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L. Honigberg · SciRah

Researcher profile · Semantic Scholar

L. Honigberg

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L. Honigberg — researcher profile on SciRah

h-index: 22
Works: 55
Citations: 5,695

Most-cited papers

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
A. Begovich, V. Carlton, L. Honigberg, Steven J. Schrodi +24 more
2004American Journal of Human Genetics1,590 citations Open access
Semantic Scholar
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
L. Honigberg, Ashley M. Smith, M. Sirisawad, E. Verner +7 more
2010Proceedings of the National Academy of Sciences of the United States of America1,523 citations Open access
Semantic Scholar
Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials
F. Holz, S. Sadda, B. Busbee, E. Chew +10 more
2018JAMA ophthalmology327 citations Open access
Semantic Scholar
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
R. Fuji, Michael Flagella, M. Baca, M. Baptista +28 more
2015Science Translational Medicine318 citations
Semantic Scholar
Identification of Substrates of Human Protein-tyrosine Phosphatase PTPN22*
Jiansheng Wu, Anjali Katrekar, L. Honigberg, Ashley M. Smith +8 more
2006Journal of Biological Chemistry259 citations Open access
Semantic Scholar
Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position.
J. Harris, L. Honigberg, Naomi Robinson, C. Kenyon
1996Development190 citations
Semantic Scholar
Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration
B. Yaspan, David F. Williams, F. Holz, C. Regillo +12 more
2017Science Translational Medicine186 citations Open access
Semantic Scholar
Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease
S. Ostrowitzki, T. Bittner, K. Sink, H. Mackey +23 more
2022JAMA Neurology167 citations Open access
Semantic Scholar
Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer’s disease (BLAZE)
S. Salloway, L. Honigberg, William Cho, Michael A. Ward +15 more
2018Alzheimer's Research & Therapy134 citations Open access
Semantic Scholar
Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q
Svetlana Pidasheva, S. Trifari, A. Phillips, J. Hackney +9 more
2011PLoS ONE128 citations Open access
Semantic Scholar
Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics
Kristin R. Wildsmith, S. Schauer, Ashley M. Smith, D. Arnott +5 more
2014Molecular Neurodegeneration127 citations Open access
Semantic Scholar
The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier coh
P. Tariot, F. Lopera, J. Langbaum, Ronald G. Thomas +19 more
2018Alzheimer's & Dementia121 citations Open access
Semantic Scholar
ABBY
J. Cummings, S. Cohen, C. van Dyck, M. Brody +13 more
2018Neurology86 citations Open access
Semantic Scholar
Inhibition of IgE-mediated Secretion from Human Basophils with a Highly Selective Bruton’s Tyrosine Kinase, Btk, Inhibitor
D. MacGlashan, L. Honigberg, Ashley M. Smith, J. Buggy +1 more
2011International Immunopharmacology65 citations Open access
Semantic Scholar
The dance of the Hox genes: patterning the anteroposterior body axis of Caenorhabditis elegans.
C. Kenyon, J. Austin, M. Costa, D. Cowing +9 more
1997Cold Spring Harbor Symposia on Quantitative Biology60 citations
Semantic Scholar
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy
I. Tom, Victoria C. Pham, K. Katschke, Wei Li +15 more
2020Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer’s disease
K. Yoshida, A. Moein, T. Bittner, S. Ostrowitzki +4 more
2020Alzheimer's Research & Therapy40 citations Open access
Semantic Scholar
Macular Sensitivity Endpoints in Geographic Atrophy: Exploratory Analysis of Chroma and Spectri Clinical Trials
D. Chang, Natalia F. Callaway, Verena Steffen, K. Csaky +10 more
