Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

K. Kirby · SciRah

Researcher profile · Semantic Scholar

K. Kirby

Share profile

K. Kirby — researcher profile on SciRah

h-index: 28
Works: 115
Citations: 2,190

Most-cited papers

X-Ray Structures of Native HIV-1 Capsid Protein Reveal Conformational Variability
A. Gres, K. Kirby, V. KewalRamani, J. Tanner +2 more
2015Science229 citations Open access
Semantic Scholar
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
K. Zandi, Katie Musall, Adrian Oo, D. Cao +11 more
2021Microorganisms120 citations Open access
Semantic Scholar
Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities
Sanjeev Kumar V. Vernekar, Zheng Liu, É. Nagy, L. Miller +6 more
2014Journal of Medicinal Chemistry111 citations Open access
Semantic Scholar
4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms*
E. Michailidis, Andrew D. Huber, Emily M. Ryan, Ong T. Yee +11 more
2014Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)
Li-Sa-Lie Zhe, K. Kirby, E. Michailidis, B. Marchand +6 more
2016Proceedings of the National Academy of Sciences of the United States of America98 citations Open access
Semantic Scholar
Avoiding Drug Resistance in HIV Reverse Transcriptase
Maria E. Cilento, K. Kirby, S. Sarafianos
2021Chemical Reviews85 citations Open access
Semantic Scholar
Rotten to the core: antivirals targeting the HIV-1 capsid core
William M. McFadden, A. Snyder, K. Kirby, P. Tedbury +3 more
2021Retrovirology55 citations Open access
Semantic Scholar
Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.
J. Kankanala, K. Kirby, Feng Liu, L. Miller +5 more
2016Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
A small molecule inhibitor that stabilizes the autoinhibited conformation of the oncogenic tyrosine phosphatase SHP2
Xiao-Qin Wu, Gang Xu, Xiaobo Li, Wei-Ren Xu +7 more
2018Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Antiviral therapies: focus on Hepatitis B reverse transcriptase
E. Michailidis, K. Kirby, A. Hachiya, W. Yoo +4 more
2012International Journal of Biochemistry and Cell Biology44 citations Open access
Semantic Scholar
3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations
Jing Tang, Feng Liu, É. Nagy, L. Miller +6 more
2016Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine
K. Kirby, E. Michailidis, Tracy L. Fetterly, M. Steinbach +10 more
2013Antimicrobial Agents and Chemotherapy38 citations Open access
Semantic Scholar
Double-winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity
Sanjeev Kumar V. Vernekar, Jing Tang, Bulan Wu, Andrew D. Huber +8 more
2017Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
J. Kankanala, K. Kirby, Andrew D. Huber, Mary C. Casey +3 more
2017European journal of medicinal chemistry37 citations Open access
Semantic Scholar
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
E. Michailidis, Emily M. Ryan, A. Hachiya, K. Kirby +10 more
2013Retrovirology37 citations Open access
Semantic Scholar
Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
Kamalendra Singh, J. Flores, K. Kirby, U. Neogi +7 more
2014Viruses36 citations Open access
Semantic Scholar
Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase
K. Kirby, B. Marchand, Y. T. Ong, Tanyaradzwa P. Ndongwe +10 more
2012Antimicrobial Agents and Chemotherapy36 citations Open access
Semantic Scholar
Preparation of Biologically Active Single-Chain Variable Antibody Fragments that Target the HIV-1 gp120 V3 Loop
Y. T. Ong, K. Kirby, A. Hachiya, Leslie A. Chiang +6 more
2012Cellular and Molecular Biology32 citations
Semantic Scholar
SAMHD1 Has Differential Impact on the Efficacies of HIV Nucleoside Reverse Transcriptase Inhibitors
Andrew D. Huber, E. Michailidis, Megan L. Schultz, Y. T. Ong +8 more
2014Antimicrobial Agents and Chemotherapy31 citations Open access
