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A. Bach · SciRah

Researcher profile · Semantic Scholar

A. Bach

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A. Bach — researcher profile on SciRah

h-index: 30
Works: 69
Citations: 2,568

Most-cited papers

Common Structural Basis for Constitutive Activity of the Ghrelin Receptor Family*
B. Holst, Nicholas D. Holliday, A. Bach, C. Elling +2 more
2004Journal of Biological Chemistry350 citations Open access
Semantic Scholar
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
A. Bach, B. Clausen, Magda Møller, B. Vestergaard +11 more
2012Proceedings of the National Academy of Sciences of the United States of America185 citations Open access
Semantic Scholar
A Conserved Aromatic Lock for the Tryptophan Rotameric Switch in TM-VI of Seven-transmembrane Receptors*
B. Holst, R. Nygaard, Louise Valentin-Hansen, A. Bach +4 more
2009Journal of Biological Chemistry150 citations Open access
Semantic Scholar
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling.
B. Holst, E. Brandt, A. Bach, A. Heding +1 more
2005Molecular Endocrinology128 citations Open access
Semantic Scholar
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
T. Thorsen, K. L. Madsen, N. Rebola, Mette Rathje +13 more
2009Proceedings of the National Academy of Sciences of the United States of America115 citations Open access
Semantic Scholar
Ghrelin Receptor Inverse Agonists: Identification of an Active Peptide Core and Its Interaction Epitopes on the Receptor
B. Holst, Manja Lang, E. Brandt, A. Bach +4 more
2006Molecular Pharmacology94 citations
Semantic Scholar
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases.
Jakob S. Pallesen, Kim T Tran, A. Bach
2018Journal of Medicinal Chemistry90 citations Open access
Semantic Scholar
Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.
A. Bach, Jonas N. N. Eildal, N. Stuhr-Hansen, Rasmus Deeskamp +4 more
2011Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
Kim T Tran, Jakob S. Pallesen, Sara M. Ø. Solbak, D. Narayanan +6 more
2019Journal of Medicinal Chemistry82 citations Open access
Semantic Scholar
Ligand binding by PDZ domains
Celestine N. Chi, A. Bach, K. Strømgaard, S. Gianni +1 more
2012Biofactors63 citations Open access
Semantic Scholar
Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.
A. Bach, Celestine N. Chi, Thomas Olsen, Søren W. Pedersen +5 more
2008Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Acid Ceramidase in Melanoma
N. Realini, F. Palese, Daniela Pizzirani, S. Pontis +4 more
2015Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Unique Interaction Pattern for a Functionally Biased Ghrelin Receptor Agonist*
Bjørn B. Sivertsen, Manja Lang, T. Frimurer, Nicholas D. Holliday +8 more
2011Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction.
A. Bach, Celestine N. Chi, Gar F Pang, L. Olsen +3 more
2009Angewandte Chemie53 citations
Semantic Scholar
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Jakob S. Pallesen, D. Narayanan, Kim T Tran, Sara M. Ø. Solbak +13 more
2021Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains.
S. R. Haq, Celestine N. Chi, A. Bach, Jakob Dogan +8 more
2012Journal of the American Chemical Society51 citations Open access
Semantic Scholar
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Ulrike Leurs, A. Klein, E. McSpadden, Nane Griem-Krey +25 more
2021Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
The dynamics of linear polyubiquitin
Alexander Jussupow, A. C. Messias, R. Stehle, A. Geerlof +5 more
2020Science Advances46 citations Open access
Semantic Scholar
A sequential binding mechanism in a PDZ domain.
Celestine N. Chi, A. Bach, Å. Engström, Huiqun Wang +3 more
2009Biochemistry44 citations
Semantic Scholar
Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions
A. Bach, Søren W. Pedersen, L. Dorr, Gary Vallon +3 more
2015Scientific Reports42 citations Open access
Semantic Scholar
Energetic pathway sampling in a protein interaction domain.
G. Hultqvist, S. R. Haq, A. Punekar, Celestine N. Chi +6 more
2013Structure41 citations Open access
Semantic Scholar
Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
D. Narayanan, Kim T Tran, Jakob S. Pallesen, Sara M. Ø. Solbak +13 more
2022Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Small-molecule modulators of tumor necrosis factor signaling.
Henri Chédotal, D. Narayanan, Katrine Povlsen, C. Gotfredsen +4 more
2023Drug Discovery Today37 citations Open access
Semantic Scholar
Benzoxazolone Carboxamides: Potent and Systemically Active Inhibitors of Intracellular Acid Ceramidase
Daniela Pizzirani, A. Bach, N. Realini, A. Armirotti +8 more
2014Angewandte Chemie37 citations Open access
Semantic Scholar
Acid Ceramidase in Melanoma EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION
N. Realini, F. Palese, Daniela Pizzirani, S. Pontis +4 more
201636 citations
Semantic Scholar
Structure–activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
A. Bach, N. Stuhr-Hansen, T. Thorsen, N. Bork +8 more
