech, X. Brazzolotto, S. Betzi +3 more
2014PLoS Pathogens28 citations Open access
Semantic Scholar
Prevalence, Specificity and Determinants of Lipid-Interacting PDZ Domains from an In-Cell Screen and In Vitro Binding Experiments
Y. Ivarsson, A. Wawrzyniak, R. Kashyap, J. Polanowska +9 more
2013PLoS ONE24 citations Open access
Semantic Scholar
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
K. Hammam, M. Saez-Ayala, E. Rebuffet, L. Gros +15 more
2017Nature Communications19 citations Open access
Semantic Scholar
Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex
Y. Cherrak, I. Filella-Merce, V. Schmidt, D. Byrne +7 more
2021mBio14 citations Open access
Semantic Scholar
Stability of the Human Hsp90-p50Cdc37 Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2
S. Olesen, D. Ingles, Jin-Yi Zhu, Mathew P. Martin +4 more
2015Molecules14 citations Open access
Semantic Scholar
Stereoselective synthesis of original spirolactams displaying promising folded structures.
Guilhem Chaubet, T. Coursindel, X. Morelli, S. Betzi +7 more
2013Organic and biomolecular chemistry14 citations
Semantic Scholar
From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia
M. Saez-Ayala, L. Hoffer, Sébastien Abel, Khaoula Ben Yaala +18 more
2023Nature Communications11 citations Open access
Semantic Scholar
Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
L. Hoffer, Manon Garcia, R. Leblanc, M. Feracci +7 more
2023Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Revisiting the Molecular Interactions between the Tumor Protein TCTP and the Drugs Sertraline/Thioridazine
F. Malard, E. Jacquet, N. Nhiri, C. Sizun +7 more
2021ChemMedChem10 citations Open access
Semantic Scholar
Structural recognition mechanisms between human Src Homology domain 3 (SH3) and ALG-2-Interacting protein X (Alix)
Xiao-Li Shi, S. Betzi, A. Lugari, Sandrine Opi +9 more
2012FEBS Letters10 citations Open access
Semantic Scholar
ChemoDOTS: a web server to design chemistry-driven focused libraries
L. Hoffer, Guillaume Charifi-Hoareau, S. Barelier, S. Betzi +3 more
2024Nucleic Acids Research6 citations Open access
Semantic Scholar
CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation
Kendall Carrasco, C. Montersino, C. Derviaux, M. Saez-Ayala +10 more
2021bioRxiv6 citations Open access
Semantic Scholar
PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2.
Marta Montserrat-Gomez, G. Gógl, Kendall Carrasco, S. Betzi +11 more
2023Biochimica et Biophysica Acta - Proteins and Proteomics5 citations Open access
Semantic Scholar
Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island
Julien Piron, S. Betzi, Jessica Pastour, A. Restouin +5 more
2022PeerJ5 citations Open access
Semantic Scholar
CRL2FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer.
Bashir Ahmed, D. Salaun, J. Jordan, Avais M. Daulat +17 more
2026Molecules and Cells3 citations
Semantic Scholar
4’-Ethynyl-2’-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
Marissa L. Calbert, Gurushankar Chandramouly, Clare I. M. Adams, M. Saez-Ayala +24 more
2023Molecular Cancer Therapeutics1 citations Open access
Semantic Scholar
Discovery of small molecule inhibitors of the PTK7/β-catenin inter-action targeting the Wnt signaling pathway in colorectal cancer
Laetitia Ganier, S. Betzi, C. Derviaux, P. Roche +5 more
2021bioRxiv1 citations Open access
Semantic Scholar
CDK2 in complex with inhibitor RC-1-148
S. Betzi, R. Alam, H. Han, A. Becker +1 more
20121 citations
Semantic Scholar
CDK2 in complex with inhibitor L3-3
S. Betzi, R. Alam, H. Han, A. Becker +1 more
20121 citations
Semantic Scholar
Abstract 2425: Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design
M. Storder, F. Cordier, S. Barelier, K. Barral +10 more
2026Cancer Research0 citations
Semantic Scholar
Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design
M. Storder, S. Barelier, F. Cordier, T. Yacoub +14 more
2025bioRxiv0 citations Open access
Semantic Scholar
P–509 Patients’ Uses and Experiences of Medically-Assisted Reproduction in France in 2020
N. Paton, S. Betzi, G. Buisson, V. Rio +1 more
2021Human Reproduction0 citations
Semantic Scholar
FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR #17
B. Raux, S. Betzi
20180 citations
Semantic Scholar
FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR F1
B. Raux, S. Betzi
20180 citations
Semantic Scholar
Crystal Structure of GRASP55 GRASP domain in complex with JAM-B C-terminus
N. Shi, Xiaoli Shi, X. Morelli, S. Betzi +1 more
20170 citations
Semantic Scholar
Crystal structure of dCK mutant C3S in complex with masitinib and UDP
E. Rebuffet, K. Hammam, M. Saez-Ayala, L. Gros +15 more
20170 citations
Semantic Scholar
Crystal Structure of GRASP Domain of GRASP55 with N terminal extra residues
N. Shi, X. Shi, X. Morelli, S. Betzi +1 more
20170 citations
Semantic Scholar
Crystal structure of dCK mutant C3S
M. Saez-Ayala, E. Rebuffet, K. Hammam, L. Gros +15 more
20170 citations
Semantic Scholar
FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione
B. Raux, Etienne Rebuffet, S. Betzi, S. Priet +1 more
20160 citations
Semantic Scholar
FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-(4-Chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione
B. Raux, E. Rebuffet, S. Betzi, X. Morelli
20160 citations
Semantic Scholar
First domain of human bromodomain BRD4 in complex with inhibitor 8-(5-Amino-1H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(4-chlorobenzyl)-7-ethyl-3,7-dihydropurine-2,6-dione
B. Raux, E. Rebuffet, S. Betzi, X. Morelli
20160 citations
Semantic Scholar
FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-({1-[(3-methylphe methyl]piperidin-4-yl}methyl)butanamide
B. Raux, E. Rebuffet, S. Betzi, X. Morelli
20160 citations
Semantic Scholar
E. cloacae C115D MurA in complex with UDP
Jin-Yi Zhu, S. Betzi, Yan Yang, E. Schönbrunn
20130 citations
Semantic Scholar
CDK2 in complex with inhibitor NSK-MC1-12
S. Betzi, R. Alam, H. Han, A. Becker +1 more
20120 citations
Semantic Scholar

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