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R. Huijgen · SciRah

Researcher profile · Semantic Scholar

R. Huijgen

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R. Huijgen — researcher profile on SciRah

h-index: 26
Works: 65
Citations: 2,156

Most-cited papers

Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The Netherlands.
A. H. Pijlman, R. Huijgen, S. N. Verhagen, B. Imholz +5 more
2010Atherosclerosis286 citations
Semantic Scholar
Statins in Familial Hypercholesterolemia: Consequences for Coronary Artery Disease and All-Cause Mortality.
J. Besseling, G. Hovingh, R. Huijgen, J. Kastelein +1 more
2016Journal of the American College of Cardiology172 citations Open access
Semantic Scholar
Determining When to Add Nonstatin Therapy: A Quantitative Approach.
J. Robinson, R. Huijgen, K. Ray, Jane E. Persons +2 more
2016Journal of the American College of Cardiology131 citations Open access
Semantic Scholar
Two Years after Molecular Diagnosis of Familial Hypercholesterolemia: Majority on Cholesterol-Lowering Treatment but a Minority Reaches Treatment Goal
R. Huijgen, I. Kindt, S. Verhoeven, Eric J. G. Sijbrands +3 more
2010PLoS ONE113 citations Open access
Semantic Scholar
Molecular Basis of Autosomal Dominant Hypercholesterolemia: Assessment in a Large Cohort of Hypercholesterolemic Children
A. van der Graaf, H. Avis, D. Kusters, M. N. Vissers +7 more
2011Circulation105 citations Open access
Semantic Scholar
Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia.
M. Motazacker, J. Pirruccello, R. Huijgen, R. Do +9 more
2012European Heart Journal102 citations
Semantic Scholar
Familial hypercholesterolemia: current treatment and advances in management
R. Huijgen, M. N. Vissers, J. Defesche, P. Lansberg +2 more
2008Expert Review of Cardiovascular Therapy89 citations
Semantic Scholar
Discriminative Ability of LDL-Cholesterol to Identify Patients With Familial Hypercholesterolemia: A Cross-Sectional Study in 26 406 Individuals Tested for Genetic FH
R. Huijgen, B. Hutten, I. Kindt, M. N. Vissers +1 more
2012Circulation: Cardiovascular Genetics81 citations Open access
Semantic Scholar
Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: a study among 29,365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants.
R. Huijgen, I. Kindt, J. Defesche, J. Kastelein
2012European Heart Journal80 citations Open access
Semantic Scholar
Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: a 12-week, multicenter, randomized, double-blind, controlled trial.
R. Huijgen, E. Abbink, E. Bruckert, A. Stalenhoef +7 more
2010Clinical Therapeutics80 citations
Semantic Scholar
Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study.
B. van Zaane, A. Squizzato, R. Huijgen, A. P. van Zanten +5 more
2010Blood70 citations Open access
Semantic Scholar
Venous thrombosis is associated with hyperglycemia at diagnosis: a case–control study
J. Hermanides, D. Cohn, J. DeVries, P. Kamphuisen +4 more
2009Journal of Thrombosis and Haemostasis61 citations Open access
Semantic Scholar
Assessment of Carotid Atherosclerosis in Normocholesterolemic Individuals With Proven Mutations in the Low-Density Lipoprotein Receptor or Apolipoprotein B Genes
R. Huijgen, M. N. Vissers, I. Kindt, M. Trip +3 more
2011Circulation: Cardiovascular Genetics53 citations
Semantic Scholar
Functionality of sequence variants in the genes coding for the low‐density lipoprotein receptor and apolipoprotein B in individuals with inherited hypercholesterolemia
R. Huijgen, I. Kindt, S. Fouchier, J. Defesche +3 more
2010Human Mutation50 citations Open access
Semantic Scholar
Founder mutations in the Netherlands: geographical distribution of the most prevalent mutations in the low-density lipoprotein receptor and apolipoprotein B genes
D. Kusters, R. Huijgen, J. Defesche, M. N. Vissers +3 more
2011Netherlands Heart Journal48 citations Open access
Semantic Scholar
Plasma levels of PCSK9 and phenotypic variability in familial hypercholesterolemia[S]
