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L. Gattinoni · SciRah

Researcher profile · Semantic Scholar

L. Gattinoni

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L. Gattinoni — researcher profile on SciRah

h-index: 70
Works: 168
Citations: 25K

Most-cited papers

A human memory T-cell subset with stem cell-like properties
L. Gattinoni, E. Lugli, Yun Ji, Z. Pós +13 more
2011Nature Medicine1,923 citations Open access
Semantic Scholar
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.
Madhusudhanan Sukumar, Jie Liu, Yun Ji, Murugan Subramanian +12 more
2013Journal of Clinical Investigation918 citations Open access
Semantic Scholar
Paths to stemness: building the ultimate antitumour T cell
L. Gattinoni, C. Klebanoff, N. Restifo
2012Nature Reviews. Cancer592 citations Open access
Semantic Scholar
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
Tuo-Qi Wu, Yun Ji, E. Moseman, Hai-Feng C. Xu +11 more
2016Science immunology579 citations Open access
Semantic Scholar
T memory stem cells in health and disease
L. Gattinoni, D. Speiser, M. Lichterfeld, C. Bonini
2017Nature Medicine575 citations Open access
Semantic Scholar
Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8+ T cell Persistence in Chronic Infection
Chen Yao, Hong-Wei Sun, Neal E. Lacey, Yun Ji +18 more
2019Nature Immunology480 citations Open access
Semantic Scholar
Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy
Madhusudhanan Sukumar, Jie Liu, Gautam U. Mehta, Shashank J. Patel +21 more
2015Cell Metabolism374 citations Open access
Semantic Scholar
Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies.
M. Sabatino, Jinhui Hu, M. Sommariva, S. Gautam +11 more
2016Blood367 citations Open access
Semantic Scholar
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics
Joseph G. Crompton, Madhusudhanan Sukumar, R. Roychoudhuri, D. Clever +20 more
2014Cancer Research325 citations Open access
Semantic Scholar
Superior T memory stem cell persistence supports long-lived T cell memory.
E. Lugli, Maria Dominguez, L. Gattinoni, Pratip K. Chattopadhyay +11 more
2013Journal of Clinical Investigation319 citations Open access
Semantic Scholar
BACH2 represses effector programmes to stabilize Treg-mediated immune homeostasis - a new target in tumor immunotherapy?
R. Roychoudhuri, K. Hirahara, K. Mousavi, D. Clever +11 more
2013Journal of Immunotherapy for Cancer318 citations Open access
Semantic Scholar
BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
R. Roychoudhuri, D. Clever, Peng Li, Y. Wakabayashi +22 more
2016Nature Immunology306 citations Open access
Semantic Scholar
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer
Jan C. Dudda, B. Salaun, Yun Ji, D. Palmer +15 more
2013Immunity304 citations Open access
Semantic Scholar
Sorting through subsets: Which T cell populations mediate highly effective adoptive immunotherapy?
C. Klebanoff, L. Gattinoni, N. Restifo
2012Journal of immunotherapy282 citations Open access
Semantic Scholar
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans
G. Galletti, G. De Simone, E. Mazza, S. Puccio +28 more
2020Nature Immunology255 citations Open access
Semantic Scholar
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection
K. Omilusik, J. Best, Bing-Fei Yu, S. Goossens +13 more
2015Journal of Experimental Medicine240 citations Open access
Semantic Scholar
T cell oxygen-sensing proteins establish an immunologically tolerant metastatic niche
D. Clever, R. Roychoudhuri, Michael G. Constantinides, Michael H. Askenase +13 more
2016Cell225 citations Open access
Semantic Scholar
Lineage relationship of effector and memory T cells
N. Restifo, L. Gattinoni
2013Current Opinion in Immunology225 citations Open access
Semantic Scholar
Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.
C. Klebanoff, C. D. Scott, A. Leonardi, Tori N. Yamamoto +23 more
2015Journal of Clinical Investigation223 citations Open access
Semantic Scholar
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity
D. Hermans, S. Gautam, J. García-Cañaveras, D. Gromer +16 more
2020Proceedings of the National Academy of Sciences of the United States of America211 citations Open access
Semantic Scholar
Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells
E. Lugli, L. Gattinoni, Alessandra Roberto, D. Mavilio +3 more
2012Nature Protocols201 citations Open access
Semantic Scholar
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy.
C. Klebanoff, Joseph G. Crompton, A. Leonardi, Tori N. Yamamoto +15 more
2017JCI Insight198 citations Open access
Semantic Scholar
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance
D. Palmer, G. Guittard, Zulmarie Franco, Joseph G. Crompton +16 more
2015Journal of Experimental Medicine197 citations Open access
Semantic Scholar
Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1.
Gang-Qing Hu, Dustin E. Schones, Kai-Rong Cui, R. Ybarra +6 more
2011Genome Research189 citations Open access
Semantic Scholar
A Novel Chimeric Antigen Receptor Against Prostate Stem Cell Antigen Mediates Tumor Destruction in a Humanized Mouse Model of Pancreatic Cancer
Daniel Abate-Daga, Kiran H. Lagisetty, E. Tran, Zhi-Li Zheng +10 more
2014Human Gene Therapy181 citations Open access
Semantic Scholar
BACH2 Enforces the Transcriptional and Epigenetic Programs of Stem-Like CD8+ T cells
Chen Yao, Guohua Lou, Hong-Wei Sun, Ziang Zhu +18 more
2021Nature Immunology172 citations Open access
Semantic Scholar
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity
S. Gautam, J. Fioravanti, Wei Zhu, J. L. Le Gall +17 more
2019Nature Immunology167 citations Open access
Semantic Scholar
TCF1 is required for the T follicular helper cell response to viral infection
Tuo-Qi Wu, Hyunjin Shin, E. Moseman, Yun Ji +7 more
