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M. Macchia · SciRah

Researcher profile · Semantic Scholar

M. Macchia

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M. Macchia — researcher profile on SciRah

h-index: 39
Works: 261
Citations: 6,227

Most-cited papers

Flexible Automation and Intelligent Manufacturing , FAIM 2017 , 27-30 June 2017 , Modena , Italy A review of the roles of Digital Twin in CPS-based production systems
Elisa Negria, Luca Fumagallia, M. Macchia
20171,521 citations
Semantic Scholar
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation
S. Carpi, E. Scoditti, M. Massaro, Beatrice Polini +12 more
2019Nutrients91 citations Open access
Semantic Scholar
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells
S. Fogli, Chiara Arena, S. Carpi, Beatrice Polini +9 more
2016Nutrition and Cancer79 citations Open access
Semantic Scholar
Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer.
Beatrice Polini, M. Digiacomo, S. Carpi, S. Bertini +6 more
2018Toxicology in Vitro71 citations Open access
Semantic Scholar
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.
F. Gado, L. di Cesare Mannelli, E. Lucarini, S. Bertini +8 more
2018Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease.
Zi-wei Chen, M. Digiacomo, Ya-Lin Tu, Qiong Gu +11 more
2017European journal of medicinal chemistry62 citations Open access
Semantic Scholar
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.
M. Digiacomo, Zi-wei Chen, Sheng-Nan Wang, A. Lapucci +6 more
2015Bioorganic & Medicinal Chemistry Letters62 citations Open access
Semantic Scholar
VenomPred 2.0: A Novel In Silico Platform for an Extended and Human Interpretable Toxicological Profiling of Small Molecules
Miriana Di Stefano, Salvatore Galati, Lisa Piazza, Carlotta Granchi +5 more
2023Journal of Chemical Information and Modeling61 citations Open access
Semantic Scholar
Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds
Carlotta Granchi, Emilia Calvaresi, T. Tuccinardi, Ilaria Paterni +4 more
2013Organic and biomolecular chemistry60 citations Open access
Semantic Scholar
Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor
Emilia Calvaresi, Carlotta Granchi, T. Tuccinardi, V. Di Bussolo +7 more
2013ChemBioChem54 citations Open access
Semantic Scholar
Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
Carlotta Granchi, F. Rizzolio, Stefano Palazzolo, S. Carmignani +6 more
2016Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Identification and characterization of a new reversible MAGL inhibitor.
T. Tuccinardi, Carlotta Granchi, F. Rizzolio, Isabella Caligiuri +5 more
2014Bioorganic & Medicinal Chemistry53 citations Open access
Semantic Scholar
CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides
Valentina Lucchesi, Dow P. Hurst, Derek M. Shore, S. Bertini +12 more
2014Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Phenylpropanoids and Flavonoids from Phlomis kurdica as Inhibitors of Human Lactate Dehydrogenase
A. Bader, T. Tuccinardi, Carlotta Granchi, A. Martinelli +4 more
2015Phytochemistry50 citations Open access
Semantic Scholar
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists.
G. Chiellini, Giulia Nesi, M. Digiacomo, Rossella Malvasi +11 more
2015Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress
L. Giusti, C. Angeloni, M. Barbalace, S. Lacerenza +9 more
2018International Journal of Molecular Sciences49 citations Open access
Semantic Scholar
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.
Carlotta Granchi, Margherita Lapillo, S. Glasmacher, G. Bononi +10 more
2019Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
Mojgan Aghazadeh Tabrizi, P. Baraldi, S. Baraldi, E. Ruggiero +13 more
2018Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Olive Mill Wastewater as Source of Polyphenols with Nutraceutical Properties
Doretta Cuffaro, Andrea Bertolini, S. Bertini, Claudio Ricci +5 more
2023Nutrients47 citations Open access
Semantic Scholar
Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.
T. Tuccinardi, Carlotta Granchi, J. Iegre, Ilaria Paterni +6 more
2013Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
VenomPred: A Machine Learning Based Platform for Molecular Toxicity Predictions
Salvatore Galati, Miriana Di Stefano, E. Martinelli, M. Macchia +3 more
2022International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.
G. Bononi, Carlotta Granchi, Margherita Lapillo, M. Giannotti +14 more
2018European journal of medicinal chemistry39 citations Open access
Semantic Scholar
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme.
S. Sestito, Giulia Nesi, S. Daniele, A. Martelli +12 more
2015European journal of medicinal chemistry38 citations Open access
Semantic Scholar
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.
C. Manera, A. Malfitano, Teija Parkkari, Valentina Lucchesi +14 more
2015European journal of medicinal chemistry37 citations Open access
Semantic Scholar
miRNA Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells
S. Carpi, Beatrice Polini, C. Manera, M. Digiacomo +4 more
2020Frontiers in Pharmacology36 citations Open access
Semantic Scholar
Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors
Carlotta Granchi, Isabella Caligiuri, E. Bertelli, G. Poli +5 more
2017Journal of Enzyme Inhibition and Medicinal Chemistry34 citations Open access
Semantic Scholar
Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment
Doretta Cuffaro, S. Bertini, M. Macchia, M. Digiacomo
2023Nutrients33 citations Open access
Semantic Scholar
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
G. Poli, Margherita Lapillo, Vibhu Jha, N. Mouawad +6 more
2019Journal of Enzyme Inhibition and Medicinal Chemistry33 citations Open access
Semantic Scholar
Estrogen receptor ligands: a patent review update
Ilaria Paterni, S. Bertini, Carlotta Granchi, M. Macchia +1 more
2013Expert Opinion on Therapeutic Patents33 citations
Semantic Scholar
