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E. Vigna · SciRah

Researcher profile · Semantic Scholar

E. Vigna

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E. Vigna — researcher profile on SciRah

h-index: 29
Works: 75
Citations: 5,437

Most-cited papers

Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.
L. Naldini, E. Vigna, Radha P. Narsimhan, G. Gaudino +3 more
1991Oncogene728 citations
Semantic Scholar
Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.
L. Naldini, K. Weidner, E. Vigna, G. Gaudino +6 more
1991EMBO Journal669 citations Open access
Semantic Scholar
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
L. Naldini, L. Tamagnone, E. Vigna, M. Sachs +6 more
1992EMBO Journal588 citations Open access
Semantic Scholar
Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy
E. Vigna, L. Naldini
2000Journal of Gene Medicine371 citations
Semantic Scholar
Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters
Mario Amendola, M. Venneri, A. Biffi, E. Vigna +1 more
2005Nature Biotechnology329 citations
Semantic Scholar
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation.
R. Taulli, Francesca Bersani, Valentina Foglizzo, A. Linari +4 more
2009Journal of Clinical Investigation273 citations Open access
Semantic Scholar
Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction (*)
L. Naldini, E. Vigna, A. Bardelli, A. Follenzi +2 more
1995Journal of Biological Chemistry266 citations Open access
Semantic Scholar
Identification of Myocardial and Vascular Precursor Cells in Human and Mouse Epicardium
Federica Limana, A. Zacheo, D. Mocini, A. Mangoni +10 more
2007Circulation Research246 citations
Semantic Scholar
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.
G. Hartmann, L. Naldini, K. Weidner, M. Sachs +3 more
1992Proceedings of the National Academy of Sciences of the United States of America226 citations Open access
Semantic Scholar
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation
L. Naldini, E. Vigna, Riccardo Ferracini, P. Longati +3 more
1991Molecular and Cellular Biology181 citations Open access
Semantic Scholar
Tivantinib (ARQ197) Displays Cytotoxic Activity That Is Independent of Its Ability to Bind MET
C. Basilico, Selma Pennacchietti, E. Vigna, C. Chiriaco +5 more
2013Clinical Cancer Research169 citations Open access
Semantic Scholar
Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors.
E. Vigna, S. Cavalieri, L. Ailles, M. Geuna +3 more
2002Molecular Therapy159 citations Open access
Semantic Scholar
MET overexpression turns human primary osteoblasts into osteosarcomas.
S. Patané, S. Avnet, N. Coltella, B. Costa +10 more
2006Cancer Research131 citations Open access
Semantic Scholar
Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase.
R. Ferracini, P. Longati, L. Naldini, E. Vigna +1 more
1991Journal of Biological Chemistry123 citations Open access
Semantic Scholar
Hepatocyte Growth Factor Is a Regulator of Monocyte-Macrophage Function1
F. Galimi, E. Cottone, E. Vigna, N. Arena +4 more
2001Journal of Immunology82 citations Open access
Semantic Scholar
Monovalency Unleashes the Full Therapeutic Potential of the DN-30 Anti-Met Antibody*
G. Pacchiana, C. Chiriaco, M. Stella, F. Petronzelli +6 more
2010Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET
E. Vigna, Daniela Gramaglia, P. Longati, A. Bardelli +1 more
1999Oncogene75 citations Open access
Semantic Scholar
Efficient Tet-dependent expression of human factor IX in vivo by a new self-regulating lentiviral vector.
E. Vigna, Mario Amendola, F. Benedicenti, A. Simmons +2 more
2005Molecular Therapy70 citations Open access
Semantic Scholar
Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene.
E. Vigna, L. Naldini, L. Tamagnone, P. Longati +4 more
1994Cellular and Molecular Biology49 citations
Semantic Scholar
Targeting the oncogenic Met receptor by antibodies and gene therapy
E. Vigna, P. Comoglio
2014Oncogene43 citations Open access
Semantic Scholar
"Active" cancer immunotherapy by anti-Met antibody gene transfer.
E. Vigna, G. Pacchiana, M. Mazzone, C. Chiriaco +4 more
2008Cancer Research43 citations Open access
Semantic Scholar
Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
V. Martin, C. Chiriaco, Chiara Modica, A. Acquadro +8 more
2019British Journal of Cancer40 citations Open access
Semantic Scholar
Quiescent neuronal progenitors are activated in the juvenile guinea pig lateral striatum and give rise to transient neurons
F. Luzzati, G. Nato, Livio Oboti, E. Vigna +5 more
2014Development37 citations Open access
Semantic Scholar
A Highly Potent and Specific MET Therapeutic Protein Antagonist with Both Ligand-Dependent and Ligand-Independent Activity
S. Olwill, C. Joffroy, Hendrik Gille, E. Vigna +12 more
2013Molecular Cancer Therapeutics36 citations Open access
Semantic Scholar
Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process.
D. Avitabile, A. Crespi, C. Brioschi, Valeria Parente +13 more
2011American Journal of Physiology. Heart and Circulatory Physiology36 citations
Semantic Scholar
Protein tyrosine phosphatase PTP-S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met.
E. Villamoruzzi, F. Puntoni, A. Bardelli, E. Vigna +2 more
1998Biochemical Journal36 citations Open access
Semantic Scholar
T Cell Receptor (TCR) Gene Transfer with Lentiviral Vectors Allows Efficient Redirection of Tumor Specificity in Naive and Memory T Cells Without Prior Stimulation of Endogenous TCR
