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G. Thatcher · SciRah

Researcher profile · Semantic Scholar

G. Thatcher

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G. Thatcher — researcher profile on SciRah

h-index: 36
Works: 187
Citations: 7,402

Most-cited papers

Nucleic Acids Research
G. Blackburn, G. E. Taylor, G. Thatcher, A. McLennan
2010Nucleic Acids Research2,994 citations Open access
Semantic Scholar
Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity
Zheng-Nan Shen, K. Ratia, L. Cooper, Deyu Kong +9 more
2021Journal of Medicinal Chemistry172 citations Open access
Semantic Scholar
Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein*
I. Kastrati, Marton I. Siklos, Esther L. Calderon-Gierszal, Lamiaa El-Shennawy +4 more
2015Journal of Biological Chemistry127 citations Open access
Semantic Scholar
GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species (ROS)-MicroRNA-27a:ZBTB10-Specificity Protein (Sp) Pathway
Satya S. Pathi, Indira Jutooru, G. Chadalapaka, Sandeep Sreevalsan +3 more
2010Molecular Cancer Research119 citations Open access
Semantic Scholar
Amyloid-β Pathology and APOE Genotype Modulate Retinoid X Receptor Agonist Activity in Vivo*
Leon M. Tai, Kevin P. Koster, Jia Luo, Sue H. Lee +5 more
2014Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Furoxans (1, 2, 5 Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents
Isaac T. Schiefer, Lawren Vandevrede, M. Fa', O. Arancio +1 more
2012Journal of Medicinal Chemistry73 citations Open access
Semantic Scholar
Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism
R. Abdelhamid, Jia Luo, Lawren Vandevrede, Indraneel Kundu +7 more
2011ACS Chemical Neuroscience72 citations Open access
Semantic Scholar
Novel Selective Estrogen Receptor Downregulators (SERDs) Developed Against Treatment-Resistant Breast Cancer
R. Xiong, Jiong Zhao, Lauren M. Gutgesell, Yue-Ting Wang +6 more
2017Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
Selective human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer
R. Xiong, H. Patel, Lauren M. Gutgesell, Jiong Zhao +9 more
2015Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery
M. Hollas, Manel Ben Aissa, Sue H. Lee, Jesse Gordon-Blake +1 more
2018Nitric oxide51 citations Open access
Semantic Scholar
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain
Manel Ben Aissa, Alycia F. Tipton, Zachariah Bertels, Ronak P Gandhi +9 more
2017Cephalalgia51 citations Open access
Semantic Scholar
Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice
C. Overk, P. Lu, Yue-Ting Wang, Jaewoo Choi +3 more
2011Neurobiology of Disease47 citations Open access
Semantic Scholar
Hops (Humulus lupulus) inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)
L. P. Madhubhani, P. Hemachandra, R. Esala, P. Chandrasena +8 more
2011Cancer Prevention Research46 citations Open access
Semantic Scholar
Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer's Disease.
Manel Ben Aissa, Sue H. Lee, B. Bennett, G. Thatcher
2016Current Medicinal Chemistry45 citations
Semantic Scholar
G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer
Kaitlyn J. Andreano, S. Wardell, Jennifer G. Baker, Taylor K. Desautels +14 more
2020Breast Cancer Research and Treatment40 citations Open access
Semantic Scholar
Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures
Zheng-Nan Shen, K. Ratia, L. Cooper, Deyu Kong +9 more
2021bioRxiv38 citations Open access
Semantic Scholar
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry
I. Silvestri, Haining Lyu, F. Fata, G. Boumis +13 more
2018ACS Chemical Biology36 citations Open access
Semantic Scholar
Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors
I. Gaisina, Sue H. Lee, N. Kaidery, Manel Ben Aissa +11 more
2018ACS Chemical Neuroscience36 citations Open access
Semantic Scholar
Rexinoids as Therapeutics for Alzheimer's Disease: Role of APOE.
Kevin P. Koster, Conor Smith, A. Valencia-Olvera, G. Thatcher +2 more
2017Current Topics in Medicinal Chemistry36 citations
Semantic Scholar
MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3
S. Singh, Sandeep Kumar, N. Viswakarma, D. Principe +9 more
2021Oncogene35 citations Open access
Semantic Scholar
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer
Yunlong Lu, Lauren M. Gutgesell, R. Xiong, Jiong Zhao +16 more
2019Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease
Jia Luo, Sue H. Lee, Lawren Vandevrede, Zhi-Hui Qin +11 more
2016Molecular Neurodegeneration35 citations Open access
Semantic Scholar
Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors
Isaac T. Schiefer, S. Tapadar, V. Litosh, Marton Siklos +10 more
2013Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Design and Synthesis of Neuroprotective Methylthiazoles and Modification as NO-Chimeras for Neurodegenerative Therapy
Zhi-Hui Qin, Jia Luo, Lawren Vandevrede, E. Tavassoli +4 more
2012Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Characterization of lead compounds targeting the selenoprotein thioredoxin glutathione reductase for treatment of schistosomiasis
Haining Lyu, P. Petukhov, Paul R Banta, A. Jadhav +7 more
2020ACS Infectious Diseases33 citations Open access
Semantic Scholar
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib
Yang-Feng Li, Jiong Zhao, Lauren M. Gutgesell, Zheng-Nan Shen +8 more
2020Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors.
Taha Y. Taha, Shaimaa M Aboukhatwa, Rachel C. Knopp, N. Ikegaki +7 more