2015Cell Reports160 citations Open access
Semantic Scholar
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
Fei Mo, Zhi-Ya Yu, Peng Li, Jangsuk Oh +19 more
2021Nature159 citations Open access
Semantic Scholar
Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells
C. Klebanoff, S. Spencer, P. Torabi-Parizi, J. Grainger +19 more
2013Journal of Experimental Medicine149 citations Open access
Semantic Scholar
T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy
Tori N. Yamamoto, Ping-Hsien Lee, S. Vodnala, Devikala Gurusamy +14 more
2019Journal of Clinical Investigation137 citations Open access
Semantic Scholar
Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity.
Karolina Pilipow, Eloise Scamardella, S. Puccio, S. Gautam +10 more
2018JCI Insight125 citations Open access
Semantic Scholar
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines
Yun Ji, C. Wrzesinski, Zhi-Ya Yu, Jinhui Hu +13 more
2014Proceedings of the National Academy of Sciences of the United States of America119 citations Open access
Semantic Scholar
Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
Shan He, Yongnian Liu, Lijun Meng, Hongxing Sun +12 more
2017Nature Communications118 citations Open access
Semantic Scholar
Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy.
A. B. van der Waart, Noortje M. P. van de Weem, F. Maas, Cynthia S M Kramer +8 more
2014Blood114 citations Open access
Semantic Scholar
Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape
Joseph G. Crompton, Manikandan Narayanan, Suresh Cuddapah, R. Roychoudhuri +13 more
2015Cellular & Molecular Immunology110 citations Open access
Semantic Scholar
Bach2 represses effector programmes to stabilize Treg-mediated immune homeostasis
R. Roychoudhuri, K. Hirahara, K. Mousavi, D. Clever +26 more
2013Nature98 citations Open access
Semantic Scholar
Genetic engineering of murine CD8+ and CD4+ T cells for pre-clinical adoptive immunotherapy studies
Sid P. Kerkar, L. Sanchez-Perez, Shi-Cheng Yang, Zachary A Borman +11 more
2011Journal of immunotherapy98 citations Open access
Semantic Scholar
Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails
Shi-Cheng Yang, Yun Ji, L. Gattinoni, Ling Zhang +4 more
2012Cancer Immunology and Immunotherapy96 citations Open access
Semantic Scholar
ONC201 kills breast cancer cells in vitro by targeting mitochondria
Yoshimi Endo Greer, N. Porat-Shliom, K. Nagashima, C. Stuelten +22 more
2018OncoTarget92 citations Open access
Semantic Scholar
miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
Yun Ji, J. Fioravanti, Wei Zhu, Hong-Jun A. Wang +18 more
2019Nature Communications82 citations Open access
Semantic Scholar
Targeting lactate metabolism for cancer immunotherapy - a matter of precision.
C. Heuser, K. Renner, M. Kreutz, L. Gattinoni
2022Seminars in Cancer Biology71 citations Open access
Semantic Scholar
Moving T memory stem cells to the clinic.
L. Gattinoni, N. Restifo
2013Blood69 citations Open access
Semantic Scholar
Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.
Jacob S. Bowers, Michelle H. Nelson, K. Majchrzak, Stefanie R. Bailey +5 more
2017JCI Insight64 citations Open access
Semantic Scholar
The transcription factor BACH2 promotes tumor immunosuppression.
R. Roychoudhuri, Robert L. Eil, D. Clever, C. Klebanoff +18 more
2016Journal of Clinical Investigation60 citations Open access
Semantic Scholar
New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
D. Stroncek, C. Berger, M. Cheever, R. Childs +14 more
2012Journal of Translational Medicine56 citations Open access
Semantic Scholar
Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy
C. M. Mousset, W. Hobo, Yun Ji, H. Fredrix +9 more
2018Oncoimmunology47 citations Open access
Semantic Scholar
CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential
G. De Simone, E. Mazza, Antonino Cassotta, A. Davydov +25 more
2019Journal of Immunology41 citations Open access
Semantic Scholar
Enhancing adoptive T cell immunotherapy with microRNA therapeutics
Yun Ji, James D. Hocker, L. Gattinoni
2015Seminars in Immunology41 citations Open access
Semantic Scholar
Identification of the Genomic Insertion Site of Pmel-1 TCR α and β Transgenes by Next-Generation Sequencing
Yun Ji, Natalie Abrams, Wei Zhu, E. Salinas +8 more
2014PLoS ONE32 citations Open access
Semantic Scholar

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N. Restifo×31
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N. Restifo — researcher profile on SciRah
Yun Ji×25
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Yun Ji — researcher profile on SciRah
C. Klebanoff×19
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C. Klebanoff — researcher profile on SciRah
Zhi-Ya Yu×16
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Zhi-Ya Yu — researcher profile on SciRah

R. Roychoudhuri

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R. Roychoudhuri — researcher profile on SciRah

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D. Palmer — researcher profile on SciRah

Madhusudhanan Sukumar×12

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Madhusudhanan Sukumar — researcher profile on SciRah

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D. Clever — researcher profile on SciRah

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E. Wang — researcher profile on SciRah

Joseph G. Crompton×9

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Joseph G. Crompton — researcher profile on SciRah

Robert L. Eil×9

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Robert L. Eil — researcher profile on SciRah

F. Marincola×8

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F. Marincola — researcher profile on SciRah