R. Huijgen, S. Fouchier, M. Denoun, B. Hutten +3 more
2012Journal of Lipid Research46 citations Open access
Semantic Scholar
Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: a nested case-control study.
R. Huijgen, S. Boekholdt, B. Arsenault, W. Bao +8 more
2012Journal of the American College of Cardiology44 citations Open access
Semantic Scholar
Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL‐Cl Levels
R. Huijgen, B. Sjouke, K. Vis, J. D. de Randamie +4 more
2012Human Mutation44 citations
Semantic Scholar
PCSK9 inhibition: the way forward in the treatment of dyslipidemia
R. Stoekenbroek, J. Kastelein, R. Huijgen
2015BMC Medicine38 citations Open access
Semantic Scholar
Maternal inheritance of familial hypercholesterolemia caused by the V408M low-density lipoprotein receptor mutation increases mortality.
J. Versmissen, I. P. G. Botden, R. Huijgen, D. Oosterveer +7 more
2011Atherosclerosis37 citations Open access
Semantic Scholar
Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance
S. Homsma, R. Huijgen, S. Middeldorp, E. Sijbrands +1 more
2008European Journal of Human Genetics37 citations Open access
Semantic Scholar
Follow-up of children diagnosed with familial hypercholesterolemia in a national genetic screening program.
H. Avis, D. Kusters, M. N. Vissers, R. Huijgen +6 more
2012Jornal de Pediatria35 citations
Semantic Scholar
Increased carotid intima-media thickness predicts cardiovascular events in aortic coarctation.
P. Luijendijk, Huang-Ling Lu, Frederike B Heynneman, R. Huijgen +6 more
2014International Journal of Cardiology34 citations
Semantic Scholar
UvA-DARE (Digital Academic Repository) Two Years after Molecular Diagnosis of Familial Hypercholesterolemia: Majority on Cholesterol-Lowering Treatment but a Minority Reaches Treatment Goal
R. Huijgen, I. Kindt, S. Verhoeven, E. Sijbrands +4 more
201034 citations
Semantic Scholar
Inheritance pattern of familial hypercholesterolemia and markers of cardiovascular risk[S]
D. Kusters, H. Avis, M. J. Braamskamp, R. Huijgen +4 more
2013Journal of Lipid Research26 citations Open access
Semantic Scholar
Hip surgery sequentially induces stress hyperglycaemia and activates coagulation.
J. Hermanides, R. Huijgen, C. Henny, N. H. Mohammad +3 more
2009Netherlands Journal of Medicine26 citations
Semantic Scholar
Achieved LDL cholesterol levels in patients with heterozygous familial hypercholesterolemia: A model that explores the efficacy of conventional and novel lipid-lowering therapy.
M. L. Hartgers, J. Besseling, E. Stroes, Janneke Wittekoek +8 more
2018Journal of Clinical Lipidology25 citations Open access
Semantic Scholar
Plasma PCSK 9 Levels and Clinical Outcomes in the TNT ( Treating to New Targets ) Trial A Nested Case-Control Study
R. Huijgen, S. Boekholdt, B. Arsenault, W. Bao +8 more
201225 citations
Semantic Scholar
Risk Factors for Cholecystectomy After Laparoscopic Roux-En-Y Gastric Bypass
S. Haal, Djoeke Rondagh, B. Hutten, Y. Acherman +4 more
2019Obesity Surgery23 citations Open access
Semantic Scholar
Carotid Atherosclerosis Progression in Familial Hypercholesterolemia Patients: A Pooled Analysis of the ASAP, ENHANCE, RADIANCE 1, and CAPTIVATE Studies
M. Vergeer, Rong Zhou, M. Bots, R. Duivenvoorden +14 more
2010Circulation Cardiovascular Imaging23 citations Open access
Semantic Scholar
Extreme xanthomatosis in patients with both familial hypercholesterolemia and cerebrotendinous xanthomatosis
R. Huijgen, A. Stork, J. Defesche, J. Peter +5 more
2012Clinical Genetics21 citations
Semantic Scholar
Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach
J. Versmissen, D. Oosterveer, M. Yazdanpanah, A. Dehghan +44 more
2014European Journal of Human Genetics17 citations Open access
Semantic Scholar
Statin therapy reduces plasma angiopoietin-like 3 (ANGPTL3) concentrations in hypercholesterolemic patients via reduced liver X receptor (LXR) activation.
