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D. Ewton · SciRah

Researcher profile · Semantic Scholar

D. Ewton

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D. Ewton — researcher profile on SciRah

h-index: 37
Works: 56
Citations: 6,432

Most-cited papers

Growth hormone and the insulin-like growth factor system in myogenesis.
J. Florini, D. Ewton, S. A. Coolican
1996Endocrine reviews1,214 citations
Semantic Scholar
The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways*
S. A. Coolican, Derina S. Samuel, D. Ewton, F. McWade +1 more
1997Journal of Biological Chemistry708 citations Open access
Semantic Scholar
Hormones, growth factors, and myogenic differentiation.
J. Florini, D. Ewton, K. A. Magri
1991Annual Review of Physiology428 citations
Semantic Scholar
"Spontaneous" differentiation of skeletal myoblasts is dependent upon autocrine secretion of insulin-like growth factor-II.
J. Florini, K. A. Magri, D. Ewton, Payton L. James +2 more
1991Journal of Biological Chemistry378 citations Open access
Semantic Scholar
Insulin-like growth factor-I stimulates terminal myogenic differentiation by induction of myogenin gene expression.
J. Florini, D. Ewton, S. Roof
1991Molecular Endocrinology266 citations
Semantic Scholar
The Stress-activated Protein Kinases p38α and JNK1 Stabilize p21Cip1 by Phosphorylation*
Geum-Yi Kim, S. Mercer, D. Ewton, Zhong-Fa Yan +2 more
2002Journal of Biological Chemistry217 citations Open access
Semantic Scholar
The type II insulin-like growth factor (IGF) receptor has low affinity for IGF-I analogs: pleiotypic actions of IGFs on myoblasts are apparently mediated by the type I receptor.
D. Ewton, Susan L. Falen, J. Florini
1987Endocrinology203 citations Open access
Semantic Scholar
Transforming growth factor-beta. A very potent inhibitor of myoblast differentiation, identical to the differentiation inhibitor secreted by Buffalo rat liver cells.
J. Florini, A. Roberts, D. Ewton, S. L. Falen +2 more
1986Journal of Biological Chemistry199 citations Open access
Semantic Scholar
Effects of the somatomedins and insulin on myoblast differentiation in vitro.
D. Ewton, J. Florini
1981Developmental Biology184 citations
Semantic Scholar
Biphasic concentration dependency of stimulation of myoblast differentiation by somatomedins.
J. Florini, D. Ewton, S. L. Falen, J. V. van Wyk
1986American Journal of Physiology164 citations
Semantic Scholar
The Cyclin-dependent Kinase Inhibitor p27Kip1 Is Stabilized in G0 by Mirk/dyrk1B Kinase*
Xiao-Bing Deng, S. Mercer, Sejal Shah, D. Ewton +1 more
2004Journal of Biological Chemistry152 citations Open access
Semantic Scholar
The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
Geum-Yi Kim, S. Mercer, D. Ewton, Zhong-Fa Yan +2 more
2002Journal of Biological Chemistry137 citations
Semantic Scholar
Mirk/dyrk1B Kinase Destabilizes Cyclin D1 by Phosphorylation at Threonine 288*
Yonglong Zou, D. Ewton, Xiao-Bing Deng, S. Mercer +1 more
2004Journal of Biological Chemistry122 citations Open access
Semantic Scholar
Modulation of insulin‐like growth factor actions in L6A1 myoblasts by insulin‐like growth factor binding protein (IGFBP)‐4 and IGFBP‐5: A dual role for IGFBP‐5
D. Ewton, S. A. Coolican, S. Mohan, S. Chernausek +1 more
1998Journal of Cellular Physiology120 citations
Semantic Scholar
Relative effects of the somatomedins, multiplication-stimulating activity, and growth hormone on myoblasts and myotubes in culture.
D. Ewton, J. Florini
1980Endocrinology120 citations
Semantic Scholar
IGF‐II is more active than IGF‐I in stimulating L6A1 myogenesis: Greater mitogenic actions of IGF‐I delay differentiation
D. Ewton, S. Roof, K. A. Magri, Frank J. McWade +1 more
1994Journal of Cellular Physiology105 citations
