Researcher profile · Semantic Scholar

L. Macedo

h-index: 21
Works: 36
Citations: 1,323

Most-cited papers

Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole.
L. Macedo, Zhiyong Guo, Syreeta L. Tilghman, G. Sabnis +2 more
2006Cancer Research160 citations Open access
Semantic Scholar
Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole.
D. Jelovac, G. Sabnis, B. Long, L. Macedo +2 more
2005Cancer Research137 citations Open access
Semantic Scholar
Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model.
D. Jelovac, L. Macedo, O. Goloubeva, Venkatesh D. Handratta +1 more
2005Cancer Research119 citations
Semantic Scholar
Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen
G. Sabnis, A. Schayowitz, O. Goloubeva, L. Macedo +1 more
2009Cancer Research115 citations Open access
Semantic Scholar
Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model.
L. Macedo, G. Sabnis, O. Goloubeva, A. Brodie
2008Cancer Research91 citations Open access
Semantic Scholar
Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol.
Alcides J. M. da Silva, C. Buarque, Flávia V. Brito, L. Aurelian +11 more
2002Bioorganic & Medicinal Chemistry81 citations
Semantic Scholar
Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer
X. Hou, Fei Huang, L. Macedo, S. Harrington +7 more
2011Cancer Research78 citations Open access
Semantic Scholar
Stopping treatment can reverse acquired resistance to letrozole.
G. Sabnis, L. Macedo, O. Goloubeva, A. Schayowitz +1 more
2008Cancer Research57 citations Open access
Semantic Scholar
Therapeutic observations in MCF-7 aromatase xenografts.
A. Brodie, D. Jelovac, L. Macedo, G. Sabnis +2 more
2005Clinical Cancer Research53 citations
Semantic Scholar
Model systems: mechanisms involved in the loss of sensitivity to letrozole.
A. Brodie, D. Jelovac, G. Sabnis, B. Long +2 more
2005Journal of Steroid Biochemistry and Molecular Biology47 citations
Semantic Scholar
GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells
T. Abrhale, A. Brodie, G. Sabnis, L. Macedo +3 more
2011BMC Cancer45 citations Open access
Semantic Scholar
Aromatase Inhibitors and Breast Cancer
L. Macedo, G. Sabnis, A. Brodie
2009Annals of the New York Academy of Sciences37 citations
Semantic Scholar
Sensitivity to aromatase inhibitor letrozole is prolonged after a “break” in treatment
G. Sabnis, O. Goloubeva, R. Gilani, L. Macedo +1 more
2010Molecular Cancer Therapeutics34 citations Open access
Semantic Scholar
Steroidogenic Enzyme Inhibitors and Hormone Dependent Cancer
A. Brodie, V. Njar, L. Macedo, Vasaits Tadas Sean +1 more
2009Urologic oncology33 citations Open access
Semantic Scholar
Effects of Exemestane and Tamoxifen in a Postmenopausal Breast Cancer Model
D. Jelovac, L. Macedo, Venkatesh D. Handratta, B. Long +3 more
2004Clinical Cancer Research33 citations Open access
Semantic Scholar
Preclinical modeling of endocrine response and resistance
L. Macedo, G. Sabnis, A. Brodie
2008Cancer32 citations Open access
Semantic Scholar
Xenograft models for aromatase inhibitor studies.
A. Brodie, G. Sabnis, L. Macedo
2007Journal of Steroid Biochemistry and Molecular Biology27 citations
Semantic Scholar
Aromatase Resistance Mechanisms in Model Systems in vivo
A. Brodie, L. Macedo, G. Sabnis
2009Journal of Steroid Biochemistry and Molecular Biology24 citations Open access
Semantic Scholar
Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells
S. Burks, L. Macedo, Eugene D. Barth, K. Tkaczuk +5 more
2010Breast Cancer Research and Treatment22 citations Open access
Semantic Scholar
ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole
M. Smollich, M. Götte, Jeanett Fischgräbe, L. Macedo +5 more
2010Breast Cancer Research and Treatment21 citations Open access
