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Jean Quancard · SciRah

Researcher profile · Semantic Scholar

Jean Quancard

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Jean Quancard — researcher profile on SciRah

h-index: 15
Works: 36
Citations: 1,250

Most-cited papers

Palladium-catalyzed enantioselective C-3 allylation of 3-substituted-1H-indoles using trialkylboranes.
B. Trost, Jean Quancard
2006Journal of the American Chemical Society410 citations Open access
Semantic Scholar
Targeted inhibition of the COP9 signalosome for treatment of cancer
Anita Schlierf, E. Altmann, Jean Quancard, A. B. Jefferson +11 more
2016Nature Communications164 citations Open access
Semantic Scholar
A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.
Jean Quancard, B. Bollbuck, P. Janser, D. Angst +14 more
2012Chemistry and Biology103 citations Open access
Semantic Scholar
An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
Jean Quancard, T. Klein, Shan-Yu Fung, M. Renatus +16 more
2019Nature Chemical Biology60 citations
Semantic Scholar
The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition
Maureen Bardet, Adeline Unterreiner, C. Malinverni, F. Lafossas +18 more
2018Immunology and Cell Biology59 citations
Semantic Scholar
Development of potent inhibitors of botulinum neurotoxin type B.
Christine Anne, Serge Turcaud, Jean Quancard, F. Teffo +3 more
2003Journal of Medicinal Chemistry55 citations
Semantic Scholar
Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology
Kea Martin, U. Junker, E. Tritto, Esther Sutter +17 more
2020Frontiers in Immunology40 citations Open access
Semantic Scholar
Asymmetric synthesis of 3-substituted proline chimeras bearing polar side chains of proteinogenic amino acids.
Jean Quancard, Aurélie Labonne, Y. Jacquot, G. Chassaing +2 more
2004Journal of Organic Chemistry38 citations
Semantic Scholar
Amino-zinc-enolate carbometalation reactions: application to ring closure of terminally substituted olefin for the asymmetric synthesis of cis- and trans-3-prolinoleucine.
P. Karoyan, Jean Quancard, J. Vaissermann, G. Chassaing
2003Journal of Organic Chemistry35 citations
Semantic Scholar
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
Carole Pissot Soldermann, Olivera Simić, M. Renatus, P. Erbel +22 more
2020Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
E. Altmann, P. Erbel, M. Renatus, M. Schaefer +12 more
2017Angewandte Chemie25 citations
Semantic Scholar
An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.
D. Angst, P. Janser, Jean Quancard, P. Buehlmayer +9 more
2012Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.
Jean Quancard, Olivera Simić, Carole Pissot Soldermann, R. Aichholz +18 more
2020Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.
A. Schlapbach, L. Révész, Carole Pissot Soldermann, T. Zoller +13 more
2018Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism
M. Bigaud, Z. Dincer, B. Bollbuck, J. Dawson +11 more
2016PLoS ONE18 citations Open access
Semantic Scholar
The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes
Jean Quancard, Brian Cox, D. Finsinger, Stéphanie M. Guéret +5 more
2020ChemMedChem14 citations Open access
Semantic Scholar
Substituted Prolines: Syntheses and Applications in Structure—Activity Relationship Studies of Biologically Active Peptides
P. Karoyan, S. Sagan, O. Lequin, Jean Quancard +2 more
200614 citations
Semantic Scholar
Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor.
S. Sagan, Jean Quancard, O. Lequin, P. Karoyan +2 more
2005Chemistry and Biology14 citations Open access
Semantic Scholar
Amino-zinc-ene-enolate cyclisation: a short access to (2S,3R)- and (2S,3S)-3-benzylprolines (3-benzylpyrrolidine-2-carboxylic acids)
