R. Ebright

Most-cited papers

1. Structural basis of transcription-translation coupling

   Cheng-Yuan Wang, V. Molodtsov, E. Firlar, J. Kaelber +3 more

   2020Science150 citations Open access

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2. The Infectious Diseases Society of America's 10 × '20 Initiative (10 New Systemic Antibacterial Agents US Food and Drug Administration Approved by 2020): Is 20 × '20 a Possibility?

   G. Talbot, Amanda Jezek, B. Murray, Ronald N. Jones +5 more

   2019Clinical Infectious Diseases130 citations Open access

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3. AI is a viable alternative to high throughput screening: a 318-target study

   Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho +496 more

   2024Scientific Reports112 citations Open access

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4. Structural basis of Rho-dependent transcription termination

   V. Molodtsov, Cheng-Yuan Wang, E. Firlar, J. Kaelber +1 more

   2023Nature79 citations Open access

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5. Structural basis of ECF-sigma-factor-dependent transcription initiation.

   Wei Lin, Sukhendu Mandal, David Degen, Sung-Cho Min +3 more

   201847 citations Open access

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6. Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates

   R. Gabizon, Antony Lee, H. Vahedian-Movahed, R. Ebright +1 more

   2018Nature Communications44 citations Open access

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7. RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription

   Ling-Ting Li, V. Molodtsov, Wei Lin, R. Ebright +1 more

   2019Proceedings of the National Academy of Sciences of the United States of America41 citations Open access

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8. Closing and opening of the RNA polymerase trigger loop

   Abhishek Mazumder, Miao-Xin Lin, A. Kapanidis, R. Ebright

   2019Proceedings of the National Academy of Sciences of the United States of America40 citations Open access

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9. Structural basis of Q-dependent antitermination

   Z. Yin, J. Kaelber, R. Ebright

   2019Proceedings of the National Academy of Sciences of the United States of America37 citations Open access

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10. Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens

    Zhen-Kun Ma, Shi-Jie He, Ying Yuan, Zhi-Jun Zhuang +15 more

    2022Journal of Medicinal Chemistry31 citations Open access

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11. An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2

    J. van Helden, C. Butler, G. Achaz, B. Canard +12 more

    2021The Lancet30 citations Open access

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12. Transcription initiation at a consensus bacterial promoter proceeds via a ‘bind-unwind-load-and-lock’ mechanism

    Abhishek Mazumder, R. Ebright, A. Kapanidis

    2021bioRxiv24 citations Open access

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13. Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance

    Tian Lan, Uday S. Ganapathy, S. Sharma, Yong-Mo Ahn +9 more

    2022Angewandte Chemie20 citations Open access

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14. XACT-seq comprehensively defines the promoter-position and promoter-sequence determinants for initial-transcription pausing

    Jared T. Winkelman, Chirangini Pukhrambam, I. Vvedenskaya, Yuan-Chao Zhang +4 more

    2019bioRxiv19 citations Open access

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15. Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain

    Marianna Iorio, Sahar Davatgarbenam, S. Serina, Paolo Criscenzo +6 more

    2021Scientific Reports16 citations Open access

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16. RNA polymerase clamp conformational dynamics: long-lived states and modulation by crowding, cations, and nonspecific DNA binding

    Abhishek Mazumder, Anna Wang, Heesoo Uhm, R. Ebright +1 more

    2020bioRxiv16 citations Open access

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17. Structural and mechanistic basis of σ-dependent transcriptional pausing

    Chirangini Pukhrambam, V. Molodtsov, Mahdi Kooshkbaghi, Ammar Tareen +8 more

    2022bioRxiv13 citations Open access

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18. Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli

    Kyle S. Skalenko, Ling-Ting Li, Yuan-Chao Zhang, I. Vvedenskaya +8 more

    2021Proceedings of the National Academy of Sciences of the United States of America12 citations Open access

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19. Structural basis of archaeal FttA-dependent transcription termination

    Linlin You, Cheng-Yuan Wang, V. Molodtsov, Konstantin Kuznedelov +9 more

    2024Nature11 citations Open access

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20. Structural basis of RfaH-mediated transcription-translation coupling

    V. Molodtsov, Cheng-Yuan Wang, Jing Zhang, J. Kaelber +2 more

    2024Nature Structural & Molecular Biology10 citations Open access

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21. Structural basis of archaeal FttA-dependent transcription termination

    Cheng-Yuan Wang, V. Molodtsov, Travis J. Sanders, C. Marshall +4 more

    2023bioRxiv10 citations Open access

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22. Functionalised Bicyclic Tetramates Derived from Cysteine as Antibacterial Agents

    Tharindi D Panduwawala, S. Iqbal, A. Thompson, Miro Genov +7 more

    2019Organic and biomolecular chemistry10 citations Open access

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23. Structural basis of long-range transcription-translation coupling

    Cheng-Yuan Wang, V. Molodtsov, Shashank Shandilya, Linlin You +6 more

    2024bioRxiv8 citations Open access

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24. Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase

    Ian C. Nova, Jonathan M. Craig, Abhishek Mazumder, Andrew H. Laszlo +12 more

    2024Proceedings of the National Academy of Sciences of the United States of America8 citations

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25. In transcription antitermination by Qλ, NusA induces refolding of Qλ to form a nozzle that extends the RNA polymerase RNA-exit channel

    Z. Yin, Jeremy G Bird, J. Kaelber, B. Nickels +1 more

    2022Proceedings of the National Academy of Sciences of the United States of America7 citations Open access

