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L. Gediya · SciRah

Researcher profile · Semantic Scholar

L. Gediya

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L. Gediya — researcher profile on SciRah

h-index: 19
Works: 41
Citations: 1,483

Most-cited papers

Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
Venkatesh D. Handratta, T. Vasaitis, V. Njar, L. Gediya +7 more
2005Journal of Medicinal Chemistry250 citations Open access
Semantic Scholar
Promise and challenges in drug discovery and development of hybrid anticancer drugs
L. Gediya, V. Njar
2009Expert Opinion on Drug Discovery211 citations
Semantic Scholar
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.
V. Njar, L. Gediya, P. Purushottamachar, P. Chopra +6 more
2006Bioorganic & Medicinal Chemistry140 citations
Semantic Scholar
Androgen Receptor Inactivation Contributes to Antitumor Efficacy of CYP17 Inhibitor VN/124-1 in Prostate Cancer
T. Vasaitis, A. Belosay, A. Schayowitz, A. Khandelwal +6 more
2008Molecular Cancer Therapeutics93 citations Open access
Semantic Scholar
Systematic Structure Modifications of Multi-target Prostate Cancer Drug Candidate Galeterone to Produce Novel Androgen Receptor Down-regulating Agents as an Approach to Treatment of Advanced Prostate Cancer
P. Purushottamachar, Abhijit Godbole, L. Gediya, Marlena S. Martin +5 more
2013Journal of Medicinal Chemistry92 citations Open access
Semantic Scholar
A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.
L. Gediya, P. Chopra, P. Purushottamachar, N. Maheshwari +1 more
2005Journal of Medicinal Chemistry81 citations
Semantic Scholar
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001) analogs: Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model
R. D. Bruno, T. Vasaitis, L. Gediya, P. Purushottamachar +4 more
2011Steroids63 citations Open access
Semantic Scholar
First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines
S. Ramalingam, L. Gediya, Andrew K. Kwegyir-Afful, Vidya P Ramamurthy +3 more
2014OncoTarget57 citations Open access
Semantic Scholar
4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors
T. Dexheimer, L. Gediya, A. Stephen, Iwona E. Weidlich +7 more
2009Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.
L. Gediya, A. Belosay, A. Khandelwal, P. Purushottamachar +1 more
2008Bioorganic & Medicinal Chemistry51 citations Open access
Semantic Scholar
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
J. Patel, Carlic Huynh, Venkatesh D. Handratta, L. Gediya +6 more
2004Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.
K. Tran, R. Risingsong, Darlene B. Royce, C. Williams +5 more
2013Carcinogenesis45 citations Open access
Semantic Scholar
Three-dimensional quantitative structure activity relationships (3-D-QSAR) of antihyperglycemic agents.
S. Kulkarni, L. Gediya, V. Kulkarni
1999Bioorganic & Medicinal Chemistry36 citations
Semantic Scholar
Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.
L. Gediya, A. Khandelwal, J. Patel, A. Belosay +4 more
2008Journal of Medicinal Chemistry33 citations
Semantic Scholar
Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent.
P. Purushottamachar, A. Khandelwal, T. Vasaitis, R. D. Bruno +2 more
2008Bioorganic & Medicinal Chemistry31 citations
Semantic Scholar
The retinamide VNLG-152 inhibits f-AR/AR-V7 and MNK–eIF4E signaling pathways to suppress EMT and castration-resistant prostate cancer xenograft growth
Vidya P Ramamurthy, S. Ramalingam, L. Gediya, Vincent C. O. Njar
2018The FEBS Journal30 citations Open access
Semantic Scholar
First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents.
P. Purushottamachar, A. Khandelwal, P. Chopra, N. Maheshwari +5 more
2007Bioorganic & Medicinal Chemistry27 citations Open access
Semantic Scholar
The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
S. Ramalingam, Vidya P Ramamurthy, L. Gediya, Francis N. Murigi +8 more
2019Cancers24 citations Open access
Semantic Scholar
Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines
Vidya P Ramamurthy, S. Ramalingam, L. Gediya, Andrew K. Kwegyir-Afful +1 more
2014OncoTarget24 citations Open access
Semantic Scholar
First Chemical Feature Based Pharmacophore Modeling of Potent Retinoidal Retinoic Acid Metabolism Blocking Agents (RAMBAs): Identification of Novel RAMBA Scaffolds
P. Purushottamachar, J. Patel, L. Gediya, O. Clement +1 more
2011European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Retinoic Acid Metabolism Blocking Agents (RAMBAs) for Treatment of Cancer and Dermatological Diseases
