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Adam J. Shaywitz · SciRah

Researcher profile · Semantic Scholar

Adam J. Shaywitz

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Adam J. Shaywitz — researcher profile on SciRah

h-index: 20
Works: 54
Citations: 5,463

Most-cited papers

CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.
Adam J. Shaywitz, M. Greenberg
1999Annual Review of Biochemistry2,228 citations
Semantic Scholar
Calcium regulation of neuronal gene expression
A. E. West, Wen G. Chen, M. Dalva, R. Dolmetsch +5 more
2001Proceedings of the National Academy of Sciences of the United States of America1,082 citations Open access
Semantic Scholar
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1
N. Wu, B. Zheng, Adam J. Shaywitz, Y. Dagon +8 more
2013Molecules and Cells638 citations Open access
Semantic Scholar
CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events.
J. Kornhauser, C. W. Cowan, Adam J. Shaywitz, R. Dolmetsch +5 more
2002Neuron302 citations Open access
Semantic Scholar
Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.
Clapton S. Dias, Adam J. Shaywitz, S. Wasserman, Brian Smith +12 more
2012Journal of the American College of Cardiology250 citations Open access
Semantic Scholar
Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration.
J. Cohen-Pfeffer, S. Gururangan, T. Lester, D. Lim +3 more
2017Pediatric Neurology142 citations Open access
Semantic Scholar
Hypocalcaemia in patients with metastatic bone disease treated with denosumab.
J. Body, H. Bone, R. De Boer, A. Stopeck +14 more
2015European Journal of Cancer133 citations Open access
Semantic Scholar
Magnitude of the CREB-Dependent Transcriptional Response Is Determined by the Strength of the Interaction between the Kinase-Inducible Domain of CREB and the KIX Domain of CREB-Binding Protein
Adam J. Shaywitz, Simon L. Dove, J. Kornhauser, A. Hochschild +1 more
2000Molecular and Cellular Biology82 citations Open access
Semantic Scholar
Best practices for the use of intracerebroventricular drug delivery devices.
I. Slavc, J. Cohen-Pfeffer, S. Gururangan, J. Krauser +5 more
2018Molecular Genetics and Metabolism70 citations Open access
Semantic Scholar
Immunogenicity of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients With Morquio A Syndrome: Results From MOR-004, a Phase III Trial.
Becky Schweighardt, T. Tompkins, Kelly Lau, Lynne A. Jesaitis +7 more
2015Clinical Therapeutics61 citations
Semantic Scholar
Long-term endurance and safety of elosulfase alfa enzyme replacement therapy in patients with Morquio A syndrome.
C. Hendriksz, R. Parini, M. AlSayed, J. Raiman +13 more
2016Molecular Genetics and Metabolism60 citations Open access
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Evaluation of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients with Morquio A Syndrome
Yu-Lan Qi, D. Musson, Becky Schweighardt, T. Tompkins +4 more
2014Clinical Pharmacokinetics41 citations Open access
Semantic Scholar
Erratum to: Tolerability of High-Volume Subcutaneous Injections of a Viscous Placebo Buffer: A Randomized, Crossover Study in Healthy Subjects
Clapton S. Dias, Bassam Abosaleem, C. Crispino, Bing Gao +1 more
2015AAPS PharmSciTech38 citations Open access
Semantic Scholar
Safety and physiological effects of two different doses of elosulfase alfa in patients with morquio a syndrome: A randomized, double‐blind, pilot study
Barbara K. Burton, K. Berger, G. Lewis, M. Tarnopolsky +11 more
2015American Journal of Medical Genetics. Part A37 citations Open access
Semantic Scholar
Safety and clinical activity of elosulfase alfa in pediatric patients with Morquio A syndrome (mucopolysaccharidosis IVA) less than 5 y
S. Jones, M. Bialer, R. Parini, K. Martin +4 more
2015Pediatric Research35 citations Open access
Semantic Scholar
Grizzly bears exhibit augmented insulin sensitivity while obese prior to a reversible insulin resistance during hibernation.
O. Nelson, H. Jansen, E. Galbreath, Kurt Morgenstern +8 more
2014Cell Metabolism34 citations Open access
Semantic Scholar
Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III
Arunabha Ghosh, E. Shapiro, S. Rust, Kathleen A. Delaney +9 more
2017Orphanet Journal of Rare Diseases30 citations Open access
