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T. Dexheimer · SciRah

Researcher profile · Semantic Scholar

T. Dexheimer

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T. Dexheimer — researcher profile on SciRah

h-index: 38
Works: 161
Citations: 4,728

Most-cited papers

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses
Qin Liang, T. Dexheimer, Ping Zhang, Andrew S. Rosenthal +14 more
2014Nature Chemical Biology251 citations Open access
Semantic Scholar
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
W. Stafford, Xiao-Xiao Peng, M. Olofsson, Xiao-Nan Zhang +16 more
2018Science Translational Medicine215 citations Open access
Semantic Scholar
Suppression of the FOXM1 transcriptional program via novel small molecule inhibition
Michael V. Gormally, T. Dexheimer, Giovanni Marsico, Deborah A. Sanders +8 more
2014Nature Communications214 citations Open access
Semantic Scholar
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells
G. Nguyen, T. Dexheimer, Andrew S. Rosenthal, Wai-Kit Chu +15 more
2013Chemistry and Biology149 citations Open access
Semantic Scholar
DNA Repair Pathways and Mechanisms
T. Dexheimer
2013109 citations
Semantic Scholar
Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins
Corey L Jones, Evert Njomen, B. Sjögren, T. Dexheimer +1 more
2017ACS Chemical Biology87 citations Open access
Semantic Scholar
Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death
Mengyu Liu, De-Xin Sui, T. Dexheimer, Stacy L. Hovde +15 more
2020Molecular Neurobiology78 citations Open access
Semantic Scholar
Synthesis and Structure−Activity Relationship Studies of N‐Benzyl-2- phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer
T. Dexheimer, Andrew S. Rosenthal, D. Luci, Qin Liang +8 more
201459 citations
Semantic Scholar
Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells
Sean A. Misek, K. Appleton, T. Dexheimer, Erika M. Lisabeth +4 more
2019Oncogene53 citations Open access
Semantic Scholar
Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions
Mengyu Liu, T. Dexheimer, De-Xin Sui, Stacy L. Hovde +4 more
2020Scientific Reports50 citations Open access
Semantic Scholar
Spermine in semen of male sea lamprey acts as a sex pheromone
A. M. Scott, Zhe Zhang, Liang Jia, Ke Li +8 more
2019PLoS Biology50 citations Open access
Semantic Scholar
Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds
E. Lisabeth, Dylan Kahl, I. Gopallawa, S. Haynes +9 more
2018bioRxiv46 citations Open access
Semantic Scholar
Chemerin-induced arterial contraction is Gi- and calcium-dependent
David J. Ferland, Emma S. Darios, R. Neubig, B. Sjögren +5 more
2016Vascular pharmacology43 citations Open access
Semantic Scholar
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)
Joshua A. Sommers, Tomasz Kulikowicz, D. Croteau, T. Dexheimer +6 more
2019PLoS ONE42 citations Open access
Semantic Scholar
Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex
T. Dexheimer, Andrew S. Rosenthal, Qin Liang, Junjun Chen +6 more
201438 citations
Semantic Scholar
5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Reponse Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma
Dylan Kahl, K. Hutchings, E. Lisabeth, A. Haak +11 more
2019Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Analysis of Infected Host Gene Expression Reveals Repurposed Drug Candidates and Time-Dependent Host Response Dynamics for COVID-19
Jing Xing, Rama Shankar, A. Drelich, S. Paithankar +6 more
2020bioRxiv31 citations Open access
Semantic Scholar
Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays
Jonathan A. Lee, P. Shinn, S. Jaken, S. Oliver +21 more
2015PLoS ONE23 citations Open access
Semantic Scholar
Biochemical assays for the discovery of TDP1 inhibitors
C. Marchand, Shar-yin N. Huang, T. Dexheimer, W. Lea +13 more
2014Molecular Cancer Therapeutics22 citations Open access
Semantic Scholar
Neuroprotection and repair of 3′-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1)
Dongyu Guo, T. Dexheimer, Y. Pommier, H. Nash
2014Proceedings of the National Academy of Sciences of the United States of America20 citations Open access
Semantic Scholar
HTS384 NCI60: The Next Phase of the NCI60 Screen
Mark W. Kunkel, N. Coussens, Joel Morris, Ronald C Taylor +4 more
2024Cancer Research19 citations Open access
Semantic Scholar
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy
M. Gandelman, W. Dansithong, Stephen C. Kales, Sharan Paul +13 more
2021Journal of Biological Chemistry19 citations Open access
Semantic Scholar
A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein
Joseph Carver, T. Dexheimer, Dennis J. Hsu, Meng-Tzu Weng +5 more
2014PLoS ONE18 citations Open access
Semantic Scholar
Convergent olfactory trace amine-associated receptors detect biogenic polyamines with distinct motifs via a conserved binding site
Liang Jia, Shengju Li, Wenxuan Dai, Lingna Guo +10 more
2021Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems–based Resource
Joel Morris, M. Kunkel, Stephen L White, D. Wishka +17 more
2023Molecular Cancer Therapeutics16 citations Open access
Semantic Scholar
A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2
D. Scoles, M. Gandelman, Sharan Paul, T. Dexheimer +12 more
2022Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides
Ho-Jun Jung, Vineet Kumar, T. Dexheimer, Iwona Wedlich +3 more
2017European Journal of Pharmaceutical Sciences15 citations Open access
Semantic Scholar
Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs
T. Dexheimer, N. Coussens, T. Silvers, J. Wright +3 more
2023Cancer Research Communications12 citations Open access
Semantic Scholar
Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase
Andrew S. Rosenthal, T. Dexheimer, G. Nguyen, O. Gileadi +5 more
201312 citations
Semantic Scholar
Two highly related odorant receptors specifically detect α-bile acid pheromones in sea lamprey (Petromyzon marinus)
Zhe Zhang, Qing-Hua Zhang, T. Dexheimer, Jian-Feng Ren +2 more
2020Journal of Biological Chemistry10 citations Open access
Semantic Scholar
Inhibition of the Myocardin-Related Transcription Factor Pathway Increases Efficacy of Trametinib in NRAS-Mutant Melanoma Cell Lines
K. Appleton, C. Palsuledesai, Sean A. Misek, Maja K. Blake +4 more
2019bioRxiv10 citations Open access
Semantic Scholar
Investigation of novel chemotherapeutics for feline oral squamous cell carcinoma
Hunter J. Piegols, M. Takada, Maciej Parys, T. Dexheimer +1 more
2018OncoTarget10 citations Open access
Semantic Scholar
Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids.
N. Coussens, T. Dexheimer, T. Silvers, Phillip R. Sanchez +5 more
2025SLAS discovery : advancing life sciences R & D7 citations Open access
Semantic Scholar
Combination screen in multi-cell type tumor spheroids reveals interaction between aryl hydrocarbon receptor antagonists and E1 ubiquitin-activating enzyme inhibitor
T. Dexheimer, N. Coussens, T. Silvers, Eric M. Jones +6 more
2024SLAS discovery : advancing life sciences R & D6 citations Open access
Semantic Scholar
BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors
Sean A. Misek, Bardees M. Foda, T. Dexheimer, M. Akram +4 more
2021bioRxiv6 citations Open access
Semantic Scholar
Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3′- and 5′-phosphodiester-DNA bond cleavage
E. Kiselev, T. Dexheimer, C. Marchand, Shar-yin N. Huang +1 more
2018DNA Repair6 citations Open access
Semantic Scholar
Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay
Vanessa Benham, B. Bullard, T. Dexheimer, Matthew P. Bernard +3 more
2019Scientific Reports5 citations Open access
Semantic Scholar
Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids
T. Dexheimer, Z. Davoudi, N. Coussens, T. Silvers +6 more
2025SLAS discovery : advancing life sciences R & D4 citations Open access
Semantic Scholar
Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators
Sophia D Staerz, E. Lisabeth, Evert Njomen, T. Dexheimer +2 more
2023ACS Omega4 citations Open access
Semantic Scholar
Targeted therapy combinations with ipatasertib in multi-cell type 3D tumor spheroid models
Beverly A. Teicher, Naoko Takebe, T. Dexheimer, T. Silvers +3 more
2025Academia oncology3 citations
Semantic Scholar
Polymerase Ѳ inhibitors combinations with approved and investigational agents in patient-derived tumor multi-cell type (mct) spheroids
Beverly A. Teicher, T. Dexheimer, Li Chen, T. Silvers +4 more
2025Experimental and molecular pathology (Print)3 citations Open access
Semantic Scholar
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19
Jing Xing, Rama Shankar, A. Drelich, S. Paithankar +6 more
20203 citations
Semantic Scholar
Abstract 1: A small molecule inhibits Nrf2 expression and activity in cancer cells
Di Zhang, Corbin K. Livingston, T. Dexheimer, Edmund Ellsworth +2 more
2019Cancer Chemistry3 citations
Semantic Scholar
Abstract 4884: Targeted investigational oncology agents (IOA) in the NCI60: a phenotypic systems-based resource
Joel Morris, M. Kunkel, Stephen L White, D. Wishka +13 more
2023Cancer Research2 citations
Semantic Scholar
Rho-mediated MRTF and YAP1 activation contributes to BRAF inhibitor resistance in Sox9High/Sox10Low melanoma cells.
Sean A. Misek, K. Appleton, T. Dexheimer, E. Lisabeth +4 more
20182 citations Open access
Semantic Scholar
A platform to enable the pharmacological profiling of small molecules in gel-based electrophoretic mobility shift assays
Timothy L. Foley, D. Dorjsuren, T. Dexheimer, M. Burkart +2 more
2016Journal of biomolecular screening2 citations Open access
Semantic Scholar
High-throughput combination screening of Pidnarulex and other G-quadruplex ligands in multi-cell type tumor spheroids
T. Dexheimer, N. Coussens, T. Silvers, Poorva Juneja +5 more
2025SLAS discovery : advancing life sciences R & D1 citations Open access
Semantic Scholar
RAS Pathway Inhibitors Combined with Targeted Agents Are Active in Patient-Derived Spheroids with Oncogenic KRAS Variants from Multiple Cancer Types
Z. Davoudi, T. Dexheimer, N. Coussens, T. Silvers +8 more
2025Cancer Research Communications1 citations
Semantic Scholar
Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning
Smita Sahay, Jingran Wen, D. Scoles, A. Simeonov +7 more
2025Biology1 citations Open access
Semantic Scholar
Drug combinations with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids
N. Coussens, T. Dexheimer, T. Silvers, Phillip R. Sanchez +3 more
2024bioRxiv1 citations Open access
Semantic Scholar

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