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H. Inuzuka · SciRah

Researcher profile · Semantic Scholar

H. Inuzuka

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H. Inuzuka — researcher profile on SciRah

h-index: 52
Works: 138
Citations: 9,232

Most-cited papers

Roles of F-box proteins in cancer
Zhi-Wei Wang, Pengda Liu, H. Inuzuka, Wenyi Wei
2014Nature Reviews. Cancer497 citations Open access
Semantic Scholar
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
Pengda Liu, M. Begley, W. Michowski, H. Inuzuka +21 more
2014Nature365 citations Open access
Semantic Scholar
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy
Yang Gao, N. T. Nihira, Xia Bu, C. Chu +23 more
2020Nature Cell Biology357 citations Open access
Semantic Scholar
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
Xiangpeng Dai, Wenjian Gan, Xiaoning Li, Shang-Qian Wang +28 more
2017Nature Medicine299 citations Open access
Semantic Scholar
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis
Pengda Liu, Wenjian Gan, H. Inuzuka, A. Lazorchak +17 more
2013Nature Cell Biology267 citations Open access
Semantic Scholar
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
Wenjian Gan, Xiangpeng Dai, Andrea Lunardi, Zhen Li +11 more
2015Molecules and Cells212 citations Open access
Semantic Scholar
Acetylation-Dependent Regulation of Skp2 Function
H. Inuzuka, Da-Ming Gao, Lydia W. S. Finley, Wen Yang +14 more
2012Cell211 citations Open access
Semantic Scholar
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependentmanner
Jian-ping Guo, Abhishek A. Chakraborty, Pengda Liu, Wenjian Gan +14 more
2016Science197 citations Open access
Semantic Scholar
Tumor Suppressor Functions of FBW7 in Cancer Development and Progression
Zhi-Wei Wang, H. Inuzuka, Jia-Teng Zhong, L. Wan +3 more
2012FEBS Letters164 citations Open access
Semantic Scholar
SGK3 mediates INPP4B-dependent PI 3-Kinase signaling in breast cancer
Jessica A. Gasser, H. Inuzuka, Alan Lau, Wenyi Wei +2 more
2014Molecules and Cells149 citations Open access
Semantic Scholar
Cyclin C is a haploinsufficient tumor suppressor
Na Li, A. Fassl, J. Chick, H. Inuzuka +34 more
2014Nature Cell Biology148 citations Open access
Semantic Scholar
Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase
Sang-Hyun Min, Alan Lau, T. Lee, H. Inuzuka +13 more
2012Molecules and Cells147 citations Open access
Semantic Scholar
APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction
L. Wan, M. Tan, Jie Yang, H. Inuzuka +11 more
2014Developmental Cell138 citations Open access
Semantic Scholar
Cdc20: a potential novel therapeutic target for cancer treatment
Zhi-Wei Wang, L. Wan, Jia-Teng Zhong, H. Inuzuka +3 more
2013Current pharmaceutical design126 citations Open access
Semantic Scholar
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1
Tao Zhang, Dai-Chao Xu, Elijah Trefts, Ming-Ming Lv +36 more
2023Science110 citations Open access
Semantic Scholar
G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells
Li-Jun Liu, W. Michowski, H. Inuzuka, K. Shimizu +14 more
2017Nature Cell Biology107 citations Open access
Semantic Scholar
Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle
Jing Liu, Yun-Hua Peng, Le Shi, L. Wan +16 more
2020Cell Research104 citations Open access
Semantic Scholar
SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.
Alan Lau, Pengda Liu, H. Inuzuka, Da-Ming Gao
2014American Journal of Cancer Research97 citations
Semantic Scholar
Skp2 is a promising therapeutic target in breast cancer
Zhi-Wei Wang, H. Fukushima, H. Inuzuka, L. Wan +4 more
2012Frontiers in Oncology92 citations Open access
Semantic Scholar
Necroptosis pathways in tumorigenesis
Tao Zhang, Ying-Nan Wang, H. Inuzuka, Wenyi Wei
2022Seminars in Cancer Biology90 citations Open access
Semantic Scholar
SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2
S. Shaik, C. Nucera, H. Inuzuka, Da-Ming Gao +13 more
2012Journal of Experimental Medicine89 citations Open access
Semantic Scholar
FBW7 loss promotes chromosomal instability and tumorigenesis via Cyclin E1/CDK2-mediated phosphorylation of CENP-A
M. Takada, Weiguo Zhang, Aussie Suzuki, Taruho S. Kuroda +13 more
2017Cancer Research80 citations Open access
Semantic Scholar
Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
N. T. Nihira, K. Ogura, K. Shimizu, B. North +4 more
2017Science Signaling76 citations Open access
Semantic Scholar
Degradation of the Transcription Factor Twist, an Oncoprotein that Promotes Cancer Metastasis
Jia-Teng Zhong, K. Ogura, Zhi-Wei Wang, H. Inuzuka
2013Discover medicine76 citations
Semantic Scholar
SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression
H. Fukushima, K. Ogura, L. Wan, Ying Lu +8 more
2013Cell Reports75 citations Open access
Semantic Scholar
SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
Li-Yu Huang, Junjie Zhao, Hao Chen, L. Wan +9 more
2018Nature Communications70 citations Open access
Semantic Scholar