Semantic Scholar
Mirk/Dyrk1B Mediates Survival during the Differentiation of C2C12 Myoblasts*
S. Mercer, D. Ewton, Xiao-Bing Deng, Seunghwan Lim +2 more
2005Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T.
J. Florini, D. Ewton
1990Journal of Biological Chemistry95 citations Open access
Semantic Scholar
Mirk/Dyrk1B Maintains the Viability of Quiescent Pancreatic Cancer Cells by Reducing Levels of Reactive Oxygen Species
Xiao-Bing Deng, D. Ewton, E. Friedman
2009Cancer Research94 citations Open access
Semantic Scholar
Mirk/dyrk1B Is a Rho-induced Kinase Active in Skeletal Muscle Differentiation*
Xiao-Bing Deng, D. Ewton, B. Pawlikowski, M. M. Maimone +1 more
2003Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Decrease in transforming growth factor-beta binding and action during differentiation in muscle cells.
D. Ewton, G. Spizz, E. N. Olson, J. Florini
1988Journal of Biological Chemistry78 citations Open access
Semantic Scholar
Mirk/dyrk1B Decreases the Nuclear Accumulation of Class II Histone Deacetylases during Skeletal Muscle Differentiation*
Xiao-Bing Deng, D. Ewton, S. Mercer, E. Friedman
2005Journal of Biological Chemistry74 citations Open access
Semantic Scholar
Inactivation of Mirk/Dyrk1b Kinase Targets Quiescent Pancreatic Cancer Cells
D. Ewton, Jing Hu, M. Vilenchik, Xiao-Bing Deng +6 more
2011Molecular Cancer Therapeutics69 citations Open access
Semantic Scholar
The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.
Xiao-Bing Deng, D. Ewton, Sheena Li, A. Naqvi +3 more
2005Cancer Research69 citations Open access
Semantic Scholar
IGFs and muscle differentiation.
J. Florini, D. Ewton, K. A. Magri, F. J. Mangiacapra
1993Advances in Experimental Medicine and Biology68 citations
Semantic Scholar
Stimulation of Myogenic Differentiation by a Neuregulin, Glial Growth Factor 2
J. Florini, Derina S. Samuel, D. Ewton, C. Kirk +1 more
1996Journal of Biological Chemistry65 citations Open access
Semantic Scholar
IGF binding proteins-4, -5 and -6 may play specialized roles during L6 myoblast proliferation and differentiation.
D. Ewton, J. Florini
1995Journal of Endocrinology65 citations
Semantic Scholar
Mirk Regulates the Exit of Colon Cancer Cells from Quiescence*
Kideok Jin, D. Ewton, Sunju Park, Jing Hu +1 more
2009Journal of Biological Chemistry59 citations Open access
Semantic Scholar
Skeletal muscle fiber types and myosin ATPase activity do not change with age or growth hormone administration.
J. Florini, D. Ewton, L. Roof, Joseph J. Ostuni
1989Journal of Gerontology57 citations
Semantic Scholar
The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.
Kideok Jin, Sunju Park, D. Ewton, E. Friedman
2007Cancer Research55 citations Open access
Semantic Scholar
Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas.
S. Mercer, D. Ewton, Sejal Shah, A. Naqvi +1 more
2006Cancer Research48 citations Open access
Semantic Scholar
The role of polyamines in somatomedin‐stimulated differentiation of L6 myoblasts
D. Ewton, B. G. Erwin, A. Pegg, J. Florini
1984Journal of Cellular Physiology47 citations
Semantic Scholar
Polyamine depletion inhibits the differentiation of L6 myoblast cells.
B. G. Erwin, D. Ewton, J. Florini, A. Pegg
1983Biochemical and Biophysical Research Communications - BBRC46 citations
Semantic Scholar
Negative feedback regulation of insulin-like growth factor-II gene expression in differentiating myoblasts in vitro.
K. A. Magri, M. R. Benedict, D. Ewton, J. Florini
1994Endocrinology44 citations
Semantic Scholar
Igfbp‐3 mediates TGFβ1 proliferative response in colon cancer cells
S. Kansra, D. Ewton, Jing-ping Wang, E. Friedman
200043 citations Open access
Semantic Scholar
IGF-I regulation of elastogenesis: comparison of aortic and lung cells.
