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A. McLennan · SciRah

Researcher profile · Semantic Scholar

A. McLennan

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A. McLennan — researcher profile on SciRah

h-index: 30
Works: 123
Citations: 5,854

Most-cited papers

Nucleic Acids Research
G. Blackburn, G. E. Taylor, G. Thatcher, A. McLennan
2010Nucleic Acids Research2,994 citations Open access
Semantic Scholar
The Nudix hydrolase superfamily
A. McLennan
2005Cellular and Molecular Life Sciences (CMLS)620 citations Open access
Semantic Scholar
The Diadenosine Hexaphosphate Hydrolases fromSchizosaccharomyces pombe andSaccharomyces cerevisiae Are Homologues of the Human Diphosphoinositol Polyphosphate Phosphohydrolase
S. Safrany, S. Ingram, J. Cartwright, J. Falck +3 more
1999Journal of Biological Chemistry108 citations Open access
Semantic Scholar
The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives.
Lakhdar Gasmi, A. McLennan
2001Biochemical Journal102 citations Open access
Semantic Scholar
Cloning, Expression, and Characterization of a Human Inosine Triphosphate Pyrophosphatase Encoded by the ITPAGene*
Shengrong Lin, A. McLennan, K. Ying, Zhao Wang +8 more
2001Journal of Biological Chemistry91 citations Open access
Semantic Scholar
The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review).
A. McLennan
1999International Journal of Molecular Medicine84 citations
Semantic Scholar
The IalA invasion gene of Bartonella bacilliformis encodes a (de)nucleoside polyphosphate hydrolase of the MutT motif family and has homologs in other invasive bacteria.
J. Cartwright, Phillip Britton, M. Minnick, A. McLennan
1999Biochemical and Biophysical Research Communications - BBRC80 citations
Semantic Scholar
Ap4A and Other Dinucleoside Polyphosphates
A. McLennan
199278 citations
Semantic Scholar
Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein.
S. Abdelraheim, D. Spiller, A. McLennan
2003Biochemical Journal74 citations Open access
Semantic Scholar
The heat shock response of the cryptobiotic brine shrimp Artemia — II. Heat shock proteins
David Miller, A. McLennan
198873 citations
Semantic Scholar
The Saccharomyces cerevisiae PCD1 Gene Encodes a Peroxisomal Nudix Hydrolase Active toward Coenzyme A and Its Derivatives*
J. Cartwright, Lakhdar Gasmi, D. Spiller, A. McLennan
2000Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?
A. McLennan
2013Cellular and Molecular Life Sciences69 citations Open access
Semantic Scholar
Nudix Hydrolases That Degrade Dinucleoside and Diphosphoinositol Polyphosphates Also Have 5-Phosphoribosyl 1-Pyrophosphate (PRPP) Pyrophosphatase Activity That Generates the Glycolytic Activator Ribose 1,5-Bisphosphate*
David I. Fisher, S. Safrany, P. Strike, A. McLennan +1 more
2002Journal of Biological Chemistry68 citations Open access
Semantic Scholar
The Saccharomyces cerevisiae YOR163w Gene Encodes a Diadenosine 5′,5‴-P 1,P 6-Hexaphosphate (Ap6A) Hydrolase Member of the MutT Motif (Nudix Hydrolase) Family*
J. Cartwright, A. McLennan
1999Journal of Biological Chemistry65 citations Open access
Semantic Scholar
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms.
S. Bailey, S. Sedelnikova, G. Blackburn, H. Abdelghany +3 more
2002Structure60 citations Open access
Semantic Scholar
Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif.
Lakhdar Gasmi, J. Cartwright, A. McLennan
1999Biochemical Journal51 citations Open access
Semantic Scholar
The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes.
S. Abdelraheim, J. Cartwright, Lakhdar Gasmi, A. McLennan
2001Archives of Biochemistry and Biophysics48 citations
Semantic Scholar
Ap4A induces apoptosis in human cultured cells
A. Vartanian, I. Alexandrov, Igor Prudowski, A. McLennan +1 more
1999FEBS Letters45 citations
Semantic Scholar
The g5R (D250) Gene of African Swine Fever Virus Encodes a Nudix Hydrolase That Preferentially Degrades Diphosphoinositol Polyphosphates
J. Cartwright, S. Safrany, L. Dixon, E. Darżynkiewicz +3 more
2002Journal of Virology44 citations Open access
Semantic Scholar
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
N. Leslie, A. McLennan, S. Safrany
2002BMC Biochemistry42 citations Open access
Semantic Scholar
Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose).
Shengrong Lin, Lakhdar Gasmi, Yi Xie, K. Ying +9 more
2002Biochimica et Biophysica Acta39 citations
Semantic Scholar
The repair of ultraviolet light-induced DNA damage in plant cells
A. McLennan
198739 citations
Semantic Scholar
The complex enzymology of mRNA decapping: Enzymes of four classes cleave pyrophosphate bonds
S. Kramer, A. McLennan
2018Wiley Interdisciplinary Reviews - RNA38 citations Open access
Semantic Scholar
Cloning, characterisation and crystallisation of a diadenosine 5',5"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans.
H. Abdelghany, Lakhdar Gasmi, J. Cartwright, Scott Bailey +2 more
2001Biochimica et Biophysica Acta38 citations
Semantic Scholar