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
Tao Zhang, Dai-Chao Xu, Jianping Liu, Min Wang +35 more
2023Nature Cell Biology67 citations Open access
Semantic Scholar
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
L. Wan, Ming Chen, Juxiang Cao, Xiangpeng Dai +18 more
2017Cancer Discovery67 citations Open access
Semantic Scholar
An evolving role for DEPTOR in tumor development and progression.
Zhi-Wei Wang, Jia-Teng Zhong, H. Inuzuka, Da-Ming Gao +3 more
2012Neoplasia64 citations Open access
Semantic Scholar
DNA Damage Regulates UHRF1 Stability via the SCFβ-TrCP E3 Ligase
Hao Chen, Honghui Ma, H. Inuzuka, J. Diao +4 more
2013Molecular and Cellular Biology61 citations Open access
Semantic Scholar
Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
K. Shimizu, Gi Min, Shugo Suzuki, B. North +6 more
2021Cell Reports59 citations Open access
Semantic Scholar
Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy
Yun-Hua Peng, Jing Liu, H. Inuzuka, Wenyi Wei
2023Journal of Biological Chemistry55 citations Open access
Semantic Scholar
The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis
K. Shimizu, H. Fukushima, K. Ogura, Evan C. Lien +17 more
2017Science Signaling55 citations Open access
Semantic Scholar
FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC
F. Morra, C. Luise, F. Merolla, I. Poser +14 more
2015OncoTarget55 citations Open access
Semantic Scholar
Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors
E. Clement, H. Inuzuka, N. T. Nihira, Wenyi Wei +1 more
2018Science Signaling54 citations Open access
Semantic Scholar
Physiological Functions of FBW7 in Cancer and Metabolism
K. Shimizu, N. T. Nihira, H. Inuzuka, Wenyi Wei
2018Cellular Signalling52 citations Open access
Semantic Scholar
SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration
Jia-Teng Zhong, S. Shaik, L. Wan, Adriana E. Tron +4 more
2013OncoTarget50 citations Open access
Semantic Scholar
SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway
Jia Liu, L. Wan, Pengda Liu, H. Inuzuka +3 more
2014OncoTarget46 citations Open access
Semantic Scholar
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation
Xiaoming Dai, Cong Jiang, Qiwei Jiang, L. Fang +10 more
2023Nature Metabolism44 citations Open access
Semantic Scholar
Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
Fabin Dang, Li Nie, Jin Zhou, K. Shimizu +12 more
2021Nature Communications44 citations Open access
Semantic Scholar
SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradation
Zhi-Wei Wang, Xiangpeng Dai, Jia-Teng Zhong, H. Inuzuka +8 more
2015Nature Communications44 citations Open access
Semantic Scholar
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
Cong Jiang, Jing Liu, Shaohui He, Wei Xu +11 more
2023Cell Metabolism43 citations Open access
Semantic Scholar
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction
Zhi-Wei Wang, H. Inuzuka, Jia-Teng Zhong, H. Fukushima +3 more
2012OncoTarget43 citations Open access
Semantic Scholar
NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis
H. Fukushima, K. Shimizu, Asami Watahiki, Seira Hoshikawa +15 more
2017Molecules and Cells40 citations Open access
Semantic Scholar
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2
Zhi-Wei Wang, H. Inuzuka, Jia-Teng Zhong, Pengda Liu +3 more
2012OncoTarget40 citations Open access
Semantic Scholar
PROTACs technology for treatment of Alzheimer’s disease: Advances and perspectives
H. Inuzuka, Jing Liu, Wenyi Wei, A. Rezaeian
2022Acta Materia Medica37 citations Open access
Semantic Scholar
Smurf1 regulation of DAB2IP controls cell proliferation and migration
Xiaoning Li, Xiangpeng Dai, L. Wan, H. Inuzuka +2 more
2016OncoTarget33 citations Open access
Semantic Scholar
Negative regulation of DAB2IP by Akt and SCFFbw7 pathways
Xiangping Dai, B. North, H. Inuzuka
2014OncoTarget30 citations Open access
Semantic Scholar
Regulation of APCCdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7
Alan Lau, H. Inuzuka, H. Fukushima, L. Wan +4 more
2013Cell Research29 citations Open access
Semantic Scholar
SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction
H. Fukushima, Akinobu Matsumoto, H. Inuzuka, Bo Zhai +11 more
2025Cell Reports27 citations Open access
Semantic Scholar

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Pengda Liu×15
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Da-Ming Gao — researcher profile on SciRah

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H. Fukushima×10

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Jinfang Zhang×9

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Jinfang Zhang — researcher profile on SciRah

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S. Shaik — researcher profile on SciRah

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K. Shimizu — researcher profile on SciRah

Jia-Teng Zhong×8

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Jing Liu — researcher profile on SciRah