Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

Lynn Leffet · SciRah

Researcher profile · Semantic Scholar

Lynn Leffet

Share profile

Lynn Leffet — researcher profile on SciRah

h-index: 15
Works: 25
Citations: 1,713

Most-cited papers

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity.
Xiangdong Liu, N. Shin, H. Koblish, Geng-Jie Yang +18 more
2010Blood534 citations Open access
Semantic Scholar
INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Eddy W. Yue, R. Sparks, Padmaja Polam, D. Modi +22 more
2017ACS Medicinal Chemistry Letters257 citations Open access
Semantic Scholar
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.
Eddy W. Yue, B. Douty, Brian R. Wayland, M. Bower +15 more
2009Journal of Medicinal Chemistry207 citations Open access
Semantic Scholar
Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344
C. Brodmerkel, R. Huber, M. Covington, S. Diamond +21 more
2005Journal of Immunology198 citations Open access
Semantic Scholar
Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries.
S. P. Ho, D. Britton, B. Stone, D. Behrens +4 more
1996Nucleic Acids Research168 citations Open access
Semantic Scholar
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Liang-Xing Wu, Colin Zhang, Chunhong He, D.-W. Qian +21 more
2021Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
INCB38579, a novel and potent histamine H₄ receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions.
N. Shin, M. Covington, D. Bian, J. Zhuo +18 more
2012European Journal of Pharmacology40 citations
Semantic Scholar
Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN.
Edimara Reis, Rebecca A Buonpane, Hamza Celik, Caroline Marty +31 more
2024Blood38 citations Open access
Semantic Scholar
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy
N. Shin, M. Stubbs, H. Koblish, Eddy W. Yue +33 more
2020Journal of Pharmacology and Experimental Therapeutics38 citations Open access
Semantic Scholar
Analysis of site-specific phosphorylation of the retinoblastoma protein during cell cycle progression.
J. Boylan, Diane M. Sharp, Lynn Leffet, Alex J. Bowers +1 more
1999Experimental Cell Research35 citations
Semantic Scholar
Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2.
N. Shin, F. Baribaud, K. Wang, Gen-Jie Yang +10 more
2009Biochemical and Biophysical Research Communications - BBRC34 citations
Semantic Scholar
INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies
N. Shin, Yun-Long Li, Song Mei, K. Wang +28 more
2018Journal of Pharmacology and Experimental Therapeutics22 citations Open access
Semantic Scholar
Abstract 4712: Discovery of INCB059872, a novel FAD-directed LSD1 inhibitor that is effective in preclinical models of human and murine AML
Sang Hyun Lee, M. Stubbs, X. Liu, M. Diamond +17 more
201622 citations
Semantic Scholar
Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
Artem Shvartsbart, Jeremy J. Roach, Michael R. Witten, H. Koblish +22 more
2022Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach.
Minh-Hai Nguyen, Hai-Fen Ye, Yao Xu, L. Truong +22 more
2023ACS Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Abstract 771: Preclinical characterization of the selective FGFR inhibitor INCB054828
Phillip C. C. Liu, Liang-Xing Wu, H. Koblish, Kevin J. Bowman +19 more
201512 citations
Semantic Scholar
Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor.
Minh-Hai Nguyen, Anlai Wang, Lisa Truong, Ke Zhang +22 more
2025ACS Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Selective inhibition of indoleamine 2 , 3-dioxygenase ( IDO 1 ) effectively regulates mediators of antitumor immunity
Xiangdong Liu, N. Shin, H. Koblish, Geng-Jie Yang +18 more
20106 citations
Semantic Scholar
Abstract 5416: Activity of the pan-PIM kinase inhibitor INCB053914 in models of acute myelogenous leukemia
H. Koblish, N. Shin, Leslie Hall, Sybil O’Connor +15 more
20152 citations
Semantic Scholar
Abstract 5397: Characterization of INCB053914, a novel pan-PIM kinase inhibitor
N. Shin, M. Covington, R. Wynn, Yan-Long Li +23 more
20152 citations
Semantic Scholar
660 Discovery of a novel series of indoleamine 2,3-dioxygenase 2 (IDO2) selective inhibitors for probing IDO2 function in cancer
Xiangdong Liu, Geng-Jie Yang, Qian Wang, Lynn Leffet +6 more
20101 citations
Semantic Scholar
Discovery of Pyrazolopyrimidines as Potent and Orally Bioavailable MRGPRX2 Antagonists
Minh-Hai Nguyen, Hai-Fen Ye, Heeoon Han, Yong Li +15 more
2026ACS Medicinal Chemistry Letters0 citations
Semantic Scholar
Abstract 5162: Discovery of INCB098377: a potent inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ)
D. A. Arias, Stephen M. Douglass, L. Truong, Qian Wang +19 more
2023Cancer Research0 citations
Semantic Scholar
Parsaclisib Is a Next-Generation PI3Kδ Inhibitor With Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy a
N. Shin, M. Stubbs, H. Koblish, Eddy W. Yue +37 more
20200 citations
Semantic Scholar
Abstract C106: Discovery and characterization of INCB024360, a potent and selective inhibitor of indoleamine 2,3‐dioxygenase (IDO1) as a novel agent for cancer immunotherapy
Xiangdong Liu, N. Shin, H. Koblish, Geng-Jie Yang +16 more
20090 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

P. Scherle×16
Invite
P. Scherle — researcher profile on SciRah
H. Koblish×14
Invite
H. Koblish — researcher profile on SciRah
M. Covington×13
Invite
M. Covington — researcher profile on SciRah
N. Shin×12
Invite
N. Shin — researcher profile on SciRah

×12

Invite

T. Burn — researcher profile on SciRah

Kevin J. Bowman×11

Invite

Kevin J. Bowman — researcher profile on SciRah

Invite

R. Newton — researcher profile on SciRah

Invite

W. Yao — researcher profile on SciRah

Invite

Qian Wang — researcher profile on SciRah

Yan-Long Li×10

Invite

Yan-Long Li — researcher profile on SciRah

Invite

R. Wynn — researcher profile on SciRah

Invite

A. Combs — researcher profile on SciRah