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26. Structural and mechanistic basis of reiterative transcription initiation

    Yu Liu, Li-Bing Yu, Chirangini Pukhrambam, Jared T. Winkelman +5 more

    2021Proceedings of the National Academy of Sciences of the United States of America7 citations Open access

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27. CHAPTER 1. The Transition from Transcription Initiation to Transcription Elongation: Start-site Selection, Initial Transcription, and Promoter Escape

    Jared T. Winkelman, B. Nickels, R. Ebright

    2021RNA Polymerases as Molecular Motors7 citations

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28. Total synthesis of pargamicin A

    Yassin M. Elbatrawi, Taylor A. Gerrein, Avraz Anwar, K. Makwana +3 more

    2022Organic Letters5 citations Open access

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29. Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B. Tong, Wenxia Lin, Tiantian Kong +5 more

    2025bioRxiv4 citations Open access

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30. Stabilizing pseudouridimycin: Synthesis, RNA-polymerase inhibitory activity, and antibacterial activity of dipeptide-modified analogues

    Avraz Anwar, Christopher F. Cain, M. Garza, David Degen +2 more

    2023ChemMedChem4 citations Open access

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31. Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) containing 5nt RNA with 6nt spacer

    W. Lin, K. Das, Yu Feng, R. Ebright

    20194 citations

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32. Bacillus subtilis σA and Escherichia coli σ70 lacking σ region 1.1 are not released during transcription initiation and elongation

    Aniruddha Tewary, Shreya Sengupta, Soumya Mukherjee, Nilanjana Hazra +3 more

    2025Proceedings of the National Academy of Sciences of the United States of America3 citations Open access

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33. Total Synthesis of Marformycins A and D

    Avraz Anwar, Yassin M. Elbatrawi, David Degen, R. Ebright +1 more

    2024Organic Letters3 citations

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34. Identification and Structural Modeling of the RNA Polymerase Omega Subunits in Chlamydiae and Other Obligate Intracellular Bacteria

    Andrew Cheng, Danny Wan, Arkaprabha Ghatak, Cheng-Yuan Wang +4 more

    2023mBio3 citations Open access

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35. Structural basis of RfaH-mediated transcription-translation coupling

    V. Molodtsov, Cheng-Yuan Wang, J. Kaelber, Gregor Blaha +1 more

    2023bioRxiv3 citations Open access

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36. Correction to: Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp.

    H. M. Hassan, David Degen, K. Jang, R. Ebright +1 more

    2022Journal of antibiotics (Tokyo. 1968)3 citations Open access

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37. RNA Polymerase Reaches 60: Transcription Initiation, Elongation, Termination, and Regulation in Prokaryotes.

    R. Ebright, F. Werner, Xiao-Dong Zhang

    2019Journal of Molecular Biology3 citations

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38. Structural basis of translation in transcription-translation coupling

    Jing Zhang, Guoliang Lu, Wei Zhou, V. Molodtsov +12 more

    2026bioRxiv2 citations Open access

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39. Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

    Izhar Denzil Kong Gregory Adrian Adrian Andreana Ann Mar Wallach Bernard Nguyen Ho Morrison Stecula Rosnik , Izhar Wallach, Denzil Bernard, Kong Nguyen +496 more

    2024Scientific Reports2 citations Open access

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40. Implementing governmental oversight of enhanced potential pandemic pathogen research

    R. Ebright, Raina Macintyre, J. Dudley, Colin D. Butler +15 more

    2024Journal of Virology2 citations Open access

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41. Structural basis of transcription antitermination by Qλ: NusA induces refolding of Qλ to form nozzle for RNA polymerase exit channel

    Z. Yin, Jeremy G Bird, J. Kaelber, B. Nickels +1 more

    2022bioRxiv2 citations Open access

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42. Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 4 nt

    Y. Zhang, L. Li, R. Ebright

    20202 citations

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43. Author response: Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

    Jeremy G Bird, Urmimala Basu, David Kuster, A. Ramachandran +8 more

    20182 citations Open access

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44. Solid-phase synthesis and biological evaluation of des-hydroxy pseudouridimycin analogs

    Avraz Anwar, Linlin You, David Degen, Katie Burns +3 more

    2026ACS Medicinal Chemistry Letters1 citations Open access

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45. Structural basis of long-range transcription-translation coupling

    Cheng-Yuan Wang, V. Molodtsov, Shashank Shandilya, Linlin You +6 more

    2026Proceedings of the National Academy of Sciences of the United States of America1 citations Open access

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46. Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B. Tong, Wenxia Lin, Tiantian Kong +5 more

    2025eLife1 citations Open access

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47. Structural basis of Rho-dependent transcription termination

    V. Molodtsov, Cheng-Yuan Wang, Emre Firlar, J. Kaelber +1 more

    2022bioRxiv1 citations Open access

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48. Chinese scientists and US leadership in the life sciences

    S. Holtzman, R. Cohen, Jeremy M. Levin, J. Maraganore +219 more

    2019Nature Biotechnology1 citations

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49. Single-molecule nanopore-tweezers analysis of transcription elongation by intact and “stalk-less” yeast RNA polymerase II

    Shuya Yang, Matthew Chen, Andrew H. Laszlo, Jonathan M. Craig +3 more

    2026bioRxiv0 citations Open access

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50. Nanopore-tweezers analysis of translocation by Escherichia coli RNA polymerase and yeast RNA polymerase II

    Shuya Yang, Ian C. Nova, Andrew H. Laszlo, I. Derrington +4 more

    2024Biophysical Journal0 citations Open access

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