Semantic Scholar
Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani +7 more
2020Acta Pharmaceutica Sinica B30 citations Open access
Semantic Scholar
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity
Lei Wang, Jing Tang, Andrew D. Huber, Mary C. Casey +7 more
2018European journal of medicinal chemistry28 citations Open access
Semantic Scholar
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H
Lei Wang, Jing Tang, Andrew D. Huber, Mary C. Casey +6 more
2018European journal of medicinal chemistry27 citations Open access
Semantic Scholar
Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules
Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Mary C. Casey, J. Kankanala +8 more
2020Viruses26 citations Open access
Semantic Scholar
The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells
Andrew D. Huber, J. Wolf, Dandan Liu, A. Gres +11 more
2018Msphere24 citations Open access
Semantic Scholar
Chemical Profiling of HIV-1 Capsid-Targeting Antiviral PF74
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, H. Do +9 more
2020European journal of medicinal chemistry22 citations Open access
Semantic Scholar
Impact of HIV-1 Integrase L74F and V75I Mutations in a Clinical Isolate on Resistance to Second-Generation Integrase Strand Transfer Inhibitors
A. Hachiya, K. Kirby, Y. Ido, Urara Shigemi +6 more
2017Antimicrobial Agents and Chemotherapy21 citations Open access
Semantic Scholar
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an Inhibitor Scaffold of HIV Reverase Transcriptase: Impacts of the 3-OH on Inhibiting RNase H and Polymerase
Jing Tang, K. Kirby, Andrew D. Huber, Mary C. Casey +4 more
2017European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Evaluation of Combinations of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine with Clinically Used Antiretroviral Drugs
A. Hachiya, Aaron B. Reeve, B. Marchand, E. Michailidis +9 more
2013Antimicrobial Agents and Chemotherapy21 citations Open access
Semantic Scholar
Novel HIV-1 Capsid-Targeting Small Molecules of the PF74 Binding Site
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani +9 more
2020European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: tolerance of a nonflexible linker
Jing Tang, H. Do, Andrew D. Huber, Mary C. Casey +6 more
2019European journal of medicinal chemistry20 citations Open access
Semantic Scholar
3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H
Andrew D. Huber, E. Michailidis, Jing Tang, M. Puray-Chavez +11 more
2017Antimicrobial Agents and Chemotherapy18 citations Open access
Semantic Scholar
Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization
A. Gres, K. Kirby, W. M. McFadden, Hai-Juan Du +11 more
2023Nature Communications16 citations Open access
Semantic Scholar
Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74
Rajkumar Lalji Sahani, Raquel Diana-Rivero, Sanjeev Kumar V. Vernekar, Lei Wang +9 more
2021Viruses16 citations Open access
Semantic Scholar
Novel Hepatitis B Virus Capsid-Targeting Antiviral that Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores
Andrew D. Huber, Dallas L. Pineda, Dandan Liu, Kelsey N Boschert +12 more
2018ACS Infectious Diseases15 citations Open access
Semantic Scholar
Molecular Dynamics Free Energy Simulations Reveal the Mechanism for the Antiviral Resistance of the M66I HIV-1 Capsid Mutation
Qinfang Sun, R. Levy, K. Kirby, Zheng-Qiang Wang +2 more
2021Viruses14 citations Open access
Semantic Scholar
Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches
Sameera Senaweera, Haijuan Du, Huan-Chun Zhang, K. Kirby +4 more
2021Viruses13 citations Open access
Semantic Scholar
Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket
Pierrick Craveur, A. Gres, K. Kirby, Dandan Liu +7 more
2019mBio13 citations Open access
