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W. Langdon · SciRah

Researcher profile · Semantic Scholar

W. Langdon

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W. Langdon — researcher profile on SciRah

h-index: 54
Works: 157
Citations: 11K

Most-cited papers

Cbl: many adaptations to regulate protein tyrosine kinases
C. Thien, W. Langdon
2001Nature reviews. Molecular cell biology651 citations
Semantic Scholar
Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors
Philippe Soubeyran, Katarzyna Kowanetz, I. Szymkiewicz, W. Langdon +1 more
2002Nature594 citations
Semantic Scholar
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein.
P. Peschard, Tanya M. Fournier, L. Lamorte, M. Naujokas +3 more
2001Molecules and Cells467 citations Open access
Semantic Scholar
The E3 Ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
M. Paolino, A. Choidas, S. Wallner, Blanka Pranjić +20 more
2014Nature431 citations Open access
Semantic Scholar
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.
C. Thien, W. Langdon
2005Biochemical Journal263 citations Open access
Semantic Scholar
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling
E. Wong, C. Fong, Jormay Lim, P. Yusoff +3 more
2002EMBO Journal241 citations Open access
Semantic Scholar
RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.
C. Thien, F. Walker, W. Langdon
2001Molecules and Cells182 citations Open access
Semantic Scholar
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling
E. Sandilands, B. Serrels, David G. McEwan, J. Morton +10 more
2011Nature Cell Biology180 citations
Semantic Scholar
Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia
Juan Tang, Sha Tu, Guoxin Lin, Hui Guo +18 more
2020Journal of Experimental Medicine165 citations Open access
Semantic Scholar
The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation
C. Andoniou, N. L. Lill, C. Thien, M. Lupher +5 more
2000Molecular and Cellular Biology136 citations Open access
Semantic Scholar
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.
J. Molero, T. Jensen, P. Withers, Michelle Couzens +8 more
2004Journal of Clinical Investigation119 citations Open access
Semantic Scholar
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.
C. Rathinam, C. Thien, W. Langdon, Hua Gu +1 more
2008Genes & Development117 citations Open access
Semantic Scholar
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.
C. Rathinam, C. Thien, R. Flavell, W. Langdon
2010Cancer Cell100 citations Open access
Semantic Scholar
Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b–Regulated T Cell Functions
M. Paolino, C. Thien, Thomas Gruber, Reinhard Hinterleitner +3 more
2011Journal of Immunology97 citations
Semantic Scholar
Inhibition of CBL-B protects from lethal C. albicans sepsis
Gerald Wirnsberger, Florian Zwolanek, T. Asaoka, I. Kozieradzki +9 more
2016Nature Medicine96 citations Open access
Semantic Scholar
Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-restricted progenitor.
P. Sathe, D. Metcalf, D. Vremec, S. Naik +4 more
2014Immunity93 citations Open access
Semantic Scholar
The Adapter Type Protein CMS/CD2AP Binds to the Proto-oncogenic Protein c-Cbl through a Tyrosine Phosphorylation-regulated Src Homology 3 Domain Interaction*
K. H. Kirsch, M. Georgescu, Tomoyuki Shishido, W. Langdon +2 more
2001Journal of Biological Chemistry93 citations Open access
Semantic Scholar
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
Juan Tang, Guoxin Lin, W. Langdon, L. Tao +1 more
2018Frontiers in Immunology92 citations Open access
Semantic Scholar
Regulation of immune responses by E3 ubiquitin ligase Cbl-b
Rong Tang, W. Langdon, Jian Zhang
2018Cellular Immunology83 citations Open access
Semantic Scholar
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1
S. Kojo, C. Elly, Yohsuke Harada, W. Langdon +2 more
2009Proceedings of the National Academy of Sciences of the United States of America83 citations Open access
Semantic Scholar
Loss of c‐Cbl RING finger function results in high‐intensity TCR signaling and thymic deletion
C. Thien, Frøydis D. Blystad, Y. Zhan, A. Lew +3 more
2005EMBO Journal82 citations
Semantic Scholar
Targeting CBLB as a Potential Therapeutic Approach for Disseminated Candidiasis
Yun-Peng Xiao, Juan Tang, Hui Guo, Yixia Zhao +11 more
2016Nature Medicine78 citations Open access
Semantic Scholar
E3 ubiquitin ligase Cbl-b in innate and adaptive immunity
Qing-Jun Liu, Hong Zhou, W. Langdon, Jian Zhang
2014Cell Cycle75 citations Open access
Semantic Scholar
E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity
Hui Guo, Guilin Qiao, Haiyan Ying, Zhenping Li +7 more
2012Cell Reports75 citations Open access
Semantic Scholar
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal‐Center Reaction
Xin Li, A.J. Gadzinsky, Liying Gong, H. Tong +8 more
2018Immunity71 citations Open access
Semantic Scholar
A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis
