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S. Ehrt · SciRah

Researcher profile · Semantic Scholar

S. Ehrt

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S. Ehrt — researcher profile on SciRah

h-index: 64
Works: 183
Citations: 15K

Most-cited papers

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis
M. DeJesus, Elias R. Gerrick, Weizhen Xu, Sae Woong Park +8 more
2017mBio563 citations Open access
Semantic Scholar
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis
B. Bosch, M. DeJesus, Nicholas C. Poulton, Wen-Zhu Zhang +11 more
2021Cell272 citations Open access
Semantic Scholar
Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis
S. Ehrt, D. Schnappinger, K. Rhee
2018Nature Reviews Microbiology238 citations Open access
Semantic Scholar
Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes
E. Johnson, E. LaVerriere, Emma Office, M. Stanley +40 more
2019Nature150 citations Open access
Semantic Scholar
An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity
Olga Danilchanka, Jim Sun, Mikhail Pavlenok, C. Maueröder +11 more
2014Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development
Tiago Beites, K. O'Brien, Divya Tiwari, Curtis A. Engelhart +16 more
2019Nature Communications117 citations Open access
Semantic Scholar
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
Clare M. Smith, Richard E. Baker, Megan K. Proulx, B. Mishra +22 more
2022eLife109 citations Open access
Semantic Scholar
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis
Weizhen Xu, M. DeJesus, N. Rücker, Curtis A. Engelhart +8 more
2017Antimicrobial Agents and Chemotherapy105 citations Open access
Semantic Scholar
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis
Jae Jin Lee, Sun-Kyung Lee, Naomi Song, Temitope O Nathan +5 more
2019Nature Communications104 citations Open access
Semantic Scholar
Glucose Phosphorylation Is Required for Mycobacterium tuberculosis Persistence in Mice
Joeli Marrero, C. Trujillo, K. Rhee, S. Ehrt
2013PLoS Pathogens99 citations Open access
Semantic Scholar
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis
Susan E. Puckett, C. Trujillo, Zhe Wang, Hyungjin Eoh +6 more
2017Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis
Avishek Mitra, A. Speer, Kan Lin, S. Ehrt +1 more
2017mBio95 citations Open access
Semantic Scholar
LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis
R. Gaur, K. Ren, A. Blumenthal, S. Bhamidi +6 more
2014PLoS Pathogens89 citations Open access
Semantic Scholar
Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity
Alexandre Gouzy, C. Healy, Katherine A. Black, K. Rhee +1 more
2021Proceedings of the National Academy of Sciences of the United States of America80 citations Open access
Semantic Scholar
Mycobacterium tuberculosis releases an antacid that remodels phagosomes
J. Buter, T. Cheng, Marwan Ghanem, A. Grootemaat +26 more
2019Nature Chemical Biology77 citations Open access
Semantic Scholar
Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis
Joanna C. Evans, C. Trujillo, Zhe Wang, Hyungjin Eoh +6 more
2016ACS Infectious Diseases67 citations Open access
Semantic Scholar
Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis
Susan E. Puckett, C. Trujillo, Hyungjin Eoh, Joeli Marrero +5 more
2014PLoS Pathogens67 citations Open access
Semantic Scholar
Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages
A. Speer, Jim Sun, Olga Danilchanka, V. Meikle +7 more
2015Molecular Microbiology66 citations Open access
Semantic Scholar
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense
Kan Lin, K. O'Brien, C. Trujillo, Ruo-Jun Wang +3 more
2016PLoS Pathogens65 citations Open access
Semantic Scholar
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis
U. Ganapathy, Joeli Marrero, Susannah F. Calhoun, Hyungjin Eoh +3 more
2015Nature Communications63 citations Open access
Semantic Scholar
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress
H. Botella, Julien Vaubourgeix, M. Lee, Naomi Song +4 more
2017EMBO Journal60 citations Open access
Semantic Scholar
Multiform antimicrobial resistance from a metabolic mutation
Sarah M. Schrader, H. Botella, R. Jansen, S. Ehrt +3 more
2021Science Advances54 citations Open access
Semantic Scholar
Mycobacterial Genes Essential for the Pathogen's Survival in the Host
S. Ehrt, K. Rhee, D. Schnappinger
2015Immunological Reviews54 citations Open access
Semantic Scholar
Fumarase deficiency causes protein and metabolite succination and intoxicates Mycobacterium tuberculosis
Nadine Ruecker, R. Jansen, C. Trujillo, Susan E. Puckett +6 more
2017Cell Chemical Biology52 citations Open access
Semantic Scholar
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis
H. Botella, Guang-Li Yang, O. Ouerfelli, S. Ehrt +2 more
