J. Mekalanos

Most-cited papers

A view to a kill: the bacterial type 6 secretion system
B. Ho, Tao G. Dong, J. Mekalanos
2013Cell Host and Microbe593 citations Open access
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Tit-for-tat: Type VI secretion system counterattack during bacterial cell-cell interactions
M. Basler, B. Ho, J. Mekalanos
2013Cell541 citations Open access
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PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike
M. Shneider, S. Buth, B. Ho, M. Basler +2 more
2013Nature528 citations Open access
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Bacterial cGAS-like enzymes synthesize diverse nucleotide signals
A. T. Whiteley, J. Eaglesham, C. C. de Oliveira Mann, B. R. Morehouse +7 more
2019Nature364 citations Open access
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Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance
Wen Zhou, A. T. Whiteley, C. C. de Oliveira Mann, B. R. Morehouse +5 more
2018Cell358 citations Open access
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Tn-Seq Analysis of Vibrio cholerae Intestinal Colonization Reveals a Role for T6SS-Mediated Antibacterial Activity in the Host
Yang Fu, M. Waldor, J. Mekalanos
2013Cell Host and Microbe238 citations Open access
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CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection
B. Lowey, A. T. Whiteley, A. Keszei, B. R. Morehouse +11 more
2020Cell211 citations Open access
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Cyclic Dinucleotides and the Innate Immune Response
Olga Danilchanka, J. Mekalanos
2013Cell211 citations Open access
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Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity
R. Lau, Q. Ye, Erica A. Birkholz, K. R. Berg +11 more
2019bioRxiv189 citations Open access
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Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence
Wenjing Zhao, Florence Caro, William P. Robins, J. Mekalanos
2018Science183 citations Open access
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Generation of reactive oxygen species by lethal attacks from competing microbes
Tao G. Dong, Shiqi Dong, Christy Catalano, R. Moore +2 more
2015Proceedings of the National Academy of Sciences of the United States of America164 citations Open access
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Proteomic analysis of Vibrio cholerae outer membrane vesicles
E. Altindis, Yang Fu, J. Mekalanos
2014Proceedings of the National Academy of Sciences of the United States of America163 citations Open access
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The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism
L. Kamareddine, William P. Robins, Cristin D. Berkey, J. Mekalanos +1 more
2018Cell Metabolism156 citations Open access
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Fitness cost of antibiotic susceptibility during bacterial infection
D. Roux, Olga Danilchanka, T. Guillard, V. Cattoir +9 more
2015Science Translational Medicine154 citations Open access
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Microbiota-targeted maternal antibodies protect neonates from enteric infection
Wen Zheng, Wenjing Zhao, Meng Wu, Xinyang Song +7 more
2020Nature142 citations Open access
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Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing
D. Skurnik, D. Roux, V. Cattoir, Olga Danilchanka +12 more
2013Proceedings of the National Academy of Sciences of the United States of America141 citations Open access
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Type 6 Secretion System-Mediated Immunity to Type 4 Secretion System-Mediated Horizontal Gene Transfer
B. Ho, Marek Basler, J. Mekalanos
2013Science130 citations Open access
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Cholera toxin promotes pathogen acquisition of host-derived nutrients
Fabian Rivera-Chávez, J. Mekalanos
2019Nature114 citations Open access
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Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system
J. Toska, B. Ho, J. Mekalanos
2018Proceedings of the National Academy of Sciences of the United States of America112 citations Open access
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The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism
Sai-Yu Hang, A. Purdy, William P. Robins, Zhipeng Wang +4 more
2014Cell Host and Microbe109 citations Open access
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Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases
Masato Suzuki, Olga Danilchanka, J. Mekalanos
2014Cell Host and Microbe103 citations Open access
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Secretome Analysis of Vibrio cholerae Type VI Secretion System Reveals a New Effector-Immunity Pair
E. Altindis, Tao G. Dong, Christy Catalano, J. Mekalanos
2015mBio101 citations Open access
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Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages
M. Hoque, Iftekhar Bin Naser, S. M. Nayeemul Bari, Jun Zhu +2 more
2016Scientific Reports95 citations Open access
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Gut complement induced by the microbiota combats pathogens and spares commensals
Meng Wu, Wen Zheng, Xinyang Song, B. Bao +20 more
2024Cell85 citations
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Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples
S. Bari, M. Roky, M. Mohiuddin, M. Kamruzzaman +2 more
2013Proceedings of the National Academy of Sciences of the United States of America77 citations Open access
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Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells
B. Ho, Yang Fu, Tao G. Dong, J. Mekalanos
2017Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
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Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans.