M. Kundu, S. Pathak, K. Kumawat, Sanchita Basu +8 more
2009Nature Immunology71 citations
Semantic Scholar
Mini ReviewNegative regulation of PTK signalling by Cbl proteins
C. Thien, W. Langdon
2005Growth Factors66 citations
Semantic Scholar
CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies
K. Lv, Jing Jiang, Ryan Donaghy, C. Riling +15 more
2017Genes & Development65 citations Open access
Semantic Scholar
E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation
Guilin Qiao, Haiyan Ying, Yixia Zhao, Yan-Ran Liang +10 more
2014Cell Reports65 citations Open access
Semantic Scholar
T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells
Guilin Qiao, Yixia Zhao, Zhenping Li, Peter Q. Tang +3 more
2013Journal of Immunology56 citations Open access
Semantic Scholar
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor
M. Oksvold, C. Thien, Jannicke Widerberg, A. Chantry +2 more
2003Oncogene54 citations Open access
Semantic Scholar
Identification of 14‐3‐3ζ as an EGF receptor interacting protein
M. Oksvold, Henrik S. Huitfeldt, W. Langdon
2004FEBS Letters50 citations
Semantic Scholar
A Mouse with a Loss-of-function Mutation in the c-Cbl TKB Domain Shows Perturbed Thymocyte Signaling without Enhancing the Activity of the ZAP-70 Tyrosine Kinase
C. Thien, R. Scaife, J. Papadimitriou, M. A. Murphy +2 more
2003Journal of Experimental Medicine50 citations Open access
Semantic Scholar
Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action
J. Molero, N. Turner, C. Thien, W. Langdon +2 more
2006Diabetes48 citations Open access
Semantic Scholar
E3 Ubiquitin Ligases Cbl-b Regulates Thymic- Derived CD4+CD25+ Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination
Yixia Zhao, Hui Guo, Guilin Qiao, M. Zucker +2 more
2015Journal of Immunology47 citations Open access
Semantic Scholar
Cbl-b Is a Negative Regulator of Inflammatory Cytokines Produced by IgE-Activated Mast Cells1
Sonja E. Gustin, C. Thien, W. Langdon
2006Journal of Immunology44 citations
Semantic Scholar
Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib
Samuel J. Taylor, Johanna M. Duyvestyn, Samantha A. Dagger, Emma J. Dishington +5 more
2017Science Translational Medicine43 citations
Semantic Scholar
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation
Yun-Peng Xiao, Guilin Qiao, Juan Tang, Rong Tang +5 more
2015Journal of Immunology43 citations Open access
Semantic Scholar
Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling.
Samuel J. Taylor, Samantha A. Dagger, C. Thien, M. Wikström +1 more
2012Blood42 citations Open access
Semantic Scholar
The Loss of Cbl-Phosphatidylinositol 3-Kinase Interaction Perturbs RANKL-mediated Signaling, Inhibiting Bone Resorption and Promoting Osteoclast Survival*
N. Adapala, M. Barbe, W. Langdon, Mary C. Nakamura +2 more
2010Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Negative regulation of receptor tyrosine kinases by ubiquitination: Key roles of the Cbl family of E3 ubiquitin ligases
Rong Tang, W. Langdon, Jian Zhang
2022Frontiers in Endocrinology37 citations Open access
Semantic Scholar
The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly
R. Scaife, S. Courtneidge, W. Langdon
2003Journal of Cell Science37 citations Open access
Semantic Scholar
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome
Juan Tang, Yizhi Xiao, Guoxin Lin, Hui Guo +9 more
2021Science Signaling35 citations Open access
Semantic Scholar
Human IgG1 antibodies suppress angiogenesis in a target-independent manner
S. Bogdanovich, Young-hee Kim, Takeshi Mizutani, Reo Yasuma +32 more
2016Signal Transduction and Targeted Therapy35 citations Open access
Semantic Scholar
Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling.
Lorena Buitrago, W. Langdon, A. Sanjay, S. Kunapuli
2011Blood33 citations Open access
Semantic Scholar
Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion.
Tanya M. Fournier, L. Lamorte, C. Maroun, M. Lupher +3 more
2000Molecular Biology of the Cell33 citations Open access
Semantic Scholar
Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cbl.
R. Scaife, D. Job, W. Langdon
2003Molecular Biology of the Cell32 citations Open access
Semantic Scholar
The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation.
Tomoyuki Shishido, T. Akagi, Toru Ouchi, M. Georgescu +2 more
2000Proceedings of the National Academy of Sciences of the United States of America29 citations Open access
Semantic Scholar
Cbl-b Is a Novel Physiologic Regulator of Glycoprotein VI-dependent Platelet Activation*
J. Daniel, C. Dangelmaier, S. Mada, Lorena Buitrago +5 more
2010Journal of Biological Chemistry28 citations Open access
Semantic Scholar
The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells.
M. Oksvold, Samantha A. Dagger, C. Thien, W. Langdon
2008Molecular Immunology28 citations Open access
Semantic Scholar

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