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H. Scheerens · SciRah

Researcher profile · Semantic Scholar

H. Scheerens

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H. Scheerens — researcher profile on SciRah

h-index: 29
Works: 58
Citations: 6,677

Most-cited papers

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.
David Yen, J. Cheung, H. Scheerens, F. Poulet +11 more
2006Journal of Clinical Investigation1,666 citations Open access
Semantic Scholar
Lebrikizumab treatment in adults with asthma.
J. Corren, R. Lemanske, N. Hanania, P. Korenblat +10 more
2011New England Journal of Medicine1,451 citations
Semantic Scholar
Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase
Z. Pan, H. Scheerens, Shyr-Jiann Li, B. Schultz +12 more
2007ChemMedChem670 citations
Semantic Scholar
Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies
N. Hanania, M. Noonan, J. Corren, P. Korenblat +14 more
2015Thorax372 citations Open access
Semantic Scholar
Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.
S. Ruuls, R. Hoek, Vu N. Ngo, T. McNeil +8 more
2001Immunity274 citations Open access
Semantic Scholar
Oxygen and xenobiotic reductase activities of cytochrome P450.
A. Goeptar, H. Scheerens, N. Vermeulen
1995Critical Reviews in Toxicology258 citations
Semantic Scholar
Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids.
M. Noonan, P. Korenblat, Sofia Mosesova, H. Scheerens +6 more
2013Journal of Allergy and Clinical Immunology180 citations
Semantic Scholar
The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge
H. Scheerens, J. Arron, Yanan Zheng, W. Putnam +6 more
2013Clinical and Experimental Allergy128 citations Open access
Semantic Scholar
Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production
G. Gauvreau, Jeffrey M. Harris, L. Boulet, H. Scheerens +14 more
2014Science Translational Medicine125 citations
Semantic Scholar
Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL‐10– / – mice and Rag‐2– / – mice reconstituted with CD4+CD45RBhigh T cells
H. Scheerens, E. Hessel, R. de Waal Malefyt, Michael W. Leach +1 more
2001European Journal of Immunology119 citations Open access
Semantic Scholar
Current Status of Companion and Complementary Diagnostics: Strategic Considerations for Development and Launch
H. Scheerens, Audrey Malong, Katia Bassett, Zachary S. Boyd +13 more
2017Clinical and Translational Science113 citations Open access
Semantic Scholar
OX40L blockade and allergen-induced airway responses in subjects with mild asthma
G. Gauvreau, L. Boulet, D. Cockcroft, J. Fitzgerald +15 more
2013Clinical and Experimental Allergy108 citations Open access
Semantic Scholar
A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma
Jeffrey M. Harris, R. Maciuca, Mary S. Bradley, Christopher R. Cabanski +15 more
2016Respiratory Research104 citations Open access
Semantic Scholar
Accelerated Alveolar Bone Loss in Mice Lacking Interleukin-10
A. Al-Rasheed, H. Scheerens, D. Rennick, H. Fletcher +1 more
2003Journal of dentistry research87 citations
Semantic Scholar
A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria.
Jeffrey M. Harris, Christopher R. Cabanski, H. Scheerens, D. Samineni +6 more
2016Journal of Allergy and Clinical Immunology81 citations
Semantic Scholar
Long-term topical exposure to toluene diisocyanate in mice leads to antibody production and in vivo airway hyperresponsiveness three hours after intranasal challenge.
H. Scheerens, T. Buckley, Thea Leusink Muis, J. Garssen +3 more
1999American Journal of Respiratory and Critical Care Medicine73 citations
Semantic Scholar
Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines*
Christoph Spiess, Jack Bevers, J. Jackman, Nancy Chiang +20 more
2013Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
W. Young, J. Barbosa, Peter A. Blomgren, Meire C. D. Bremer +24 more
2015Bioorganic & Medicinal Chemistry Letters61 citations Open access
Semantic Scholar
Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma.
J. Arron, D. Choy, H. Scheerens, J. Matthews
2013Annals of the American Thoracic Society61 citations
Semantic Scholar
Targeting IgE production in mice and humans.
Lawren C. Wu, H. Scheerens
2014Current Opinion in Immunology60 citations Open access
Semantic Scholar
Toluene diisocyanate-induced in vitro tracheal hyperreactivity in the mouse.
H. Scheerens, T. Buckley, E. Davidse, J. Garssen +2 more
1996American Journal of Respiratory and Critical Care Medicine58 citations
Semantic Scholar
Regulation of postischemic liver injury following different durations of ischemia.
Ian N. Hines, J. Hoffman, H. Scheerens, B. Day +8 more
2003American Journal of Physiology - Gastrointestinal and Liver Physiology55 citations
Semantic Scholar
The involvement of sensory neuropeptides in toluene diisocyanate‐induced tracheal hyperreactivity in the mouse airways
H. Scheerens, T. Buckley, T. Muis, H. Loveren +1 more
1996British Journal of Pharmacology55 citations Open access
Semantic Scholar
A simple and rapid in vitro test system for the screening of histamine H3 ligands.
R. C. Vollinga, O. Zuiderveld, H. Scheerens, A. Bast +1 more
1992Methods and Findings in Experimental and Clinical Pharmacology48 citations
Semantic Scholar
Translational Pharmacokinetics and Pharmacodynamics of an FcRn‐Variant Anti‐CD4 Monoclonal Antibody From Preclinical Model to Phase I Study
