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J. Boylan · SciRah

Researcher profile · Semantic Scholar

J. Boylan

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J. Boylan — researcher profile on SciRah

h-index: 33
Works: 104
Citations: 4,307

Most-cited papers

The Systemic Inflammatory Response to Cardiac Surgery: Implications for the Anesthesiologist
D. Warltier, J. Laffey, J. Boylan, D. Cheng
2002Anesthesiology893 citations Open access
Semantic Scholar
Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation.
T. Sielecki, J. Boylan, P. Benfield, G. Trainor
2000Journal of Medicinal Chemistry285 citations
Semantic Scholar
Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.
A. Tolcher, W. Messersmith, S. Mikulski, K. Papadopoulos +16 more
2012Journal of Clinical Oncology253 citations Open access
Semantic Scholar
The level of CRABP-I expression influences the amounts and types of all-trans-retinoic acid metabolites in F9 teratocarcinoma stem cells.
J. Boylan, L. Gudas
1992Journal of Biological Chemistry243 citations Open access
Semantic Scholar
Hypercapnic acidosis attenuates endotoxin-induced acute lung injury.
J. Laffey, D. Honan, N. Hopkins, J. Hyvelin +2 more
2004American Journal of Respiratory and Critical Care Medicine206 citations Open access
Semantic Scholar
Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
Leopoldo L. Luistro, Wei He, M. Smith, K. Packman +13 more
2009Cancer Research192 citations Open access
Semantic Scholar
SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia
Alex J. Bowers, S. Scully, J. Boylan
2003Oncogene153 citations
Semantic Scholar
Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury*
D. Ó’Cróinín, A. Nichol, N. Hopkins, J. Boylan +4 more
2008Critical Care Medicine139 citations
Semantic Scholar
Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.
Alex J. Bowers, J. Boylan
2004Gene107 citations
Semantic Scholar
Systematic Reviews of Anesthesiologic Interventions Reported as Statistically Significant: Problems with Power, Precision, and Type 1 Error Protection
G. Imberger, C. Gluud, J. Boylan, J. Wetterslev
2015Anesthesia and Analgesia92 citations Open access
Semantic Scholar
Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?
S. Fröhlich, J. Boylan, P. McLoughlin
2013American Journal of Respiratory Cell and Molecular Biology88 citations
Semantic Scholar
Multimodal analgesia before thoracic surgery does not reduce postoperative pain.
B. P. Kavanagh, Joel Katz, Alan N. Sandler, H. Nierenberg +3 more
1994British Journal of Anaesthesia85 citations Open access
Semantic Scholar
Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.
Hui-Sheng Wang, S. Daouti, Wen-hui Li, Yang Wen +7 more
2011Cancer Research81 citations
Semantic Scholar
Airway Management in the Lateral Position: A Randomized Controlled Trial
C. McCaul, D. Harney, M. Ryan, C. Moran +2 more
2005Anesthesia and Analgesia77 citations Open access
Semantic Scholar
The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma
C. Huynh, L. Poliseno, M. Segura, R. Medicherla +9 more
2011PLoS ONE73 citations Open access
Semantic Scholar
Inactivation of Mirk/Dyrk1b Kinase Targets Quiescent Pancreatic Cancer Cells
D. Ewton, Jing Hu, M. Vilenchik, Xiao-Bing Deng +6 more
2011Molecular Cancer Therapeutics69 citations Open access
Semantic Scholar
BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines
Brenden Chen, Christine Tardell, Brian Higgins, K. Packman +2 more
2012PLoS ONE66 citations Open access
Semantic Scholar
Differences in the pharmacokinetic properties of orally administered all-trans-retinoic acid and 9-cis-retinoic acid in the plasma of nude mice.
C. Achkar, J. Bentel, J. Boylan, H. Scher +2 more
1994Drug Metabolism And Disposition63 citations
Semantic Scholar
Discovery of siRNA lipid nanoparticles to transfect suspension leukemia cells and provide in vivo delivery capability.
Wei He, Michael J. Bennett, Leopoldo L. Luistro, D. Carvajal +9 more
2014Molecular Therapy59 citations Open access
Semantic Scholar
Acute respiratory distress syndrome: underrecognition by clinicians.
S. Fröhlich, N. Murphy, A. Doolan, Orla Ryan +1 more
2013Journal of critical care56 citations
Semantic Scholar
Hypercapnic acidosis does not modulate the severity of bacterial pneumonia–induced lung injury
D. Ó’Cróinín, N. Hopkins, Michael M. Moore, J. Boylan +2 more
2005Critical Care Medicine53 citations
Semantic Scholar
Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis
A. Nichol, Donall F. O'Cronin, Katherine Howell, Finola Naughton +6 more
2009Critical Care Medicine52 citations
Semantic Scholar
Decrease in bispectral index preceding intraoperative hemodynamic crisis: evidence of acute alteration of propofol pharmacokinetics.
D. Honan, P. Breen, J. Boylan, N. McDonald +1 more
2002Anesthesiology52 citations Open access
Semantic Scholar
Remote ischemic preconditioning does not affect the incidence of acute kidney injury after elective abdominal aortic aneurysm repair.
N. Murphy, A. Vijayan, S. Fröhlich, F. O'Farrell +4 more
2014Journal of Cardiothoracic and Vascular Anesthesia51 citations
Semantic Scholar
High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ‐secretase inhibitor, RO4929097