Jean Quancard, Hervé Magellan, S. Lavielle, G. Chassaing +1 more
200414 citations
Semantic Scholar
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery
Jean Quancard, A. Bach, Brian Cox, Russell Craft +7 more
2021ChemMedChem12 citations
Semantic Scholar
Prolinoamino acids as a tool to stabilize β-turns with the side chain of natural amino acids
Jean Quancard, P. Karoyan, O. Lequin, E. Wenger +3 more
200412 citations
Semantic Scholar
Characterization of the bioactive conformation of the C-terminal tripeptide Gly-Leu-Met-NH2 of substance P using [3-prolinoleucine10]SP analogues.
Jean Quancard, P. Karoyan, S. Sagan, O. Convert +3 more
2003European Journal of Biochemistry11 citations Open access
Semantic Scholar
Prolinoamino Acids as Tools to Build Bifunctionalized, Stable β‐Turns in Water
C. Mothes, M. Larregola, Jean Quancard, N. Goasdoué +4 more
2009ChemBioChem9 citations Open access
Semantic Scholar
Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver.
D. Nandi, E. Lightcap, Y. Koo, Xing-Liang Lu +2 more
2003International Journal of Biochemistry and Cell Biology9 citations
Semantic Scholar
Requirement of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor–Induced Arthritis, but Not Fcγ Receptor–Mediated Platelet Elimination, in Mice
Kea Martin, Ratiba Touil, Grozdan Cvijetic, Laura Israel +21 more
2020Arthritis & Rheumatology8 citations
Semantic Scholar
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead
Jean Quancard, Anders Bach, Chiara Borsari, Russell Craft +13 more
2025ChemMedChem7 citations Open access
Semantic Scholar
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit Generation
Jean Quancard, A. Vulpetti, A. Bach, Brian Cox +7 more
2023ChemMedChem7 citations
Semantic Scholar
Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity
N. Hughes, P. Erbel, F. Bornancin, C. Wiesmann +18 more
20207 citations
Semantic Scholar
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space
S. C. K. Sukuru, Florian Nigsch, Jean Quancard, M. Renatus +9 more
2010Protein Science7 citations Open access
Semantic Scholar
Identification of TAK-756, A Potent TAK1 Inhibitor for the Treatment of Osteoarthritis through Intra-Articular Administration.
Jean-Baptiste Langlois, Silke Brenneisen, S. Rodde, Eric Vangrevelinghe +29 more
2024Journal of Medicinal Chemistry2 citations
Semantic Scholar
A first-in-class small molecule inhibitor of the COP9 signalosome subunit 5 for the treatment of cancer
E. Altmann, Anita Schlierf, A. B. Jefferson, M. Renatus +11 more
20161 citations
Semantic Scholar
The Phenotypic Hit-to-Probe Challenge
Sven Herschel, Thomas Ullrich, Enrico Schmidt, Jean Quancard +1 more
2026Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
Abstract 1879: Pyrazolopyrimidines as novel selective allosteric MALT1 inhibitors with in vivo activity in ABC-DLBCL
A. Weiss, Thomas Radimerski, D. Wyss, R. Andraos +16 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
The Sphingosine 1-Phosphate Receptor Subtype-1 Is the Primary Target of Fingolimod in the CNS: Interruption of the Pro-inflammatory S1P-S1P1 Cascade (P05.145)
Volker Brinkmann, M. Streiff, K. Kaupmann, A. Billich +5 more
2013Neurology0 citations
Semantic Scholar
Inside Cover: Prolinoamino Acids as Tools to Build Bifunctionalized, Stable β‐Turns in Water (ChemBioChem 1/2010)
C. Mothes, M. Larregola, Jean Quancard, N. Goasdoué +4 more
20090 citations Open access
Semantic Scholar
Corrigendum to “Prolinoamino acids as a tool to stabilize β-turns with the side chain of natural amino acids”: [Tetrahedron Lett. 45 (2004) 623]
Jean Quancard, P. Karoyan, O. Lequin, E. Wenger +3 more
20040 citations
Semantic Scholar

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