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E. Krynetski · SciRah

Researcher profile · Semantic Scholar

E. Krynetski

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E. Krynetski — researcher profile on SciRah

h-index: 30
Works: 43
Citations: 5,738

Most-cited papers

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance
Charles R. Yates, E. Krynetski, T. Loennechen, M. Fessing +4 more
1997Annals of Internal Medicine773 citations
Semantic Scholar
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
M. Relling, M. Hancock, G. Rivera, J. Sandlund +4 more
1999Journal of the National Cancer Institute719 citations
Semantic Scholar
Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
H. McLeod, E. Krynetski, M. Relling, William E. Evans
2000Leukemia444 citations
Semantic Scholar
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.
W. Evans, Yuen Y. Hon, L. Bomgaars, S. Coutre +18 more
2001Journal of Clinical Oncology421 citations
Semantic Scholar
Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
Hung-Liang Tai, E. Krynetski, Charles R. Yates, T. Loennechen +3 more
1996American Journal of Human Genetics332 citations
Semantic Scholar
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.
E. Krynetski, J. Schuetz, A. Galpin, C. Pui +2 more
1995Proceedings of the National Academy of Sciences of the United States of America308 citations Open access
Semantic Scholar
Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.
Yi-Hon Yuen, M. Fessing, Ching-Hon Pui, M. Relling +2 more
1999Human Molecular Genetics279 citations Open access
Semantic Scholar
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.
Hung-Liang Tai, E. Krynetski, E. Schuetz, Y. Yanishevski +1 more
1997Proceedings of the National Academy of Sciences of the United States of America268 citations Open access
Semantic Scholar
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
E. Krynetski, Hung-Liang Tai, Charles R. Yates, M. Fessing +4 more
1996Pharmacogenetics (London)255 citations
Semantic Scholar
Genetic Polymorphism of Thiopurine S-Methyltransferase: Molecular Mechanisms and Clinical Importance
E. Krynetski, W. Evans
2000Pharmacology153 citations
Semantic Scholar
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
T. Dervieux, J. Blanco, E. Krynetski, E. Vanin +2 more
2001Cancer Research144 citations
Semantic Scholar
Pharmacogenetics of cancer therapy: getting personal.
E. Krynetski, William E. Evans
1998American Journal of Human Genetics144 citations Open access
Semantic Scholar
Drug methylation in cancer therapy: lessons from the TPMT polymorphism
E. Krynetski, W. Evans
2003Oncogene140 citations
Semantic Scholar
Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C.
Hung-Liang Tai, M. Fessing, Eric Bonten, Yuri Yanishevsky +3 more
1999Pharmacogenetics (London)124 citations
Semantic Scholar
A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.
E. Krynetski, N. Krynetskaia, M. Bianchi, W. Evans
2003Cancer Research121 citations
Semantic Scholar
Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation.
V. M. Belkov, E. Krynetski, J. Schuetz, Y. Yanishevski +6 more
1999Blood115 citations
Semantic Scholar
Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.
E. Krynetski, N. Krynetskaia, Y. Yanishevski, W. Evans
1995Molecular Pharmacology114 citations
Semantic Scholar
Pharmacogenetics as a Molecular Basis for Individualized Drug Therapy: The Thiopurine S-methyltransferase Paradigm
E. Krynetski, W. Evans
1999Pharmaceutical Research112 citations
Semantic Scholar
A Novel CRM1-mediated Nuclear Export Signal Governs Nuclear Accumulation of Glyceraldehyde-3-phosphate Dehydrogenase following Genotoxic Stress*
V. Brown, E. Krynetski, N. Krynetskaia, D. Grieger +5 more
2004Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation.
O. McDonald, E. Krynetski, W. Evans
2002Pharmacogenetics (London)76 citations
Semantic Scholar
Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults.
H. McLeod, E. Krynetski, J. Wilimas, W. Evans
1995Pharmacogenetics (London)76 citations
Semantic Scholar
Isolation of a human thiopurine S‐methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans
T. Loennechen, Charles R. Yates, M. Fessing, M. Relling +2 more
1998Clinical pharmacology and therapy75 citations
Semantic Scholar
Structure and Dynamics of Thioguanine-modified Duplex DNA* 210
L. Somerville, E. Krynetski, N. Krynetskaia, R. Beger +4 more
2003Journal of Biological Chemistry72 citations Open access
Semantic Scholar
A novel protein complex distinct from mismatch repair binds thioguanylated DNA.