2023Ophthalmology Science39 citations Open access
Semantic Scholar
Deep Learning to Predict Geographic Atrophy Area and Growth Rate from Multi-modal Imaging (90 characters; max 135 characters).
N. Anegondi, Simon S. Gao, Verena Steffen, R. Spaide +10 more
2022Ophthalmology Retina39 citations Open access
Semantic Scholar
A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
J. Katz, J. Rothstein, M. Cudkowicz, A. Genge +19 more
2022Annals of Clinical and Translational Neurology35 citations Open access
Semantic Scholar
Neurofilament light as a predictive biomarker of unresolved chemotherapy-induced peripheral neuropathy in subjects receiving paclitaxel and carboplatin
B. L. Burgess, E. Cho, L. Honigberg
2022Scientific Reports34 citations Open access
Semantic Scholar
Systems genomics in age-related macular degeneration
A. den Hollander, R. Mullins, Luz D. Orozco, A. Voigt +17 more
2022Experimental Eye Research28 citations Open access
Semantic Scholar
Phase I Study of the Anti-HtrA1 Antibody-Binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-Related Macular Degeneration.
A. Khanani, Vrinda S. Hershberger, D. Pieramici, R. Khurana +8 more
2021American journal of ophthalmology-glaucoma21 citations Open access
Semantic Scholar
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CRENEZUMAB IN PATIENTS WITH MILD TO MODERATE ALZHEIMER'S DISEASE
J. Cummings, William Cho, Michael A. Ward, M. Friesenhahn +6 more
2014Alzheimer's & Dementia21 citations Open access
Semantic Scholar
A Phase I Dose Escalation Study of the Btk Inhibitor PCI-32765 in Relapsed and Refractory B Cell Non-Hodgkin Lymphoma and Use of a Novel Fluorescent Probe Pharmacodynamic Assay.
D. Pollyea, Sonali M. Smith, N. Fowler, T. Boyd +5 more
200914 citations
Semantic Scholar
Inter-Reader Agreement and Longitudinal Progression of Incomplete/Complete Retinal Pigment Epithelium and Outer Retinal Atrophy in AMD.
S. Schmitz-Valckenberg, M. Saßmannshausen, Martina D. Braun, Verena Steffen +5 more
2023Ophthalmology Retina13 citations Open access
Semantic Scholar
Alternative Complement Pathway Inhibition by Lampalizumab
R. Edmonds, Verena Steffen, L. Honigberg, Michael C. Chang
2023Ophthalmology Science12 citations Open access
Semantic Scholar
Conversion from Intermediate Age-Related Macular Degeneration to Geographic Atrophy in a Proxima B Subcohort Using a Multimodal Approach
S. Schmitz-Valckenberg, Martina D. Braun, S. Thiele, D. Ferrara +6 more
2021Ophthalmologica11 citations Open access
Semantic Scholar
Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays
S. Schauer, William R. Jr Mylott, Mou-Cun Yuan, Rand G. Jenkins +3 more
2018Alzheimer's Research & Therapy11 citations Open access
Semantic Scholar
The Role of the Complement Pathway in Clinical Progression of Geographic Atrophy
R. Edmonds, Verena Steffen, L. Honigberg, Michael C. Chang
2023Ophthalmology Science7 citations Open access
Semantic Scholar
Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma.
H. Scheerens, Ashley Smith, O. Li, L. Honigberg +3 more
2019Journal of Allergy and Clinical Immunology7 citations
Semantic Scholar
Longitudinal Exposure—Response Modeling of Multiple Indicators of Alzheimer’s Disease Progression
D. Polhamus, M. Dolton, J. Rogers, L. Honigberg +3 more
2023The journal of prevention of Alzheimer's disease6 citations Open access
Semantic Scholar
Design and synthesis of beta-amino-alpha-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth.
Martin Sendzik, J. Janc, Ronnel Cabuslay, L. Honigberg +4 more
2004Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Resting-state functional magnetic resonance imaging in a randomized clinical trial for Alzheimer's disease
