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N. Krynetskaia · SciRah

Researcher profile · Semantic Scholar

N. Krynetskaia

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N. Krynetskaia — researcher profile on SciRah

h-index: 18
Works: 50
Citations: 1,526

Most-cited papers

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
Hung-Liang Tai, E. Krynetski, Charles R. Yates, T. Loennechen +3 more
1996American Journal of Human Genetics332 citations
Semantic Scholar
Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells
B. Diouf, Qing Cheng, N. Krynetskaia, Wen-Jian Yang +14 more
2011Nature Medicine125 citations Open access
Semantic Scholar
A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.
E. Krynetski, N. Krynetskaia, M. Bianchi, W. Evans
2003Cancer Research121 citations
Semantic Scholar
Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.
E. Krynetski, N. Krynetskaia, Y. Yanishevski, W. Evans
1995Molecular Pharmacology114 citations
Semantic Scholar
Thiopurine pathway
G. Zaza, M. Cheok, N. Krynetskaia, C. Thorn +8 more
2010Pharmacogenetics & Genomics96 citations Open access
Semantic Scholar
A Novel CRM1-mediated Nuclear Export Signal Governs Nuclear Accumulation of Glyceraldehyde-3-phosphate Dehydrogenase following Genotoxic Stress*
V. Brown, E. Krynetski, N. Krynetskaia, D. Grieger +5 more
2004Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage
N. Krynetskaia, Manali S. Phadke, Sachin H. Jadhav, Evgeny Krynetskiy
2009Molecular Cancer Therapeutics76 citations Open access
Semantic Scholar
Structure and Dynamics of Thioguanine-modified Duplex DNA* 210
L. Somerville, E. Krynetski, N. Krynetskaia, R. Beger +4 more
2003Journal of Biological Chemistry72 citations Open access
Semantic Scholar
A novel protein complex distinct from mismatch repair binds thioguanylated DNA.
E. Krynetski, N. Krynetskaia, A. Gallo, K. Murti +1 more
2001Molecular Pharmacology68 citations
Semantic Scholar
Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6-deoxythioguanosine incorporation into DNA.
N. Krynetskaia, E. Krynetski, W. Evans
1999Molecular Pharmacology61 citations
Semantic Scholar
Glyceraldehyde 3-Phosphate Dehydrogenase Depletion Induces Cell Cycle Arrest and Resistance to Antimetabolites in Human Carcinoma Cell Lines
Manali S. Phadke, N. Krynetskaia, A. Mishra, Evgeny Krynetskiy
2009Journal of Pharmacology and Experimental Therapeutics49 citations Open access
Semantic Scholar
Accelerated Cellular Senescence Phenotype of GAPDH-depleted Human Lung Carcinoma Cells
Manali S. Phadke, N. Krynetskaia, A. Mishra, Evgeny Krynetskiy
2011Biochemical and Biophysical Research Communications - BBRC45 citations Open access
Semantic Scholar
High Mobility Group Protein B1 Is an Activator of Apoptotic Response to Antimetabolite Drugs
N. Krynetskaia, Hongbo M. Xie, S. Vucetic, Z. Obradovic +1 more
2008Molecular Pharmacology43 citations Open access
Semantic Scholar
Thioguanine substitution alters DNA cleavage mediated by topoisomerase II
N. Krynetskaia, Xiang-Jun Cai, J. Nitiss, E. Krynetski +1 more
2000The FASEB Journal43 citations
Semantic Scholar
Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique
T. Nasedkina, O. Fedorova, A. Glotov, Natalia V Chupova +15 more
2006European Journal of Human Genetics36 citations
Semantic Scholar
TPMT Genetic Variations in Populations of the Russian Federation
E. Samochatova, Natalia V Chupova, A. Rudneva, Olga Makarova +10 more
2009Pediatric Blood & Cancer33 citations Open access
Semantic Scholar
Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication.
Surendrachary Munagala, G. Sirasani, Praveen Kokkonda, Manali S. Phadke +12 more
