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Huan-Chun Zhang · SciRah

Researcher profile · Semantic Scholar

Huan-Chun Zhang

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Huan-Chun Zhang — researcher profile on SciRah

h-index: 15
Works: 30
Citations: 829

Most-cited papers

Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Chalet Tan, R. D. de Noronha, A. J. Roecker, B. Pyrzynska +11 more
2005Cancer Research162 citations Open access
Semantic Scholar
Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA5 and NHERF2
Songbai Lin, S. Yeruva, Pei-Jian He, A. Singh +10 more
2009Gastroenterology105 citations Open access
Semantic Scholar
Lysophosphatidic Acid Facilitates Proliferation of Colon Cancer Cells via Induction of Krüppel-like Factor 5*
Huan-Chun Zhang, A. Bialkowska, Raluca Rusovici, Sengthong Chanchevalap +4 more
2007Journal of Biological Chemistry88 citations Open access
Semantic Scholar
Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor.
Dong-Sheng Wang, Huan-Chun Zhang, F. Lang, C. Yun
2007American Journal of Physiology - Cell Physiology70 citations Open access
Semantic Scholar
mRNA-binding Protein ZFP36 is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells
Huan-Chun Zhang, W. Taylor, Giji K. Joseph, V. Caracciolo +5 more
2013Arteriosclerosis, Thrombosis and Vascular Biology67 citations Open access
Semantic Scholar
IRBIT, Inositol 1,4,5-Triphosphate (IP3) Receptor-binding Protein Released with IP3, Binds Na+/H+ Exchanger NHE3 and Activates NHE3 Activity in Response to Calcium*
Pei-Jian He, Huan-Chun Zhang, C. Yun
2008Journal of Biological Chemistry65 citations Open access
Semantic Scholar
MAGI-3 regulates LPA-induced activation of Erk and RhoA.
Huan-Chun Zhang, Dong-Sheng Wang, Hong Sun, R. Hall +1 more
2007Cellular Signalling59 citations Open access
Semantic Scholar
Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani +7 more
2020Acta Pharmaceutica Sinica B30 citations Open access
Semantic Scholar
Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules
Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Mary C. Casey, J. Kankanala +8 more
2020Viruses26 citations Open access
Semantic Scholar
Chemical Profiling of HIV-1 Capsid-Targeting Antiviral PF74
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, H. Do +9 more
2020European journal of medicinal chemistry22 citations Open access
Semantic Scholar
Novel HIV-1 Capsid-Targeting Small Molecules of the PF74 Binding Site
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani +9 more
2020European journal of medicinal chemistry20 citations Open access
Semantic Scholar
The mRNa-Binding Protein Zfp36 Is Upregulated by β-Adrenergic Stimulation and Represses IL-6 Production in 3T3-L1 Adipocytes
P. Brahma, Huan-Chun Zhang, B. Murray, Feng-Jue Shu +3 more
2011Obesity20 citations Open access
Semantic Scholar
Nirmatrelvir Resistance in SARS-CoV-2 Omicron_BA.1 and WA1 Replicons and Escape Strategies
S. Lan, Grace Neilsen, R. Slack, William A. Cantara +8 more
2023bioRxiv18 citations Open access
Semantic Scholar
Discovery of nirmatrelvir resistance mutations in SARS-CoV-2 3CLpro: A computational-experimental approach
Brandon Havranek, Robel Demissie, Hyun Lee, Shui-Yun Lan +4 more
2023Journal of Chemical Information and Modeling16 citations
Semantic Scholar
Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74
Rajkumar Lalji Sahani, Raquel Diana-Rivero, Sanjeev Kumar V. Vernekar, Lei Wang +9 more
2021Viruses16 citations Open access
Semantic Scholar
Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches
