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A. Giralt · SciRah

Researcher profile · Semantic Scholar

A. Giralt

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A. Giralt — researcher profile on SciRah

h-index: 39
Works: 96
Citations: 5,458

Most-cited papers

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue*
E. Hondares, R. Iglesias, A. Giralt, F. Gonzalez +3 more
2011Journal of Biological Chemistry602 citations Open access
Semantic Scholar
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
A. Sànchez-Dànes, Y. Richaud-Patin, Iria Carballo-Carbajal, S. Jiménez-Delgado +15 more
2012EMBO Molecular Medicine568 citations Open access
Semantic Scholar
SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.
A. Giralt, F. Villarroya
2012Biochemical Journal254 citations Open access
Semantic Scholar
Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype*
A. Giralt, E. Hondares, J. Villena, F. Ribas +4 more
2011Journal of Biological Chemistry211 citations Open access
Semantic Scholar
Caveolin-1 deficiency causes cholesterol dependent mitochondrial dysfunction and apoptotic susceptibility
M. Bosch, M. Marí, A. Herms, A. Fernández +17 more
2011Current Biology206 citations Open access
Semantic Scholar
E2F1, a Novel Regulator of Metabolism
Pierre-Damien Denechaud, L. Fajas, A. Giralt
2017Frontiers in Endocrinology200 citations Open access
Semantic Scholar
Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease
Benoît de Pins, C. Cifuentes-Díaz, A. Farah, L. López-Molina +9 more
2019Journal of Neuroscience186 citations Open access
Semantic Scholar
Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.
A. Giralt, M. Puigdellívol, Olga Carretón, Paola Paoletti +5 more
2012Human Molecular Genetics154 citations Open access
Semantic Scholar
Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.
A. Miguez, G. Garcia-Diaz Barriga, Verónica Brito, M. Straccia +4 more
2015Human Molecular Genetics131 citations Open access
Semantic Scholar
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.
Pierre-Damien Denechaud, Isabel C. Lopez-Mejia, A. Giralt, Qiuwen Lai +8 more
2016Journal of Clinical Investigation125 citations Open access
Semantic Scholar
Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.
A. Giralt, A. Saavedra, Olga Carretón, X. Xifró +2 more
2011Human Molecular Genetics123 citations
Semantic Scholar
Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression.
A. Giralt, T. Rodrigo, E. Martín, J. R. González +5 more
2009Neuroscience118 citations
Semantic Scholar
Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.
Verónica Brito, A. Giralt, L. Enríquez-Barreto, M. Puigdellívol +8 more
2014Journal of Clinical Investigation111 citations Open access
Semantic Scholar
Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
A. Giralt, Olga Carretón, Cristina Lao-Peregrin, E. Martín +1 more
2011Molecular Neurodegeneration109 citations Open access
Semantic Scholar
Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model
A. Giralt, Verónica Brito, Quentin Chevy, Clémence Simonnet +8 more
2017Nature Communications100 citations Open access
Semantic Scholar
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models
S. Marco, A. Giralt, M. Petrovic, M. Pouladi +14 more
2013Nature Medicine96 citations Open access
Semantic Scholar
Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study.
L. Sabater, A. Giralt, A. Boronat, K. Hankiewicz +5 more
2009Journal of Neuroimmunology95 citations
Semantic Scholar
PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model
A. Giralt, A. Saavedra, Olga Carretón, Helena Arumí +3 more
2013Hippocampus85 citations
Semantic Scholar
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy
S. Fernández-García, A. Sancho-Balsells, Sophie Longueville, D. Hervé +4 more
2020Cell Death and Disease79 citations Open access
Semantic Scholar
STriatal-Enriched protein tyrosine Phosphatase expression and activity in Huntington's disease - a STEP in the resistance to excitotoxicity
A. Saavedra, A. Giralt, Laura Rué, X. Xifró +6 more
2011Journal of Neuroscience76 citations Open access
Semantic Scholar
Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms
A. Giralt, A. Saavedra, J. Alberch, E. Pérez-Navarro
2012Journal of Huntington's Disease74 citations Open access
Semantic Scholar
CDK4 is an essential insulin effector in adipocytes.
S. Lagarrigue, Isabel C. Lopez-Mejia, Pierre-Damien Denechaud, X. Escoté +18 more
2016Journal of Clinical Investigation73 citations Open access
Semantic Scholar
CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.
Isabel C. Lopez-Mejia, S. Lagarrigue, A. Giralt, Laia Martínez-Carreres +12 more
2017Molecules and Cells65 citations Open access
Semantic Scholar
PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease
A. Giralt, Benoit de Pins, C. Cifuentes-Díaz, L. López-Molina +7 more
2018Experimental Neurology64 citations Open access
Semantic Scholar
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
Laura Rué, Mónica Báñez-Coronel, J. Creus-Muncunill, A. Giralt +9 more
2016Journal of Clinical Investigation64 citations Open access
Semantic Scholar
Regulation of Hippocampal cGMP Levels as a Candidate to Treat Cognitive Deficits in Huntington’s Disease