P. Circosta, L. Granziero, A. Follenzi, E. Vigna +11 more
2009Human Gene Therapy35 citations
Semantic Scholar
CSPG4-specific CAR.CIK lymphocytes as a novel therapy for the treatment of multiple soft tissue sarcoma histotypes
V. Leuci, C. Donini, G. Grignani, R. Rotolo +20 more
2020Clinical Cancer Research34 citations Open access
Semantic Scholar
MET/HGF Co-Targeting in Pancreatic Cancer: A Tool to Provide Insight into the Tumor/Stroma Crosstalk
Chiara Modica, D. Tortarolo, P. Comoglio, C. Basilico +1 more
2018International Journal of Molecular Sciences32 citations Open access
Semantic Scholar
Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody.
Emanuela Pupo, Nadia Ducano, B. Lupo, E. Vigna +5 more
2016Cancer Research26 citations Open access
Semantic Scholar
Retroviral vectors containing Tet-controlled bidirectional transcription units for simultaneous regulation of two gene activities
R. Loew, E. Vigna, D. Lindemann, L. Naldini +1 more
2006Journal of Molecular and Genetic Medicine22 citations Open access
Semantic Scholar
Efficacy of CAR-T immunotherapy in MET overexpressing tumors not eligible for anti-MET targeted therapy
C. Chiriaco, C. Donini, Marco Cortese, S. Ughetto +11 more
2022Journal of experimental & clinical cancer research : CR20 citations Open access
Semantic Scholar
Inhibition of ligand‐independent constitutive activation of the Met oncogenic receptor by the engineered chemically‐modified antibody DN30
E. Vigna, C. Chiriaco, Simona Cignetto, Lara Fontani +3 more
2015Molecular Oncology19 citations Open access
Semantic Scholar
Targeting the MET oncogene by concomitant inhibition of receptor and ligand via an antibody‐“decoy” strategy
C. Basilico, Chiara Modica, F. Maione, E. Vigna +1 more
2018International Journal of Cancer16 citations Open access
Semantic Scholar
Cardiac concentric hypertrophy promoted by activated Met receptor is mitigated in vivo by inhibition of Erk1,2 signalling with Pimasertib.
V. Sala, Simona Gallo, S. Gatti, E. Medico +9 more
2016Journal of Molecular and Cellular Cardiology16 citations
Semantic Scholar
Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1+ Chemoresistant Lung Cancer Cells
R. Rotolo, V. Leuci, C. Donini, F. Galvagno +26 more
2022Clinical Cancer Research15 citations Open access
Semantic Scholar
Targeted therapy by gene transfer of a monovalent antibody fragment against the Met oncogenic receptor
E. Vigna, G. Pacchiana, C. Chiriaco, Simona Cignetto +3 more
2013Journal of molecular medicine15 citations Open access
Semantic Scholar
Functional properties of cells obtained from human cord blood CD34+ stem cells and mouse cardiac myocytes in coculture.
A. Orlandi, F. Pagani, D. Avitabile, G. Bonanno +7 more
2008American Journal of Physiology. Heart and Circulatory Physiology14 citations Open access
Semantic Scholar
hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
I. Martinelli, Chiara Modica, C. Chiriaco, C. Basilico +5 more
2022Journal of experimental & clinical cancer research : CR12 citations Open access
Semantic Scholar
HGF/MET Axis Induces Tumor Secretion of Tenascin-C and Promotes Stromal Rewiring in Pancreatic Cancer
Chiara Modica, M. Olivero, Francesca Zuppini, M. Milan +2 more
2021Cancers12 citations Open access
Semantic Scholar
Protein tyrosine phosphatase PTP-S binds to the juxtamembrane region of the hepatocyte growth factor receptor
E. Villamoruzzi, F. Puntoni, A. Bardelli, E. Vigna +2 more
199812 citations
Semantic Scholar
Dual Constant Domain‐Fab: A novel strategy to improve half‐life and potency of a Met therapeutic antibody
Simona Cignetto, Chiara Modica, C. Chiriaco, Lara Fontani +4 more
2016Molecular Oncology11 citations Open access
Semantic Scholar
Structure and functions of the HGF receptor (c-Met)
P. Comoglio, E. Vigna
199510 citations
Semantic Scholar
A receptor-antibody hybrid hampering MET-driven metastatic spread
Chiara Modica, C. Basilico, C. Chiriaco, Nicla Borrelli +2 more
2021Journal of experimental & clinical cancer research : CR7 citations Open access
Semantic Scholar
Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor
C. Desole, Simona Gallo, Annapia Vitacolonna, E. Vigna +9 more
2021Frontiers in Immunology7 citations Open access
Semantic Scholar
Cancer Therapy : Preclinical Tivantinib ( ARQ 197 ) Displays Cytotoxic Activity That Is Independent of Its Ability to Bind MET
C. Basilico, Selma Pennacchietti, E. Vigna, C. Chiriaco +5 more
20135 citations
Semantic Scholar
Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody
Chiara Modica, Simona Gallo, C. Chiriaco, M. Spilinga +4 more
2020Cancers4 citations Open access
Semantic Scholar
Anti-Differentiation Effect of Oncogenic Met Receptor in Terminally-Differentiated Myotubes
V. Sala, Simona Gallo, S. Gatti, E. Vigna +2 more
2015Biomedicines3 citations Open access
Semantic Scholar
Genetic Ablation of the MET Oncogene Defines a Crucial Role of the HGF/MET Axis in Cell-Autonomous Functions Driving Tumor Dissemination
Chiara Modica, Marco Cortese, Francesca Bersani, A. M. Lombardi +5 more
2023Cancers1 citations Open access
Semantic Scholar
Correction: hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
I. Martinelli, Chiara Modica, C. Chiriaco, C. Basilico +5 more
2022Journal of experimental & clinical cancer research : CR1 citations Open access
Semantic Scholar

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