Sameera Senaweera, Haijuan Du, Huan-Chun Zhang, K. Kirby +4 more
2021Viruses13 citations Open access
Semantic Scholar
Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease
Grace Neilsen, Shui-Yun Lan, Ryan L. Slack, Z. C. Lorson +14 more
2025Science Advances12 citations Open access
Semantic Scholar
Design and Synthesis of New GS-6207 Subtypes for Targeting HIV-1 Capsid Protein
Thamina Akther, W. M. McFadden, Huan-Chun Zhang, K. Kirby +2 more
2024International Journal of Molecular Sciences8 citations Open access
Semantic Scholar
Quinazolinone-based Subchemotypes for Targeting HIV-1 Capsid Protein: Design and Synthesis
Thamina Akther, W. M. McFadden, Huan-Chun Zhang, K. Kirby +2 more
2024Medicinal Chemistry Research3 citations
Semantic Scholar
Monkeypox Virus Is Inhibited by Nucleoside Analogues Including the Acyclic Phosphonates Adefovir and Tenofovir In Vitro
Jasper Lee, Huan-Chun Zhang, E. A. Boggs, J. Kilcullen +8 more
2025Journal of Medical Virology2 citations
Semantic Scholar
Mpox Virus is Inhibited By Nucleoside Analogues Including the Acyclic Phosphonates Tenofovir and Adefovir
Jasper Lee, E. A. Boggs, Huan-Chun Zhang, P. Tedbury +1 more
2023bioRxiv2 citations Open access
Semantic Scholar
Potency and metabolic stability: a molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein.
Rajkumar Lalji Sahani, Thamina Akther, Maria E. Cilento, A. E. Castaner +5 more
2021RSC Medicinal Chemistry2 citations Open access
Semantic Scholar
Stalling the Enemy: Targeting Nsp13 for Next-Generation SARS-CoV-2 Antivirals
Jose M. Castro, Ryan L. Slack, Ong T. Yee, Huan-Chun Zhang +10 more
2026International Journal of Molecular Sciences1 citations Open access
Semantic Scholar
Structural, biophysical, and virological mechanistic characterization of HIV-1 capsid-targeting antivirals
K. Kirby, W. M. McFadden, Lei Wang, Hai-Juan Du +17 more
2025bioRxiv1 citations Open access
Semantic Scholar
Design, synthesis and profiling of highly potent antivirals targeting emerging drug-resistant HIV-1 variants
Nicolas Jamey, D. M. Nirosh Udayanga, Huan-Chun Zhang, Shreya M. Ravichandran +9 more
2025bioRxiv1 citations Open access
Semantic Scholar
Breakthrough Design of Highly Potent Antivirals Against Wild-Type HIV-1 and Lenacapavir-Resistant M66I Variant.
Nicolas Jamey, D. M. Nirosh Udayanga, Huan-Chun Zhang, Roshan Katekar +10 more
2026Angewandte Chemie0 citations Open access
Semantic Scholar
Inside Front Cover: Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant
Nicolas Jamey, D. M. Nirosh Udayanga, Huan-Chun Zhang, Roshan Katekar +9 more
2026Angewandte Chemie International Edition0 citations
Semantic Scholar
1,4-Dihydroxy-1,8-napthyridinone (DHN) analogs as HIV-1 reverse transcriptase-associated RNase H inhibitors
Muhammad Syafiq Bin Shahari, Samuel Offei, Huan-Chun Zhang, J. Prahlad +4 more
2026Bioorganic chemistry (Print)0 citations Open access
Semantic Scholar
S1668 The PDZ Proteins, MAGI-3 and NHERF2, Reciprocally Regulate the Oncogenic Effects of LPA2 Receptor
Sei-Jung Lee, Huan-Chun Zhang, H. Shim, C. Yun
20100 citations Open access
Semantic Scholar
M1718 LPA Stimulates NHE3 Activity via LPA5 Receptor
Pei-Jian He, Songbai Lin, Huan-Chun Zhang, Dong-Sheng Wang +1 more
20080 citations
Semantic Scholar
Acute activation of Na + / H + exchanger NHE 3 by dexamethasone correlates with activation of SGK 1 and requires a functional glucocorticoid receptor
Dong-Sheng Wang, Huan-Chun Zhang, F. Lang, C. Yun
20060 citations
Semantic Scholar

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