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Dirk A. Lamprecht · SciRah

Researcher profile · Semantic Scholar

Dirk A. Lamprecht

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Dirk A. Lamprecht — researcher profile on SciRah

h-index: 15
Works: 24
Citations: 863

Most-cited papers

Ergothioneine maintains redox and bioenergetic homeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis
V. Saini, Bridgette M. Cumming, Loni Guidry, Dirk A. Lamprecht +12 more
2016Cell Reports145 citations Open access
Semantic Scholar
Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
V. Saini, K. Chinta, V. P. Reddy, J. Glasgow +11 more
2020Nature Communications100 citations Open access
Semantic Scholar
Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection
Shannon L. Russell, Dirk A. Lamprecht, Tawanda Mandizvo, Terrence Jones +7 more
2019Cell Reports87 citations Open access
Semantic Scholar
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization
Dinakaran Murugesan, Peter C. Ray, Tracy Bayliss, G. A. Prosser +27 more
2018ACS Infectious Diseases64 citations Open access
Semantic Scholar
Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
J. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H Adamson +9 more
2020Nature Communications63 citations Open access
Semantic Scholar
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
Dirk A. Lamprecht, Peter Finin, Md. Aejazur Rahman, Bridgette M. Cumming +4 more
2016Nature Communications61 citations Open access
Semantic Scholar
Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis
C. Foo, Andréanne Lupien, M. Kienle, Anthony Vocat +8 more
2018mBio58 citations Open access
Semantic Scholar
Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c
Atica Moosa, Dirk A. Lamprecht, Kriti Arora, C. Barry +5 more
2017Antimicrobial Agents and Chemotherapy49 citations Open access
Semantic Scholar
Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection
Bridgette M. Cumming, Md. Aejazur Rahman, Dirk A. Lamprecht, Kyle H. Rohde +4 more
2017PLoS Pathogens49 citations Open access
Semantic Scholar
The Physiology and Genetics of Oxidative Stress in Mycobacteria
Bridgette M. Cumming, Dirk A. Lamprecht, R. M. Wells, V. Saini +2 more
2014Microbiology spectrum43 citations Open access
Semantic Scholar
New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis
Andréanne Lupien, C. Foo, Svetlana Savina, Anthony Vocat +8 more
2020PLoS Pathogens37 citations Open access
Semantic Scholar
Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites
Richard M. Beteck, R. Seldon, D. Coertzen, Mariëtte E. van der Watt +18 more
2018Communications Chemistry29 citations Open access
Semantic Scholar
Mycobacterium tuberculosis H2S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility
Tafara T. R. Kunota, Md. Aejazur Rahman, Barry E. Truebody, J. Mackenzie +8 more
2021bioRxiv25 citations Open access
Semantic Scholar
Targeting de novo purine biosynthesis for tuberculosis treatment
Dirk A. Lamprecht, Richard J. Wall, Annelies Leemans, Barry E. Truebody +42 more
2025Nature21 citations Open access
Semantic Scholar
Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection
Bridgette M. Cumming, Md. Aejazur Rahman, Dirk A. Lamprecht, Kyle H. Rohde +4 more
2017PLoS Pathogens16 citations Open access
Semantic Scholar
An enzyme-initiated Smiles rearrangement enables the development of an assay of MshB, the GlcNAc-Ins deacetylase of mycothiol biosynthesis.
Dirk A. Lamprecht, N. O. Muneri, Hayden Eastwood, Kevin J. Naidoo +2 more
2012Organic and biomolecular chemistry8 citations
Semantic Scholar
A high-throughput target-based screening approach for the identification and assessment of Mycobacterium tuberculosis mycothione reductase inhibitors
Natalia Smiejkowska, Lauren Oorts, Kevin van Calster, L. De Vooght +9 more
2024Microbiology spectrum7 citations Open access
Semantic Scholar
Structural and mechanistic study of a novel inhibitor analogue of M. tuberculosis cytochrome bc1:aa3
A. K. Verma, Robbert Q. Kim, Dirk A. Lamprecht, Clara Aguilar-Pérez +7 more
2025npj Drug Discovery3 citations Open access
Semantic Scholar
Integrating chemical, genetic, and feasibility assessments for anti-tubercular target validation
Dirk Schnappinger, S. Berthel, H. Boshoff, Inna V. Krieger +19 more
2026EMBO Molecular Medicine0 citations Open access
Semantic Scholar
Natural product-based putative efflux inhibitors restore bedaquiline susceptibility in a drug-resistant Mycobacterium tuberculosis mutant
Robin Chacha, Maes Valerie, Mathew P. Ngugi, Edwin Murungi +2 more
2026bioRxiv0 citations Open access
Semantic Scholar
Menaquinone depletion resensitises bedaquiline-resistant tuberculosis
Jennefer Wetzel, John Dallow, Ellie Davis, William Pearson +41 more
2026bioRxiv0 citations Open access
Semantic Scholar
Susceptibility of cytochrome oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome .
Atica Moosa, Dirk A. Lamprecht, Kriti Arora, C. Barry +5 more
20170 citations
Semantic Scholar
315 - Hydrogen Sulfide Alters M. Tuberculosis Bioenergetics and Promotes Tuberculosis Disease
V. Saini, A. Stein, K. Chinta, V. P. Reddy +5 more
20150 citations
Semantic Scholar
Development of a drug discovery protocol through the expression of key mycothiol biosynthetic enzymes for Mycobacterium tuberculosis
Dirk A. Lamprecht
20080 citations
Semantic Scholar

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