2010Organic and biomolecular chemistry35 citations Open access
Semantic Scholar
Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.
Sara M. Ø. Solbak, Jie Zang, D. Narayanan, L. Høj +7 more
2020Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood–Brain Barrier Adherence, Uptake, and Permeation
M. Kristensen, K. Kucharz, Eduardo Felipe Alves Fernandes, K. Strømgaard +7 more
2020Pharmaceutics31 citations Open access
Semantic Scholar
Selectivity, efficacy and toxicity studies of UCCB01‐144, a dimeric neuroprotective PSD‐95 inhibitor
A. Bach, B. Clausen, L. Kristensen, M. G. Andersen +12 more
2019Neuropharmacology30 citations Open access
Semantic Scholar
Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies.
A. Bach, Daniela Pizzirani, N. Realini, Valentina Vozella +5 more
2015Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
A high‐affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain
N. R. Christensen, Marta De Luca, Michael B. Lever, Mette Richner +21 more
2020EMBO Molecular Medicine29 citations Open access
Semantic Scholar
Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example*
Celestine N. Chi, A. Bach, Marie Gottschalk, Anders S. Kristensen +2 more
2010Journal of Biological Chemistry29 citations Open access
Semantic Scholar
PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression
K. Kucharz, Ida Søndergaard Rasmussen, A. Bach, K. Strømgaard +1 more
2017Journal of Cerebral Blood Flow and Metabolism26 citations Open access
Semantic Scholar
Biophysical Characterization of the Complex between Human Papillomavirus E6 Protein and Synapse-associated Protein 97*♦
Celestine N. Chi, A. Bach, Å. Engström, K. Strømgaard +3 more
2010Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Molecular architecture of the Jumonji C family histone demethylase KDM5B
J. Dorosz, L. H. Kristensen, N. G. Aduri, O. Mirza +13 more
2019Scientific Reports25 citations Open access
Semantic Scholar
UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801.
J. Andreasen, A. Bach, Mikko Gynther, A. Nasser +3 more
2013Neuropharmacology23 citations
Semantic Scholar
Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family
Klaus B. Nissen, Linda M. Haugaard-Kedström, Theis S. Wilbek, L. Nielsen +5 more
2015PLoS ONE17 citations Open access
Semantic Scholar
Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
Nicole Fadahunsi, Jonas Petersen, Sophia Metz, Alexander Jakobsen +18 more
2024Science Advances16 citations Open access
Semantic Scholar
Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist
Kaare V. Grunddal, T. Diep, N. Petersen, I. Tough +16 more
2021Molecular Metabolism16 citations Open access
Semantic Scholar
PDZ Domain-Mediated Interactions of G Protein-Coupled Receptors with Postsynaptic Density Protein 95: Quantitative Characterization of Interactions
Thor C. Møller, Volker F. Wirth, Nina I. Roberts, Julia Bender +6 more
2013PLoS ONE16 citations Open access
Semantic Scholar
In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury
J. Sommer, A. Bach, Hana Malá, K. Strømgaard +2 more
2017European Journal of Neuroscience15 citations
Semantic Scholar
A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.
T. Thorsen, K. L. Madsen, T. Dyhring, A. Bach +4 more
2011Combinatorial chemistry & high throughput screening15 citations
Semantic Scholar
Rigidified Clicked Dimeric Ligands for Studying the Dynamics of the PDZ1‐2 Supramodule of PSD‐95
Jonas N. N. Eildal, A. Bach, Jakob Dogan, F. Ye +3 more
2015ChemBioChem14 citations
Semantic Scholar
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery
Jean Quancard, A. Bach, Brian Cox, Russell Craft +7 more
2021ChemMedChem12 citations
Semantic Scholar
The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo
Emma Lisa Al Humaidan, S. Pedersen, Annette Burkhart, Charlotte L. M. Rasmussen +8 more
2022Frontiers in Drug Delivery11 citations Open access
Semantic Scholar
Targeting Oxidative Stress in Stroke
A. Bach
201711 citations
Semantic Scholar
Design, synthesis, and characterization of fatty acid derivatives of a dimeric peptide-based postsynaptic density-95 (PSD-95) inhibitor.
Klaus B. Nissen, J. Andersen, Linda M. Haugaard-Kedström, A. Bach +1 more
2015Journal of Medicinal Chemistry11 citations
Semantic Scholar
Detecting Protein–Protein Interactions in Living Cells: Development of a Bioluminescence Resonance Energy Transfer Assay to Evaluate the PSD-95/NMDA Receptor Interaction
Marie Gottschalk, A. Bach, J. L. Hansen, P. Krogsgaard‐Larsen +2 more
2009Neurochemical Research10 citations
Semantic Scholar
Chemical synthesis of a reported p47phox/p22phox inhibitor and characterization of its instability and irreproducible activity
Jie Zang, Y. Cambet, V. Jaquet, A. Bach
2023Frontiers in Pharmacology9 citations Open access
Semantic Scholar
Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor
A. Bach, Thomas B. Pedersen, K. Strømgaard
20168 citations Open access
Semantic Scholar

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