C. Rich, D. Ewton, Bernice M. Martin, J. Florini +3 more
1992American Journal of Physiology42 citations
Semantic Scholar
Induction of gene expression in muscle by the IGFs.
J. Florini, D. Ewton
1992Growth regulation41 citations
Semantic Scholar
Inhibition of myoblast differentiation in vitro by a protein isolated from liver cell medium
M. J. Evinger-Hodges, D. Ewton, Sarah C. Seifert, J. Florini
1982Journal of Cell Biology37 citations Open access
Semantic Scholar
Rapid turnover of cell‐cycle regulators found in Mirk/dyrk1B transfectants
D. Ewton, Kangmoon Lee, Xiao-Bing Deng, Seunghwan Lim +1 more
2003International Journal of Cancer35 citations
Semantic Scholar
The role of the IGFs in myogenic differentiation.
K. A. Magri, D. Ewton, J. Florini
1991Advances in Experimental Medicine and Biology32 citations
Semantic Scholar
Raf-1 activation stimulates proliferation and inhibits IGF-stimulated differentiation in L6A1 myoblasts.
Derina S. Samuel, D. Ewton, S. A. Coolican, T. Petley +2 more
1999Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme31 citations
Semantic Scholar
Paradoxical decrease in myf-5 messenger RNA levels during induction of myogenic differentiation by insulin-like growth factors.
F. J. Mangiacapra, S. Roof, D. Ewton, J. Florini
1992Molecular Endocrinology31 citations Open access
Semantic Scholar
Mirk/dyrk1B kinase is upregulated following inhibition of mTOR
Xiao-Bing Deng, Jing Hu, D. Ewton, E. Friedman
2014Carcinogenesis30 citations Open access
Semantic Scholar
Insulin‐like growth factor‐I has a biphasic effect on colon carcinoma cells through transient inactivation of forkhead1, initially mitogenic, then mediating growth arrest and differentiation
D. Ewton, S. Kansra, Seunghwan Lim, E. Friedman
2002International Journal of Cancer30 citations
Semantic Scholar
IGFBP-3 mediates TGF beta 1 proliferative response in colon cancer cells.
S. Kansra, D. Ewton, J. Wang, E. Friedman
2000International Journal of Cancer30 citations
Semantic Scholar
Actions of transforming growth factor‐β on muscle cells
J. Florini, D. Ewton
198829 citations
Semantic Scholar
Nucleic acid synthesis in HeLa cells infected with Shope fibroma virus.
D. Ewton, M. Hodes
1967Virology19 citations
Semantic Scholar
Effects of Insulin-Like Growth Factors and Transforming Growth Factor-β on the Growth and Differentiation of Muscle Cells in Culture
D. Ewton, J. Florini
1990Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine17 citations
Semantic Scholar
Transforming growth factor‐beta isoform expression in insulin‐like growth factor stimulated myogenesis
William J. Bosche, D. Ewton, J. Florini
1995Journal of Cellular Physiology15 citations
Semantic Scholar
Actions of anabolic hormones and growth factors on cultured neonatal heart cells.
J. Florini, D. Ewton
1995Growth regulation13 citations
Semantic Scholar

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J. Florini×31
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J. Florini — researcher profile on SciRah
E. Friedman×18
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E. Friedman — researcher profile on SciRah
Xiao-Bing Deng×10
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Xiao-Bing Deng — researcher profile on SciRah
S. Mercer×8
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K. A. Magri — researcher profile on SciRah

S. A. Coolican×4

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S. A. Coolican — researcher profile on SciRah

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Derina S. Samuel×3

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S. Roof — researcher profile on SciRah

Seunghwan Lim×3

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S. Kansra — researcher profile on SciRah