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R. de Waal Malefyt · SciRah

Researcher profile · Semantic Scholar

R. de Waal Malefyt

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R. de Waal Malefyt — researcher profile on SciRah

h-index: 79
Works: 221
Citations: 55K

Most-cited papers

Development, cytokine profile and function of human interleukin 17–producing helper T cells
N. Wilson, K. Boniface, J. Chan, B. McKenzie +12 more
2007Nature Immunology2,208 citations
Semantic Scholar
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis
J. Chan, W. Blumenschein, E. Murphy, Caroline Diveu +12 more
2006Journal of Experimental Medicine712 citations Open access
Semantic Scholar
TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.
Yong-Jun Liu, V. Soumelis, N. Watanabe, T. Ito +5 more
2007Annual Review of Immunology690 citations
Semantic Scholar
T helper type 1 and 17 cells Determine Efficacy of IFN-β in Multiple Sclerosis and Experimental Encephalomyelitis
R. Axtell, B. D. de Jong, K. Boniface, Laura F. van der Voort +15 more
2010Nature Medicine559 citations Open access
Semantic Scholar
Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells1
V. Bryant, Cindy S. Ma, D. Avery, Y. Li +4 more
2007Journal of Immunology516 citations Open access
Semantic Scholar
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
K. Boniface, K. S. Bak-Jensen, Ying Li, W. Blumenschein +6 more
2009Journal of Experimental Medicine503 citations Open access
Semantic Scholar
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
M. Kleinschek, K. Boniface, S. Sadekova, J. Grein +9 more
2009Journal of Experimental Medicine466 citations Open access
Semantic Scholar
TSLP-elicited basophil responses can mediate the pathogenesis of eosinophilic esophagitis
M. Noti, E. Tait Wojno, Brian S. Kim, M. Siracusa +26 more
2013Nature Medicine384 citations Open access
Semantic Scholar
IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells
Caroline Diveu, M. McGeachy, K. Boniface, Jason S. Stumhofer +9 more
2009Journal of Immunology354 citations
Semantic Scholar
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
Y. Lei, A. M. Ripen, N. Ishimaru, I. Ohigashi +8 more
2011Journal of Experimental Medicine301 citations Open access
Semantic Scholar
IL-21-Induced Isotype Switching to IgG and IgA by Human Naive B Cells Is Differentially Regulated by IL-41
D. Avery, V. Bryant, Cindy S. Ma, R. de Waal Malefyt +1 more
2008Journal of Immunology292 citations Open access
Semantic Scholar
Development and function of TH17 cells in health and disease.
Jennifer Louten, K. Boniface, R. de Waal Malefyt
2009Journal of Allergy and Clinical Immunology275 citations Open access
Semantic Scholar
Pulmonary arterial remodeling induced by a Th2 immune response
E. Daley, C. Emson, C. Guignabert, R. de Waal Malefyt +8 more
2008Journal of Experimental Medicine265 citations Open access
Semantic Scholar
Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells
M. Hoeve, N. Savage, T. de Boer, Dennis M. L. Langenberg +3 more
2006European Journal of Immunology265 citations Open access
Semantic Scholar
From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited
K. Boniface, B. Blom, Yong-Jun Liu, R. de Waal Malefyt
2008Immunological Reviews236 citations Open access
Semantic Scholar
Interleukin-10 Promotes Mycobacterium tuberculosis Disease Progression in CBA/J Mice
Gillian Beamer, D. Flaherty, B. Assogba, P. Stromberg +4 more
2008Journal of Immunology221 citations Open access
Semantic Scholar
Human Th17 Cells Comprise Heterogeneous Subsets Including IFN-γ–Producing Cells with Distinct Properties from the Th1 Lineage
K. Boniface, W. Blumenschein, Katherine Brovont-Porth, M. McGeachy +6 more