D. Clayton, A. Coimbra, F. Faraji, T. Bengtsson +4 more
2021Neuroimage: Reports3 citations Open access
Semantic Scholar
P32 Phase III studies of crenezumab in early (prodromal-to-mild) Alzheimers disease (CREAD/CREAD2): Biomarker results
Tobias Bittner, T. Duning, C. Rabe, D. Clayton +10 more
2020Clinical Neurophysiology3 citations
Semantic Scholar
Human IL23R R381Q Genetic Variant Implicated in Crohn's Disease Pathogenesis is Hypomorphic Resulting in Reduced Function of the Receptor
Hilary F. Clark, Svetlana Pidasheva, S. Trifari, J. Hackney +8 more
20113 citations
Semantic Scholar
Targeting Btk in Lymphoma: PCI-32765 Inhibits Tumor Growth in Mouse Lymphoma Models and a Fluorescent Analog of PCI-32765 Is an Active-Site Probe That Enables Assessment of Btk Inhibition In Vivo.
L. Honigberg, Ashley M. Smith, Jun Chen, P. Thiemann +1 more
20073 citations
Semantic Scholar
Lampalizumab for geographic atrophy (GA) in age-related macular degeneration (AMD): pooled results of the Chroma and Spectri phase 3 randomized clinical trials (RCTs)
D. Pieramici, F. Holz, J. Heier, S. Sadda +12 more
20182 citations
Semantic Scholar
Identification of MicroRNA Markers of Sensitivity to the Novel Bruton’s Tyrosine Kinase (BTK) Inhibitor PCI-32765 in Non-Hodgkin’s Lymphoma.
S. Balasubramanian, Jun Chen, L. Honigberg, L. Tee +1 more
20082 citations
Semantic Scholar
Bruton’s Tyrosine Kinase (BTK) Is Not Required for BCR-ABL-Mediated Transformation of Hematopoietic Cells.
Mary MacPartlin, L. Honigberg, B. Druker, M. Deininger
20072 citations
Semantic Scholar
DESIGN AND OPTIMIZATION OF IBRUTINIB SOLID LIPID NANOPARTICLES USING DESIGN OF EXPERIMENT
Arun Jarpula, D. Bhikshapathi, P. Mamatha, P. Mamatha +80 more
2021International Journal of Biology Pharmacy and Allied Sciences1 citations Open access
Semantic Scholar
Phase 1 safety study of intravitreal (ITV) Anti-High Temperature Requirement A1 (aHtrA1), a novel serine protease inhibitor, in patients with Geographic Atrophy (GA)
D. Pieramici, A. Khanani, F. Brunstein, Hao Chen +6 more
20201 citations
Semantic Scholar
Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics
Kristin R. Wildsmith, S. Schauer, Ashley M. Smith, D. Arnott +5 more
2014Molecular Neurodegeneration1 citations Open access
Semantic Scholar
Sa.94. The Selective Btk Inhibitor PCI-32765 Blocks B Cell and Mast Cell Activation and Prevents Mouse Collagen Induced Arthritis
L. Honigberg, Ashley M. Smith, Jun Chen, Margaret Nguyen +2 more
20081 citations
Semantic Scholar
Tyrosine kinase inhibitors of Bruton
L. Honigberg, E. Verner, Z. Pan
20061 citations
Semantic Scholar
P1‐284: BASELINE RECOVERY AND LONGITUDINAL STABILITY OF CEREBROSPINAL FLUID AMYLOID‐β PEPTIDES: AN EVALUATION OF COLLECTION METHODS, LONGITUDINAL ASSAY PERFORMANCE, AND BIOMARKER STABILITY OVER A 2‐YEAR PERIOD
S. Schauer, Kristin R. Wildsmith, C. Rabe, L. Honigberg
20180 citations
Semantic Scholar
Function and Physiology Lysosomal Storage Disease: Revealing Lysosomal
D. Brooks, M. Yaylaoglu, Shuo Zhang, Haitao Zhu +38 more
20150 citations
Semantic Scholar
P1–177: Effects of aliquot size, Tween‐20 and tube type on beta‐amyloid 42, tau and p‐tau(181) measurements
S. Schauer, Kristin R. Wildsmith, L. Honigberg
20130 citations
Semantic Scholar
P1–168: Multiplexed MRM assay verifies candidate Alzheimer's disease biomarkers in CSF
Kristin R. Wildsmith, S. Schauer, Surinder Kaur, W. Mathews +1 more
20130 citations Open access
Semantic Scholar
Abstract 3849: Mast cell inhibition by Btk inhibitor PCI-32765 as a potential cancer therapy
L. Soucek, L. Honigberg, R. Kortlever, J. Buggy +2 more
20100 citations
Semantic Scholar

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