E. Krynetski, N. Krynetskaia, A. Gallo, K. Murti +1 more
2001Molecular Pharmacology68 citations
Semantic Scholar
Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6-deoxythioguanosine incorporation into DNA.
N. Krynetskaia, E. Krynetski, W. Evans
1999Molecular Pharmacology61 citations
Semantic Scholar
Promoter and Intronic Sequences of the Human Thiopurine S-Methyltransferase (TPMT) Gene Isolated from a Human Pacl Genomic Library
E. Krynetski, M. Fessing, C. R. Yates, Daxi Sun +2 more
1997Pharmaceutical Research50 citations
Semantic Scholar
Thioguanine substitution alters DNA cleavage mediated by topoisomerase II
N. Krynetskaia, Xiang-Jun Cai, J. Nitiss, E. Krynetski +1 more
2000The FASEB Journal43 citations
Semantic Scholar
Functional characterization of the human thiopurine S-methyltransferase (TPMT) gene promoter.
M. Fessing, E. Krynetski, G. Zambetti, William E. Evans
1998European Journal of Biochemistry39 citations
Semantic Scholar
High yield expression of functionally active human liver CYP2D6 in yeast cells.
E. Krynetski, V. L. Drutsa, I. Kovaleva, V. N. Luzikov
1995Pharmacogenetics (London)35 citations
Semantic Scholar
TPMT Genetic Variations in Populations of the Russian Federation
E. Samochatova, Natalia V Chupova, A. Rudneva, Olga Makarova +10 more
2009Pediatric Blood & Cancer33 citations Open access
Semantic Scholar
Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice.
N. Krynetskaia, T. Brenner, E. Krynetski, W. Du +3 more
2003Molecular Pharmacology13 citations
Semantic Scholar
Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug
N. Krynetskaia, Joy Y. Feng, E. Krynetski, J. V. Garcia +3 more
2001The FASEB Journal13 citations
Semantic Scholar
Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S‐methyltransferase (TPMT)
M. Fessing, V. M. Belkov, E. Krynetski, William E. Evans
1998FEBS Letters12 citations
Semantic Scholar
Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation
V. M. Belkov, E. Krynetski, J. Schuetz, Y. Yanishevski +6 more
19997 citations
Semantic Scholar
Elucidating the Targets of Antileukemic Agents: Molecular Mechanisms of Mercaptopurine Action
N. Krynetskaia, E. Krynetski
2000Molecular Biology3 citations
Semantic Scholar
Structural and functional analysis of the human TPMT gene promoter.
M. Fessing, E. Krynetski, J. Schuetz, W. Evans
1998Advances in Experimental Medicine and Biology3 citations
Semantic Scholar
Synthesis of modified thiopurine nucleosides for structural characterization of human thiopurine S-methyltransferase.
G. Korshunova, E. Krynetski, M. Mtchedlidze, Denis V. Agapkin +2 more
1999Nucleosides and Nucleotides2 citations
Semantic Scholar
CANCER GENETICS '98 Pharmacogenetics of Cancer Therapy: Getting Personal
E. Krynetski, W. Evans
19982 citations
Semantic Scholar
Msh 2 Deficiency Attenuates But Does Not Abolish Thiopurine Hematopoietic Toxicity in Msh 2 / Mice
N. Krynetskaia, T. Brenner, E. Krynetski, W. Du +3 more
20031 citations
Semantic Scholar
MOLECULAR DIAGNOSIS OF THIOPURINE S-METHYLTRANSFERASE DEFICIENCY. AUTHORS'REPLY
R. Blank, E. Krynetski, W. Evans
19971 citations
Semantic Scholar
Structure and Dynamics of Thioguanine-modified Duplex DNA in Comparison with Unmodified DNA; Structure of Unmodified Duplex DNA
L. Somerville, E. Krynetski, N. Krynetskaia, R. Beger +4 more
20020 citations
Semantic Scholar
Analysis of the human TPMT gene promoter
M. Fessing, E. Krynetski, J. Schuetz, W. Evans
19970 citations
Semantic Scholar
TPMT3 is the most prevalent mutant allele associated with thiopurine S‐methyltransferase (TPMT) deficiency in caucasians
Charles R. Yates, E. Krynetski, Hung-Liang Tai, T. Loennechen +1 more
19960 citations
Semantic Scholar

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W. Evans×17
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N. Krynetskaia×15
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M. Relling×12
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M. Fessing×11
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William E. Evans

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C. Pui — researcher profile on SciRah

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J. Schuetz — researcher profile on SciRah

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T. Loennechen×5

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Hung-Liang Tai×4

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Y. Yanishevski×4

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William E. Evans×3

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