2014Bioorganic & Medicinal Chemistry31 citations
Semantic Scholar
Establishing a model for assessing DNA damage in murine brain cells as a molecular marker of chemotherapy-associated cognitive impairment
Evgeny Krynetskiy, N. Krynetskaia, Diana Rihawi, K. Wieczerzak +2 more
2013Life Science23 citations Open access
Semantic Scholar
Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice.
N. Krynetskaia, T. Brenner, E. Krynetski, W. Du +3 more
2003Molecular Pharmacology13 citations
Semantic Scholar
Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug
N. Krynetskaia, Joy Y. Feng, E. Krynetski, J. V. Garcia +3 more
2001The FASEB Journal13 citations
Semantic Scholar
Determining Candidate Single Nucleotide Polymorphisms in Acquired Laryngotracheal Stenosis
Mursalin M. Anis, N. Krynetskaia, Zhi-Gen Zhao, Evgeny Krynetskiy +1 more
2018The Laryngoscope12 citations
Semantic Scholar
Cytotoxicity of chemotherapeutic agents in glyceraldehyde-3-phosphate dehydrogenase-depleted human lung carcinoma A549 cells with the accelerated senescence phenotype
Manali S. Phadke, N. Krynetskaia, Evgeny Krynetskiy
2013Anti-Cancer Drugs11 citations
Semantic Scholar
Disruption of NAD(+) binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions.
Manali S. Phadke, N. Krynetskaia, A. Mishra, C. Barrero +3 more
2015World Journal of Biological Chemsitry9 citations Open access
Semantic Scholar
Elucidating the Targets of Antileukemic Agents: Molecular Mechanisms of Mercaptopurine Action
N. Krynetskaia, E. Krynetski
2000Molecular Biology3 citations
Semantic Scholar
Synthesis of modified thiopurine nucleosides for structural characterization of human thiopurine S-methyltransferase.
G. Korshunova, E. Krynetski, M. Mtchedlidze, Denis V. Agapkin +2 more
1999Nucleosides and Nucleotides2 citations
Semantic Scholar
[Oligodeoxyribonucleotides containing 2'-amino-2'-deoxypyrimidine nucleosides].
L. Kuznetsova, E. A. Romanova, E. Volkov, V. Tashlitskii +3 more
1993Bioorganicheskaia khimiia2 citations
Semantic Scholar
[Hybridase cleavage of RNA. I. Oligonucleotide probes for regiospecific RNA cleavage].
V. Metelev, N. Krynetskaia, A. Purmal, Z. Shabarova
1990Bioorganicheskaia khimiia2 citations
Semantic Scholar
Targeting the intranuclear functions of GAPDH: phosphoThr99‐GAPDH is translocated into nucleus of A549 cells after genotoxic stress (739.6)
Evgeny Krynetskiy, N. Krynetskaia, Manali S. Phadke, A. Mishra +3 more
20141 citations
Semantic Scholar
Msh 2 Deficiency Attenuates But Does Not Abolish Thiopurine Hematopoietic Toxicity in Msh 2 / Mice
N. Krynetskaia, T. Brenner, E. Krynetski, W. Du +3 more
20031 citations
Semantic Scholar
[Synthesis of cyclic oligodeoxyribonucleotides with non-nucleotide inserts].
T. S. Oretskaia, N. G. Dolinnaia, I. Merenkova, N. Krynetskaia +5 more
1994Bioorganicheskaia khimiia1 citations
Semantic Scholar
[3'-phosphorylation of oligodeoxyribonucleotides].
N. Krynetskaia, G. V. Zaiakina, A. A. Elov, Z. Shabarova +1 more
1985Doklady Akademii nauk SSSR1 citations
Semantic Scholar
Is RNA Binding in the Rossmann Fold Essential for GAPDH Intranuclear Functions
N. Krynetskaia, Manali S. Phadke, Evgeny Krynetskiy
20160 citations Open access
Semantic Scholar
Abstract 1131: Disruption of the NAD+- binding site affects GAPDH interactions in the nuclei of cancer cells outside glucose metabolism
Evgeny Krynetskiy, Manali S. Phadke, N. Krynetskaia, A. Mishra +3 more
20150 citations
Semantic Scholar
Are glycyrrhizin derivatives specific inhibitors of HMGB1/DNA interactions
Sivakumar Annadurai, D. Canney, D. Lebo, N. Krynetskaia +1 more
20110 citations
Semantic Scholar
