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Pengda Liu · SciRah

Researcher profile · Semantic Scholar

Pengda Liu

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Pengda Liu — researcher profile on SciRah

h-index: 40
Works: 79
Citations: 7,189

Most-cited papers

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer.
Le Yu, Jessica Wei, Pengda Liu
2021Seminars in Cancer Biology720 citations
Semantic Scholar
Roles of F-box proteins in cancer
Zhi-Wei Wang, Pengda Liu, H. Inuzuka, Wenyi Wei
2014Nature Reviews. Cancer497 citations Open access
Semantic Scholar
CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
Bartlomiej Bartkowiak, Pengda Liu, Hemali P. Phatnani, Nicholas J. Fuda +5 more
2010Genes & Development407 citations Open access
Semantic Scholar
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
Pengda Liu, M. Begley, W. Michowski, H. Inuzuka +21 more
2014Nature365 citations Open access
Semantic Scholar
PtdIns(3,4,5)P3-dependent Activation of the mTORC2 Kinase Complex
Pengda Liu, Wenjian Gan, Y. R. Chin, K. Ogura +8 more
2015Cancer Discovery359 citations Open access
Semantic Scholar
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
Xiangpeng Dai, Wenjian Gan, Xiaoning Li, Shang-Qian Wang +28 more
2017Nature Medicine299 citations Open access
Semantic Scholar
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis
Pengda Liu, Wenjian Gan, H. Inuzuka, A. Lazorchak +17 more
2013Nature Cell Biology267 citations Open access
Semantic Scholar
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Le Yu, Pengda Liu
2021Signal Transduction and Targeted Therapy257 citations Open access
Semantic Scholar
mTOR drives its own activation via SCFβ-TRCP-dependent degradation of the mTOR inhibitor DEPTOR
Da-Ming Gao, H. Inuzuka, M. Tan, H. Fukushima +13 more
2011Molecules and Cells254 citations Open access
Semantic Scholar
Structural basis of nucleosome-dependent cGAS inhibition
J. Boyer, C. Spangler, J. Strauss, A. Cesmat +3 more
2020Science213 citations Open access
Semantic Scholar
Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy
B. Kim, Yunkyung Hong, Seunghoon Lee, Pengda Liu +5 more
2015International Journal of Molecular Sciences213 citations Open access
Semantic Scholar
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
Wenjian Gan, Xiangpeng Dai, Andrea Lunardi, Zhen Li +11 more
2015Molecules and Cells212 citations Open access
Semantic Scholar
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependentmanner
Jian-ping Guo, Abhishek A. Chakraborty, Pengda Liu, Wenjian Gan +14 more
2016Science197 citations Open access
Semantic Scholar
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
Bin Wang, Zu-Liang Jie, Donghyun Joo, A. Ordureau +12 more
2017Nature186 citations Open access
Semantic Scholar
mTOR signaling in tumorigenesis
Kai Xu, Pengda Liu, Wenyi Wei
2014Biochimica et Biophysica Acta157 citations Open access
Semantic Scholar
Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions
Jian-ping Guo, Xiangpeng Dai, Benoît Laurent, Nana Zheng +10 more
2019Nature Cell Biology139 citations Open access
Semantic Scholar
cis-Proline-mediated Ser(P)5 Dephosphorylation by the RNA Polymerase II C-terminal Domain Phosphatase Ssu72*
J. Werner-Allen, Chul-Jin Lee, Pengda Liu, N. Nicely +3 more
2010Journal of Biological Chemistry135 citations Open access
Semantic Scholar
Cdc20: a potential novel therapeutic target for cancer treatment
Zhi-Wei Wang, L. Wan, Jia-Teng Zhong, H. Inuzuka +3 more
2013Current pharmaceutical design126 citations Open access
Semantic Scholar
Skp2: a novel potential therapeutic target for prostate cancer
Zhi-Wei Wang, Da-Ming Gao, H. Fukushima, H. Inuzuka +4 more
2011Biochimica et Biophysica Acta126 citations Open access
Semantic Scholar
The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168
Xiaoduo Xie, Hongli Hu, Xinyuan Tong, Long Li +23 more
2018Nature Cell Biology125 citations Open access
Semantic Scholar
BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of Snail.
Zhong-Yi Qin, Tao Wang, Siyuan Su, Li-Ting Shen +21 more
2019Cancer Research105 citations
Semantic Scholar
Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt
Jinfang Zhang, Kai Xu, Pengda Liu, Y. Geng +11 more
2016Molecules and Cells103 citations Open access
Semantic Scholar
SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.
Alan Lau, Pengda Liu, H. Inuzuka, Da-Ming Gao
2014American Journal of Cancer Research97 citations
Semantic Scholar
K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair
Pengda Liu, Wenjian Gan, Siyuan Su, Arthur V. Hauenstein +6 more
2018Science Signaling92 citations Open access
Semantic Scholar
Skp2 is a promising therapeutic target in breast cancer
