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K. Rhee · SciRah

Researcher profile · Semantic Scholar

K. Rhee

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K. Rhee — researcher profile on SciRah

h-index: 52
Works: 146
Citations: 8,032

Most-cited papers

High-fructose corn syrup enhances intestinal tumor growth in mice
M. Goncalves, Chang-Yuan Lu, Jordan Tutnauer, T. Hartman +17 more
2019Science324 citations Open access
Semantic Scholar
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis
Madhumitha Nandakumar, C. Nathan, K. Rhee
2014Nature Communications283 citations Open access
Semantic Scholar
Dietary Fructose Improves Intestinal Cell Survival and Nutrient Absorption
Samuel R. Taylor, Shakti Ramsamooj, R. Liang, Alyna Katti +14 more
2021Nature256 citations Open access
Semantic Scholar
Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis
S. Ehrt, D. Schnappinger, K. Rhee
2018Nature Reviews Microbiology238 citations Open access
Semantic Scholar
Ergothioneine maintains redox and bioenergetic homeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis
V. Saini, Bridgette M. Cumming, Loni Guidry, Dirk A. Lamprecht +12 more
2016Cell Reports145 citations Open access
Semantic Scholar
Mitochondrial ClpX activates a key enzyme for heme biosynthesis and erythropoiesis
J. Kardon, Yvette Y. Yien, Nicholas C. Huston, Diana S Branco +4 more
2015Cell118 citations Open access
Semantic Scholar
Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.
S. Chakraborty, K. Rhee
2015Cold Spring Harbor Perspectives in Medicine110 citations Open access
Semantic Scholar
Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY
Shaun R. Brinsmade, Elizabeth L. Alexander, J. Livny, Arion Stettner +3 more
2014Proceedings of the National Academy of Sciences of the United States of America103 citations Open access
Semantic Scholar
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis
Susan E. Puckett, C. Trujillo, Zhe Wang, Hyungjin Eoh +6 more
2017Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis
Chao Chen, S. Gardete, R. Jansen, Annanya Shetty +3 more
2018Antimicrobial Agents and Chemotherapy94 citations Open access
Semantic Scholar
Metabolic anticipation in Mycobacterium tuberculosis
Hyungjin Eoh, Zhe Wang, É. Layre, Poonam Rath +3 more
2017Nature Microbiology94 citations Open access
Semantic Scholar
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis
Thulasi Warrier, K. Kapilashrami, A. Argyrou, T. Ioerger +19 more
2016Proceedings of the National Academy of Sciences of the United States of America89 citations Open access
Semantic Scholar
Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis
Yumi Park, A. Pacitto, Tracy Bayliss, Laura A. T. Cleghorn +51 more
2016ACS Infectious Diseases85 citations Open access
Semantic Scholar
Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity
Alexandre Gouzy, C. Healy, Katherine A. Black, K. Rhee +1 more
2021Proceedings of the National Academy of Sciences of the United States of America80 citations Open access
Semantic Scholar
Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis.
Xiaoyun Lu, Zoe C Williams, Kiel Hards, Jian-Feng Tang +14 more
2018ACS Infectious Diseases77 citations
Semantic Scholar
The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP
F. Szeri, S. Lundkvist, Sylvia Donnelly, U. Engelke +7 more
2020PLoS Genetics76 citations Open access
Semantic Scholar
Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis
Joanna C. Evans, C. Trujillo, Zhe Wang, Hyungjin Eoh +6 more
2016ACS Infectious Diseases67 citations Open access
Semantic Scholar
Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.
M. Nixon, K. Saionz, Mi-Sun Koo, M. Szymonifka +10 more
2014Chemistry and Biology67 citations Open access
Semantic Scholar
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition
E. Ballinger, J. Mosior, T. Hartman, K. Burns-Huang +24 more
2019Science65 citations Open access
Semantic Scholar
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
R. Jansen, L. Mandyoli, Ryan Hughes, Shoko Wakabayashi +6 more
2020Nature Communications64 citations Open access
Semantic Scholar
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization
Dinakaran Murugesan, Peter C. Ray, Tracy Bayliss, G. A. Prosser +27 more
2018ACS Infectious Diseases64 citations Open access
Semantic Scholar
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress
C. Maksymiuk, Anand Balakrishnan, R. Bryk, K. Rhee +1 more
2015Proceedings of the National Academy of Sciences of the United States of America63 citations
Semantic Scholar
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis
U. Ganapathy, Joeli Marrero, Susannah F. Calhoun, Hyungjin Eoh +3 more
2015Nature Communications63 citations Open access
Semantic Scholar
Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice
Tibor I. Krisko, Hayley T. Nicholls, Curtis J. Bare, C. Holman +6 more
2020Cell Metabolism62 citations Open access