2017ACS Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Inhibition of amyloidogenesis by non-steroidal anti-inflammatory drugs and their hybrid nitrates
Isaac T. Schiefer, Samer O. Abdul-Hay, Huali Wang, Michael Vanni +2 more
2011Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Repurposing Potential of 1st Generation H1-specific Antihistamines as Anti-filovirus Therapeutics
Adam Schafer, Han Cheng, R. Xiong, V. Soloveva +5 more
2018Antiviral Research28 citations Open access
Semantic Scholar
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections
I. Gaisina, N. Peet, L. Wong, Adam Schafer +5 more
2020Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis and Application of a Lanthanide-Based Probe
Yao Yao, Loruhama Delgado-Rivera, Hamid Samareh Afsari, L. Yin +3 more
2017Inorganic Chemistry27 citations Open access
Semantic Scholar
Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry
Adam Schafer, R. Xiong, L. Cooper, Raghad M. Nowar +9 more
2021PLoS Pathogens26 citations Open access
Semantic Scholar
Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir
I. Gaisina, N. Peet, Han Cheng, Ping Li +7 more
2020Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors
L. Cooper, Adam Schafer, Yang-Feng Li, Han Cheng +9 more
2020Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity
Sandeep Kumar, S. Singh, N. Viswakarma, Gautam Sondarva +9 more
2020Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
Semantic Scholar
Quinone Induced Activation of Keap1/Nrf2 Signaling by Aspirin Prodrugs Masquerading as Nitric Oxide
Tareisha L. Dunlap, Sujeewa C Piyankarage, G. T. Wijewickrama, Samer O. Abdul-Hay +4 more
2012Chemical Research in Toxicology25 citations Open access
Semantic Scholar
Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease
M. Fa', Hong Zhang, Agnieszka Staniszewski, F. Saeed +10 more
2015Journal of Alzheimer's Disease23 citations Open access
Semantic Scholar
Interaction of oxidative stress and neurotrauma in ALDH2−/− mice causes significant and persistent behavioral and pro-inflammatory effects in a tractable model of mild traumatic brain injury
Rachel C. Knopp, Sue H. Lee, Michael A. Hollas, Emily Nepomuceno +7 more
2020Redox Biology20 citations Open access
Semantic Scholar
Discovery of Nonlipogenic ABCA1 Inducing Compounds with Potential in Alzheimer's Disease and Type 2 Diabetes.
Manel Ben Aissa, Cutler T. Lewandowski, K. Ratia, Sue H. Lee +3 more
2021ACS Pharmacology & Translational Science19 citations Open access
Semantic Scholar
Pharmacology and Molecular Mechanisms of Clinically Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for the Treatment of Endocrine-Resistant Breast Cancer
B. Abderrahman, P. Maximov, R. Curpan, Jay S. Hanspal +5 more
2020Molecular Pharmacology19 citations Open access
Semantic Scholar
Time-gated detection of cystathionine γ-lyase activity and inhibition with a selective, luminogenic hydrogen sulfide sensor
Yao Yao, C. Kong, L. Yin, Atul Jain +5 more
2016Chemistry19 citations Open access
Semantic Scholar
Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells
Sandeep Kumar, S. Singh, N. Viswakarma, Gautam Sondarva +8 more
2020Journal for ImmunoTherapy of Cancer18 citations Open access
Semantic Scholar
Novel Selective Estrogen Mimics for the Treatment of Tamoxifen-Resistant Breast Cancer
M. E. Molloy, B. Perez White, Teshome B. Gherezghiher, Bradley T. Michalsen +7 more
2014Molecular Cancer Therapeutics18 citations Open access
Semantic Scholar
Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
Cutler T. Lewandowski, M. Khan, Manel BenAissa, Oleksii Dubrovskyi +4 more
2021EBioMedicine17 citations Open access
Semantic Scholar
Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
Zhi-Hui Qin, I. Kastrati, Rezene T Ashgodom, D. Lantvit +5 more
2009Drug Metabolism And Disposition17 citations Open access
Semantic Scholar
Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase using Small Molecule Fragments.
F. Fata, I. Silvestri, M. Ardini, R. Ippoliti +9 more
2021ACS Infectious Diseases16 citations Open access
Semantic Scholar
Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome
Emily N Pierce, Sujeewa C Piyankarage, Tareisha L. Dunlap, V. Litosh +3 more
2016Chemical Research in Toxicology16 citations Open access
Semantic Scholar
Estrogen-induced apoptosis of breast epithelial cells is blocked by NO/cGMP and mediated by extranuclear estrogen receptors.
I. Kastrati, P. Edirisinghe, G. T. Wijewickrama, G. Thatcher
2010Endocrinology16 citations Open access
Semantic Scholar
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma.
Rachel C. Knopp, Ammar Jastaniah, Oleksii Dubrovskyi, I. Gaisina +2 more
2021ACS Pharmacology & Translational Science15 citations Open access
Semantic Scholar
Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine and CDK4/6 inhibitor therapy
A. Dudek, Li C. Liu, J. Fischer, E. Wiley +7 more
2020Breast Cancer Research and Treatment15 citations
Semantic Scholar

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D. Tonetti×8
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Li-Jun Rong×7
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Manel Ben Aissa

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Yang-Feng Li×6

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V. Litosh — researcher profile on SciRah

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P. Petukhov — researcher profile on SciRah

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