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A. Hochschild · SciRah

Researcher profile · Semantic Scholar

A. Hochschild

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A. Hochschild — researcher profile on SciRah

h-index: 45
Works: 126
Citations: 7,261

Most-cited papers

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
D. Bikard, Wenyan Jiang, Poulami Samai, A. Hochschild +2 more
2013Nucleic Acids Research1,122 citations Open access
Semantic Scholar
CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence
Christina L. Stallings, Nicolas C. Stephanou, L. Chu, A. Hochschild +2 more
2009Cell242 citations Open access
Semantic Scholar
Structural basis for bacterial transcription-coupled DNA repair.
A. Deaconescu, A. L. Chambers, Abigail J. Smith, B. Nickels +3 more
2006Cell206 citations Open access
Semantic Scholar
A Role for Interaction of the RNA Polymerase Flap Domain with the σ Subunit in Promoter Recognition
K. Kuznedelov, L. Minakhin, A. Niedziela-Majka, Simon L. Dove +5 more
2002Science176 citations
Semantic Scholar
Cooperativity in long-range gene regulation by the λ CI repressor
I. Dodd, K. Shearwin, A. Perkins, Tom Burr +2 more
2004171 citations Open access
Semantic Scholar
Conversion of the omega subunit of Escherichia coli RNA polymerase into a transcriptional activator or an activation target.
Simon L. Dove, A. Hochschild
1998Genes & Development168 citations Open access
Semantic Scholar
Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding.
Charles E. Bell, P. Frescura, A. Hochschild, M. Lewis
2000Cell152 citations
Semantic Scholar
A bacterial global regulator forms a prion
Andy H. Yuan, A. Hochschild
2017Science135 citations Open access
Semantic Scholar
Protein-protein contacts that activate and repress prokaryotic transcription.
A. Hochschild, Simon L. Dove
1998Cell135 citations Open access
Semantic Scholar
A bacterial two-hybrid system based on transcription activation.
Simon L. Dove, A. Hochschild
2004Methods in molecular biology118 citations
Semantic Scholar
Escherichia coli one- and two-hybrid systems for the analysis and identification of protein-protein interactions.
James C. Hu, M. Kornacker, A. Hochschild
2000Methods117 citations
Semantic Scholar
Region 4 of σ as a target for transcription regulation
Simon L. Dove, S. Darst, A. Hochschild
2003110 citations Open access
Semantic Scholar
Crystal structure of the λ repressor and a model for pairwise cooperative operator binding
S. Stayrook, P. Jaru-Ampornpan, J. Ni, A. Hochschild +1 more
2008Nature101 citations
Semantic Scholar
Cooperativity in long-range gene regulation by the lambda CI repressor.
I. Dodd, K. Shearwin, A. Perkins, Tom Burr +2 more
2004Genes & Development97 citations
Semantic Scholar
Structure of a ternary transcription activation complex.
D. Jain, B. Nickels, Li Sun, A. Hochschild +1 more
2004Molecules and Cells95 citations Open access
Semantic Scholar
Magnitude of the CREB-Dependent Transcriptional Response Is Determined by the Strength of the Interaction between the Kinase-Inducible Domain of CREB and the KIX Domain of CREB-Binding Protein
Adam J. Shaywitz, Simon L. Dove, J. Kornhauser, A. Hochschild +1 more
2000Molecular and Cellular Biology82 citations Open access
Semantic Scholar
Protein-protein and protein-DNA interactions of σ70 region 4 involved in transcription activation by λcI
B. Nickels, Simon L. Dove, K. Murakami, S. Darst +1 more
200281 citations
Semantic Scholar
The σ70 subunit of RNA polymerase mediates a promoter-proximal pause at the lac promoter
B. Nickels, J. Mukhopadhyay, Sean J. Garrity, R. Ebright +1 more
2004Nature Structural &Molecular Biology80 citations
Semantic Scholar
Isolation of peptide aptamers that inhibit intracellular processes.
Jonathan H. Blum, Simon L. Dove, A. Hochschild, J. Mekalanos
2000Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
The interaction between σ70 and the β-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation
B. Nickels, Sean J. Garrity, V. Mekler, L. Minakhin +3 more
200577 citations Open access
Semantic Scholar
Regulation of RNA polymerase through the secondary channel.
B. Nickels, A. Hochschild
2004Cell69 citations Open access
Semantic Scholar
Bacterial RNA polymerase can retain σ70 throughout transcription
Timothy T. Harden, C. Wells, L. Friedman, R. Landick +3 more
2016Proceedings of the National Academy of Sciences of the United States of America67 citations Open access
Semantic Scholar
Bacterial Two-Hybrid Analysis of Interactions between Region 4 of the ς70 Subunit of RNA Polymerase and the Transcriptional Regulators Rsd from Escherichia coli and AlgQ from Pseudomonas aeruginosa
Simon L. Dove, A. Hochschild
2001Journal of Bacteriology66 citations Open access
Semantic Scholar
Region 4 of sigma as a target for transcription regulation.
Simon L. Dove, S. Darst, A. Hochschild
2003Molecular Microbiology62 citations
Semantic Scholar
Mechanism for a transcriptional activator that works at the isomerization step.
Simon L. Dove, Franklin W. Huang, A. Hochschild
2000Proceedings of the National Academy of Sciences of the United States of America60 citations Open access
Semantic Scholar
A bacterial export system for generating extracellular amyloid aggregates
V. Sivanathan, A. Hochschild
