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D. Blom · SciRah

Researcher profile · Semantic Scholar

D. Blom

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D. Blom — researcher profile on SciRah

h-index: 30
Works: 102
Citations: 6,631

Most-cited papers

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.
M. Sabatine, R. Giugliano, S. Wiviott, F. Raal +9 more
2015New England Journal of Medicine1,149 citations Open access
Semantic Scholar
Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial.
F. Raal, Raul D. Santos, D. Blom, A. D. Marais +9 more
2010The Lancet852 citations
Semantic Scholar
Efficacy and Safety of a Microsomal Triglyceride Transfer Protein Inhibitor in Homozygous Familial Hypercholesterolemia
M. Cuchel, E. Meagher, H. du Toit Theron, D. Blom +13 more
2012The Lancet648 citations Open access
Semantic Scholar
ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
J. Kastelein, H. Ginsberg, G. Langslet, G. Hovingh +12 more
2015European Heart Journal539 citations Open access
Semantic Scholar
Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial
C. Cannon, B. Cariou, D. Blom, J. Mckenney +4 more
2015European Heart Journal390 citations Open access
Semantic Scholar
Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials.
F. Raal, R. Giugliano, M. Sabatine, M. Koren +11 more
2014Journal of the American College of Cardiology357 citations Open access
Semantic Scholar
International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia
G. Watts, S. Gidding, R. Hegele, F. Raal +18 more
2023Nature Reviews Cardiology226 citations Open access
Semantic Scholar
Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study.
F. Raal, G. Hovingh, D. Blom, Raul D. Santos +11 more
2017The Lancet Diabetes and Endocrinology201 citations
Semantic Scholar
PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor’s role[S]
F. Raal, R. Giugliano, M. Sabatine, M. Koren +13 more
2016Journal of Lipid Research201 citations Open access
Semantic Scholar
Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance
M. Agostini, E. Schoenmakers, C. Mitchell, I. Szatmári +20 more
2006Cell Metabolism192 citations Open access
Semantic Scholar
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia
A. Beigneux, K. Miyashita, M. Ploug, D. Blom +21 more
2017New England Journal of Medicine144 citations Open access
Semantic Scholar
Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia: The ODYSSEY HoFH Trial.
D. Blom, M. Harada-Shiba, P. Rubba, D. Gaudet +10 more
2020Journal of the American College of Cardiology136 citations Open access
Semantic Scholar
PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo
E. Villard, A. Thedrez, J. Blankenstein, M. Croyal +12 more
2016JACC: Basic to Translational Science128 citations Open access
Semantic Scholar
Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia.
D. Blom, M. Averna, E. Meagher, H. du Toit Theron +11 more
2017Circulation114 citations Open access
Semantic Scholar
Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS)
N. Danchin, W. Almahmeed, K. Al-Rasadi, J. Azuri +11 more
2018European Journal of Preventive Cardiology106 citations Open access
Semantic Scholar
Homozygous FH Patients with Identical Mutations Variably Express the LDL Receptor: Implications for the Efficacy of Evolocumab
A. Thedrez, D. Blom, S. Ramin-Mangata, V. Blanchard +10 more
2017Arteriosclerosis, Thrombosis and Vascular Biology87 citations Open access
Semantic Scholar
Characterizing familial chylomicronemia syndrome: Baseline data of the APPROACH study.
D. Blom, L. O’Dea, A. Digenio, V. Alexander +7 more
2017Journal of Clinical Lipidology71 citations Open access
Semantic Scholar
Effects of Evolocumab on Vitamin E and Steroid Hormone Levels: Results From the 52-Week, Phase 3, Double-Blind, Randomized, Placebo-Controlled DESCARTES Study.
D. Blom, C. Djedjos, M. Monsalvo, I. Bridges +3 more
2015Circulation Research71 citations Open access
Semantic Scholar
Long-term efficacy and safety of lerodalcibep in heterozygous familial hypercholesterolaemia: the LIBerate-HeFH trial
F. Raal, Nyda Fourie, Russell S. Scott, D. Blom +5 more
2023European Heart Journal68 citations Open access