Inhibition of sequence independent DNA-binding activity of human recombinant HMGB1 protein with natural triterpenes.
Sivakumar Annadurai, N. Krynetskaia, Manali S. Phadke, Evgeny Krynetskiy +1 more
20100 citations
Semantic Scholar
Abstract 1579: Depletion of GAPDH promotes p53 signaling, cell senescence and altered response to chemotherapeutic agents in human carcinoma cells
Manali S. Phadke, N. Krynetskaia, Evgeny Krynetskiy
20100 citations
Semantic Scholar
Glycolytic and non-glycolytic functions of GAPDH in cellular response to genotoxic drugs
Manali S. Phadke, N. Krynetskaia, Evgeny Krynetskiy
20080 citations
Semantic Scholar
RUNNING TITLE PAGE Running title : HMGB 1 is an activator of apoptosis caused by chemotherapy
N. Krynetskaia, Hongbo M. Xie, S. Vucetic, Z. Obradovic +1 more
20070 citations
Semantic Scholar
Structure and Dynamics of Thioguanine-modified Duplex DNA in Comparison with Unmodified DNA; Structure of Unmodified Duplex DNA
L. Somerville, E. Krynetski, N. Krynetskaia, R. Beger +4 more
20020 citations
Semantic Scholar
[Targets of antileukemia agents: molecular mechanisms of mercaptopurine action].
N. Krynetskaia, E. I. Krynetskiĭ
2000Молекулярная биология0 citations
Semantic Scholar
[Interaction of cobalt phthalocyanine complex with DNA duplexes].
M. Timchenko, E. V. Pervushina, V. Tashlitskii, E. Kubareva +1 more
2000Молекулярная биология0 citations
Semantic Scholar
[Cobalt-corrin oligonucleotide derivatives as reagents for selective cleavage of nucleic acids].
V. M. Belkov, N. Krynetskaia, E. Volkov, Z. Shabarova +3 more
1995Bioorganicheskaia khimiia0 citations
Semantic Scholar
[Antisense oligonucleotides containing 1-(beta-D-2'-deoxy-threo-pentofuranosyl)thymine at the 3'- and 5'-end].
N. Krynetskaia, O. Chebotar, K. K. Ibragim, E. A. Romanova +4 more
1994Bioorganicheskaia khimiia0 citations
Semantic Scholar
[Interaction of RNAase H from E. coli with modified hybrid duplexes. I. Duplexes modified at the carbohydrate residue].
N. Krynetskaia, I. Alekseev, V. M. Belkov, K. K. Ibragim +3 more
1994Bioorganicheskaia khimiia0 citations
Semantic Scholar
[Hybridase cleavage of RNA. III. Use of UV-spectroscopy for studying the kinetic properties of E. coli RNAase properties].
N. Krynetskaia, V. Tashlitskii, V. M. Belkov, V. Metelev +1 more
1991Биохимия0 citations
Semantic Scholar
[Hybridase cleavage of RNA. V. Complementary precision of cleavage].
V. Metelev, N. Krynetskaia, E. Volkov, T. S. Oretskaia +1 more
1991Молекулярная биология0 citations
Semantic Scholar
[Hybridase cleavage of RNA. IV. Oligonucleotide probes containing 2'-deoxy-2'-fluoronucleoside and arabinofuranosylcytosine].
S. Shmidt, L. Kuznetsova, E. A. Romanova, A. Nimann +4 more
1991Bioorganicheskaia khimiia0 citations
Semantic Scholar
[Hybridase cleavage of RNA. II. Automatic synthesis of mixed oligonucleotide probes].
E. A. Romanova, T. S. Oretskaia, V. V. Sukhomlinov, N. Krynetskaia +2 more
1990Bioorganicheskaia khimiia0 citations
Semantic Scholar
[Chemico-enzymatic method of synthesis of mixed oligonucleotides].
G. V. Zaiakina, N. Krynetskaia, V. Metelev, Z. Shabarova
1987Bioorganicheskaia khimiia0 citations
Semantic Scholar
[Increased selectivity of directed RNA hydrolysis mediated by RNAse H from E. coli using mixed oligo(deoxyribo-ribo)nucleotides].
V. Metelev, N. Krynetskaia, G. V. Zaiakina, N. Rodionova +1 more
1987Bioorganicheskaia khimiia0 citations
Semantic Scholar

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Evgeny Krynetskiy×18
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E. Krynetski×15
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Manali S. Phadke×12
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