2013Nature Protocols59 citations Open access
Semantic Scholar
The σ70 Subunit of RNA Polymerase Is Contacted by the λQ Antiterminator during Early Elongation
B. Nickels, C. W. Roberts, Haitao Sun, Jeffrey W. Roberts +1 more
200256 citations Open access
Semantic Scholar
Conversion of a yeast prion protein to an infectious form in bacteria
Sean J. Garrity, V. Sivanathan, Jijun Dong, S. Lindquist +1 more
2010Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
The bacteriophage λ Q antiterminator protein contacts the β-flap domain of RNA polymerase
P. Deighan, C. M. Diez, Mark Leibman, A. Hochschild +1 more
2008Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
The Bacteriophage T4 Transcription Activator MotA Interacts with the Far-C-Terminal Region of the σ70 Subunit of Escherichia coli RNA Polymerase
S. Pande, Anna Makela, Simon L. Dove, B. Nickels +2 more
2002Journal of Bacteriology54 citations Open access
Semantic Scholar
Generating extracellular amyloid aggregates using E. coli cells.
V. Sivanathan, A. Hochschild
2012Genes & Development53 citations Open access
Semantic Scholar
A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme.
Brian D. Gregory, B. Nickels, Sean J. Garrity, E. Severinova +6 more
2004Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
The interaction between sigma70 and the beta-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation.
B. Nickels, Sean J. Garrity, V. Mekler, L. Minakhin +3 more
2005Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
CbtA toxin of Escherichia coli inhibits cell division and cell elongation via direct and independent interactions with FtsZ and MreB
Danielle M. Heller, Mrinalini Tavag, A. Hochschild
2017PLoS Genetics44 citations Open access
Semantic Scholar
A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary sigma subunit.
X. Rao, P. Deighan, Zi-Yu Hua, Xiao-Mei Hu +7 more
200944 citations
Semantic Scholar
Rsd family proteins make simultaneous interactions with regions 2 and 4 of the primary sigma factor
Andy H. Yuan, Brian D. Gregory, Josh S. Sharp, Katherine D. McCleary +2 more
2008Molecular Microbiology44 citations Open access
Semantic Scholar
A family of anti-sigma70 proteins in T4-type phages and bacteria that are similar to AsiA, a Transcription inhibitor and co-activator of bacteriophage T4.
M. Pineda, Brian D. Gregory, B. Szczypinski, Kimberly Baxter +3 more
2004Journal of Molecular Biology40 citations
Semantic Scholar
The sigma 70 subunit of RNA polymerase mediates a promoter-proximal pause at the lac promoter.
B. Nickels, J. Mukhopadhyay, Sean J. Garrity, R. Ebright +1 more
2004Nature Structural & Molecular Biology40 citations
Semantic Scholar
A σ‐core interaction of the RNA polymerase holoenzyme that enhances promoter escape
Mark Leibman, A. Hochschild
2007EMBO Journal39 citations Open access
Semantic Scholar
Alternative transcription cycle for bacterial RNA polymerase
Timothy T. Harden, Karina S. Herlambang, Mathew Chamberlain, Jean-Benoît Lalanne +6 more
2019Nature Communications38 citations Open access
Semantic Scholar
Initial transcribed region sequences influence the composition and functional properties of the bacterial elongation complex.
P. Deighan, Chirangini Pukhrambam, B. Nickels, A. Hochschild
2011Genes & Development38 citations Open access
Semantic Scholar
The bacteriophage λ CI protein finds an asymmetric solution
A. Hochschild, M. Lewis
2009Current Opinion in Structural Biology37 citations Open access
Semantic Scholar
The structural basis of cooperative regulation at an alternate genetic switch.
H. Pinkett, K. Shearwin, S. Stayrook, I. Dodd +4 more
2006Molecules and Cells36 citations Open access
Semantic Scholar
The bacteriophage λQ anti‐terminator protein regulates late gene expression as a stable component of the transcription elongation complex
P. Deighan, A. Hochschild
2007Molecular Microbiology33 citations Open access
Semantic Scholar
RNA-mediated destabilization of the sigma(70) region 4/beta flap interaction facilitates engagement of RNA polymerase by the Q antiterminator.
B. Nickels, C. W. Roberts, Jeffrey W. Roberts, A. Hochschild
2006Molecules and Cells31 citations Open access
Semantic Scholar
Prion propagation can occur in a prokaryote and requires the ClpB chaperone
Andy H. Yuan, Sean J. Garrity, E. Nako, A. Hochschild
2014eLife30 citations Open access
Semantic Scholar
Promoter-Specific Transcription Inhibition in Staphylococcus aureus by a Phage Protein
Joseph S Osmundson, Cristina Montero-Diez, L. Westblade, A. Hochschild +1 more
2012Cell30 citations Open access
Semantic Scholar
An Open Letter to Elias Zerhouni
S. Altman, B. Bassler, J. Beckwith, M. Belfort +46 more
2005Science29 citations
Semantic Scholar
Protein-protein and protein-DNA interactions of sigma70 region 4 involved in transcription activation by lambdacI.
B. Nickels, Simon L. Dove, K. Murakami, S. Darst +1 more
2002Journal of Molecular Biology29 citations
Semantic Scholar
A bacteria-based genetic assay detects prion formation
E. Fleming, Andy H. Yuan, Danielle M. Heller, A. Hochschild
2019Proceedings of the National Academy of Sciences of the United States of America27 citations Open access
Semantic Scholar

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