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Steven M. Orr · SciRah

Researcher profile · Semantic Scholar

Steven M. Orr

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Steven M. Orr — researcher profile on SciRah

h-index: 10
Works: 25
Citations: 328

Most-cited papers

Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells*
Eric C. Hales, Steven M. Orr, Amanda Larson Gedman, J. Taub +1 more
2013Journal of Biological Chemistry46 citations Open access
Semantic Scholar
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors
Lei Wang, Adrianne Wallace, Sudhir Raghavan, S. M. Deis +13 more
2015Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
The Hyatt Regency skywalk collapse: an EMS-based disaster response.
Steven M. Orr, William A. Robinson
1983Annals of Emergency Medicine39 citations
Semantic Scholar
Dual targeting of epithelial ovarian cancer via folate receptor α and the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine antifolates
Z. Hou, L. Gattoc, C. O'Connor, Si Yang +9 more
2017Molecular Cancer Therapeutics38 citations Open access
Semantic Scholar
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carbo
S. Mitchell-Ryan, Yiqiang Wang, Sudhir Raghavan, M. Ravindra +6 more
2013Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter
Lalit K. Golani, C. George, Sai Zhao, Sudhir Raghavan +6 more
2014Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Novel 5-Substituted Pyrrolo[2,3-d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents
Yiqiang Wang, S. Mitchell-Ryan, Sudhir Raghavan, C. George +4 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Tumor-Targeting with Novel Non-Benzoyl 6-Substituted Straight Chain Pyrrolo[2,3-d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de novo Purine Nucleotide Biosynthesis
Yiqiang Wang, C. Cherian, Steven M. Orr, S. Mitchell-Ryan +4 more
2013Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency
Z. Hou, Steven M. Orr, L. Matherly
2014Bioscience Reports11 citations Open access
Semantic Scholar
Central cord syndrome.
D. Szymanski, R. Collier, Steven M. Orr
1983Annals of Emergency Medicine10 citations
Semantic Scholar
Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11
Jeremiah N. Shields, Eric C. Hales, Lillian E Ranspach, Xi-Xia Luo +8 more
2019Toxics8 citations Open access
Semantic Scholar
Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1
Z. Hou, C. O'Connor, J. Frühauf, Steven M. Orr +3 more
2019Biochemical Journal3 citations Open access
Semantic Scholar
Abstract 4116: Notch1 regulates AKT-T308 dephosphorylation through modulation of the PP2A phosphatase in GSI-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells.
Eric C. Hales, Steven M. Orr, A. Gedman, J. Taub +1 more
20132 citations
Semantic Scholar
Abstract 5493: Tumor-targeting with novel non-benzoyl 6-substituted pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition ofde novopurine nucleotide biosynthesis.
C. Cherian, Yiqiang Wang, S. Mitchell-Ryan, Steven M. Orr +3 more
20132 citations
Semantic Scholar
Correction to Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter
Lalit K. Golani, C. George, Sai Zhao, Sudhir Raghavan +6 more
2016Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
Abstract 873: Acute regulation of human reduced folate carrier by folates as a novel adaptive mechanism to folate deprivation.
Z. Hou, Steven M. Orr, Erika Etnyre, C. Cherian +1 more
20131 citations
Semantic Scholar
Abstract 4765: Synthesis and evaluation of nonclassical 6-substituted pyrrolo[2,3-d]pyrimidine antifolates: Role of terminal amino acid moiety in membrane transport and antitumor activity.
A. Gangjee, L. Kumar, C. Cherian, Steven M. Orr +2 more
20121 citations
Semantic Scholar
Abstract 5491: Identification of transcriptional controls responsible for differential gene expression of the proton-coupled folate transporter in human solid tumors
Z. Hou, C. O'Connor, Steven M. Orr, L. Matherly
20170 citations
Semantic Scholar
Abstract 4483: Impact of loss of folate receptor alpha on antitumor effects of novel 6-substituted pyrrolo[2,3-d]pyrimidine antifolates with substrate activities for both folate receptors and the proton-coupled folate transporter
Z. Hou, Steven M. Orr, C. George, Adrianne Wallace +4 more
20150 citations
Semantic Scholar
Abstract 2706: Tumor-targeting with novel pyridyl 6-substituted pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor (FR) α and the proton-coupled folate transporter (PCFT) and inhibition ofde novopurine nucleotide biosynthesis
C. Cherian, Lei Wang, Adrianne Wallace, Steven M. Orr +3 more
20140 citations
Semantic Scholar
Abstract 1620: Synthesis and preclinical evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as targeted antifolates
Lalit K. Golani, A. Gangjee, C. Cherian, Steven M. Orr +4 more
20140 citations
Semantic Scholar
Abstract 5492: Study the variation of the glutamate moiety of AG94, a targeted, potent GARFTase inhibitor, as antitumor agents with the 2-amino-6-substituted pyrrolo[2,3-d]pyrimidine scaffold.
A. Gangjee, Sai Zhao, L. Kumar, C. Cherian +4 more
20130 citations
Semantic Scholar
Abstract 5494: Novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate regioisomers target folate receptor alpha positive ovarian cancer cells via inhibition of de novo purine nucleotide biosynthesis.
S. Mitchell-Ryan, Lei Wang, Steven M. Orr, Sita Kugel +3 more
20130 citations
Semantic Scholar
Abstract 2226: Mechanisms for cross-talk between Notch1 and AKT signaling in T-cell acute lymphoblastic leukemia
Eric C. Hales, Steven M. Orr, A. Gedman, J. Taub +1 more
20120 citations
Semantic Scholar
Abstract 3823: 2-Methyl-6-substituted pyrrolo[2,3-d]pyrimidine classical antifolates as selective folate receptor substrates, glycinamide ribonucleotide formyltransferase inhibitors and antitumor agents
A. Gangjee, Sai Zhao, Lei Wang, Steven M. Orr +4 more
20120 citations
Semantic Scholar

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Z. Hou×15
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Sudhir Raghavan

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