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H. Fredrix · SciRah

Researcher profile · Semantic Scholar

H. Fredrix

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H. Fredrix — researcher profile on SciRah

h-index: 20
Works: 44
Citations: 1,227

Most-cited papers

A Human Minor Histocompatibility Antigen Specific for B Cell Acute Lymphoblastic Leukemia
H. Dolstra, H. Fredrix, F. Maas, P. Coulie +6 more
1999Journal of Experimental Medicine234 citations Open access
Semantic Scholar
Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation
W. Hobo, T. Novobrantseva, H. Fredrix, J. Wong +6 more
2013Cancer Immunology and Immunotherapy119 citations
Semantic Scholar
Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL.
H. Dolstra, H. Fredrix, F. Preijers, E. Goulmy +3 more
1997Journal of Immunology106 citations Open access
Semantic Scholar
Immunogenicity of dendritic cells pulsed with MAGE3, Survivin and B-cell maturation antigen mRNA for vaccination of multiple myeloma patients
W. Hobo, L. Strobbe, F. Maas, H. Fredrix +9 more
2013Cancer Immunology and Immunotherapy71 citations
Semantic Scholar
Bi‐directional allelic recognition of the human minor histocompatibility antigen HB‐1 by cytotoxic T lymphocytes
H. Dolstra, B. de Rijke, H. Fredrix, A. Balas +8 more
2002European Journal of Immunology63 citations
Semantic Scholar
B and T Lymphocyte Attenuator Mediates Inhibition of Tumor-Reactive CD8+ T Cells in Patients After Allogeneic Stem Cell Transplantation
W. Hobo, W. Norde, N. Schaap, H. Fredrix +7 more
2012Journal of Immunology62 citations Open access
Semantic Scholar
Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1-reactive cytotoxic T cells.
W. Norde, I. Overes, F. Maas, H. Fredrix +8 more
2009Blood53 citations
Semantic Scholar
Association of disparities in known minor histocompatibility antigens with relapse-free survival and graft-versus-host-disease after allogeneic stem cell transplantation
W. Hobo, K. Broen, W. van der Velden, Annelies Greupink-Draaisma +14 more
2012Biology of Blood and Marrow Transplantation49 citations Open access
Semantic Scholar
Expression of P2X5 in lymphoid malignancies results in LRH‐1‐specific cytotoxic T‐cell‐mediated lysis
I. Overes, B. de Rijke, Agnes van Horssen-Zoetbrood, H. Fredrix +7 more
2008British Journal of Haematology49 citations
Semantic Scholar
Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8+ T cells for adoptive immunotherapy
C. M. Mousset, W. Hobo, Yun Ji, H. Fredrix +9 more
2018Oncoimmunology47 citations Open access
Semantic Scholar
Efficient Nontoxic Delivery of PD-L1 and PD-L2 siRNA Into Dendritic Cell Vaccines Using the Cationic Lipid SAINT-18
M. Roeven, W. Hobo, R. van der Voort, H. Fredrix +5 more
2015Journal of immunotherapy46 citations
Semantic Scholar
siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8+ T cells in NOD/SCID/IL2Rg(null) mice
A. B. van der Waart, H. Fredrix, R. van der Voort, N. Schaap +2 more
2015Cancer Immunology and Immunotherapy44 citations Open access
Semantic Scholar
CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses
T. Hutten, S. Thordardottir, H. Fredrix, L. Janssen +12 more
2016Journal of Immunology40 citations Open access
Semantic Scholar
TCRγδ cytotoxic T lymphocytes expressing the killer cell-inhibitory receptor p58.2 (CD158b) selectively lyse acute myeloid leukemia cells
Harry Dolstra, H. Fredrix, A. V. D. van der Meer, T. de Witte +2 more
2001Bone Marrow Transplantation38 citations Open access
Semantic Scholar
Partial T cell-depleted allogeneic stem cell transplantation following reduced-intensity conditioning creates a platform for immunotherapy with donor lymphocyte infusion and recipient dendritic cell vaccination in multiple myeloma.
H. Levenga, N. Schaap, F. Maas, B. Esendam +5 more