L. Reeskamp, T. Tromp, R. Huijgen, E. Stroes +2 more
2020Atherosclerosis15 citations Open access
Semantic Scholar
Increased coagulation factor VIII activity in patients with familial hypercholesterolemia.
R. Huijgen, J. Kastelein, J. Meijers
2011Blood15 citations
Semantic Scholar
LDL-cholesterol target achievement in patients with heterozygous familial hypercholesterolemia at Groote Schuur Hospital: Minority at target despite large reductions in LDL-C.
Xander M. van Delden, R. Huijgen, K. H. Wolmarans, B. C. Brice +3 more
2018Atherosclerosis14 citations
Semantic Scholar
Clinical phenotype in relation to the distance-to-index-patient in familial hypercholesterolemia.
J. Besseling, R. Huijgen, Seth S. Martin, B. Hutten +2 more
2016Atherosclerosis11 citations
Semantic Scholar
Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.
R. Huijgen, D. Blom, M. L. Hartgers, K. Chemello +15 more
2020Arteriosclerosis, Thrombosis and Vascular Biology9 citations Open access
Semantic Scholar
Discriminative Ability of LDL-Cholesterol to Identify Patients With Familial HypercholesterolemiaClinical Perspective
R. Huijgen, B. Hutten, I. Kindt, M. N. Vissers +1 more
20129 citations Open access
Semantic Scholar
Quality Assessment of the Genetic Test for Familial Hypercholesterolemia in The Netherlands
I. Kindt, R. Huijgen, M. Boekel, K. J. van der Gaag +3 more
2013Cholesterol8 citations Open access
Semantic Scholar
Adherence to statin treatment in patients with familial hypercholesterolemia: A dynamic prediction model.
A. Cupido, M. Hof, L. D. de Boer, R. Huijgen +4 more
2022Journal of Clinical Lipidology7 citations Open access
Semantic Scholar
L6 EFFICACY OF 15 YEARS OF GENETIC CASCADE SCREENING FOR FAMILIAL HYPERCHOLESTEROLEMIA IN THE NETHERLANDS IN PREVENTION OF CORONARY ARTERY DISEASE
R. Huijgen, J. Versmissen, D. Oosterveer, I. Kindt +2 more
20105 citations
Semantic Scholar
Interpretation of laboratory results after gastric bypass surgery: the effects of weight loss and time on 30 blood tests in a 5-year follow-up program.
A. W. van de Laar, Victor E. A. Gerdes, R. Huijgen, Y. Acherman +2 more
2020Surgery for Obesity and Related Diseases3 citations Open access
Semantic Scholar
The impact of LDLR function on fibroblast growth factor 21 levels.
J. Besseling, Leung-Ong Kwok, R. Huijgen, K. Rye +3 more
2015Atherosclerosis3 citations Open access
Semantic Scholar
Abstract 19939: Familial Hypercholesterolemia: Classification of Mutation Severity According To Percentile Low-Density Lipoprotein Cholesterol Useful for Predicting Coronary Artery Disease Risk
M. L. Hartgers, G. Hovingh, J. Kastelein, R. Huijgen
20162 citations
Semantic Scholar
Abstract: P870 IDENTIFICATION OF APOB AND PCSK9 MUTATIONS CAUSING A NON-ADH PHENOTYPE IN MOLECULAR DIAGNOSED ADH PATIENTS
S. Fouchier, R. Huijgen, K. Vis, J. Defesche +1 more
20092 citations
Semantic Scholar
Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) Trial (Retraction of vol 59, pg 1778, 2012)
R. Huijgen, S. Boekholdt, B. Arsenault, W. Bao +8 more
20131 citations
Semantic Scholar
Hyperthyroidism as a Risk Factor for Venous Thromboembolism: A Case-Control Study
B. van Zaane, A. Squizzato, R. Huijgen, A. P. van Zanten +4 more
20081 citations
Semantic Scholar
Abstract 2223: Carotid Intima Media Thickness Progression is Modest in Statin-Treated Familial Hypercholesterolemia Patients - Results from a Patient Level Meta-Analysis of 1257 Patients
M. Vergeer, Rong Zhou, R. Duivenvoorden, J. Koglin +11 more
20081 citations
Semantic Scholar
Statins Reduce Hepatic Angptl3 Expression And Secretion, Likely By Interfering With Lxr-Mediated Transcription
A. Grefhorst, L. Reeskamp, R. Huijgen, G. Hovingh
2019Atherosclerosis0 citations
Semantic Scholar
Familial hypercholesterolemia patients with unexplained low ldl-c: a role for angptl3?
L. Reeskamp, R. Huijgen, A. Grefhorst, G. Hovingh
2019Atherosclerosis0 citations
Semantic Scholar

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