Y. Zheng, H. Scheerens, JC Davis, R. Deng +4 more
2011Clinical pharmacology and therapy45 citations
Semantic Scholar
Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450.
A. Goeptar, E. Groot, H. Scheerens, J. Commandeur +1 more
1994Cancer Research45 citations
Semantic Scholar
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
W. Young, J. Barbosa, Peter A. Blomgren, Meire C. D. Bremer +24 more
2016Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Accelerated alveolar bone loss in mice lacking interleukin-10: late onset.
A. Al-Rasheed, H. Scheerens, A. Srivastava, D. Rennick +1 more
2004Journal of Periodontal Research38 citations
Semantic Scholar
Redefining approaches to asthma: developing targeted biologic therapies.
J. Arron, H. Scheerens, J. Matthews
2013Advances in Pharmacology30 citations
Semantic Scholar
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties
Xiaojing Wang, J. Barbosa, Peter A. Blomgren, Meire C. D. Bremer +29 more
2017ACS Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Peripheral blood gene expression predicts clinical benefit from anti-IL-13 in asthma.
D. Choy, G. Jia, Alexander R. Abbas, Katrina B. Morshead +15 more
2016Journal of Allergy and Clinical Immunology26 citations Open access
Semantic Scholar
MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments
H. Scheerens, Zheng Su, B. Irving, M. Townsend +5 more
2011Arthritis Research & Therapy21 citations Open access
Semantic Scholar
Bioanalytical challenges and improved detection of circulating levels of IL-13.
Fang Cai, H. Hornauer, Kun Peng, Cheryl Schofield +2 more
2016Bioanalysis18 citations
Semantic Scholar
Efficacy and Safety of Lebrikizumab in Severe Uncontrolled Asthma: Results from the Lute and Verse Phase II Randomized, Double-Blind, Placebo-Controlled Trials
N. Hanania, M. Noonan, J. Corren, P. Korenblat +11 more
201418 citations Open access
Semantic Scholar
Lebrikizumab Treatment Reduces Serum Periostin Levels In Asthma Patients With Elevated Baseline Levels Of Periostin
H. Scheerens, J. Arron, D. Choy, Sofia Mosesova +2 more
2012Asian Test Symposium13 citations
Semantic Scholar
Treatment With MEMP1972A, An Anti-M1 Prime Monoclonal Antibody, Reduced Serum IgE In Healthy Volunteers And Patients With Allergic Rhinitis
H. Scheerens, W. Putnam, Yanan Zheng, Yehong Wang +6 more
2012Asian Test Symposium12 citations
Semantic Scholar
Increased IgE+ B Cells in Sputum, but Not Blood, Bone Marrow, or Tonsils, after Inhaled Allergen Challenge in Subjects with Asthma.
J. Oliveria, B. Salter, Jonathan Maclean, Shweta G. Kotwal +5 more
2017American Journal of Respiratory and Critical Care Medicine11 citations
Semantic Scholar
Predictive and Pharmacodynamic Biomarkers of Interleukin-13 Blockade: Effect of Lebrikizumab on Late Phase Asthmatic Response to Allergen Challenge
H. Scheerens, J. Arron, Zheng Su, Yanan Zheng +7 more
201111 citations
Semantic Scholar
Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors.
David Sperandio, Vincent Tai, Julia Lohman, B. Hirschbein +14 more
2006Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Integrated systems modeling of severe asthma: Exploration of IL‐33/ST2 antagonism
K. Gadkar, Justin Feigelman, S. Sukumaran, M. Rodrigo +7 more
2022CPT: Pharmacometrics & Systems Pharmacology8 citations Open access
Semantic Scholar
Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma.
H. Scheerens, Ashley Smith, O. Li, L. Honigberg +3 more
2019Journal of Allergy and Clinical Immunology7 citations
Semantic Scholar
Effect Of An Anti-M1 Prime Monoclonal Antibody, MEMP1972A, In A Phase II Proof-Of-Activity Allergen Challenge Study In Patients With Mild Asthma
G. Gauvreau, L. Boulet, D. Cockcroft, B. Davis +9 more
2012Asian Test Symposium6 citations
Semantic Scholar
LATE-BREAKING ABSTRACT: Serum IL-13 is a peripheral biomarker for Type 2 asthma
Fang Cai, D. Choy, J. Brumm, C. Holweg +4 more
20155 citations
Semantic Scholar
Nasal Biomarkers Characterization In Lebrikizumab Bronchoscopy Study (CLAVIER)
Fang Cai, Francis Abreu, Han-Ting Ding, D. Choy +12 more
20183 citations
Semantic Scholar
Lebrikizumab reduces serum periostin in asthma patients with elevated baseline periostin
H. Scheerens, J. Arron, D. Choy, Sofia Mosesova +2 more
20122 citations
Semantic Scholar
Clinical Pharmacology of an Anti-CD4 Monoclonal Antibody with Enhanced FcRn Binding Affinity in a Phase I Study for Rheumatoid Arthritis
H. Scheerens, Yanan Zheng, John C. Davis, Zheng Su +5 more
20102 citations
Semantic Scholar
Abstracts of papers and posters
R. Anthonio, A. Willemsen, T. Visser, A. Waarde +259 more
2005Pharmacy World & Science2 citations
Semantic Scholar
Predictive performance of non-invasive Type 2 biomarkers for asthmatic sputum eosinophilia in Bobcat and U-Biopred studies
D. Choy, Fang Cai, R. Knowles, R. Djukanović +10 more
20161 citations
Semantic Scholar
Effects of anti-M1 prime monoclonal antibody, MEMP1972A following allergen challenge in patients with mild asthma
G. Gauvreau, L. Boulet, D. Cockcroft, B. Davis +9 more
20121 citations
Semantic Scholar
A Selective Small Molecule Factor VIIa Inhibitor, CRA-027483, Suppresses Acute Inflammation in Mice.
S. Dalrymple, Florentino D. San Pablo, J. Sukbuntherng, J. Janc +3 more
20051 citations
Semantic Scholar

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