2017mBio49 citations Open access
Semantic Scholar
Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection
C. Trujillo, A. Blumenthal, Joeli Marrero, K. Rhee +2 more
2014mBio47 citations Open access
Semantic Scholar
Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host
C. Healy, Alexandre Gouzy, S. Ehrt
2020mBio45 citations Open access
Semantic Scholar
CinA mediates multidrug tolerance in Mycobacterium tuberculosis
Kaj M. Kreutzfeldt, R. Jansen, T. Hartman, Alexandre Gouzy +11 more
2022Nature Communications43 citations Open access
Semantic Scholar
Regulated Expression Systems for Mycobacteria and Their Applications
D. Schnappinger, S. Ehrt
2014Microbiology spectrum43 citations Open access
Semantic Scholar
Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis.
Flora Ngadjeua, E. Braud, Saidbakhrom Saidjalolov, L. Iannazzo +8 more
2018Chemistry40 citations
Semantic Scholar
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice
Jan Korte, M. Alber, C. Trujillo, Karl Syson +10 more
2016PLoS Pathogens38 citations Open access
Semantic Scholar
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis
M. Gengenbacher, M. Zimmerman, J. Sarathy, F. Kaya +9 more
2020Antimicrobial Agents and Chemotherapy36 citations Open access
Semantic Scholar
Construction of conditional knockdown mutants in mycobacteria.
D. Schnappinger, K. O'Brien, S. Ehrt
2015Methods in molecular biology36 citations
Semantic Scholar
Chemical–genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy
Eun-ik Koh, P. Oluoch, Nadine Ruecker, Megan K. Proulx +20 more
2021bioRxiv35 citations Open access
Semantic Scholar
Targeting protein biotinylation enhances tuberculosis chemotherapy
Divya Tiwari, S. W. Park, Maram M. Essawy, Surendra Dawadi +13 more
2018Science Translational Medicine33 citations Open access
Semantic Scholar
Disruption of an M. tuberculosis Membrane Protein Causes a Magnesium-dependent Cell Division Defect and Failure to Persist in Mice
Nichole I Goodsmith, Xinzheng V. Guo, O. Vandal, Julien Vaubourgeix +8 more
2015PLoS Pathogens32 citations Open access
Semantic Scholar
Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection
Tiago Beites, R. Jansen, Ruo-Jun Wang, A. Jinich +3 more
2021Nature Communications30 citations Open access
Semantic Scholar
Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis
Nan Zhao, Crystal M. Darby, Jennifer L. Small, D. Bachovchin +14 more
2014ACS Chemical Biology30 citations Open access
Semantic Scholar
Nonredundant functions of Mycobacterium tuberculosis chaperones promote survival under stress
Alexa P Harnagel, Landys Lopez Quezada, S. W. Park, C. Baranowski +11 more
2020Molecular Microbiology29 citations Open access
Semantic Scholar
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA‐damage response and leads to cell death
A. Zaveri, Ruo-Jun Wang, Laure Botella, Ritu S. Sharma +7 more
2020Molecular Microbiology28 citations Open access
Semantic Scholar
A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis
Lei Zhang, J. E. Kent, Meredith Whitaker, D. Young +9 more
2022Nature Communications27 citations Open access
Semantic Scholar
Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division
Ruo-Jun Wang, Kaj M. Kreutzfeldt, H. Botella, Julien Vaubourgeix +2 more
2019eLife23 citations Open access
Semantic Scholar
Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models
Xin Wang, Hong-Wei Su, Joshua B. Wallach, Jeffrey C. Wagner +21 more
2025Nature Microbiology22 citations Open access
Semantic Scholar
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis
Nan Zhao, Ming-Na Sun, K. Burns-Huang, Xiu-Ju Jiang +5 more
2015PLoS ONE21 citations Open access
Semantic Scholar
The spectrum of latent tuberculosis: rethinking the goals of prophylaxis
C. Barry, H. Boshoff, V. Dartois, T. Dick +5 more
201421 citations
Semantic Scholar
Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis
Andrew I. Wong, Tiago Beites, Kyle Planck, Rachael A. Fieweger +8 more
2022bioRxiv20 citations Open access
Semantic Scholar
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity
Hong-Wei Su, Kan Lin, Divya Tiwari, C. Healy +5 more
2021Journal of Experimental Medicine18 citations Open access
Semantic Scholar
Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
Ritu Sharma, T. Hartman, Tiago Beites, J. Kim +8 more
2023mBio16 citations Open access
Semantic Scholar
Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation
Yuanyuan Xu, S. Ehrt, D. Schnappinger, Tiago Beites
2023bioRxiv16 citations Open access
Semantic Scholar
Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression
Siddharth Subramaniyam, M. DeJesus, A. Zaveri, Clare M. Smith +5 more
2019BMC Bioinformatics16 citations Open access
Semantic Scholar

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