Semantic Scholar
Tolerability of High-Volume Subcutaneous Injections of a Viscous Placebo Buffer: A Randomized, Crossover Study in Healthy Subjects
Clapton S. Dias, Bassam Abosaleem, C. Crispino, Bing Gao +1 more
2015AAPS PharmSciTech30 citations Open access
Semantic Scholar
Gene-based therapeutics for rare genetic neurodevelopmental psychiatric disorders
Beverly L. Davidson, G. Gao, E. Berry-Kravis, Allison M. Bradbury +13 more
2022Molecular Therapy23 citations Open access
Semantic Scholar
EFFECTS OF AMG 145, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST PCSK9, ON LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN SUBJECTS TAKING STATINS: A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, ASCENDING MULTIPLE-DOSE STUDY
Clapton S. Dias, Adam J. Shaywitz, Blaire P. Cooke, Stephen Uy +8 more
201221 citations Open access
Semantic Scholar
A phase I/II study on intracerebroventricular tralesinidase alfa in patients with Sanfilippo syndrome type B
N. Muschol, A. Koehn, K. von Cossel, I. Okur +15 more
2022Journal of Clinical Investigation16 citations Open access
Semantic Scholar
Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B
A. Grover, Danielle Crippen-Harmon, Lacey Nave, Jon Vincelette +23 more
2020Drug Delivery and Translational Research15 citations Open access
Semantic Scholar
Analysis of Phosphorylation-Dependent Protein-Protein Interactions Using a Bacterial Two-Hybrid System
Adam J. Shaywitz, Simon L. Dove, M. Greenberg, A. Hochschild
2002Science's STKE15 citations
Semantic Scholar
Longitudinal natural history of pediatric subjects affected with mucopolysaccharidosis IIIB.
I. Okur, F. Ezgü, R. Giugliani, N. Muschol +17 more
2022Jornal de Pediatria13 citations Open access
Semantic Scholar
PI3K Enters Beta-Testing
Adam J. Shaywitz, K. Courtney, A. Patnaik, L. Cantley
2008Cell Metabolism12 citations Open access
Semantic Scholar
Abstract 10701: A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Ascending Single Dose Study to Evaluate the Safety, Tolerability and Pharmacodynamics of AMG145
Clapton S. Dias, Adam J. Shaywitz, Brian G. Smith, M. Emery +10 more
20119 citations
Semantic Scholar
ICV-administered BMN 250 (NAGLU-IGF2) is well tolerated and reduces heparan sulfate accumulation in the CNS of subjects with Sanfilippo syndrome type B (MPS IIIB)
N. Muschol, M. Cleary, M. Couce, Adam J. Shaywitz +6 more
20188 citations
Semantic Scholar
ICV-administered tralesinidase alfa (BMN 250 NAGLU-IGF2) is well-tolerated and reduces heparan sulfate accumulation in the CNS of subjects with Sanfilippo syndrome type B (MPS IIIB)
M. Cleary, N. Muschol, M. Couce, P. Harmatz +13 more
2019Molecular Genetics and Metabolism7 citations
Semantic Scholar
Impact of Elosulfase Alfa on Pain in Patients with Morquio A Syndrome over 52 Weeks
M. Treadwell, P. Harmatz, B. Burton, John J. Mitchell +10 more
20175 citations Open access
Semantic Scholar
Cardiopulmonary Exercise Testing Reflects Improved Exercise Capacity in Response to Treatment in Morquio A Patients: Results of a 52-Week Pilot Study of Two Different Doses of Elosulfase Alfa.
K. Berger, B. Burton, G. Lewis, M. Tarnopolsky +9 more
2018JIMD Reports4 citations Open access
Semantic Scholar
Hypocalcemia in patients with metastatic bone disease receiving denosumab.
J. Body, A. Lipton, D. Henry, A. Stopeck +14 more
20134 citations
Semantic Scholar
Urine N-Acetylaspartate Distinguishes Phenotypes in Canavan Disease
A. Nagy, Florian Eichler, Annette Bley, Janna Bredow +7 more
2024Human Gene Therapy3 citations Open access
Semantic Scholar
Impact of elosulfase alfa on pain in patients with Morquio syndrome type A
P. Harmatz, M. Treadwell, B. Burton, John J. Mitchell +9 more
20153 citations
Semantic Scholar
AMG 145, a Fully Human Monoclonal Antibody Against PCSK9, Reduces LDL-C in Healthy Volunteers and Patients on Stable Doses of Statins†
Adam J. Shaywitz, Clapton S. Dias, Brian G. Smith, Bing Gao +13 more
20123 citations
Semantic Scholar
Design and rationale of ongoing observational and treatment studies for BMN 250: a novel enzyme replacement therapy for Sanfilippo syndrome type B
Adam J. Shaywitz, S. Maricich, Yu Hua, S. Kent
20172 citations
Semantic Scholar
