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Jiashu Xie · SciRah

Researcher profile · Semantic Scholar

Jiashu Xie

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Jiashu Xie — researcher profile on SciRah

h-index: 17
Works: 48
Citations: 709

Most-cited papers

Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment
Jiashu Xie, Zheng-Qiang Wang
2021Acta Pharmaceutica Sinica B63 citations Open access
Semantic Scholar
5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors.
Teng Ai, Daniel J. Wilson, Swati S. More, Jiashu Xie +1 more
2016Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides potently inhibit HIV-1 integrase and RNase H
Bulan Wu, Jing Tang, Daniel J. Wilson, Andrew D. Huber +6 more
2016Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani +7 more
2020Acta Pharmaceutica Sinica B30 citations Open access
Semantic Scholar
Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo
Swetha Pavani Rao, Wei Xie, Ye In Christopher Kwon, Nicholas Juckel +5 more
2022Redox Biology28 citations Open access
Semantic Scholar
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity
Lei Wang, Jing Tang, Andrew D. Huber, Mary C. Casey +7 more
2018European journal of medicinal chemistry28 citations Open access
Semantic Scholar
Bisubstrate Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 Nsp14 Methyltransferase
Eun-Bin Jung, Ruben Soto-Acosta, Jiashu Xie, Daniel J. Wilson +5 more
2022ACS Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules
Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Mary C. Casey, J. Kankanala +8 more
2020Viruses26 citations Open access
Semantic Scholar
5-Aminothiophene-2,4-dicarboxamide Analogues as Hepatitis B Virus Capsid Assembly Effectors
Jing Tang, Andrew D. Huber, Dallas L. Pineda, Kelsey N Boschert +5 more
2018European journal of medicinal chemistry24 citations Open access
Semantic Scholar
Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.
R. Muthyala, W. Shin, Jiashu Xie, Y. Sham
2015Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Chemical Profiling of HIV-1 Capsid-Targeting Antiviral PF74
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, H. Do +9 more
2020European journal of medicinal chemistry22 citations Open access
Semantic Scholar
Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors
Carlos J. A. Ribeiro, J. Kankanala, Jiashu Xie, Jessica M Williams +2 more
2018Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Novel HIV-1 Capsid-Targeting Small Molecules of the PF74 Binding Site
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani +9 more
2020European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Novel deazaflavin analogues potently inhibited tyrosyl DNA phosphodiesterase 2 (TDP2) and strongly sensitized cancer cells toward treatment with topoisomerase II (TOP2) poison etoposide
J. Kankanala, Carlos J. A. Ribeiro, E. Kiselev, A. Ravji +5 more
2019Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Discovery of 1-hydroxypyridine-2(1H)-thiones-6-carboxylic acid as a low-cytotoxic, nanomolar metallo β-lactamase inhibitor
Woo-Shik Shin, Alexander Bergstrom, Jiashu Xie, R. Bonomo +3 more
2017ChemMedChem20 citations Open access
Semantic Scholar
Discovery of Irreversible p97 Inhibitors.
Rui Ding, Ting Zhang, Daniel J. Wilson, Jiashu Xie +4 more
2019Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase.
Jonathan M. O. Rawson, M. Roth, Jiashu Xie, M. B. Daly +7 more
2016Bioorganic & Medicinal Chemistry18 citations
Semantic Scholar
In Vitro and In Vivo Antimetastatic Effect of Glutathione Disulfide Liposomes
Satya Sadhu, Sheng-Gang Wang, Rakesh Dachineni, R. Averineni +5 more
2017Cancer Growth and Metastasis17 citations Open access
Semantic Scholar
Dual anti-HIV mechanism of clofarabine
M. B. Daly, M. Roth, L. Bonnac, J. Maldonado +5 more
2016Retrovirology17 citations Open access
Semantic Scholar
Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74
Rajkumar Lalji Sahani, Raquel Diana-Rivero, Sanjeev Kumar V. Vernekar, Lei Wang +9 more
2021Viruses16 citations Open access
Semantic Scholar
γ-Glutamyl-Transpeptidase-Resistant Glutathione Analog Attenuates Progression of Alzheimer’s Disease-like Pathology and Neurodegeneration in a Mouse Model
Ye In Christopher Kwon, Wei Xie, Haizhou Zhu, Jiashu Xie +5 more
2021Antioxidants16 citations Open access
Semantic Scholar
Novel Deazaflavin Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Inhibitors
E. Kiselev, A. Ravji, J. Kankanala, Jiashu Xie +2 more
2019DNA Repair16 citations Open access
Semantic Scholar
Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches
Sameera Senaweera, Haijuan Du, Huan-Chun Zhang, K. Kirby +4 more
2021Viruses13 citations Open access
Semantic Scholar
Guanabenz Attenuates Acetaminophen-Induced Liver Toxicity and Synergizes Analgesia in Mice.
Wei Xie, Jiashu Xie, R. Vince, Swati S. More
2020Chemical Research in Toxicology13 citations
Semantic Scholar
A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity.
Wenbo Zhou, Yan Wang, Jiashu Xie, R. Geraghty
2017Biochemical and Biophysical Research Communications - BBRC13 citations
Semantic Scholar
5-Azacytidine Enhances the Mutagenesis of HIV-1 by Reduction to 5-Aza-2′-Deoxycytidine