Semantic Scholar
Effects of the Antiestrogen Tamoxifen and the Aromatase Inhibitor Letrozole on Serum Hormones and Bone Characteristics in a Preclinical Tumor Model for Breast Cancer
N. Núñez, D. Jelovac, L. Macedo, D. Berrigan +4 more
2004Clinical Cancer Research21 citations Open access
Semantic Scholar
Ochratoxin A and Portuguese children: Urine biomonitoring, intake estimation and risk assessment.
Liliana J. G. Silva, L. Macedo, A. Pereira, S. Duarte +2 more
2019Food and Chemical Toxicology19 citations
Semantic Scholar
Complete IGF Signaling Blockade by the Dual-Kinase Inhibitor, BMS-754807, Is Sufficient To Overcome Tamoxifen and Letrozole Resistance In Vitro and In Vivo.
P. Haluska, X. Hou, Fei Huang, S. Harrington +6 more
200917 citations
Semantic Scholar
Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model.
G. Sabnis, L. Macedo, O. Goloubeva, A. Schayowitz +2 more
2008Journal of Steroid Biochemistry and Molecular Biology10 citations Open access
Semantic Scholar
Combination of HDACi entinostat (SNDX-275) with letrozole provides control over tumor growth in MDA-MB-231 xenograft model.
G. Sabnis, O. Goloubeva, L. Macedo, R. Gilani +3 more
20094 citations
Semantic Scholar
Expression of ERα and Aromatase in MDA-MB-231 Tumors by HDAC Inhibitor Entinostat Leads to Growth Inhibition by Aromatase Inhibitor Letrozole.
G. Sabnis, O. Goloubeva, R. Gilani, N. Nguyen +4 more
20093 citations
Semantic Scholar
Developing Better Herbal Medicines in the Post-Genomic Era
A. F. Macedo, L. Macedo
20122 citations
Semantic Scholar
Abstract 2035: A 3-dimensional tumoroid model made up of lung cancer cells, fibroblasts, and endothelial cells is predictive of drug activity in animal models
L. Macedo, Elizabeth A. Kaiser, B. Heidrich, Barbara S. Bushey +2 more
20141 citations
Semantic Scholar
Abstract A190: Colon tumor cells expressing CD24 have oncogenic properties and are inhibited by monoclonal antibody immunotherapy.
L. Macedo, Elizabeth A. Kaiser, Hai-Yan Jiang, Hillary J. Millar +12 more
20130 citations
Semantic Scholar
Abstract C189: CD24 plays an important role on NSCLC cell functions relevant to tumor growth.
L. Macedo, Elizabeth A. Kaiser, Hai-Yan Jiang, Hillary J. Millar +5 more
20130 citations
Semantic Scholar
The dual IGF-1 R / InsR inhibitor , BMS-754807 , demonstrates synergy in combination with hormonal agents in vitro and enhances in vivo activity in an estrogen-dependent breast cancer model
X. Hou, Fei Huang, L. Macedo, S. Harrington +7 more
20110 citations
Semantic Scholar
Therapeutics , Targets , and Chemical Biology Dual IGF-1 R / InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer
X. Hou, Fei Huang, L. Macedo, S. Harrington +7 more
20110 citations
Semantic Scholar
Abstract 2334: A novel αVintegrin antibody, intetumumab (CNTO 95), enhances anti-tumor activity against human non-small cell lung cancer through disruption of the FAK/ERK/AKT pathway and regulation of p27KIP1
B. Heidrich, Qiming Chen, L. Macedo, Catherine Ferrante +4 more
20100 citations
Semantic Scholar
The Growth Factor GP88 (Progranulin) Confers Aromatase Inhibitor Resistance to Breast Cancer Cells.
G. Serrero, A. Brodie, G. Sabnis, L. Macedo +1 more
20090 citations
Semantic Scholar
Specific endothelin-A-receptor antagonist ZD4054 inhibits breast cancer growth in vitro and in vivo
M. Smollich, M. Götte, J. Fischgräbe, I. Radke +3 more
20080 citations
Semantic Scholar
The Human Breast Cancer Cell DNA Synthesome Can Serve as a Novel In Vitro Model System for Studying the Mechanisms of Action of Anticancer Drugs
L. Macedo, L. Malkas
20010 citations
Semantic Scholar

D. Jelovac

×6

X. Hou×4

Fei Huang×4

A. Greer×4

M. Gottardis×4

J. Carboni×4

P. Haluska×4

B. Long×3