Semantic Scholar
Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease
Grace Neilsen, Shui-Yun Lan, Ryan L. Slack, Z. C. Lorson +14 more
2025Science Advances12 citations Open access
Semantic Scholar
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase
K. Kirby, Nataliya A. Myshakina, Martin T. Christen, Yue-Lei Chen +12 more
2017Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition
W. M. McFadden, Mary C. Casey-Moore, Grant A L Bare, K. Kirby +14 more
2024Cell Chemical Biology11 citations Open access
Semantic Scholar
Adapting a trapped ion mobility spectrometry-Q-TOF for high m/z native mass spectrometry and surface-induced dissociation
Yu-Fu Lin, Benjamin J Jones, M. Ridgeway, Erin M. Panczyk +9 more
2025Analytical Chemistry10 citations Open access
Semantic Scholar
Design and Synthesis of New GS-6207 Subtypes for Targeting HIV-1 Capsid Protein
Thamina Akther, W. M. McFadden, Huan-Chun Zhang, K. Kirby +2 more
2024International Journal of Molecular Sciences8 citations Open access
Semantic Scholar
Restriction fragment mass polymorphism (RFMP) analysis based on MALDI-TOF mass spectrometry for detecting antiretroviral resistance in HIV-1 infected patients
J.-H. Lee, A. Hachiya, S.-K. Shin, J. Lee +9 more
2013Clinical Microbiology and Infection8 citations Open access
Semantic Scholar
Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid
Qinfang Sun, Avik Biswas, R. Vijayan, Pierrick Craveur +7 more
2022Journal of Computer-Aided Molecular Design7 citations Open access
Semantic Scholar
TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection
A. Selyutina, Lacy M. Simons, K. Kirby, Á. Bulnes-Ramos +4 more
2022Viruses7 citations Open access
Semantic Scholar
Subgenomic SARS-CoV-2 replicon and reporter replicon cell lines enable ultrahigh throughput antiviral screening and mechanistic studies with antivirals, viral mutations or host factors that affect COVID-19 replication
S. Lan, P. Tedbury, Y. T. Ong, Raven Shah +11 more
2021bioRxiv7 citations Open access
Semantic Scholar
Specific mutations in the HIV-1 G-tract of the 3'-polypurine tract cause resistance to integrase strand transfer inhibitors.
A. Hachiya, M. Kubota, Urara Shigemi, H. Ode +4 more
2021Journal of Antimicrobial Chemotherapy7 citations Open access
Semantic Scholar
Structural basis of clade‐specific HIV‐1 neutralization by humanized anti‐V3 monoclonal antibody KD‐247
K. Kirby, Y. T. Ong, A. Hachiya, T. G. Laughlin +11 more
2015The FASEB Journal5 citations Open access
Semantic Scholar
Considerations for Capsid-targeting Antiretrovirals in Pre-exposure prophylaxis (PrEP)
W. M. McFadden, Mia Faerch, K. Kirby, Robert A. Dick +2 more
2025Trends in Molecular Medicine4 citations Open access
Semantic Scholar
Quinazolinone-based Subchemotypes for Targeting HIV-1 Capsid Protein: Design and Synthesis
Thamina Akther, W. M. McFadden, Huan-Chun Zhang, K. Kirby +2 more
2024Medicinal Chemistry Research3 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

S. Sarafianos×41
Invite
S. Sarafianos — researcher profile on SciRah
Zheng-Qiang Wang×24
Invite
Zheng-Qiang Wang — researcher profile on SciRah
M. Parniak×16
Invite
M. Parniak — researcher profile on SciRah
Andrew D. Huber×13
Invite
Andrew D. Huber — researcher profile on SciRah

×12

Invite

A. Hachiya — researcher profile on SciRah

Kamalendra Singh×11

Invite

Kamalendra Singh — researcher profile on SciRah

Mary C. Casey×11

Invite

Mary C. Casey — researcher profile on SciRah

Invite

P. Tedbury — researcher profile on SciRah

Daniel J. Wilson×9

Invite

Daniel J. Wilson — researcher profile on SciRah

J. Kankanala×9

Invite

J. Kankanala — researcher profile on SciRah

E. Michailidis×9

Invite

E. Michailidis — researcher profile on SciRah

Invite

Jing Tang — researcher profile on SciRah