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V. Njar · SciRah

Researcher profile · Semantic Scholar

V. Njar

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V. Njar — researcher profile on SciRah

h-index: 40
Works: 163
Citations: 6,455

Most-cited papers

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652
D. Klionsky, K. Abdelmohsen, A. Abe, M. Abedin +496 more
20161,544 citations Open access
Semantic Scholar
Regulation of androgen receptor activity by tyrosine phosphorylation.
Zhiyong Guo, B. Dai, Tianyun Jiang, Ke-Xin Xu +12 more
2006Cancer Cell383 citations Open access
Semantic Scholar
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.
R. D. Bruno, V. Njar
2007Bioorganic & Medicinal Chemistry243 citations Open access
Semantic Scholar
Promise and challenges in drug discovery and development of hybrid anticancer drugs
L. Gediya, V. Njar
2009Expert Opinion on Drug Discovery211 citations
Semantic Scholar
CYP17 inhibitors for prostate cancer therapy
T. Vasaitis, R. D. Bruno, V. Njar
2010Journal of Steroid Biochemistry and Molecular Biology197 citations Open access
Semantic Scholar
Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer.
V. Njar, A. Brodie
2015Journal of Medicinal Chemistry181 citations Open access
Semantic Scholar
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.
V. Njar, L. Gediya, P. Purushottamachar, P. Chopra +6 more
2006Bioorganic & Medicinal Chemistry140 citations
Semantic Scholar
Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo
Andrew K. Kwegyir-Afful, S. Ramalingam, P. Purushottamachar, Vidya P Ramamurthy +1 more
2015OncoTarget99 citations Open access
Semantic Scholar
Androgen Receptor Inactivation Contributes to Antitumor Efficacy of CYP17 Inhibitor VN/124-1 in Prostate Cancer
T. Vasaitis, A. Belosay, A. Schayowitz, A. Khandelwal +6 more
2008Molecular Cancer Therapeutics93 citations Open access
Semantic Scholar
Systematic Structure Modifications of Multi-target Prostate Cancer Drug Candidate Galeterone to Produce Novel Androgen Receptor Down-regulating Agents as an Approach to Treatment of Advanced Prostate Cancer
P. Purushottamachar, Abhijit Godbole, L. Gediya, Marlena S. Martin +5 more
2013Journal of Medicinal Chemistry92 citations Open access
Semantic Scholar
A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.
L. Gediya, P. Chopra, P. Purushottamachar, N. Maheshwari +1 more
2005Journal of Medicinal Chemistry81 citations
Semantic Scholar
Competitive Antagonism between the Nicotinic Allosteric Potentiating Ligand Galantamine and Kynurenic Acid at α7* Nicotinic Receptors
C. Lopes, E. Pereira, Hui Wu, P. Purushottamachar +3 more
2007Journal of Pharmacology and Experimental Therapeutics80 citations
Semantic Scholar
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001) analogs: Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model
R. D. Bruno, T. Vasaitis, L. Gediya, P. Purushottamachar +4 more
2011Steroids63 citations Open access
Semantic Scholar
Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro
A. Schayowitz, G. Sabnis, V. Njar, A. Brodie
2008Molecular Cancer Therapeutics60 citations
Semantic Scholar
17α-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response
R. D. Bruno, T. Gover, A. Burger, A. Brodie +1 more
2008Molecular Cancer Therapeutics59 citations Open access
Semantic Scholar
First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines
S. Ramalingam, L. Gediya, Andrew K. Kwegyir-Afful, Vidya P Ramamurthy +3 more
2014OncoTarget57 citations Open access
Semantic Scholar
4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors
T. Dexheimer, L. Gediya, A. Stephen, Iwona E. Weidlich +7 more
2009Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.
L. Gediya, A. Belosay, A. Khandelwal, P. Purushottamachar +1 more
2008Bioorganic & Medicinal Chemistry51 citations Open access
Semantic Scholar
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
D. Klionsky, K. Abdelmohsen, A. Abe, J. Abedin +496 more
201650 citations Open access
Semantic Scholar
The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.
K. Tran, R. Risingsong, Darlene B. Royce, C. Williams +5 more
2013Carcinogenesis45 citations Open access
Semantic Scholar
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
V. Moreira, T. Vasaitis, V. Njar, J. Salvador
2007Steroids45 citations Open access
Semantic Scholar
Dissecting major signaling pathways in prostate cancer development and progression: Mechanisms and novel therapeutic targets
S. Ramalingam, Vidya P Ramamurthy, V. Njar
2016Journal of Steroid Biochemistry and Molecular Biology44 citations Open access
Semantic Scholar
Structure-based screen identifies a potent small-molecule inhibitor of Stat5a/b with therapeutic potential for prostate cancer and chronic myeloid leukemia
Zhi-Yong Liao, L. Gu, J. Vergalli, S. Mariani +22 more
2015Molecular Cancer Therapeutics44 citations Open access
Semantic Scholar
Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth
J. Patel, J. Mehta, A. Belosay, G. Sabnis +4 more
2007British Journal of Cancer43 citations Open access
Semantic Scholar
CYP17 inhibitors for prostate cancer treatment--an update.
V. Moreira, J. Salvador, T. Vasaitis, V. Njar