Zhi-Wei Wang, H. Fukushima, H. Inuzuka, L. Wan +4 more
2012Frontiers in Oncology92 citations Open access
Semantic Scholar
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
Wenjian Gan, Xiao-Ming Dai, Xiangpeng Dai, Jun Xie +17 more
2020Nature Cell Biology88 citations Open access
Semantic Scholar
Mcl-1 Ubiquitination and Destruction
H. Inuzuka, H. Fukushima, S. Shaik, Pengda Liu +2 more
2011OncoTarget81 citations Open access
Semantic Scholar
SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression
H. Fukushima, K. Ogura, L. Wan, Ying Lu +8 more
2013Cell Reports75 citations Open access
Semantic Scholar
Akt-mediated Phosphorylation of XLF Impairs Non-homologous End Joining DNA Repair
Pengda Liu, Wenjian Gan, Chun-Guang Guo, Anyong Xie +8 more
2015Molecules and Cells74 citations Open access
Semantic Scholar
Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain.
Pengda Liu, J. Kenney, J. Stiller, A. Greenleaf
2010Molecular biology and evolution68 citations Open access
Semantic Scholar
STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity
Zhichuan Zhu, Xin‐ping Zhou, Hongwei Du, Erica W. Cloer +10 more
2022Advancement of science67 citations Open access
Semantic Scholar
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
L. Wan, Ming Chen, Juxiang Cao, Xiangpeng Dai +18 more
2017Cancer Discovery67 citations Open access
Semantic Scholar
SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth
Siyuan Su, Jianfeng Chen, Yao Jiang, Ying Wang +10 more
2021Advancement of science61 citations Open access
Semantic Scholar
The E3 ubiquitin ligase SCF(Cyclin F) transmits AKT signaling to the cell cycle machinery
Rajarshi Choudhury, T. Bonacci, Xian-Xi Wang, Andrew S. Truong +6 more
2017Cell Reports50 citations Open access
Semantic Scholar
Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
Pengda Liu, Jian-ping Guo, Wenjian Gan, Wenyi Wei
2014Protein & Cell49 citations Open access
Semantic Scholar
The two faces of FBW7 in cancer drug resistance
Zhi-Wei Wang, H. Fukushima, Da-Ming Gao, H. Inuzuka +4 more
2011Bioessays48 citations Open access
Semantic Scholar
Control of mTOR Signaling by Ubiquitin
Yao Jiang, Siyuan Su, Yanqiong Zhang, Jiayi Qian +1 more
2019Oncogene46 citations Open access
Semantic Scholar
SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway
Jia Liu, L. Wan, Pengda Liu, H. Inuzuka +3 more
2014OncoTarget46 citations Open access
Semantic Scholar
Phosphorylation of Akt at the C-terminal tail triggers Akt Activation
Pengda Liu, Zhi-Wei Wang, Wenyi Wei
2014Cell Cycle45 citations Open access
Semantic Scholar
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction
Zhi-Wei Wang, H. Inuzuka, Jia-Teng Zhong, H. Fukushima +3 more
2012OncoTarget43 citations Open access
Semantic Scholar
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2
Zhi-Wei Wang, H. Inuzuka, Jia-Teng Zhong, Pengda Liu +3 more
2012OncoTarget40 citations Open access
Semantic Scholar
TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
Ricardo J. Antonia, Johnny Castillo, Laura E. Herring, D. Serafin +4 more
2019Scientific Reports39 citations Open access
Semantic Scholar
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan +14 more
2019Nature Communications38 citations Open access
Semantic Scholar
The essential sequence elements required for RNAP II carboxyl-terminal domain function in yeast and their evolutionary conservation.
Pengda Liu, A. Greenleaf, J. Stiller
2008Molecular biology and evolution37 citations
Semantic Scholar
Roles of Ubiquitination and SUMOylation in DNA Damage Response.
Siyuan Su, Yanqiong Zhang, Pengda Liu
2019Current Issues in Molecular Biology33 citations Open access
Semantic Scholar
Development of VHL-recruiting STING PROTACs that suppress innate immunity
Zhichuan Zhu, Rebecca L. Johnson, Zhigang Zhang, Laura E. Herring +4 more
2023Cellular and Molecular Life Sciences32 citations Open access
Semantic Scholar
DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2–ECT2 pathway
Liu Liu, Xiao-Ming Dai, Shasha Yin, Pengda Liu +3 more
2022Science Signaling32 citations Open access
Semantic Scholar
Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity
Yanqiong Zhang, Zhe Ma, Ying Wang, Joshua A. Boyer +10 more
2020iScience30 citations Open access
Semantic Scholar
Regulation of APCCdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7
Alan Lau, H. Inuzuka, H. Fukushima, L. Wan +4 more
2013Cell Research29 citations Open access
Semantic Scholar
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation
Jianfeng Chen, Derek L. Bolhuis, Christian Laggner, Deyu Kong +5 more
2023Cancers24 citations Open access
Semantic Scholar

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