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A. Gangjee · SciRah

Researcher profile · Semantic Scholar

A. Gangjee

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A. Gangjee — researcher profile on SciRah

h-index: 39
Works: 296
Citations: 4,877

Most-cited papers

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer
Aamod S. Dekhne, Z. Hou, A. Gangjee, L. Matherly
2020Molecular Cancer Therapeutics58 citations Open access
Semantic Scholar
Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy
Aamod S. Dekhne, Khushbu P. Shah, Gregory S. Ducker, Jade M Katinas +21 more
2019Molecular Cancer Therapeutics48 citations Open access
Semantic Scholar
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors
Lei Wang, Adrianne Wallace, Sudhir Raghavan, S. M. Deis +13 more
2015Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer
L. Matherly, Z. Hou, A. Gangjee
2017Cancer Chemotherapy and Pharmacology40 citations Open access
Semantic Scholar
AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization
Anja Bastian, S. Matsuzaki, Kenneth M. Humphries, Gavin A. Pharaoh +4 more
2016Cancer Letters39 citations Open access
Semantic Scholar
Dual targeting of epithelial ovarian cancer via folate receptor α and the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine antifolates
Z. Hou, L. Gattoc, C. O'Connor, Si Yang +9 more
2017Molecular Cancer Therapeutics38 citations Open access
Semantic Scholar
The Design, Synthesis and Biological Evaluation of Conformationally Restricted 4-Substituted-2,6-dimethylfuro[2,3-d]pyrimidines as Multi-targeted Receptor Tyrosine Kinase and Microtubule Inhibitors as Potential Antitumor Agents
Xin Zhang, Sudhir Raghavan, M. Ihnat, E. Hamel +4 more
2015Bioorganic & Medicinal Chemistry35 citations Open access
Semantic Scholar
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis
Lalit K. Golani, Adrianne Wallace-Povirk, Siobhan M. Deis, J. Wong +16 more
2016Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells
R. K. V. Devambatla, Ojas A. Namjoshi, Shruti Choudhary, E. Hamel +4 more
2016Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism
Aamod S. Dekhne, Chang-Wen Ning, Md Junayed Nayeen, Khushbu P. Shah +9 more
2019Molecular Pharmacology32 citations Open access
Semantic Scholar
Folate transporter dynamics and therapy with classic and tumor-targeted antifolates
C. O'Connor, Adrianne Wallace-Povirk, Chang-Wen Ning, J. Frühauf +4 more
2021Scientific Reports29 citations Open access
Semantic Scholar
Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates
M. Wilson, Z. Hou, Si Yang, L. Polin +6 more
2016Molecular Pharmacology29 citations Open access
Semantic Scholar
Novel 5-Substituted Pyrrolo[2,3-d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents
Yiqiang Wang, S. Mitchell-Ryan, Sudhir Raghavan, C. George +4 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Fluorine-Substituted Pyrrolo[2,3-d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis
M. Ravindra, M. Wilson, Nian Tong, C. O'Connor +8 more
2018Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer
Anja Bastian, J. Thorpe, Bryan C. Disch, Lora C. Bailey-Downs +6 more
2015Journal of Pharmacology and Experimental Therapeutics27 citations Open access
Semantic Scholar
Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer
Adrianne Wallace-Povirk, Z. Hou, Md Junayed Nayeen, A. Gangjee +1 more
2021Cancers20 citations Open access
Semantic Scholar
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents
F. Islam, T. M. Quadery, Ruo-Li Bai, L. Luckett-Chastain +3 more
2021Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Discovery and Preclinical Evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as Single Agents with Microtubule Targeting Effects along with Triple-acting Angiokinase Inhibition as Antitumor Agents
R. Pavana, Shruti Choudhary, Anja Bastian, M. Ihnat +3 more
2016Bioorganic & Medicinal Chemistry17 citations Open access
Semantic Scholar
Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase
S. M. Deis, A. Doshi, Z. Hou, L. Matherly +2 more
2016Biochemistry17 citations Open access
Semantic Scholar
A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model
R. Towner, M. Ihnat, D. Saunders, Anja Bastian +3 more
2015BMC Cancer17 citations Open access
Semantic Scholar
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.
R. K. V. Devambatla, Shruti Choudhary, M. Ihnat, E. Hamel +2 more
2018Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.
V. Cody, J. Pace, Ojas A. Namjoshi, A. Gangjee
2015Acta Crystallographica Section F Structural Biology Communications15 citations Open access
Semantic Scholar
Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment
Adrianne Wallace-Povirk, L. Rubinsak, Agnes Malysa, Sijana H Dzinic +12 more
2022Scientific Reports14 citations Open access
Semantic Scholar
The evolving biology of the proton-coupled folate transporter: new insights into regulation, structure and mechanism
Z. Hou, A. Gangjee, L. Matherly
2022The FASEB Journal13 citations Open access
Semantic Scholar
Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De novo Purine Nucleotide Biosynthesis
M. Ravindra, Adrianne Wallace-Povirk, Mohammad Karim, M. Wilson +8 more
2018Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents
F. Islam, A. Doshi, Andrew J. Robles, T. M. Quadery +5 more