D. Skurnik, O. Clermont, T. Guillard, A. Launay +18 more
2016Molecular biology and evolution71 citations Open access
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Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli
Sanduo Zheng, Lok-To Sham, F. Rubino, Kelly P. Brock +5 more
2018Proceedings of the National Academy of Sciences of the United States of America66 citations Open access
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The Highly Conserved Bacterial RNase YbeY Is Essential in Vibrio cholerae, Playing a Critical Role in Virulence, Stress Regulation, and RNA Processing
M. Vercruysse, C. Köhrer, B. Davies, Markus F. F. Arnold +3 more
2014PLoS Pathogens63 citations Open access
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Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity
Xia Ji, J. Zou, Haibo Peng, Anne-Sophie Stolle +5 more
2019Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
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An onboard checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae
Xiao-Ye Liang, Fatima Kamal, Tong-Tong Pei, Ping Xu +2 more
2019Proceedings of the National Academy of Sciences of the United States of America57 citations Open access
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A live vaccine rapidly protects against cholera in an infant rabbit model
T. Hubbard, Gabriel Billings, Tobias Dörr, B. Sit +7 more
2018Science Translational Medicine55 citations Open access
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Intratumoral injection of schwannoma with attenuated Salmonella typhimurium induces antitumor immunity and controls tumor growth
Sherif G. Ahmed, Giulia Oliva, M. Shao, Xin-Hui Wang +2 more
2022Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
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Tracking Vibrio cholerae cell-cell interactions during infection reveals bacterial population dynamics within intestinal microenvironments
Yang Fu, B. Ho, J. Mekalanos
2018Cell Host and Microbe45 citations Open access
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Synthetic peptides that form nanostructured micelles have potent antibiotic and antibiofilm activity against polymicrobial infections
Shu-Li Chou, Huating Guo, Franz G. Zingl, Shiqing Zhang +8 more
2023Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
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Isolation of Bdellovibrio and like organisms and potential to reduce acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus.
J. Kongrueng, Pimonsri Mitraparp-arthorn, Khotchawan Bangpanwimon, William P. Robins +2 more
2017Diseases of Aquatic Organisms41 citations Open access
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Conjugate-like immunogens produced as protein capsular matrix vaccines
A. Thanawastien, Robert T. Cartee, Thomas J. Griffin, K. Killeen +1 more
2015Proceedings of the National Academy of Sciences of the United States of America41 citations Open access
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Analysis of lipoprotein transport depletion in Vibrio cholerae using CRISPRi
Florence Caro, N. Place, J. Mekalanos
2019Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
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Endogenous membrane stress induces T6SS activity in Pseudomonas aeruginosa
Anne-Sophie Stolle, B. Meader, J. Toska, J. Mekalanos
2020Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
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Sensing of intracellular Hcp levels controls T6SS expression in Vibrio cholerae
Kevin Manera, Florence Caro, Hao Li, Tong-Tong Pei +3 more
2021Proceedings of the National Academy of Sciences of the United States of America29 citations Open access
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Genomic Science in Understanding Cholera Outbreaks and Evolution of Vibrio cholerae as a Human Pathogen
William P. Robins, J. Mekalanos
2014Current Topics in Microbiology and Immunology26 citations Open access
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Type VI secretion system sheaths as nanoparticles for antigen display
E. Del Tordello, Olga Danilchanka, Andrew J. McCluskey, J. Mekalanos
2016Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
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Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center.
N. Pincus, K. Bachta, Egon A. Ozer, Jonathan P. Allen +8 more
2019Clinical Infectious Diseases22 citations Open access
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RS1 Satellite Phage Promotes Diversity of Toxigenic Vibrio cholerae by Driving CTX Prophage Loss and Elimination of Lysogenic Immunity
M. Kamruzzaman, William P. Robins, S. M. Nayeemul Bari, S. Nahar +2 more
2014Infection and Immunity22 citations Open access
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A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates
S. Pons, Eric Frapy, Y. Sereme, Charlotte Gaultier +17 more
2022bioRxiv21 citations Open access
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Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling
Denis Chang, A. T. Whiteley, Katlynn Bugda-Gwilt, W. Lencer +2 more
2020Proceedings of the National Academy of Sciences of the United States of America21 citations Open access
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DdmABC-dependent death triggered by viral palindromic DNA sequences
William P. Robins, B. Meader, J. Toska, J. Mekalanos
2024Cell Reports16 citations Open access
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A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae
Fabian Rivera-Chávez, B. Meader, Sinan Akosman, V. Koprivica +1 more
2022Toxins13 citations Open access
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Vaccine Economics: What Price Human Life?
J. Mekalanos
2013Science Translational Medicine10 citations Open access
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Vibrio parahaemolyticus and Its Specific Bacteriophages as an Indicator in Cockles (Anadara granosa) for the Risk of V. parahaemolyticus Infection in Southern Thailand
Mingkwan Yingkajorn, Natthawan Sermwitayawong, Prasit Palittapongarnpimp, M. Nishibuchi +3 more
2014Microbial Ecology7 citations Open access
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