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A. Czechowicz · SciRah

Researcher profile · Semantic Scholar

A. Czechowicz

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A. Czechowicz — researcher profile on SciRah

h-index: 19
Works: 84
Citations: 2,227

Most-cited papers

Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches
A. Czechowicz, D. Kraft, I. Weissman, Deepta Bhattacharya
2007Science415 citations Open access
Semantic Scholar
Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment
G. Ahn, D. Tseng, Cho-Hwa Liao, M. Dorie +2 more
2010Proceedings of the National Academy of Sciences of the United States of America358 citations Open access
Semantic Scholar
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin
R. Palchaudhuri, B. Saez, Jonathan Hoggatt, A. Schajnovitz +9 more
2016Nature Biotechnology203 citations Open access
Semantic Scholar
Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation
A. Czechowicz, R. Palchaudhuri, Amelia Scheck, Yu Hu +12 more
2019Nature Communications175 citations Open access
Semantic Scholar
Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging
Derrick J. Rossi, J. Seita, A. Czechowicz, Deepta Bhattacharya +2 more
2007Cell Cycle172 citations Open access
Semantic Scholar
Niche recycling through division-independent egress of hematopoietic stem cells
Deepta Bhattacharya, A. Czechowicz, A. G. Lisa Ooi, Derrick J. Rossi +2 more
2009Journal of Experimental Medicine124 citations Open access
Semantic Scholar
Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice.
Hye-Sook Kwon, A. Logan, Akanksha Chhabra, W. Pang +10 more
2019Blood85 citations Open access
Semantic Scholar
Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo
Rong Lu, A. Czechowicz, J. Seita, Du Jiang +1 more
2018Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice.
W. Pang, A. Czechowicz, A. Logan, R. Bhardwaj +4 more
2019Blood63 citations Open access
Semantic Scholar
Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth
Badreddin Edris, S. Willingham, K. Weiskopf, A. Volkmer +9 more
2013Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
S. Derderian, Padma Priya Togarrati, C. King, P. Moradi +4 more
2014Blood53 citations Open access
Semantic Scholar
Purified Hematopoietic Stem Cell Transplantation: The Next Generation of Blood and Immune Replacement
A. Czechowicz, I. Weissman
2011Hematology/Oncology Clinics of North America51 citations Open access
Semantic Scholar
Nongenotoxic antibody-drug conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice.
Chun-Yan Gao, J. Schroeder, Feng Xue, Weiqing Jing +7 more
2019Blood Advances49 citations Open access
Semantic Scholar
Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation
Zhanzhuo Li, A. Czechowicz, Amelia Scheck, Derrick J. Rossi +1 more
2019Nature Communications48 citations Open access
Semantic Scholar
Targeted Clearance of Human Hematopoietic Stem Cell Niches Via Inhibition of SCF Signaling Using Monoclonal Antibody SR-1
A. Czechowicz, R. Bhardwaj, W. Pang, Christopher Y. Park +1 more
201037 citations Open access
Semantic Scholar
Physioxia improves the selectivity of hematopoietic stem cell expansion cultures
Kyomi J. Igarashi, I. Kucinski, Yan Y. Chan, Tze-Kai Tan +13 more
2023Blood Advances29 citations Open access
Semantic Scholar
Irradiation- and busulfan-free stem cell transplantation in Fanconi anemia using an anti-CD117 antibody: a phase 1b trial
Rajni Agarwal, A. Bertaina, Charmaine F Soco, J. Long-Boyle +27 more
2025Nature Medicine23 citations Open access
Semantic Scholar
Clinical hematopoietic stem cell-based gene therapy
Tami John, A. Czechowicz
2025Molecular Therapy21 citations Open access
Semantic Scholar
Safe and Effective In Vivo Targeting and Gene Editing in Hematopoietic Stem Cells: Strategies for Accelerating Development
P. Cannon, A. Asokan, A. Czechowicz, P. Hammond +9 more
2021Human Gene Therapy20 citations Open access
Semantic Scholar