2010Journal of Immunology209 citations Open access
Semantic Scholar
LAG3+ Regulatory T Cells Restrain Interleukin‐23‐Producing CX3CR1+ Gut‐Resident Macrophages during Group 3 Innate Lymphoid Cell‐Driven Colitis
David Bauché, B. Joyce-Shaikh, Renu Jain, Jeff Grein +10 more
2018Immunity194 citations Open access
Semantic Scholar
Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
Jennifer Louten, A. Rankin, Ying Li, E. Murphy +6 more
2011International Immunology143 citations Open access
Semantic Scholar
GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.
Gongxian Liao, Sushrusha Nayak, J. Regueiro, Scott B. Berger +6 more
2010International Immunology108 citations Open access
Semantic Scholar
PD-L1 – PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
J. Perry, Lindsey A. Shallberg, J. Clark, Jodi A. Gullicksrud +15 more
2022Nature Immunology100 citations Open access
Semantic Scholar
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization
Juhan Yoon, J. Leyva-Castillo, Guo-Xing Wang, C. Galand +15 more
2016Journal of Experimental Medicine97 citations Open access
Semantic Scholar
IL-17A GENE TRANSFER INDUCES BONE LOSS AND EPIDERMAL HYPERPLASIA ASSOCIATED WITH PSORIATIC ARTHRITIS
I. Adamopoulos, E. Suzuki, Cheng-chi Chao, D. Gorman +10 more
2014Annals of the Rheumatic Diseases96 citations Open access
Semantic Scholar
An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma
P. Aspuria, S. Vivona, M. Bauer, Marie Semana +9 more
2021Science Translational Medicine71 citations
Semantic Scholar
Nod/Ripk2 signaling in dendritic cells activates IL-17A–secreting innate lymphoid cells and drives colitis in T-bet−/−.Rag2−/− (TRUC) mice
J. Ermann, T. Staton, J. Glickman, R. de Waal Malefyt +1 more
2014Proceedings of the National Academy of Sciences of the United States of America64 citations Open access
Semantic Scholar
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis
P. Hillyer, M. Larché, E. Bowman, T. Mcclanahan +6 more
2009Rheumatology60 citations Open access
Semantic Scholar
Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis.
A. Matsuda, N. Ebihara, N. Yokoi, S. Kawasaki +6 more
2010Investigative Ophthalmology and Visual Science58 citations Open access
Semantic Scholar
Proinflammatory Cytokine Gene Expression in the Stomach Correlates with Vaccine-Induced Protection against Helicobacter pylori Infection in Mice: an Important Role for Interleukin-17 during the Effector Phase
C. Flach, A. Östberg, Anne Nilsson, R. de Waal Malefyt +1 more
2010Infection and Immunity55 citations Open access
Semantic Scholar
Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen‐induced late phase cutaneous responses in atopic subjects
C. Corrigan, A. Jayaratnam, Yu Wang, Y. Liu +6 more
2009Allergy. European Journal of Allergy and Clinical Immunology53 citations
Semantic Scholar
Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction.
Bhagyashree Bhagwat, H. Cherwinski, Manjiri Sathe, W. Seghezzi +3 more
2018JIM - Journal of Immunological Methods49 citations Open access
Semantic Scholar
Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis.
J. Landheer, B. Giovannone, J. Mattson, S. Tjabringa +5 more
2013Journal of Allergy and Clinical Immunology43 citations
Semantic Scholar
Prostaglandin E 2 regulates Th 17 cell diff erentiation and function through cyclic AMP and EP 2 / EP 4 receptor signaling
K. Boniface, K. S. Bak-Jensen, Ying Li, W. Blumenschein +6 more
200942 citations
Semantic Scholar
Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease
Corinne Cayatte, B. Joyce-Shaikh, F. Vega, K. Boniface +16 more
2012Clinical and Translational Gastroenterology36 citations Open access
