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R. Palchaudhuri · SciRah

Researcher profile · Semantic Scholar

R. Palchaudhuri

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R. Palchaudhuri — researcher profile on SciRah

h-index: 19
Works: 67
Citations: 2,384

Most-cited papers

DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action.
R. Palchaudhuri, P. Hergenrother
2007Current Opinion in Biotechnology654 citations
Semantic Scholar
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
Carlotta Granchi, Sarabindu Roy, C. Giacomelli, M. Macchia +14 more
2011Journal of Medicinal Chemistry216 citations Open access
Semantic Scholar
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin
R. Palchaudhuri, B. Saez, Jonathan Hoggatt, A. Schajnovitz +9 more
2016Nature Biotechnology203 citations Open access
Semantic Scholar
Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1
Giulia Schiroli, S. Ferrari, Anthony Conway, Aurélien Jacob +15 more
2017Science Translational Medicine198 citations Open access
Semantic Scholar
Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
A. Czechowicz, R. Palchaudhuri, Amelia Scheck, Yu Hu +12 more
2019Nature Communications175 citations Open access
Semantic Scholar
The complex role of the triphenylmethyl motif in anticancer compounds.
R. Palchaudhuri, V. Nesterenko, P. Hergenrother
2008Journal of the American Chemical Society127 citations
Semantic Scholar
N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines
Jonathan A. Stefely, R. Palchaudhuri, Patricia A. Miller, R. J. Peterson +3 more
2010Journal of Medicinal Chemistry113 citations Open access
Semantic Scholar
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
R. Palchaudhuri, Michael J. Lambrecht, Rachel C. Botham, Kathryn C. Partlow +7 more
2015Cell Reports105 citations Open access
Semantic Scholar
Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death.
Joseph S. Bair, R. Palchaudhuri, P. Hergenrother
2010Journal of the American Chemical Society87 citations
Semantic Scholar
Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor
Emilia Calvaresi, Carlotta Granchi, T. Tuccinardi, V. Di Bussolo +7 more
2013ChemBioChem54 citations Open access
Semantic Scholar
Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model
N. Uchida, Ulana Stasula, Selami Demirci, Paula Germino-Watnick +21 more
2023Nature Communications48 citations Open access
Semantic Scholar
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
B. Saez, F. Ferraro, R. Yusuf, Colleen M Cook +17 more
2014Blood47 citations Open access
Semantic Scholar
Differential Effects of Procaspase-3 Activating Compounds in the Induction of Cancer Cell Death
Diana C. West, Yan Qin, Quinn P. Peterson, Diana L. Thomas +6 more
2012Molecular Pharmaceutics40 citations Open access
Semantic Scholar
Efficacy and safety of anti-CD45–saporin as conditioning agent for RAG deficiency
M. C. Castiello, M. Bosticardo, Nicolò Sacchetti, Enrica Calzoni +12 more
2020Journal of Allergy and Clinical Immunology37 citations Open access
Semantic Scholar
CD45-targeted antibody-drug-conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation.
A. Saha, S. Hyzy, T. Lamothe, Katelyn J. Hammond +13 more
2022Blood36 citations Open access
Semantic Scholar
Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism
Mirth T. Hoyt, R. Palchaudhuri, P. Hergenrother
2011Investigational new drugs36 citations
Semantic Scholar
Transcript Profiling and RNA Interference as Tools to Identify Small Molecule Mechanisms and Therapeutic Potential
R. Palchaudhuri, P. Hergenrother
2010ACS Chemical Biology32 citations Open access
Semantic Scholar
Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning
Meera Srikanthan, Olivier Humbert, Kevin G. Haworth, C. Ironside +7 more
2020Molecular Therapy: Methods & Clinical Development26 citations Open access
Semantic Scholar
Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells.
R. Palchaudhuri, P. Hergenrother
2008Bioorganic & Medicinal Chemistry Letters19 citations
Semantic Scholar
BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.
Selami Demirci, Jing Zeng, R. Palchaudhuri, Chuan-Feng Wu +37 more
2024Cell Stem Cell16 citations Open access
Semantic Scholar
A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates
J. Tisdale, R. Donahue, N. Uchida, B. Pearse +18 more
2019Blood12 citations Open access
Semantic Scholar
A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant
B. Pearse, S. McDonough, J. Proctor, Rajiv Panwar +14 more
2019Biology of Blood and Marrow Transplantation12 citations Open access
Semantic Scholar
Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins
K. Risberg, I. Guldvik, R. Palchaudhuri, Y. Xi +4 more
2011Journal of immunotherapy12 citations
Semantic Scholar
1JWSn as a solution state predictor for tungsten-tin solid state bond length in sterically crowded tungstenocene stannyl complexes
T. A. Mobley, R. Gandour, E. Gillis, K. Nti-Addae +5 more
200512 citations
Semantic Scholar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice.
A. Saha, R. Palchaudhuri, Leanne Lanieri, Sharon L. Hyzy +18 more
2024Blood11 citations Open access
Semantic Scholar
Clearing and replacing tissue-resident myeloid cells with an anti-CD45 antibody–drug conjugate
K. Gustafsson, Catherine Rhee, V. Frodermann, Elizabeth W. Scadden +7 more
2023Blood Advances11 citations Open access
Semantic Scholar
CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant
B. Pearse, S. McDonough, J. Proctor, Rajiv Panwar +14 more
2018Blood10 citations Open access
Semantic Scholar
Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings
Francesca Pala, Cristina Corsino, Enrica Calzoni, A. Villa +4 more
2023Journal of Allergy and Clinical Immunology6 citations
Semantic Scholar
A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)
Leanne Lanieri, T. Lamothe, Oliver Miske, S. McDonough +12 more
20205 citations Open access
Semantic Scholar
A Non-Genotoxic Antibody Drug Conjugate Targeting C-Kit for Hematopoietic Stem Cell Transplant Conditioning
Adam J. Hartigan, B. Pearse, S. McDonough, J. Proctor +9 more
20185 citations Open access
Semantic Scholar
CD117 Antibody Drug Conjugate-Based Conditioning Allows for Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model
N. Uchida, Ulana Stasula, Malikiya A Hinds, Paula Germino-Watnick +12 more
2021Blood3 citations Open access
Semantic Scholar
Reversing Clonal Hematopoiesis and Associated Atherosclerotic Disease By Targeted Antibody-Drug-Conjugate (ADC) Conditioning and Transplant
K. Gustafsson, Catherine Rhee, Elizabeth W. Scadden, V. Frodermann +8 more
20203 citations Open access
Semantic Scholar
A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates
N. Uchida, J. Tisdale, R. Donahue, B. Pearse +18 more
20203 citations Open access
Semantic Scholar
Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells
R. Palchaudhuri, B. Pearse, J. Proctor, S. Hyzy +19 more
2019Biology of Blood and Marrow Transplantation3 citations Open access
Semantic Scholar
A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT and Ameliorate Disease in Preclinical Autoimmune Disease Models
G. Gillard, J. Proctor, M. Brooks, T. Lamothe +12 more
20202 citations Open access
Semantic Scholar
Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models
J. Proctor, S. Hyzy, H. Adams, M. Brooks +16 more
2018Biology of Blood and Marrow Transplantation2 citations Open access
Semantic Scholar
The Impact of CD45-Antibody-Drug Conjugate Conditioning on Clonal Dynamics and Immune Tolerance Post HSPC Transplantation in Rhesus Macaques
T. Hayal, Chuanfeng Wu, Diana M. Abraham, Selami Demirci +10 more
2023Blood1 citations Open access
Semantic Scholar
CD45-Targeted Antibody Drug Conjugate Plus Post Transplant Cytoxan Is Sufficient to Enable Allogeneic Bone Marrow Transplant in a Minor Mismatch Mouse Model
S. Hyzy, R. Palchaudhuri, J. Proctor, B. Pearse +11 more
2019Biology of Blood and Marrow Transplantation1 citations Open access
Semantic Scholar
Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning
R. Palchaudhuri, B. Pearse, J. Proctor, S. Hyzy +21 more
2018Blood1 citations Open access
Semantic Scholar
Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models
R. Palchaudhuri, S. Hyzy, J. Proctor, H. Adams +11 more
2018Blood1 citations
Semantic Scholar
Non-Genotoxic Conditioning Efficiently Depletes Host Hematopoietic Stem Cells and Facilitates Robust Multi-Lineage Engraftment in a Mouse Model of Fanconi Anemia
Meera Srikanthan, Kevin G. Haworth, C. Ironside, Jerry Chen +5 more
2018Blood1 citations Open access
Semantic Scholar
Completely Non-Myeloablative/Non-Lymphoablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins
A. Czechowicz, R. Palchaudhuri, Amelia Scheck, Jonathan Hoggatt +3 more
20161 citations
Semantic Scholar
Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation
R. Palchaudhuri, B. Saez, Jonathan Hoggatt, A. Schajnovitz +3 more
20151 citations
Semantic Scholar
Hematopoietic Stem/Progenitor Cell Retention in the Bone Marrow Depends On Tissue Specific Heparan Sulfate Proteoglycans
B. Saez, F. Ferraro, R. Yusuf, Colleen M Cook +13 more
20121 citations
Semantic Scholar
CHIRAL PHASE-TRANSFER CATALYSIS (CPTC) BY MODIFIED CINCHONA ALKALOIDS
R. Palchaudhuri
20071 citations
Semantic Scholar
CD117 Antibody-Drug Conjugate Conditioning Allows Efficient Engraftment of Gene-Modified CD34+ Cells with Fertility Preservation in a Rhesus Gene Therapy Model
N. Uchida, Selami Demirci, Anh Le, Rebecca Chu +17 more
2023Blood0 citations Open access
Semantic Scholar
In Vivo Delivery of RNA By Lipid Nanoparticles (LNP) to Hematopoietic Stem Cells and T Cells in Humanized Mice and Non-Human Primates
Michael T. Monte, Han Gu, Laura Saunders, Mohit Gupta +16 more
2023Blood0 citations Open access
Semantic Scholar
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
K. Gustafsson, Catherine Rhee, V. Frodermann, Elizabeth W. Scadden +7 more
2023bioRxiv0 citations Open access
Semantic Scholar
A Single Dose of Anti-CD45 Antibody-Drug Conjugate Conditioning Enables Transplant in Nonhuman Primates
R. Palchaudhuri, Selami Demirci, Leanne Lanieri, S. Hyzy +16 more
2023Transplantation and Cellular Therapy0 citations Open access
Semantic Scholar
The Pharmacokinetic and Pharmacodynamic Characterization of Mgta-117, an Anti-CD117-Amanitin Antibody-Drug Conjugate for Targeted Conditioning Prior to Transplant, in Nonhuman Primates
K. Bertelsen, Leanne Lanieri, R. Palchaudhuri, Lisa Olson
2022Blood0 citations Open access
Semantic Scholar

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Anthony E. Boitano×17
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S. Hyzy×15
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M. Cooke×15
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P. Hergenrother

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T. Lamothe — researcher profile on SciRah