V. Njar, L. Gediya, P. Purushottamachar, P. Chopra +6 more
200619 citations
Semantic Scholar
Retinoids in clinical use.
V. Njar, L. Gediya, P. Purushottamachar, P. Chopra +2 more
2006Medicinal chemistry14 citations
Semantic Scholar
Total synthesis of cis and trans-hydroxyglimepiride: active metabolite of glimepiride
M. Gurjar, R. A. Joshi, S. Chaudhuri, S. Joshi +5 more
200314 citations
Semantic Scholar
Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model
David J. McCarty, Wei-Liang Huang, M. Kane, P. Purushottamachar +2 more
2017OncoTarget13 citations Open access
Semantic Scholar
VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats
Abhijit Godbole, S. Ramalingam, Vidya P Ramamurthy, A. Khandelwal +8 more
2014European Journal of Pharmacology6 citations Open access
Semantic Scholar
Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus
P. Goss, S. Qi, Haiqing Hu, L. Gediya +3 more
2011Breast Cancer Research and Treatment4 citations Open access
Semantic Scholar
Combination of HDACi entinostat (SNDX-275) with letrozole provides control over tumor growth in MDA-MB-231 xenograft model.
G. Sabnis, O. Goloubeva, L. Macedo, R. Gilani +3 more
20094 citations
Semantic Scholar
Effects of novel retinoic acid metabolism blocking agent (VN/14-1) on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model.
P. Goss, V. Njar, S. Qi, H. Hu +3 more
20092 citations
Semantic Scholar
The Novel Mnk1/2 Degrader VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
S. Ramalingam, Vidya P Ramamurthy, L. Gediya, Francis N. Murigi +8 more
2018bioRxiv0 citations Open access
Semantic Scholar
Abstract B30: Inhibition of eIF4E/MNK axis by novel MNKDAs reduces breast cancer tumor growth, migration, invasion and metastasis
S. Ramalingam, L. Gediya, Vidya P Ramamurthy, Yong-Woo Choi +2 more
20170 citations
Semantic Scholar
Abstract 5408: The novel retinamide VNLG-152, which targets translation by promoting degradation of MAPK-interacting kinases, has preferential activity in acute myeloid leukemia with FLT3-ITD
S. Karne, K. Natarajan, S. Ramalingam, L. Gediya +2 more
20150 citations
Semantic Scholar
Abstract 2704: Simultaneous targeting of androgen receptor (AR) and Eukaryotic Initiation Factor 4E (eIF4E) dependent translation initiation by RAMBA Retinamides promotes apoptosis and impedes cell growth, cell proliferation and matrix invasion in androgen sensitive and castration-resistant prostate
Vidya P Ramamurthy, S. Ramalingam, L. Gediya, V. Njar
20140 citations
Semantic Scholar
Abstract 756: First MNK degrading agents block phosphorylation of eIF4E, induce apoptosis, and inhibit cell growth, migration and invasion in triple-negative and HER2-overexpressing breast cancer cell lines
S. Ramalingam, L. Gediya, P. Purushottamachar, Andrew K. Kwegyir-Afful +3 more
20140 citations
Semantic Scholar
Abstract 659: Inhibiting autophagy improves the efficacy of VN/12-1 over all-trans retinoic acid in a HER2 over-expressing SK-BR3 breast cancer xenograft model
Abhijit Godbole, P. Purushottamachar, L. Gediya, V. Njar
20110 citations
Semantic Scholar
Abstract LB-340: Inhibition of autophagy enhances the anticancer activity of the retinoic acid derivative VN/12-1 in endocrine resistant human breast cancer cell lines
Abhijit Godbole, P. Purushottamachar, L. Gediya, V. Njar
20100 citations
Semantic Scholar
Edinburgh Research Explorer (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors
T. Dexheimer, L. Gediya, A. Stephen, Iwona E. Weidlich +8 more
20090 citations
Semantic Scholar
C-17 heteroaryl steroidal CYP17 inhibitors
V. Njar, A. Brodie, L. Gediya
20090 citations
Semantic Scholar
RAMBAs for Breast Cancer Prevention and Treatment
V. Njar, J. Mehta, L. Gediya, A. Khandelwa +4 more
20090 citations
Semantic Scholar
27 INVITED Novel atypical retinoic acid metabolism blocking agents (RAMBAs)/ CYP26 inhibitors for breast cancer therapy
L. Gediya, P. Purushottamachar, A. Khandelwal, J. Mehta +2 more
20080 citations
Semantic Scholar
Preclinical pharmacokinetics, absolute oral bioavailability and anti-cancer activity of VN/14-1 in human prostate cancer PC-3 cells
A. Khandelwal, L. Gediya, Vijay V. Upreti, V. Njar
20070 citations
Semantic Scholar
Total Synthesis of cis and trans‐Hydroxyglimepiride: Active Metabolite of Glimepiride.
M. Gurjar, R. A. Joshi, S. Chaudhuri, S. Joshi +5 more
20030 citations
Semantic Scholar

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V. Njar — researcher profile on SciRah
P. Purushottamachar×21
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