A. Saavedra, A. Giralt, Helena Arumí, J. Alberch +1 more
2013PLoS ONE62 citations Open access
Semantic Scholar
PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum
A. Saavedra, J. M. García-Martínez, X. Xifró, A. Giralt +6 more
2010Cell Death and Differentiation62 citations
Semantic Scholar
7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLC&ggr;1 pathway
G. Garcia-Diaz Barriga, A. Giralt, M. Anglada-Huguet, Núria Gaja-Capdevila +4 more
2017Human Molecular Genetics60 citations Open access
Semantic Scholar
Dissociation between CA3–CA1 Synaptic Plasticity and Associative Learning in TgNTRK3 Transgenic Mice
I. Sahún, J. Delgado-García, A. Amador-Arjona, A. Giralt +3 more
2007Journal of Neuroscience56 citations Open access
Semantic Scholar
A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease.
M. Puigdellívol, Marta Cherubini, Verónica Brito, A. Giralt +7 more
2015Human Molecular Genetics55 citations Open access
Semantic Scholar
The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases
Benoit de Pins, T. Mendes, A. Giralt, J. Girault
2021Frontiers in Synaptic Neuroscience54 citations Open access
Semantic Scholar
Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling.
J. Torres-Peraza, A. Giralt, J. M. García-Martínez, E. Pedrosa +2 more
2008Neurobiology of Disease50 citations Open access
Semantic Scholar
Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.
X. Xifró, A. Giralt, A. Saavedra, J. M. García-Martínez +4 more
2009Neurobiology of Disease49 citations Open access
Semantic Scholar
E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver.
Qiuwen Lai, A. Giralt, C. Le May, Lianjun Zhang +3 more
2017JCI Insight45 citations Open access
Semantic Scholar
CDK4 regulates lysosomal function and mTORC1 activation to promote cancer cell survival
Laia Martínez-Carreres, J. Puyal, L. Leal-Esteban, Meritxell Orpinell +11 more
2019Cancer Research44 citations Open access
Semantic Scholar
PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions
M. Tible, F. Mouton-Liger, J. Schmitt, A. Giralt +8 more
2019Aging Cell44 citations Open access
Semantic Scholar
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
Leticia Pérez-Sisqués, A. Sancho-Balsells, Júlia Solana-Balaguer, Genís Campoy-Campos +8 more
2021Cell Death and Disease40 citations Open access
Semantic Scholar
DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons
Olivia Engmann, A. Giralt, N. Gervasi, Lucile Marion-Poll +8 more
2015Nature Communications40 citations Open access
Semantic Scholar
Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice
A. Pupak, Ankita Singh, A. Sancho-Balsells, R. Alcalá-Vida +6 more
2022Cellular and Molecular Life Sciences39 citations Open access
Semantic Scholar
TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics
Elena Senís, Miriam Esgleas, S. Najas, V. Jiménez-Sábado +14 more
2021Frontiers in Cell and Developmental Biology38 citations Open access
Semantic Scholar
Prostaglandin E2 EP1 Receptor Antagonist Improves Motor Deficits and Rescues Memory Decline in R6/1 Mouse Model of Huntington's Disease
M. Anglada-Huguet, X. Xifró, A. Giralt, Alfonsa Zamora-Moratalla +2 more
2013Molecular Neurobiology38 citations
Semantic Scholar
Suppressing aberrant GluN3A expression rescues NMDA receptor dysfunction, synapse loss and motor and cognitive decline in Huntington's disease models
S. Marco, A. Giralt, M. Petrovic, M. Pouladi +14 more
2013Nature Medicine37 citations Open access
Semantic Scholar
Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity.
M. Anglada-Huguet, L. Vidal-Sancho, A. Giralt, G. Garcia-Diaz Barriga +2 more
2016Neurobiology of Disease35 citations Open access
Semantic Scholar
Pyk2 is essential for astrocytes mobility following brain lesion
A. Giralt, R. Coura, J. Girault
2016Glia32 citations Open access
Semantic Scholar
Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
Luka Rejc, V. Gómez‐Vallejo, A. Joya, Oscar Moreno +17 more
2021Theranostics31 citations Open access
Semantic Scholar
Activation of Elk‐1 participates as a neuroprotective compensatory mechanism in models of Huntington’s disease
M. Anglada-Huguet, A. Giralt, E. Pérez-Navarro, J. Alberch +1 more
2012Journal of Neurochemistry31 citations Open access
Semantic Scholar
Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.
I. Ballasch, E. García-García, Cristina Vila, Anna P. Perez-Gonzalez +9 more
2023Brain, behavior, and immunity29 citations Open access
Semantic Scholar
E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes
A. Giralt, Pierre-Damien Denechaud, Isabel C. Lopez-Mejia, Brigitte Delacuisine +5 more
2018Molecular Metabolism29 citations Open access
Semantic Scholar
Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes
Enrica Montalban, O. Al-Massadi, A. Sancho-Balsells, Verónica Brito +5 more
2019Translational Psychiatry28 citations Open access
Semantic Scholar
The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3‐CA1 long‐term potentiation and structural synaptic changes in old mice
A. Giralt, M. A. Gómez-Climent, R. Alcalá, S. Bretin +5 more
2017Neuropharmacology28 citations Open access
Semantic Scholar

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