The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver
D. Gabbia, S. Carpi, S. Sarcognato, L. Cannella +12 more
2021Frontiers in Nutrition32 citations Open access
Semantic Scholar
Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery.
F. Gado, Serena Meini, S. Bertini, M. Digiacomo +2 more
2019Future Medicinal Chemistry32 citations Open access
Semantic Scholar
The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs.
D. Gabbia, S. Carpi, S. Sarcognato, I. Zanotto +11 more
2022Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie31 citations Open access
Semantic Scholar
Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors
Miriana Di Stefano, Salvatore Galati, G. Ortore, Isabella Caligiuri +8 more
2022International Journal of Molecular Sciences30 citations Open access
Semantic Scholar
Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Carlotta Granchi, G. Bononi, Rebecca Ferrisi, E. Gori +15 more
2020European journal of medicinal chemistry30 citations Open access
Semantic Scholar
Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis
A. Malfitano, C. Laezza, Alba D'Alessandro, C. Procaccini +7 more
2013PLoS ONE30 citations Open access
Semantic Scholar
An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)
G. Bononi, G. Poli, F. Rizzolio, T. Tuccinardi +3 more
2020Expert Opinion on Therapeutic Patents29 citations
Semantic Scholar
4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors
Carlotta Granchi, F. Rizzolio, Vittorio Bordoni, Isabella Caligiuri +6 more
2016Journal of Enzyme Inhibition and Medicinal Chemistry29 citations Open access
Semantic Scholar
Insights into the Antioxidant/Antiradical Effects and In Vitro Intestinal Permeation of Oleocanthal and Its Metabolites Tyrosol and Oleocanthalic Acid
Doretta Cuffaro, Diana Pinto, A. M. Silva, Andrea Bertolini +5 more
2023Molecules25 citations Open access
Semantic Scholar
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
G. Bononi, Miriana Di Stefano, G. Poli, G. Ortore +16 more
2022Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Content Variations in Oleocanthalic Acid and Other Phenolic Compounds in Extra-Virgin Olive Oil during Storage
Jasmine Esposito Salsano, M. Digiacomo, Doretta Cuffaro, S. Bertini +1 more
2022Foods25 citations Open access
Semantic Scholar
Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies
Margherita Lapillo, T. Tuccinardi, A. Martinelli, M. Macchia +2 more
2019International Journal of Molecular Sciences25 citations Open access
Semantic Scholar
Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs
S. Sestito, Giulia Nesi, R. Pi, M. Macchia +1 more
2017Frontiers in Chemistry25 citations Open access
Semantic Scholar
Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors
Carlotta Granchi, A. Capecchi, Gianluca Del Frate, A. Martinelli +3 more
2015Molecules25 citations Open access
Semantic Scholar
MolBook UNIPI—Create, Manage, Analyze, and Share Your Chemical Data for Free
Salvatore Galati, Miriana Di Stefano, M. Macchia, G. Poli +1 more
2023Journal of Chemical Information and Modeling24 citations Open access
Semantic Scholar
Antioxidant and Neuroprotective Activity of Extra Virgin Olive Oil Extracts Obtained from Quercetano Cultivar Trees Grown in Different Areas of the Tuscany Region (Italy)
M. Barbalace, Lorenzo Zallocco, D. Beghelli, M. Ronci +9 more
2021Antioxidants24 citations Open access
Semantic Scholar
Waste Autochthonous Tuscan Olive Leaves (Olea europaea var. Olivastra seggianese) as Antioxidant Source for Biomedicine
Jose Gustavo de la Ossa, F. Felice, Bahareh Azimi, Jasmine Esposito Salsano +4 more
2019International Journal of Molecular Sciences24 citations Open access
Semantic Scholar
Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model
Ilaria Paterni, Simone Bertini, Carlotta Granchi, T. Tuccinardi +9 more
2015Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Immunomodulatory Activity of Electrospun Polyhydroxyalkanoate Fiber Scaffolds Incorporating Olive Leaf Extract
Jose Gustavo de la Ossa, A. Fusco, Bahareh Azimi, Jasmine Esposito Salsano +9 more
2021Applied Sciences23 citations Open access
Semantic Scholar
Composition of health-promoting phenolic compounds in two extra virgin olive oils and diversity of associated yeasts
Michela Palla, M. Digiacomo, C. Cristani, S. Bertini +4 more
2018Journal of Food Composition and Analysis23 citations Open access
Semantic Scholar
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma
S. Tampucci, S. Carpi, M. Digiacomo, Beatrice Polini +6 more
2019Molecules22 citations Open access
Semantic Scholar

Frequent co-authors

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T. Tuccinardi×25
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T. Tuccinardi — researcher profile on SciRah
M. Digiacomo×22
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M. Digiacomo — researcher profile on SciRah
Carlotta Granchi×20
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Carlotta Granchi — researcher profile on SciRah
F. Minutolo×19
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F. Minutolo — researcher profile on SciRah

×16

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C. Manera — researcher profile on SciRah

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S. Bertini — researcher profile on SciRah

A. Martinelli×14

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A. Martinelli — researcher profile on SciRah

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G. Poli — researcher profile on SciRah

F. Rizzolio×13

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F. Rizzolio — researcher profile on SciRah

Isabella Caligiuri×10

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Isabella Caligiuri — researcher profile on SciRah

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S. Carpi — researcher profile on SciRah

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P. Nieri — researcher profile on SciRah