2022Molecules12 citations Open access
Semantic Scholar
Synthesis and Evaluation of 5-(Arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents
Nilesh Zaware, R. Kisliuk, Anja Bastian, M. Ihnat +1 more
2017Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer
Adrianne Wallace-Povirk, C. O'Connor, Aamod S. Dekhne, Xun Bao +12 more
2024Molecular Cancer Therapeutics11 citations
Semantic Scholar
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
Lalit K. Golani, F. Islam, C. O'Connor, Aamod S. Dekhne +3 more
2020Bioorganic & Medicinal Chemistry11 citations Open access
Semantic Scholar
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria
Md Junayed Nayeen, Jade M Katinas, Tejashree Magdum, Khushbu P. Shah +8 more
2023Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Structure based drug design and in vitro metabolism study: discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent
Wei-Guo Xiang, Shruti Choudhary, E. Hamel, S. Mooberry +1 more
2018Bioorganic & Medicinal Chemistry10 citations Open access
Semantic Scholar
Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.
R. K. V. Devambatla, Wei Li, Nilesh Zaware, Shruti Choudhary +3 more
2017Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates
C. O'Connor, M. Schneider, Jade M Katinas, Md Junayed Nayeen +10 more
2024Molecular Pharmacology9 citations Open access
Semantic Scholar
Biology and therapeutic applications of the proton-coupled folate transporter
L. Matherly, M. Schneider, A. Gangjee, Z. Hou
2022Expert Opinion on Drug Metabolism & Toxicology9 citations Open access
Semantic Scholar
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors
Adrianne Wallace-Povirk, Nian Tong, Jennifer Wong-Roushar, C. O'Connor +9 more
2021Bioorganic & Medicinal Chemistry9 citations Open access
Semantic Scholar
Targeting Species Specific Amino Acid Residues: Design, Synthesis and Biological Evaluation of 6-Substituted Pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors and Potential Anti-Opportunistic Infection Agents
Khushbu P. Shah, Xin Lin, S. Queener, V. Cody +2 more
2018Bioorganic & Medicinal Chemistry9 citations Open access
Semantic Scholar
Potential of Substituted Quinazolines to Interact with Multiple Targets in the Treatment of Cancer
Shruti Choudhary, A. Doshi, L. Luckett-Chastain, M. Ihnat +3 more
2021Bioorganic & Medicinal Chemistry8 citations Open access
Semantic Scholar
Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause both Microtubule Depolymerizing and Stabilizing Effects
C. Rohena, April L. Risinger, R. K. V. Devambatla, Nicholas F. Dybdal-Hargreaves +4 more
2016Molecules8 citations Open access
Semantic Scholar
Simple Monocyclic Pyrimidine Analogs as Microtubule Targeting Agents Binding to the Colchicine Site
Shruti Choudhary, Krishna Kaku, Andrew J. Robles, E. Hamel +2 more
2023Bioorganic & Medicinal Chemistry7 citations Open access
Semantic Scholar
The 3-D Conformational Shape of N-Naphthyl -cyclopenta[d]pyrimidines Affects Their Potency as Microtubule Targeting Agents and Their Antitumor Activity
Wei-Guo Xiang, T. M. Quadery, E. Hamel, L. Luckett-Chastain +3 more
2020Bioorganic & Medicinal Chemistry7 citations Open access
Semantic Scholar
Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2
Jade M Katinas, Md Junayed Nayeen, M. Schneider, Khushbu P. Shah +9 more
2024Biochemistry6 citations Open access
Semantic Scholar
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport
Krishna Kaku, M. Ravindra, Nian Tong, Shruti Choudhary +8 more
2023ACS Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah +11 more
2023ACS Pharmacology & Translational Science4 citations Open access
Semantic Scholar
Sterically Induced Conformational Restriction: Discovery and Preclinical Evaluation of Novel Pyrrolo[3, 2-d]pyrimidines as Microtubule Targeting Agents
R. Pavana, Khushbu P. Shah, Taylor A. Gentile, Nicholas F. Dybdal-Hargreaves +4 more
2018Bioorganic & Medicinal Chemistry4 citations Open access
Semantic Scholar
AG488 as a therapy against gliomas
Jadith Ziegler, Anja Bastian, M. Lerner, Lora C. Bailey-Downs +7 more
2017OncoTarget4 citations Open access
Semantic Scholar
Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1
Z. Hou, C. O'Connor, J. Frühauf, Steven M. Orr +3 more
2019Biochemical Journal3 citations Open access
Semantic Scholar
Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydroxymethyltransferase inhibition in human tumors.
M. Schneider, C. O'Connor, Xun Bao, Md Junayed Nayeen +8 more
2025Drug Metabolism And Disposition2 citations Open access
Semantic Scholar
Development and Validation of Chemical Features-Based Proton-Coupled Folate Transporter/Activity and Reduced Folate Carrier/Activity Models (Pharmacophores)
Khushbu P. Shah, Sudhir Raghavan, Z. Hou, L. Matherly +1 more
2018Journal of Molecular Graphics and Modelling2 citations Open access
Semantic Scholar
Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Aamod S. Dekhne, Khushbu P. Shah, G. Ducker, Jade M Katinas +21 more
2023Molecular Cancer Therapeutics1 citations Open access
Semantic Scholar
Microtubule Stabilizers as Modifiers of Alpha‐Synucleinopathy
Anuj S. Jamenis, Tarun N. Bhatia, Kristin M. Miner, Krishna Kaku +5 more
2022The FASEB Journal1 citations
Semantic Scholar

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