2010Biology of Blood and Marrow Transplantation29 citations Open access
Semantic Scholar
A Polymorphism in the Splice Donor Site of ZNF419 Results in the Novel Renal Cell Carcinoma-Associated Minor Histocompatibility Antigen ZAPHIR
K. Broen, H. Levenga, J. Vos, Kees van Bergen +8 more
2011PLoS ONE28 citations Open access
Semantic Scholar
A phase I/II minor histocompatibility antigen-loaded dendritic cell vaccination trial to safely improve the efficacy of donor lymphocyte infusions in myeloma
L. E. Franssen, M. Roeven, W. Hobo, R. Doorn +13 more
2017Bone Marrow Transplantation26 citations Open access
Semantic Scholar
Circulating Tumour Necrosis Factor α is not involved in the development of cerebral malaria in Plasmodium berghei‐infected C57Bl mice
C. Hermsen, J. V. D. Crommert, H. Fredrix, Robert W. Sauerwein +1 more
1997Parasite immunology (Print)24 citations Open access
Semantic Scholar
TCR gamma delta cytotoxic T lymphocytes expressing the killer cell-inhibitory receptor p58.2 (CD158b) selectively lyse acute myeloid leukemia cells.
H. Dolstra, H. Fredrix, A. V. D. van der Meer, T. de Witte +2 more
2001Bone Marrow Transplantation23 citations
Semantic Scholar
Efficient Activation of LRH-1–specific CD8+ T-cell Responses From Transplanted Leukemia Patients by Stimulation With P2X5 mRNA-electroporated Dendritic Cells
I. Overes, H. Fredrix, M. Kester, J. F. Frederik Falkenburg +3 more
2009Journal of immunotherapy22 citations
Semantic Scholar
Generation of autologous cytotoxic and helper T-cell responses against the B-cell leukemia-associated antigen HB-1: relevance for precursor B-ALL-specific immunotherapy.
B. de Rijke, H. Fredrix, A. Zoetbrood, F. Scherpen +4 more
2003Blood17 citations Open access
Semantic Scholar
PD-L1 siRNA-mediated silencing in acute myeloid leukemia enhances anti-leukemic T cell reactivity
D. van Ens, C. M. Mousset, T. Hutten, A. B. van der Waart +11 more
2020Bone Marrow Transplantation15 citations
Semantic Scholar
Intraperitoneal infusion of stem cell-derived natural killer cells in recurrent epithelial ovarian cancer patients: Results of the phase 1 INTRO-01 trial.
J. H. Hoogstad-van Evert, P. D. de Jonge, P. Zusterzeel, W. Hobo +16 more
2025Gynecologic Oncology9 citations Open access
Semantic Scholar
Induction of multiple myeloma-reactive T cells during post-transplantation immunotherapy with donor lymphocytes and recipient DCs
K. Broen, Annelies Greupink-Draaisma, H. Fredrix, N. Schaap +1 more
2012Bone Marrow Transplantation6 citations Open access
Semantic Scholar
Refinement of molecular approaches to improve the chance of identification of hematopoietic-restricted minor histocompatibility antigens.
B. de Rijke, Agnes van Horssen-Zoetbrood, S. Veenbergen, H. Fredrix +3 more
2008JIM - Journal of Immunological Methods2 citations
Semantic Scholar
Annual scientific report, 1972
R. Billiau, K. Bobin, M. De Coster, H. Fredrix +1 more
19722 citations
Semantic Scholar
63 – Towards adoptive transfer of Akt-inhibited early memory CD8+ T cells for a superior graft-versus-leukemia effect
A. B. van der Waart, L. Mousset, H. Fredrix, G. Franken +3 more
20171 citations
Semantic Scholar
specific immunotherapy - B-ALL associated antigen HB-1: relevance for precursor - the B-cell leukemia Generation of autologous cytotoxic and helper T-cell responses against
W. Kemenade, H. Dolstra, H. Fredrix, A. Zoetbrood +2 more
20131 citations
Semantic Scholar
Use of RNA Electroporated DC for Activation of LRH-1 Specific Cytotoxic T Lymphocytes in the Treatment of Lymphoid Malignancies.
I. Overes, H. Fredrix, B. de Rijke, Agnes van Horssen-Zoetbrood +5 more
20061 citations
Semantic Scholar
ANNUAL SCIENTIFIC REPORT, 1969.
R. Billiau, L. Buyse, M. De Coster, H. Fredrix
19691 citations
Semantic Scholar
Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-Versus-Host-Disease Upon Allogeneic Stem Cell Transplantation,
W. Hobo, K. Broen, W. van der Velden, Annelies Greupink-Draaisma +14 more
20110 citations
Semantic Scholar
Tumor immunity and immunosurveillance (PP-093)
J. Abastado, J. Eyles, A. Puaux, J. Wang +496 more
20100 citations
Semantic Scholar
A187 T-Cell Depleted RIC Allogeneic Stem Cells Transplantation: A Platform for Immunotherapy
R. Raymakers, H. Levenga, T. Schattenberg, F. Maas +4 more
20090 citations
Semantic Scholar
A123 Vaccination of Multiple Myeloma Patients with RNA-Electroporated Mature Dendritic Cells
R. Raymakers, B. V. van Rees, H. Fredrix, F. Maas +5 more
20090 citations
Semantic Scholar
Induction of B-lineage ALL-specific autologous cytotoxic T-cells using HB-1 antigen-pulsed dendritic cells
H. Dolstra, H. Fredrix, F. Scherpen, T. de Witte +2 more
20010 citations
Semantic Scholar
Molecular identification of leukemia-associated minor histocompatibility antigens by cDNA expression cloning
B. de Rijke, A. Zoetbrood, H. Fredrix, E. Warren +3 more
20010 citations
Semantic Scholar
Induction of autologous cytotoxic T lymphocytes against the polymorphic B-cell acute lymphoblastic leukemia associated antigen HB-1
H. Dolstra, H. Fredrix, T. de Witte, C. Figdor +1 more
19990 citations
Semantic Scholar
Identification of leukemia-associated minor histocompatibility antigens
H. Dolstra, H. Fredrix, F. Maas, T. de Witte +2 more
19980 citations
Semantic Scholar
Identification of a B-cell acute lymphoblastic leukemia-associated minor histocompatibility antigen
H. Dolstra, H. Fredrix, F. Maas, E. Mensink +3 more
19980 citations
Semantic Scholar
Infusion of donor lymphocytes to treat leukemia patients who relapsed after bone marrow transplantation
E. van de Wiel-van Kemenade, H. Dolstra, A. Schattenberg, F. Maas +3 more
19980 citations
Semantic Scholar
Preferential lysis of myeloid leukemia cells by TCR-γδ positive T cells expressing p58 killer-cell inhibitory receptors
H. Dolstra, H. Fredrix, T. de Witte, E. van de Wiel-van Kemenade
19970 citations
Semantic Scholar
The genotype of T cells of leukemia patients who relapsed after BMT is a predominant factor in determining success or failure of treatment with donor lymphocyte infusions
E. van de Wiel-van Kemenade, Pascale van Tuyn, H. Dolstra, A. Schattenberg +4 more
19970 citations
Semantic Scholar
Identification of a B cell leukemia associated minor histocompatibility antigen recognized by cytotoxic T lymphocytes
H. Dolstra, H. Fredrix, F. Preijers, C. Figdor +2 more
19970 citations
Semantic Scholar
Infusion of donor lymphocytes in leukemia patients relapsed after bone marrow transplantation is successful if T cells of recipients are of donor origin
E. van de Wiel-van Kemenade, H. Dolstra, A. Schattenberg, F. Maas +6 more
19960 citations
Semantic Scholar

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H. Dolstra×37
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H. Dolstra — researcher profile on SciRah
T. de Witte×29
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E. van de Wiel-van Kemenade×17
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F. Maas — researcher profile on SciRah

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C. Figdor — researcher profile on SciRah

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R. van der Voort×9

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J. F. Frederik Falkenburg×7

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F. Preijers — researcher profile on SciRah

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Annelies Greupink-Draaisma — researcher profile on SciRah

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R. Raymakers — researcher profile on SciRah