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S. Critchlow · SciRah

Researcher profile · Semantic Scholar

S. Critchlow

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S. Critchlow — researcher profile on SciRah

h-index: 33
Works: 88
Citations: 7,458

Most-cited papers

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.
C. Chresta, B. Davies, Ian D. Hickson, Tom C. Harding +20 more
2010Cancer Research811 citations
Semantic Scholar
Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
Z. Schug, B. Peck, Dylan T. Jones, Qi-Feng Zhang +29 more
2015Cancer Cell790 citations Open access
Semantic Scholar
DNA end-joining: from yeast to man.
S. Critchlow, S. Jackson
1998TIBS -Trends in Biochemical Sciences. Regular ed623 citations
Semantic Scholar
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.
S. Critchlow, R. Bowater, S. Jackson
1997Current Biology479 citations Open access
Semantic Scholar
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
R. Le Floch, J. Chiche, Ibtissam Marchiq, Tanesha Naiken +6 more
2011Proceedings of the National Academy of Sciences of the United States of America451 citations Open access
Semantic Scholar
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.
E. Riballo, S. Critchlow, Soo-Hwang Teo, A. Doherty +9 more
1999Current Biology401 citations Open access
Semantic Scholar
Activity of the Monocarboxylate Transporter 1 inhibitor AZD3965 in Small Cell Lung Cancer
R. Polanski, Cassandra L. Hodgkinson, A. Fusi, D. Nonaka +10 more
2013Clinical Cancer Research340 citations Open access
Semantic Scholar
Crystal structure of an Xrcc4–DNA ligase IV complex
B. L. Sibanda, S. Critchlow, J. Begun, Xue Y. Pei +3 more
2001Nature Structural Biology282 citations
Semantic Scholar
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
A. Najumudeen, Fatih Ceteci, S. Fey, G. Hamm +39 more
2021Nature Genetics230 citations
Semantic Scholar
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
B. Peck, Z. Schug, Qi-Feng Zhang, Beatrice Dankworth +20 more
2016Cancer & Metabolism227 citations Open access
Semantic Scholar
MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4
C. S. Hong, N. Graham, Wen Gu, C. Camacho +18 more
2016Cell Reports223 citations Open access
Semantic Scholar
Mode of Action
A. Maxwell, S. Critchlow
1998192 citations
Semantic Scholar
Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport
Becky Bola, A. Chadwick, F. Michopoulos, K. Blount +5 more
2014Molecular Cancer Therapeutics183 citations Open access
Semantic Scholar
Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation.
R. Ward, C. Brassington, A. Breeze, A. Caputo +16 more
2012Journal of Medicinal Chemistry167 citations Open access
Semantic Scholar
Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity
N. Curtis, L. Mooney, Lorna Hopcroft, F. Michopoulos +11 more
2017OncoTarget153 citations Open access
Semantic Scholar
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma
R. A. Noble, N. Bell, H. Blair, Arti Sikka +13 more
2017Haematologica150 citations Open access
Semantic Scholar
Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper
G. Illuzzi, Anna D. Staniszewska, Sonja J. Gill, A. Pike +18 more
2022Clinical Cancer Research147 citations Open access
Semantic Scholar
The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase.
Christopher J. R. Willmott, S. Critchlow, I. Eperon, A. Maxwell
1994Journal of Molecular Biology131 citations
Semantic Scholar
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
J. Johannes, Amber Y. S. Balazs, D. Barratt, M. Biśta +39 more
2021Journal of Medicinal Chemistry127 citations Open access
Semantic Scholar
The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription.
S. Critchlow, M. H. O'Dea, Alison J. Howells, M. Couturier +2 more
1997Journal of Molecular Biology98 citations
Semantic Scholar
DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex.
S. Critchlow, A. Maxwell
1996Biochemistry89 citations
Semantic Scholar
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.
S. Boyd, J. Brookfield, S. Critchlow, I. Cumming +21 more
2015Journal of Medicinal Chemistry88 citations Open access
Semantic Scholar
Targeted profiling of polar intracellular metabolites using ion-pair-high performance liquid chromatography and -ultra high performance liquid chromatography coupled to tandem mass spectrometry: applications to serum, urine and tissue extracts.
F. Michopoulos, Nicky Whalley, G. Theodoridis, I. Wilson +2 more
2014Journal of Chromatography A80 citations
Semantic Scholar
AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo
Sarah A. Loddick, Sarah J. Ross, A. Thomason, David M Robinson +21 more
2013Molecular Cancer Therapeutics70 citations Open access
Semantic Scholar
Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging.
J. Swales, A. Dexter, G. Hamm, Anna Nilsson +10 more
2018Analytical Chemistry65 citations Open access
Semantic Scholar
Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
T. Petreuș, E. Cadogan, Gareth D. Hughes, Aaron Smith +6 more
2021Communications Biology62 citations Open access
Semantic Scholar
The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance
M. Lawson, Natalie Cureton, S. Ros, Azadeh Cheraghchi-Bashi +33 more
2023Cancer Research60 citations Open access
Semantic Scholar
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
F. Goldberg, J. Kettle, G. Lamont, D. Buttar +12 more
2022Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.
Anna D. Staniszewska, Domenic Pilger, Sonja J. Gill, K. Jamal +24 more
2023Clinical Cancer Research46 citations
Semantic Scholar
Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis.
F. Michopoulos, N. Karagianni, Nicky Whalley, M. Firth +5 more
2016Journal of Proteome Research46 citations Open access
Semantic Scholar
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance
V. Serra, Anderson T. Wang, M. Castroviejo-Bermejo, U. Polanska +36 more
2022Clinical Cancer Research44 citations Open access
Semantic Scholar
Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters
M. Mehibel, F. Ortiz-Martínez, N. Voelxen, A. Boyers +7 more
2018Scientific Reports43 citations Open access
Semantic Scholar
Large-scale pan-cancer cell line screening identifies actionable and effective drug combinations
Azadeh C Bashi, E. Coker, Krishna C. Bulusu, P. Jaaks +33 more
2024Cancer Discovery38 citations Open access
Semantic Scholar
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.
J. Johannes, Amber Y. S. Balazs, Derek G. Barratt, M. Biśta +38 more
2024Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors
James T. Lynch, U. Polanska, O. Delpuech, Urs J Hancox +14 more
2017Clinical Cancer Research33 citations Open access
Semantic Scholar
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor.
M. Finlay, D. Buttar, S. Critchlow, A. Dishington +10 more
2012Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
A functional analysis of 180 cancer cell lines reveals conserved intrinsic metabolic programs
S. Cherkaoui, Stephan Durot, J. Bradley, S. Critchlow +7 more
2022Molecular Systems Biology30 citations Open access
Semantic Scholar
Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells
A. G. Trinidad, Nicky Whalley, R. Rowlinson, O. Delpuech +3 more
2017Oncogene30 citations Open access
Semantic Scholar
Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition
Maria Dermit, P. Casado, V. Rajeeve, E. Wilkes +7 more
2016Oncogene30 citations Open access
Semantic Scholar
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
J. Kettle, P. Ballard, C. Bardelle, Mark J. Cockerill +11 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Discovery of a Thiadiazole-Pyridazine Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.
M. Finlay, M. Anderton, Andrew Bailey, S. Boyd +31 more
2019Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Combined Inhibition of PI3Kβ and mTOR Inhibits Growth of PTEN-null Tumors
James T. Lynch, U. Polanska, Urs J Hancox, O. Delpuech +11 more
2018Molecular Cancer Therapeutics25 citations Open access
Semantic Scholar
Emerging approaches to target tumor metabolism.
Sarah J. Ross, S. Critchlow
2014Current opinion in pharmacology (Print)24 citations
Semantic Scholar
Heterogeneity of the cancer cell line metabolic landscape
David Shorthouse, J. Bradley, S. Critchlow, C. Bendtsen +1 more
2021bioRxiv22 citations Open access
Semantic Scholar
Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer.
A. Pommier, M. Farren, Bhavika Patel, Mark Wappett +13 more
2016Cell Metabolism22 citations Open access
Semantic Scholar
Quinolone Antibacterials
W. Craig, S. Critchlow, A. Dalhoff, M. Everett +10 more
1998Handbook of Experimental Pharmacology22 citations
Semantic Scholar
3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Dylan T. Jones, A. Valli, S. Haider, Qi-Feng Zhang +9 more
2018Molecular Cancer Therapeutics20 citations Open access
Semantic Scholar
Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition
L. Carnevalli, Molly A. Taylor, M. King, A. Coenen-Stass +15 more
2021Molecular Cancer Therapeutics17 citations Open access
Semantic Scholar
Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress
Z. Schug, B. Peck, Dylan T. Jones, Qi-Feng Zhang +10 more
2014Cancer & Metabolism14 citations Open access
Semantic Scholar
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit.
A. Kawatkar, R. Clark, Lorna Hopcroft, D. A. Roaquin +8 more
2023ACS Chemical Biology12 citations
Semantic Scholar

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