Jonathan M. O. Rawson, M. B. Daly, Jiashu Xie, Christine L. Clouser +6 more
2016Antimicrobial Agents and Chemotherapy13 citations Open access
Semantic Scholar
N-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides: Antiproliferative Activity and Effects on mTORC1 and Autophagy.
Teng Ai, Rose A. Willett, Jessica M Williams, Rui Ding +5 more
2017ACS Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Evaluation of a dithiocarbamate derivative as a model of thiol oxidative stress in H9c2 rat cardiomyocytes
Jiashu Xie, Ashley Potter, Wei Xie, Christophina Lynch +1 more
2014Free Radical Biology & Medicine12 citations Open access
Semantic Scholar
Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV)
Sameera Senaweera, Tiffany C. Edwards, J. Kankanala, Yan Wang +4 more
2021Acta Pharmaceutica Sinica B11 citations Open access
Semantic Scholar
Glutathione Disulfide Liposomes - a Research Tool for the Study of Glutathione Disulfide Associated Functions and Dysfunctions
Satya Sadhu, Jiashu Xie, Hong-Wei Zhang, Omathanu Perumal +1 more
2016Biochemistry and Biophysics Reports11 citations Open access
Semantic Scholar
Eeyarestatin I derivatives with improved aqueous solubility.
Rui Ding, Ting Zhang, Jiashu Xie, Jessica M Williams +2 more
2016Bioorganic & Medicinal Chemistry Letters10 citations
Semantic Scholar
Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.
Teng Ai, Li Qiu, Jiashu Xie, R. Geraghty +1 more
2016Bioorganic & Medicinal Chemistry9 citations Open access
Semantic Scholar
Repurposing N-hydroxy thienopyrimidine-2,4-diones (HtPD) as inhibitors of human cytomegalovirus pUL89 endonuclease: synthesis and biological characterization
Tian-Yu He, Tiffany C. Edwards, R. Majima, E. Jung +4 more
2022Bioorganic chemistry (Print)6 citations Open access
Semantic Scholar
LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies.
Jiashu Xie, Rong-Rong Jiang, Wei Xie, Bin Cao +1 more
2021Journal of Pharmaceutical and Biomedical Analysis6 citations
Semantic Scholar
Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex
Lei Wang, Tiffany C. Edwards, Rajkumar Lalji Sahani, Jiashu Xie +3 more
2021European journal of medicinal chemistry6 citations Open access
Semantic Scholar
4,5-Dihydroxypyrimidine methyl carboxylates, carboxylic acids, and carboxamides as inhibitors of human cytomegalovirus pUL89 endonuclease
Tian-Yu He, Tiffany C. Edwards, Jiashu Xie, H. Aihara +2 more
2022Journal of Medicinal Chemistry5 citations Open access
Semantic Scholar
Orally Bioavailable Prodrugs of ψ-GSH: A Potential Treatment for Alzheimer’s Disease
Wei Xie, Bin Cao, Haizhou Zhu, A. Raza +6 more
2022Journal of Medicinal Chemistry5 citations Open access
Semantic Scholar
Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral Therapies
Ruben Soto-Acosta, Tiffany C. Edwards, Christine D. Dreis, V. Krishna +5 more
2021Viruses5 citations Open access
Semantic Scholar
Characterization of a deazaflavin analog as a potent inhibitor of multidrug resistance-associated protein 1.
Zakia Belhadj, Thamina Akther, Zheng-Qiang Wang, Jiashu Xie
2024Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie4 citations Open access
Semantic Scholar
Geometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity
Wei Xie, Rong-Rong Jiang, Jiashu Xie, R. Vince +1 more
2023Chemical Research in Toxicology3 citations Open access
Semantic Scholar
Potency and metabolic stability: a molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein.
Rajkumar Lalji Sahani, Thamina Akther, Maria E. Cilento, A. E. Castaner +5 more
2021RSC Medicinal Chemistry2 citations Open access
Semantic Scholar
Discovery and Characterization of a Hydroxypyridone-3-carboxamide Analog as an Antiviral Lead against Orthopoxviruses
Anil Pant, Ajit D. Jagtap, Jiashu Xie, Djamal Brahim Belhaouari +8 more
2025bioRxiv1 citations Open access
Semantic Scholar
Design, synthesis and profiling of highly potent antivirals targeting emerging drug-resistant HIV-1 variants
Nicolas Jamey, D. M. Nirosh Udayanga, Huan-Chun Zhang, Shreya M. Ravichandran +9 more
2025bioRxiv1 citations Open access
Semantic Scholar
Cancer sensitizing effect of deazaflavin analogs is associated with increased intracellular drug accumulation.
Zakia Belhadj, Samuel Offei, B. Jacobson, Daniel A. Cambron +3 more
2023European Journal of Pharmaceutical Sciences1 citations Open access
Semantic Scholar
Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice
Prakashkumar Dobariya, Wei Xie, Swetha Pavani Rao, Jiashu Xie +4 more
2023bioRxiv1 citations Open access
Semantic Scholar
3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors
Muhammad Syafiq Bin Shahari, Jacob P. Mahoney, Ziyue Wang, Anil Pant +5 more
2026RSC Medicinal Chemistry0 citations Open access
Semantic Scholar
Dual anti-HIV mechanism of clofarabine
M. B. Daly, M. Roth, L. Bonnac, J. Maldonado +5 more
2016Retrovirology0 citations Open access
Semantic Scholar
Evaluation and Applications of a Novel Glutathione Reductase Inhibitor as a Model of Thiol Oxidative Stress in H9C2 Rat Cardiomyocytes
Jiashu Xie
20140 citations
Semantic Scholar

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