Semantic Scholar
Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis
B. Desai, J. Mattson, Harman S. Paintal, M. Nathan +10 more
2011Experimental Lung Research36 citations
Semantic Scholar
IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice
Yuejin Liang, Zu-Liang Jie, Lifei Hou, Panpan Yi +6 more
2015European Journal of Immunology33 citations Open access
Semantic Scholar
Defining the Roles of IFN-γ and IL-17A in Inflammation and Protection against Helicobacter pylori Infection
Louise Sjökvist Ottsjö, C. Flach, S. Nilsson, R. de Waal Malefyt +2 more
2015PLoS ONE32 citations Open access
Semantic Scholar
Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4+ T Cells
Gongxian Liao, Michael S. O'Keeffe, Guo-Xing Wang, B. van Driel +4 more
2014Frontiers in Immunology31 citations Open access
Semantic Scholar
Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Regulates CD4+ T Cell-Mediated Colitis in Mice
Gongxian Liao, Cynthia Detre, Scott B. Berger, P. Engel +4 more
2011Gastroenterology30 citations Open access
Semantic Scholar
TSLP is differentially regulated by vitamin D3 and cytokines in human skin
J. Landheer, B. Giovannone, S. Sadekova, S. Tjabringa +8 more
2015Immunity, Inflammation and Disease29 citations Open access
Semantic Scholar
Biomarkers of Disease and Treatment in Murine and Cynomolgus Models of Chronic Asthma
Jennifer Louten, J. Mattson, M. Malinao, Ying Li +8 more
2012Biomarker Insights25 citations Open access
Semantic Scholar
#2202: Mucosal Autoimmunity Saturday, June 13 10:45 am–11:00 amCirculating and Gut-resident Human Th17 Cells Express CD161 and Promote Intestinal Inflammation
M. Kleinschek, K. Boniface, S. Sadekova, W. Faubion +4 more
200924 citations
Semantic Scholar
Molecular regulation of Th2 immunity by dendritic cells.
G. Grunig, Alice Banz, R. de Waal Malefyt
2005Pharmacology and Therapeutics24 citations
Semantic Scholar
Signaling Lymphocyte Activation Molecule Regulates Development of Colitis in Mice
B. van Driel, Gongxian Liao, X. Romero, Michael S. O'Keeffe +14 more
2012Gastroenterology20 citations Open access
Semantic Scholar
Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab
B. Hutchins, G. Starling, M. Mccoy, D. Herzyk +23 more
2020Molecular Cancer Therapeutics18 citations
Semantic Scholar
IL-17A produced by innate lymphoid cells is essential for intestinal ischemia reperfusion injury
M. Geha, M. Tsokos, R. Bosse, Tatyana Sannikova +4 more
2017Journal of Immunology18 citations Open access
Semantic Scholar
Interleukin-19: A Constituent of the Regulome That Controls Antigen Presenting Cells in the Lungs and Airway Responses to Microbial Products
C. Hoffman, Sung-Hyun Park, E. Daley, C. Emson +4 more
2011PLoS ONE16 citations Open access
Semantic Scholar
Modelling asthma in macaques: longitudinal changes in cellular and molecular markers
G. Ayanoglu, B. Desai, R. Fick, J. Grein +7 more
2010European Respiratory Journal16 citations Open access
Semantic Scholar
Abstract 1744: STK-012, an alpha/beta selective IL-2 mutein for the activation of the antigen-activated T cells in solid tumor
J. Emmerich, M. Bauer, Marie Semana, B. Jayaraman +9 more
2021Immunology13 citations
Semantic Scholar
ENHANCED ACUTE RESPONSES IN AN EXPERIMENTAL EXPOSURE MODEL TO BIOMASS SMOKE INHALATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
J. Mattson, Brian M. Haus, B. Desai, W. Ott +12 more
2008Experimental Lung Research10 citations
Semantic Scholar
An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy.
I. Koliesnik, Michael Totagrande, B. Jayaraman, Ryan Burgess +22 more
2025Cell Reports7 citations Open access
Semantic Scholar

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