Design and rationale of the study programs for BMN 250, a novel enzyme replacement therapy (ERT) for Sanfilippo syndrome type B
Adam J. Shaywitz, Myungshin Oh, S. Kent
20162 citations
Semantic Scholar
EFFECTS OF EVOLOCUMAB ON LIPOPROTEIN PARTICLES AND SUBCLASSES IN HYPERCHOLESTEROLEMIC AND HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA SUBJECTS ON STATIN THERAPY
Ren Y. Xu, Clapton S. Dias, M. Peach, Bing Gao +8 more
20142 citations Open access
Semantic Scholar
ODP046 Initial Lessons from a Prescreening Protocol to Identify Participants with Classic CAH Potentially Eligible for Gene Therapy Treatment with BBP-631, an Adeno-associated Virus (AAV) Serotype 5-Based Recombinant Vector Encoding the Human CYP21A2 Gene
K. Bharucha, D. Weinstein, Kathleen Kirby, R. Auchus +5 more
2022Journal of the Endocrine Society1 citations Open access
Semantic Scholar
The Pharmacokinetics of Orally Administered Calcium Pantothenate in Healthy Adults
Satish Rao, A. Wade, U. Sinha, Adam J. Shaywitz +5 more
2021Journal of Vitamins and Minerals1 citations
Semantic Scholar
Natural history data for young subjects with Sanfilippo syndrome type B (MPS IIIB)
Martha Luz Solano Villarreal, I. Okur, M. Cleary, M. J. de Castro Lopez +13 more
2018Molecular Genetics and Metabolism1 citations
Semantic Scholar
Impact of long-term elosulfase alfa treatment on pulmonary function in patients with Morquio syndrome type A
C. Hendriksz, B. Burton, M. AlSayed, R. Giugliani +12 more
20161 citations
Semantic Scholar
Immunogenicity of elosulfase alfa, an enzyme replacement therapy in patients with Morquio syndrome type A: Results from MOR-004, a phase 3 trial
Becky Schweighardt, T. Tompkins, Kelly Lau, Lynne Jesaitus +7 more
20151 citations
Semantic Scholar
Erratum to: Tolerability of High-Volume Subcutaneous Injections of a Viscous Placebo Buffer: A Randomized, Crossover Study in Healthy Subjects
Clapton S. Dias, Bassam Abosaleem, C. Crispino, Bing Gao +1 more
2015AAPS PharmSciTech1 citations Open access
Semantic Scholar
The First Multi-Center, Multi-National Retrospective and Prospective Natural History Study of Canavan Disease
Heather Lau, Adam J. Shaywitz, K. Kirby, I. Oppermann +3 more
2019Neuropediatrics0 citations
Semantic Scholar
Protéines de fusion d'enzymes lysosomales thérapeutiques ciblées, formulations associées et leurs utilisations
Saeed Moshashaee, Jason Pinkstaff, Adam J. Shaywitz
20170 citations
Semantic Scholar
Expert Opinion on the Management of Intracerebroventricular (ICV) Drug Delivery
I. Slavc, Jessica L. Cohen-Pfeffer, S. Gururangan, Elaina Jurecki +7 more
2017Neuropediatrics0 citations
Semantic Scholar
Intracerebroventricular administration of BMN 250 to cynomolgus monkeys results in elevated tissue levels and superior biodistribution in the central nervous system in comparison to intravenous delivery
A. Grover, Adam J. Shaywitz, J. Wait, Andrew C. Melton +2 more
20160 citations
Semantic Scholar
Tolerability of High-Volume Subcutaneous Injections of a Viscous Placebo Buffer: A Randomized, Crossover Study in Healthy Subjects
Clapton S. Dias, Bassam Abosaleem, C. Crispino, Bing Gao +1 more
2015AAPS PharmSciTech0 citations Open access
Semantic Scholar
Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation
O. Nelson, H. T. Jansen, E. Galbreath, Kurt Morgenstern +8 more
20150 citations
Semantic Scholar
Abstract 128: Recombinant Lecithin Cholesterol Acyltransferase Generates Mature High Density Lipoprotein with Increased Capacity to Efflux Cholesterol via ABCG1 in Cynomolgus Monkeys
M. Peach, Michelle M. Chen, Feng Cai, Joanna Z. Peng +7 more
2015Arteriosclerosis, Thrombosis and Vascular Biology0 citations
Semantic Scholar

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P. Harmatz×11
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P. Harmatz — researcher profile on SciRah
Clapton S. Dias×9
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Clapton S. Dias — researcher profile on SciRah
Bing Gao×9
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N. Muschol×9
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N. Muschol — researcher profile on SciRah

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John J. Mitchell×6

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