Semantic Scholar
Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate
Irnov Irnov, Zhe Wang, N. Jannetty, J. A. Bustamante +2 more
2017PLoS Genetics60 citations Open access
Semantic Scholar
Mass Spectrometric Identification of Urinary Biomarkers of Pulmonary Tuberculosis
F. Isa, Sean E. Collins, M. Lee, Diessy Decome +11 more
2018EBioMedicine56 citations Open access
Semantic Scholar
Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface
X. Carette, John Platig, D. Young, Michaela Helmel +18 more
2018mBio55 citations Open access
Semantic Scholar
Multiform antimicrobial resistance from a metabolic mutation
Sarah M. Schrader, H. Botella, R. Jansen, S. Ehrt +3 more
2021Science Advances54 citations Open access
Semantic Scholar
Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer
Cindy Hodakoski, B. Hopkins, Guo-an Zhang, Taojunfeng Su +5 more
2019Cancers54 citations Open access
Semantic Scholar
Mycobacterial Genes Essential for the Pathogen's Survival in the Host
S. Ehrt, K. Rhee, D. Schnappinger
2015Immunological Reviews54 citations Open access
Semantic Scholar
Fumarase deficiency causes protein and metabolite succination and intoxicates Mycobacterium tuberculosis
Nadine Ruecker, R. Jansen, C. Trujillo, Susan E. Puckett +6 more
2017Cell Chemical Biology52 citations Open access
Semantic Scholar
Metabolomics of Mycobacterium tuberculosis.
Madhumitha Nandakumar, G. A. Prosser, L. D. de Carvalho, K. Rhee
2015Methods in molecular biology52 citations
Semantic Scholar
The TB Drug Accelerator at Year Ten: What Have We Learned?
B. Aldridge, David Barros-Aguirre, C. Barry, Robert H. Bates +33 more
2021Nature Medicine48 citations Open access
Semantic Scholar
Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection
C. Trujillo, A. Blumenthal, Joeli Marrero, K. Rhee +2 more
2014mBio47 citations Open access
Semantic Scholar
Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility
Yesha Patel, V. Soni, K. Rhee, J. Helmann
2022bioRxiv45 citations Open access
Semantic Scholar
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline
Zhe Wang, V. Soni, G. Marriner, T. Kaneko +3 more
2019Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
Evolution and regulation of microbial secondary metabolism
Guillem Santamaria, C. Liao, Chloe Lindberg, Yan-Yan Chen +5 more
2022eLife44 citations Open access
Semantic Scholar
CinA mediates multidrug tolerance in Mycobacterium tuberculosis
Kaj M. Kreutzfeldt, R. Jansen, T. Hartman, Alexandre Gouzy +11 more
2022Nature Communications43 citations Open access
Semantic Scholar
Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites
Chantal T. Harris, X. Tong, Riward Campelo, Maria I. Marreiros +7 more
2023Nature Microbiology41 citations Open access
Semantic Scholar
Central Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis*
T. Noy, O. Vergnolle, T. Hartman, K. Rhee +3 more
2016Journal of Biological Chemistry41 citations Open access
Semantic Scholar
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis
Kiel Hards, Chen-Yi Cheung, Natalie Waller, C. Adolph +18 more
2022Communications Biology38 citations Open access
Semantic Scholar
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors
M. Bockman, Alvin S. Kalinda, R. Petrelli, T. De la Mora-Rey +8 more
2015Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Chemical–genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy
Eun-ik Koh, P. Oluoch, Nadine Ruecker, Megan K. Proulx +20 more
2021bioRxiv35 citations Open access
Semantic Scholar
Metabolomics of Central Carbon Metabolism in Mycobacterium tuberculosis
A. D. Baughn, K. Rhee
2014Microbiology spectrum35 citations
Semantic Scholar
Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA
Pradeep Kumar, G. Capodagli, D. Awasthi, Riju Shrestha +29 more
2018mBio34 citations Open access
Semantic Scholar
Targeting protein biotinylation enhances tuberculosis chemotherapy
Divya Tiwari, S. W. Park, Maram M. Essawy, Surendra Dawadi +13 more
2018Science Translational Medicine33 citations Open access
Semantic Scholar
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching
Victoria M. Schneider, Joseph E. Visone, Chantal T. Harris, F. Florini +7 more
2023Proceedings of the National Academy of Sciences of the United States of America31 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
S. Green, S. Davis, S. Damerow, Curtis A. Engelhart +41 more
2022Nature Communications30 citations Open access
Semantic Scholar
Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection
Tiago Beites, R. Jansen, Ruo-Jun Wang, A. Jinich +3 more
2021Nature Communications30 citations Open access
Semantic Scholar
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA‐damage response and leads to cell death
A. Zaveri, Ruo-Jun Wang, Laure Botella, Ritu S. Sharma +7 more
2020Molecular Microbiology28 citations Open access
Semantic Scholar

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