A trial of plerixafor adjunctive therapy in allogeneic hematopoietic cell transplantation with minimal conditioning for severe combined immunodeficiency
C. C. Dvorak, Biljana N. Horn, J. Puck, A. Czechowicz +3 more
2014Pediatric Transplantation16 citations Open access
Semantic Scholar
Development of multivalent CAR T cells as dual immunotherapy and conditioning agents
Q. Bubb, Mohammad Balood, G. Seir, Leah Swartzrock +9 more
2025Molecular therapy. Oncology15 citations Open access
Semantic Scholar
A Trial of Alemtuzumab Adjunctive Therapy in Allogeneic Hematopoietic Cell Transplantation with Minimal Conditioning for Severe Combined Immunodeficiency
C. Dvorak, Biljana N. Horn, J. Puck, S. Adams +3 more
2014Pediatric Transplantation15 citations Open access
Semantic Scholar
Non-Genotoxic Restoration of the Hematolymphoid System in Fanconi Anemia.
Yan Y. Chan, Pui-Yan Ho, Leah Swartzrock, Maire C. Rayburn +4 more
2022Transplantation and Cellular Therapy11 citations Open access
Semantic Scholar
First Report of Non-Genotoxic Conditioning with JSP191 (anti-CD117) and Hematopoietic Stem Cell Transplantation in a Newly Diagnosed Patient with Severe Combined Immune Deficiency
R. Agarwal, K. Weinberg, Hye-Sook Kwon, Ann Le +17 more
202011 citations Open access
Semantic Scholar
Transplantation Conditioning Regimens Induce Different Hematopoietic Stem Cell Differentiation in Mice At the Clonal Level
Rong Lu, A. Czechowicz, I. Weissman
201111 citations
Semantic Scholar
Lentiviral-mediated Gene Therapy for Patients with Fanconi Anemia [Group A]: Updated Results from Global RP-L102 Clinical Trials
A. Czechowicz, J. Sevilla, C. Booth, R. Agarwal +17 more
2022Blood9 citations Open access
Semantic Scholar
Peptide nucleic acid–dependent artifact can lead to false-positive triplex gene editing signals
Pui-Yan Ho, Zhen Zhang, M. Hayes, Andrew Curd +15 more
2021Proceedings of the National Academy of Sciences of the United States of America9 citations Open access
Semantic Scholar
Radiation and Busulfan-Free Hematopoietic Stem Cell Transplantation Using Briquilimab (JSP191) Anti-CD117 Antibody-Conditioning, Transient Immunosuppression and TCRαβ + T-Cell/CD19 + B-Cell Depleted Haploidentical Grafts in Patients with Fanconi Anemia
R. Agarwal, A. Bertaina, Charmaine F Soco, G. Saini +26 more
2023Blood8 citations Open access
Semantic Scholar
Highly efficient in vivo hematopoietic stem cell transduction using an optimized self-complementary adeno-associated virus
Carsten T. Charlesworth, Shota Homma, Anais K. Amaya, Carla Dib +13 more
2025Molecular Therapy: Methods & Clinical Development7 citations Open access
Semantic Scholar
The MarrowMiner: A Novel Minimally Invasive and Effective Device for the Harvest of Bone Marrow.
D. Kraft, Emily Walck, A. Carrasco, M. Crocker +7 more
2020Biology of Blood and Marrow Transplantation6 citations Open access
Semantic Scholar
Recruitment and Retention of Hematopoietic Cell Transplantation and Cellular Therapy Physicians: A Report from the ASTCT Talent Acquisition Task Force
Akshay Sharma, A. Czechowicz, Melissa Mavers, Nelson J. Chao +4 more
2024Transplantation and Cellular Therapy5 citations Open access
Semantic Scholar
Targeted hematopoietic stem cell depletion through SCF-blockade
Yan Y. Chan, Pui-Yan Ho, Carla Dib, Leah Swartzrock +10 more
2024Stem cell research & therapeutics5 citations
Semantic Scholar
Changing the Natural History of Fanconi Anemia Complementation Group-À with Gene Therapy: Early Results of U.S. Phase I Study of Lentiviral-Mediated Ex-Vivo FANCA Gene Insertion in Human Stem and Progenitor Cells
A. Czechowicz, P. Río, J. Bueren, B. Beard +3 more
20205 citations Open access
Semantic Scholar
In utero hematopoietic stem cell transplantation for Fanconi anemia
Leah Swartzrock, Carla Dib, Morgane Denis, Hana Willner +13 more
2024Blood Advances4 citations Open access
Semantic Scholar
Hematopoiesis after anti-CD117 monoclonal antibody treatment in the settings of wild-type and Fanconi anemia mice