2008Current Medicinal Chemistry42 citations
Semantic Scholar
Targeting Drug-Metabolizing Enzymes for Effective Chemoprevention and Chemotherapy
Hollie I. Swanson, V. Njar, Zhen Yu, David J Castro +8 more
2010Drug Metabolism And Disposition37 citations Open access
Semantic Scholar
Novel, potent anti-androgens of therapeutic potential: recent advances and promising developments.
T. Vasaitis, V. Njar
2010Future Medicinal Chemistry34 citations
Semantic Scholar
Steroidogenic Enzyme Inhibitors and Hormone Dependent Cancer
A. Brodie, V. Njar, L. Macedo, Vasaits Tadas Sean +1 more
2009Urologic oncology33 citations Open access
Semantic Scholar
Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.
L. Gediya, A. Khandelwal, J. Patel, A. Belosay +4 more
2008Journal of Medicinal Chemistry33 citations
Semantic Scholar
Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent.
P. Purushottamachar, A. Khandelwal, T. Vasaitis, R. D. Bruno +2 more
2008Bioorganic & Medicinal Chemistry31 citations
Semantic Scholar
Transcriptome profiling reveals that VNPP433‐3β, the lead next‐generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial–mesenchymal transition and stem cell markers
E. Thomas, Retheesh S. Thankan, P. Purushottamachar, Wei-Liang Huang +5 more
2022Molecular Carcinogenesis30 citations Open access
Semantic Scholar
Novel C-4 Heteroaryl 13-cis-Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in Mice
Hannah W. Mbatia, S. Ramalingam, Vidya P Ramamurthy, Marlena S. Martin +2 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents.
P. Purushottamachar, A. Khandelwal, P. Chopra, N. Maheshwari +5 more
2007Bioorganic & Medicinal Chemistry27 citations Open access
Semantic Scholar
Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo
Andrew K. Kwegyir-Afful, S. Ramalingam, Vidya P Ramamurthy, P. Purushottamachar +13 more
2019Cancers26 citations Open access
Semantic Scholar
Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth.
V. Moreira, T. Vasaitis, Zhiyong Guo, V. Njar +1 more
2008Steroids26 citations
Semantic Scholar
Effects of novel retinoic acid metabolism blocking agent (VN/14-1) on letrozole-insensitive breast cancer cells.
A. Belosay, A. Brodie, V. Njar
2006Cancer Research26 citations Open access
Semantic Scholar
The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
S. Ramalingam, Vidya P Ramamurthy, L. Gediya, Francis N. Murigi +8 more
2019Cancers24 citations Open access
Semantic Scholar
Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines
Vidya P Ramamurthy, S. Ramalingam, L. Gediya, Andrew K. Kwegyir-Afful +1 more
2014OncoTarget24 citations Open access
Semantic Scholar
Targeting Cytochrome P450 Enzymes: A New Approach in Anticancer Drug Development
R. D. Bruno, V. Njar
200722 citations
Semantic Scholar
Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole Carbamate.
P. Purushottamachar, Andrew K. Kwegyir-Afful, Marlena S. Martin, Vidya P Ramamurthy +2 more
2016ACS Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Targeting of protein translation as a new treatment paradigm for prostate cancer
Vidya P Ramamurthy, S. Ramalingam, Andrew K. Kwegyir-Afful, A. Hussain +1 more
2017Current Opinion in Oncology20 citations Open access
Semantic Scholar
Autophagy inhibition synergistically enhances anti-cancer efficacy of RAMBA, VN/12-1 in SKBR-3 cells and tumor xenografts
Abhijit Godbole, P. Purushottamachar, Marlena S. Martin, C. Daskalakis +1 more
2012Molecular Cancer Therapeutics19 citations Open access
Semantic Scholar
First Chemical Feature Based Pharmacophore Modeling of Potent Retinoidal Retinoic Acid Metabolism Blocking Agents (RAMBAs): Identification of Novel RAMBA Scaffolds
P. Purushottamachar, J. Patel, L. Gediya, O. Clement +1 more
2011European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Retinoic Acid Metabolism Blocking Agents (RAMBAs) for Treatment of Cancer and Dermatological Diseases
V. Njar, L. Gediya, P. Purushottamachar, P. Chopra +6 more
200619 citations
Semantic Scholar
Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice.
Andrew K. Kwegyir-Afful, Francis N. Murigi, P. Purushottamachar, Vidya P Ramamurthy +2 more
2017OncoTarget18 citations Open access
Semantic Scholar
Development of Benzimidazole Compounds for Cancer Therapy
P. Purushottamachar, S. Ramalingam, V. Njar
2019Chemistry and Applications of Benzimidazole and its Derivatives15 citations Open access
Semantic Scholar
New Insights into the Androgen-Targeted Therapies and Epigenetic Therapies in Prostate Cancer
Abhijit Godbole, V. Njar
2011Prostate Cancer15 citations Open access
Semantic Scholar
Targeted Degradation of Androgen Receptor by VNPP433-3β in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal Degradation
E. Thomas, Retheesh S. Thankan, P. Purushottamachar, David J. Weber +1 more
2023Cancers14 citations Open access
Semantic Scholar
Retinoids in clinical use.
V. Njar, L. Gediya, P. Purushottamachar, P. Chopra +2 more
2006Medicinal chemistry14 citations
Semantic Scholar
Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models
E. Thomas, Retheesh S. Thankan, P. Purushottamachar, Wei-Liang Huang +5 more
2022Cells13 citations Open access
Semantic Scholar

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