Semantic Scholar
Anti-Retroviral Therapy Increases the Prevalence of Dyslipidemia in South African HIV-Infected Patients
J. Dave, N. Levitt, I. Ross, M. Lacerda +2 more
2016PLoS ONE66 citations Open access
Semantic Scholar
Long-term safety and efficacy of lomitapide in patients with homozygous familial hypercholesterolemia: Five-year data from the Lomitapide Observational Worldwide Evaluation Registry (LOWER).
James A. Underberg, C. Cannon, D. Larrey, L. Makris +2 more
2020Journal of Clinical Lipidology64 citations Open access
Semantic Scholar
Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials
H. Colhoun, J. Robinson, M. Farnier, B. Cariou +5 more
2014BMC Cardiovascular Disorders64 citations Open access
Semantic Scholar
Statins and other lipid-lowering therapy and pregnancy outcomes in homozygous familial hypercholesterolaemia: A retrospective review of 39 pregnancies.
T. Botha, G. Pilcher, K. H. Wolmarans, D. Blom +1 more
2018Atherosclerosis57 citations
Semantic Scholar
A pharmacogenetic approach to the treatment of patients with PPARG mutations
M. Agostini, E. Schoenmakers, Junaid Beig, L. Fairall +14 more
2018Diabetes45 citations Open access
Semantic Scholar
LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: Rationale and design.
D. Blom, Z. Fayad, J. Kastelein, D. Larrey +4 more
2016Journal of Clinical Lipidology43 citations Open access
Semantic Scholar
Target achievement and cardiovascular event rates with Lomitapide in homozygous Familial Hypercholesterolaemia
D. Blom, M. Cuchel, M. Ager, H. Phillips
2018Orphanet Journal of Rare Diseases39 citations Open access
Semantic Scholar
Lipoprotein metabolism in familial hypercholesterolemia
K. Chemello, J. García-Nafría, A. Gallo, C. Martín +2 more
2021Journal of Lipid Research36 citations Open access
Semantic Scholar
World Heart Federation Cholesterol Roadmap.
Adrianna Murphy, J. Faria-Neto, K. Al-Rasadi, D. Blom +11 more
2017Global Heart36 citations Open access
Semantic Scholar
Normalization of low-density lipoprotein receptor expression in receptor defective homozygous familial hypercholesterolemia by inhibition of PCSK9 with alirocumab.
G. Lambert, M. Chatelais, F. Petrides, Maxime Passard +7 more
2014Journal of the American College of Cardiology33 citations Open access
Semantic Scholar
Efficacy and Safety of Alirocumab Versus Ezetimibe Over 2 Years (from ODYSSEY COMBO II).
M. El Shahawy, C. Cannon, D. Blom, J. Mckenney +5 more
2017American Journal of Cardiology32 citations Open access
Semantic Scholar
Clinical experience of lomitapide therapy in patients with homozygous familial hypercholesterolaemia.
M. Cuchel, D. Blom, M. Averna
2014Atherosclerosis Supplements30 citations Open access
Semantic Scholar
The challenge of multiple cardiovascular risk factor control outside Western Europe: Findings from the International ChoLesterol management Practice Study
D. Blom, Raul D. Santos, V. Daclin, F. Mercier +2 more
2019European Journal of Preventive Cardiology26 citations Open access
Semantic Scholar
Prevalence of dyslipidaemia in statin-treated patients in South Africa: results of the DYSlipidaemia International Study (DYSIS)
F. J. Raal, D. Blom, S. Naidoo, P. Bramlage +1 more
2013Cardiovascular Journal of Africa25 citations Open access
Semantic Scholar
RNA-based therapy in the management of lipid disorders: a review
D. Blom, A. Marais, R. Moodley, Nico van der Merwe +2 more
2022Lipids in Health and Disease24 citations Open access
Semantic Scholar
Low-density lipoprotein cholesterol goal achievement in patients with familial hypercholesterolemia in countries outside Western Europe: The International ChoLesterol management Practice Study.
D. Blom, W. Almahmeed, K. Al-Rasadi, J. Azuri +5 more
2019Journal of Clinical Lipidology22 citations Open access
Semantic Scholar
Recent advances in the treatment of homozygous familial hypercholesterolaemia
A. Marais, D. Blom
2013Current Opinion in Lipidology22 citations
Semantic Scholar
Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria
R. Hesse, F. Raal, Cert Endo, D. Blom +1 more
2022Circulation Genomic and Precision Medicine16 citations
Semantic Scholar