Morgane Denis, Leah Swartzrock, Hana Willner, Q. Bubb +5 more
2024Haematologica4 citations Open access
Semantic Scholar
Lentiviral-Mediated Gene Therapy for Patients with Fanconi Anemia [Group a]: Updated Results from Global RP-L102 Clinical Trials
A. Czechowicz, J. Sevilla, C. Booth, Josune Zubicaray +23 more
2024Blood4 citations
Semantic Scholar
Gene Therapy for Fanconi Anemia [Group A]: Interim Results of RP-L102 Clinical Trials
A. Czechowicz, J. Sevilla, R. Agarwal, C. Booth +17 more
2021Blood4 citations Open access
Semantic Scholar
Gene Therapy for Fanconi Anemia, Complementation Group a: Updated Results from Ongoing Global Clinical Studies of RP-L102
A. Czechowicz, R. Agarwal, J. Sevilla, P. Río +11 more
20204 citations Open access
Semantic Scholar
GFP-on mouse model for interrogation of in vivo gene editing
Carla Dib, Jack A. Queenan, Leah Swartzrock, Hana Willner +18 more
2025Nature Communications3 citations Open access
Semantic Scholar
Restoration of the immune system with base editing and non-genotoxic conditioning in a Rag2 point-mutant mouse model
Carla Dib, Jack A. Queenan, Hana Willner, Leah Swartzrock +10 more
2026Molecular Therapy2 citations Open access
Semantic Scholar
Antibody-Based Preparative Regimens for Cell, Tissue and Organ Transplantation
Maite Van Hentenryck, Zhanzhuo Li, P. Murphy, A. Czechowicz
2021OBM Transplantation2 citations Open access
Semantic Scholar
Αβ T-Cell/CD19 B-Cell Depleted Haploidentical Stem Cell Transplantation: A New Platform for Curing Rare and Monogenic Disorders
A. Bertaina, R. Bacchetta, D. Lewis, P. Grimm +10 more
20202 citations Open access
Semantic Scholar
Changing the Natural History of Fanconi Anemia Complementation Group-A with Gene Therapy: Early Results of U.S. Phase I Study of Lentiviral-Mediated Ex-VivoFANCA Gene Insertion in Human Stem and Progenitor Cells
A. Czechowicz, M. Roncarolo, B. Beard, Kenneth Law +5 more
2019Blood2 citations Open access
Semantic Scholar
Anti-Human CD117 Antibodies Mediate Clearance of Myelodysplastic Syndrome Hematopoietic Stem Cells and Facilitate Establishment of Normal Hematopoiesis in Transplantation
W. Pang, A. Czechowicz, Jessica Poyser, Christopher Y. Park +2 more
20182 citations Open access
Semantic Scholar
Enhanced Allogeneic Engraftment Achieved Via Prenatal Tolerance Induction and Postnatal Anti-CD45 Immunotoxin Conditioned Hematopoietic Cell Transplantation
P. McGovern, A. Czechowicz, Ali Y. Mejaddam, John Stratigis +6 more
20162 citations
Semantic Scholar
Anti-CD117 (c-Kit) Monoclonal Antibodies Deplete Human Hematopoietic Stem Cells and Facilitate Their Replacement in Humanized NOD/SCID/IL2Rγ−/− Mice: A Non-Toxic Conditioning Regimen for Allotransplantation
A. Logan, A. Czechowicz, Benjamin V. Kelley, T. Thway +7 more
20122 citations
Semantic Scholar
Engineered Invariant Natural Killer T Cells (iNKT cells) Targeting CD 117 As a Novel Treatment for Acute Myeloid Leukemia.
Chaiyaporn Boonchalermvichian, Hao Yan, Jeanette Baker, Q. Bubb +3 more
2025Transplantation and Cellular Therapy1 citations Open access
Semantic Scholar
Hematopoietic Recovery in Fanconi Anemia Patients Utilizing a Novel Anti-CD117 Antibody-Containing, Irradiation/Busulfan-Free Haploidentical Hematopoietic Stem Cell Transplant Regimen
Charmaine F Soco, Mark L. Krampf, Yan Y. Chan, Hana Willner +8 more
2025Transplantation and Cellular Therapy1 citations Open access
Semantic Scholar
Completely Non-Myeloablative/Non-Lymphoablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins
A. Czechowicz, R. Palchaudhuri, Amelia Scheck, Jonathan Hoggatt +3 more
20161 citations
Semantic Scholar
906 CKit/CD117 Identifies a Colonic Paneth-Like Cell That Contributes to the Stem Cell Niche and Regulates Crypt Homeostasis
M. Rothenberg, Y. Nusse, T. Kalisky, John M. Lee +10 more
20121 citations Open access
Semantic Scholar

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