Re-evaluation of Diadenosine Tetraphosphate (Ap4A) From a Stress Metabolite to Bona Fide Secondary Messenger
F. Ferguson, A. McLennan, M. Urbaniak, N. J. Jones +1 more
2020Frontiers in Molecular Biosciences34 citations Open access
Semantic Scholar
NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes
A. Marriott, O. Vasieva, Yong-Xiang Fang, Nikki A. Copeland +2 more
2016PLoS ONE32 citations Open access
Semantic Scholar
The Caenorhabditis elegans Y87G2A.14 Nudix hydrolase is a peroxisomal coenzyme A diphosphatase
S. Abdelraheim, A. McLennan
2002BMC Biochemistry32 citations Open access
Semantic Scholar
Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase*
J. Swarbrick, S. Buyya, D. Gunawardana, K. Gayler +2 more
2005Journal of Biological Chemistry30 citations Open access
Semantic Scholar
The heat shock response of the cryptobiotic brine Shrimp artemia—I. A comparison of the thermotolerance of cysts and larvae
David Miller, A. McLennan
198830 citations
Semantic Scholar
Characterization of the P2 receptors on the human umbilical vein endothelial cell line ECV304
A. Conant, M. J. Fisher, A. McLennan, A. Simpson
1998British Journal of Pharmacology28 citations Open access
Semantic Scholar
A biological role for the heat shock response in crustaceans
A. McLennan, David Miller
199028 citations
Semantic Scholar
Mouse Nudt13 is a Mitochondrial Nudix Hydrolase with NAD(P)H Pyrophosphohydrolase Activity
S. Abdelraheim, D. Spiller, A. McLennan
2017The Protein Journal27 citations Open access
Semantic Scholar
Characterization of the HeLa cell DNA polymerase alpha-associated Ap4A binding protein by photoaffinity labeling.
M. D. Baxi, A. McLennan, J. Vishwanatha
1994Biochemistry27 citations
Semantic Scholar
Seafood label quality and mislabelling rates hamper consumer choices for sustainability in Australia
Megan E. Cundy, Julia Santana-Garcon, A. McLennan, Marcelle E Ayad +5 more
2023Scientific Reports26 citations Open access
Semantic Scholar
Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells.
David I. Fisher, A. McLennan
2008Cancer Letters22 citations
Semantic Scholar
Characterization of a Nudix hydrolase from Deinococcus radiodurans with a marked specificity for (deoxy)ribonucleoside 5'-diphosphates
David I. Fisher, J. Cartwright, H. Harashima, H. Kamiya +1 more
2004BMC Biochemistry21 citations Open access
Semantic Scholar
Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication.
A. Marriott, Nikki A. Copeland, Ryan Cunningham, M. Wilkinson +2 more
2015DNA Repair20 citations Open access
Semantic Scholar
Decapitation: poxvirus makes RNA lose its head.
A. McLennan
2007TIBS -Trends in Biochemical Sciences. Regular ed17 citations
Semantic Scholar
The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohydrolase and phosphorylase activities.
A. McLennan, E. Mayers, S. Hankin, N. Thorne +2 more
1994Biochemical Journal16 citations Open access
Semantic Scholar
Purification and properties of GTP:GTP guanylyltransferase from encysted embryos of the brine shrimp Artemia.
J.-J. Liu, A. McLennan
1994Journal of Biological Chemistry16 citations
Semantic Scholar
Lanterns of the Firefly Photinus pyralis Contain Abundant Diadenosine 5′,5“′-P1,P4-Tetraphosphate Pyrophosphohydrolase Activity (*)
A. McLennan, E. Mayers, Ian Walker-Smith, Hai-Lan Chen
1995Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Formation of a CovalentNϵ2-Guanylylhistidyl Reaction Intermediate by the GTP:GTP Guanylyltransferase from the Brine ShrimpArtemia
J. Cartwright, A. McLennan
199914 citations
Semantic Scholar
The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.
A. Carloto, M. Costas, J. Cameselle, A. McLennan +1 more
2006Biochimica et Biophysica Acta13 citations Open access
Semantic Scholar
Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases.
A. Guranowski, Elżbieta Starzyńska, A. McLennan, J. Baraniak +1 more
2003Biochemical Journal13 citations Open access
Semantic Scholar
The Human NUDT Family of Nucleotide Hydrolases
A. McLennan, J. Cartwright, Lakhdar Gasmi
200213 citations
Semantic Scholar
Anabaena flos-aquae and other cyanobacteria possess diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) phosphorylase activity.
A. McLennan, E. Mayers, D. G. Adams
1996Biochemical Journal13 citations Open access
Semantic Scholar
CorrespondenceComment: di(1,N6-ethenoadenosine)-5′,5‴-P1,P4-tetraphosphate, a fluorescent enzymatically active derivative of Ap4A
A. McLennan
199112 citations Open access
Semantic Scholar
Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch?
Lucinda Winward, W. Whitfield, A. McLennan, S. Safrany
2010International Journal of Biochemistry and Cell Biology11 citations
Semantic Scholar
BIOS Instant Notes in Molecular Biology
A. McLennan, A. Bates, P. Turner, M. White
200011 citations
Semantic Scholar
Synthesis of bridged dinucleosides
D. Agathocleous, P. B. Bulman Page, R. Cosstick, I. Galpin +2 more
199011 citations
Semantic Scholar

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