Wei He, Leopoldo L. Luistro, D. Carvajal, M. Smith +9 more
2011Molecular Oncology51 citations Open access
Semantic Scholar
The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
J. Riggs, Mark A. Nagy, J. Elsner, Paul E. Erdman +25 more
2017Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3
Eddy W. Yue, C. Higley, Dimeo Susan, D. Carini +15 more
200245 citations Open access
Semantic Scholar
The auditory steady state response during sufentanil anaesthesia.
G. Plourde, J. Boylan
1991British Journal of Anaesthesia40 citations Open access
Semantic Scholar
Congenital stationary night blindness associated with mutations in GRM6 encoding glutamate receptor MGluR6
E. O'Connor, L. Allen, K. Bradshaw, J. Boylan +2 more
2006British Journal of Ophthalmology38 citations Open access
Semantic Scholar
Identification of selective inhibitors of cyclin dependent kinase 4.
D. Carini, R. Kaltenbach, Jie Liu, P. Benfield +15 more
2001Bioorganic & Medicinal Chemistry Letters38 citations Open access
Semantic Scholar
Hypercapnic Acidosis Reduces Oxidative Reactions in Endotoxin-induced Lung Injury
A. Nichol, Donall F. O'Cronin, Finola Naughton, N. Hopkins +2 more
2010Anesthesiology36 citations Open access
Semantic Scholar
Analysis of site-specific phosphorylation of the retinoblastoma protein during cell cycle progression.
J. Boylan, Diane M. Sharp, Lynn Leffet, Alex J. Bowers +1 more
1999Experimental Cell Research35 citations
Semantic Scholar
Altered Expression of Bone Morphogenetic Protein Accessory Proteins in Murine and Human Pulmonary Fibrosis.
N. Murphy, K. Gaynor, S. Rowan, Sinead M. Walsh +4 more
2016American Journal of Pathology34 citations Open access
Semantic Scholar
Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint
Dan Zhu, Shui-Chan Xu, Gordafaried Deyanat-Yazdi, S. Peng +10 more
2018Molecular Cancer Therapeutics33 citations Open access
Semantic Scholar
Targeted Disruption of Retinoic Acid Receptor a (RARa) and RARg Results in Receptor-Specific Alterations in Retinoic Acid-Mediated Differentiation and Retinoic Acid Metabolism
J. Boylan, T. Lufkin, C. Achkar, R. Taneja +2 more
199530 citations
Semantic Scholar
Identification of novel, potent and selective inhibitors of Polo-like kinase 1.
Shao-Qing Chen, D. Bartkovitz, Jian-Ping Cai, Yi Chen +12 more
2012Bioorganic & Medicinal Chemistry Letters29 citations
Semantic Scholar
Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.
Carmela Dantas-Barbosa, G. Bergthold, E. Daudigeos-Dubus, Heike Blockus +7 more
2015Anti-Cancer Drugs28 citations
Semantic Scholar
Inherited association of breast and colorectal cancer: limited role of CHEK2 compared with high‐penetrance genes
H. Naseem, J. Boylan, D. Speake, K. Leask +5 more
2006Clinical Genetics28 citations
Semantic Scholar
Role of the Ha-ras (RasH) oncogene in mediating progression of the tumor cell phenotype (review).
J. Boylan, J. Jackson, M. R. Steiner, T.-Y. Shih +4 more
1990Anticancer Research27 citations
Semantic Scholar
Emergency airway management: competence versus expertise?
J. Boylan, B. Kavanagh
2008Anesthesiology24 citations Open access
Semantic Scholar
Fatal fibrinolysis during orthotopic liver transplantation in patients receiving solvent/detergent-treated plasma (Octaplas).
J. Magner, K. Crowley, J. Boylan
2007Journal of Cardiothoracic and Vascular Anesthesia22 citations
Semantic Scholar
Patients’ knowledge of perioperative care
John G. Laffey, M. Coleman, J. Boylan
2000Irish Journal of Medical Science22 citations
Semantic Scholar
ARDS: progress unlikely with non-biological definition.
S. Fröhlich, N. Murphy, J. Boylan
2013British Journal of Anaesthesia19 citations Open access
Semantic Scholar
Alcoholic liver disease in the intensive care unit: outcomes and predictors of prognosis.
S. Fröhlich, N. Murphy, T. Kong, R. Ffrench-O’Carroll +3 more
2014Journal of critical care18 citations
Semantic Scholar
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.
J. Riggs, J. Elsner, Daniel K. Cashion, D. Robinson +15 more
2019Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
A phase I study of RO4929097, a novel gamma secretase inhibitor, in patients with advanced solid tumors.
A. Tolcher, S. Mikulski, W. Messersmith, E. Kwak +5 more
201017 citations
Semantic Scholar
The long-latency auditory evoked potential as a measure of the level of consciousness during sufentanil anesthesia.
Gilles Plourde, J. Boylan
1991Journal of Cardiothoracic and Vascular Anesthesia16 citations
Semantic Scholar
Abstract 4694: The humanized anti-CD47 monclonal antibody, CC-90002, has antitumor activity in vitro and in vivo
R. Narla, Hardik K. Modi, L. WongLilly, M. Abassian +16 more
201713 citations
Semantic Scholar
Does prior administration of enoxaparin influence the effects of levobupivacaine on blood clotting? Assessment using the Thrombelastograph.
S. Leonard, A. Lydon, M. Walsh, C. Fleming +2 more
2001British Journal of Anaesthesia13 citations Open access
Semantic Scholar
Erector Spinae Plane Blocks in Major Hepatopancreaticobiliary Surgery: A Case Series.
S. Nair, S. McGuinness, Fouad Masood, J. Boylan +1 more
2019A&A practice11 citations Open access
Semantic Scholar

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