Trial evaluating evolocumab, a pcsk9 antibody, in patients with homozygous fh (tesla): Results of the randomized, double-blind, placebo-controlled trial
F. Raal, N. Honarpour, D. Blom, G. Hovingh +4 more
201416 citations
Semantic Scholar
Long-term treatment with evolocumab homozygous familial hypercholesterolemia patients: Results from the trial assessing long-term use of PCSK9 inhibition in subjects with genetic LDL disorders (Taussig)
E. Stein, T. Sampietro, Raul D. Santos, M. Harada-Shiba +15 more
201614 citations
Semantic Scholar
A Case Series Assessing the Effects of Lomitapide on Carotid Intima-Media Thickness in Adult Patients with Homozygous Familial Hypercholesterolaemia in a Real-World Setting
D. Blom, D. Gaudet, R. Hegele, D. Patel +3 more
2022Advances in Therapy13 citations Open access
Semantic Scholar
Effects of evolocumab therapy and low LDL‐C levels on vitamin E and steroid hormones in Chinese and global patients with type 2 diabetes
D. Blom, Ji-Yan Chen, Zu-Yi Yuan, J. Borges +4 more
2020Endocrinology, Diabetes & Metabolism13 citations Open access
Semantic Scholar
Heterozygous familial hypercholesterolaemia in specialist centres in South Africa, Australia and Brazil: Importance of early detection and lifestyle advice.
J. Pang, A. Marais, D. Blom, B. C. Brice +7 more
2018Atherosclerosis13 citations Open access
Semantic Scholar
Abstract 16516: Sustained LDL-C Lowering and Stable Hepatic Fat Levels in Patients With Homozygous Familial Hypercholesterolemia Treated With the Microsomal Triglyceride Transfer Protein Inhibitor, Lomitapide: Results of an Ongoing Long-Term Extension Study
M. Cuchel, D. Blom, M. Averna, E. Meagher +10 more
201313 citations
Semantic Scholar
Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans
Jonathan N Katsukunya, N. Soko, Jashira Naidoo, B. Rayner +7 more
2023International Journal of Hypertension12 citations Open access
Semantic Scholar
COVID-19–Associated Graft Loss From Renal Infarction in a Kidney Transplant Recipient
C. Webb, B. Davidson, E. Jones, N. Wearne +3 more
2021Kidney International Reports12 citations Open access
Semantic Scholar
Salivary Cortisol and Cortisone do not Appear to be Useful Biomarkers for Monitoring Hydrocortisone Replacement in Addison’s Disease
I. Ross, M. Lacerda, T. Pillay, D. Blom +5 more
2016Hormone and Metabolic Research12 citations
Semantic Scholar
Familial Hypercholesterolemia in South Africa
A. Marais, J. Firth, D. Blom
2004Seminars in Vascular Medicine11 citations
Semantic Scholar
Abstract 10818: Lomitapide Observational Worldwide Evaluation Registry (LOWER): One-Year Data
D. Blom, J. Kastelein, D. Larrey, L. Makris +4 more
2015Circulation10 citations
Semantic Scholar
Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.
R. Huijgen, D. Blom, M. L. Hartgers, K. Chemello +15 more
2020Arteriosclerosis, Thrombosis and Vascular Biology9 citations Open access
Semantic Scholar
Management of low-density lipoprotein cholesterol levels in South Africa: the International ChoLesterol management Practice Study (ICLPS).
D. Blom, F. J. Raal, A. Amod, P. Naidoo +1 more
2019Cardiovascular Journal of Africa9 citations
Semantic Scholar

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Raul D. Santos×8
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Raul D. Santos — researcher profile on SciRah
A. Marais×8
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A. Marais — researcher profile on SciRah
S. Wasserman×7
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S. Wasserman — researcher profile on SciRah
E. Stein×7
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E. Stein — researcher profile on SciRah

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R. Scott — researcher profile on SciRah

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M. Cuchel — researcher profile on SciRah

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G. Hovingh — researcher profile on SciRah

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R. Pordy — researcher profile on SciRah

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F. Raal — researcher profile on SciRah

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G. Lambert — researcher profile on SciRah