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C. Austin · SciRah

Researcher profile · Semantic Scholar

C. Austin

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C. Austin — researcher profile on SciRah

h-index: 78
Works: 397
Citations: 23K

Most-cited papers

Organs-on-chips: into the next decade
L. Low, C. Mummery, B. Berridge, C. Austin +1 more
2020Nature reviews. Drug discovery844 citations Open access
Semantic Scholar
The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment
M. Haendel, C. Chute, T. Bennett, David A. Eichmann +52 more
2020J. Am. Medical Informatics Assoc.495 citations Open access
Semantic Scholar
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
Lesley A. Mathews-Griner, R. Guha, P. Shinn, Ryan M. Young +26 more
2014Proceedings of the National Academy of Sciences of the United States of America370 citations Open access
Semantic Scholar
Therapies for rare diseases: therapeutic modalities, progress and challenges ahead
E. Tambuyzer, B. Vandendriessche, C. Austin, P. Brooks +8 more
2019Nature reviews. Drug discovery305 citations Open access
Semantic Scholar
The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology
A. Richard, Ruili Huang, S. Waidyanatha, P. Shinn +20 more
2020Chemical Research in Toxicology270 citations Open access
Semantic Scholar
Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick Disease, type C1: an ad-hoc analysis of a non-randomized, open-label, phase 1/2 trial
D. Ory, E. Ottinger, N. Farhat, K. King +23 more
2017The Lancet268 citations Open access
Semantic Scholar
The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics
Ruili Huang, Ivan Grishagin, Yuhong Wang, Tongan Zhao +9 more
2019Frontiers in Pharmacology266 citations Open access
Semantic Scholar
Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization
Ruili Huang, M. Xia, S. Sakamuru, Jing-Hua Zhao +5 more
2016Nature Communications255 citations Open access
Semantic Scholar
Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative
T. Bennett, R. Moffitt, J. Hajagos, Benjamin R. C. Amor +41 more
2021JAMA Network Open232 citations Open access
Semantic Scholar
Future of Rare Diseases Research 2017–2027: An IRDiRC Perspective
C. Austin, Christine M. Cutillo, L. Lau, A. Jonker +18 more
2017Clinical and Translational Science219 citations Open access
Semantic Scholar
Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
W. Fiskus, N. Saba, M. Shen, M. Ghias +13 more
2014Cancer Research215 citations Open access
Semantic Scholar
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
Ruili Huang, S. Sakamuru, Matt T. Martin, David M. Reif +18 more
2014Scientific Reports158 citations Open access
Semantic Scholar
A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells
Yu Chen, C. Tristan, Lu Chen, V. Jovanovic +14 more
2019bioRxiv156 citations Open access
Semantic Scholar
Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential
M. Attene-Ramos, Ruili Huang, Sam G. Michael, K. Witt +5 more
2014Environmental Health Perspectives154 citations Open access
Semantic Scholar
Advancing Biological Understanding and Therapeutics Discovery with Small Molecule Probes
S. Schreiber, J. Kotz, Min Li, J. Aubé +51 more
2015Cell147 citations Open access
Semantic Scholar
From scientific discovery to treatments for rare diseases – the view from the National Center for Advancing Translational Sciences – Office of Rare Diseases Research
P. Kaufmann, Anne R. Pariser, C. Austin
2018Orphanet Journal of Rare Diseases143 citations Open access
Semantic Scholar
Progress in Rare Diseases Research 2010–2016: An IRDiRC Perspective
H. Dawkins, R. Draghia-Akli, P. Lasko, L. Lau +10 more
2017Clinical and Translational Science140 citations Open access
Semantic Scholar
Collaborative Development of 2-Hydroxypropyl-β-Cyclodextrin for the Treatment of Niemann-Pick Type C1 Disease
E. Ottinger, Mark L. Kao, Nuria Carrillo-Carrasco, N. Yanjanin +21 more
2014Current Topics in Medicinal Chemistry116 citations Open access
Semantic Scholar
Glimmers in illuminating the druggable genome
G. Rodgers, C. Austin, James Anderson, A. Pawlyk +3 more
2018Nature reviews. Drug discovery98 citations Open access
Semantic Scholar
Translating Translation
C. Austin
2018Nature reviews. Drug discovery97 citations Open access
Semantic Scholar
Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study
N. Abdo, M. Xia, Chad C. Brown, O. Kosyk +13 more
2015Environmental Health Perspectives95 citations Open access
Semantic Scholar
Medical research: Next decade's goals for rare diseases
C. Austin, H. Dawkins
2017Nature88 citations
Semantic Scholar
Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK
S. Dai, Andrés E Dulcey, Xin Hu, C. Wassif +5 more
2017Autophagy84 citations Open access
Semantic Scholar
The International Rare Diseases Research Consortium: Policies and Guidelines to maximize impact
Hanns Lochmüller, Josep Torrent I. Farnell, Y. le Cam, A. Jonker +7 more
2017European Journal of Human Genetics77 citations Open access
Semantic Scholar
Niemann-Pick disease type C: induced pluripotent stem cell-derived neuronal cells for modeling neural disease and evaluating drug efficacy
Daozhan Yu, M. Swaroop, Mengqiao Wang, U. Baxa +9 more
2014Journal of biomolecular screening77 citations Open access
Semantic Scholar
The NCATS Pharmaceutical Collection: a 10-year update.
Ruili Huang, Huahua Zhu, P. Shinn, Deborah K. Ngan +8 more
2019Drug Discovery Today66 citations
Semantic Scholar
Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research
G. Langley, C. Austin, A. Balapure, L. Birnbaum +16 more
2015Environmental Health Perspectives61 citations Open access
Semantic Scholar
Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects
J. Hoskins, Leslie O. Ofori, Catherine Z. Chen, Amit Kumar +10 more
2014Nucleic Acids Research60 citations Open access
Semantic Scholar
The National COVID Cohort Collaborative: Clinical Characterization and Early Severity Prediction
Tellen D. Bennett, R. Moffitt, J. Hajagos, Benjamin R. C. Amor +41 more
2021medRxiv57 citations Open access
Semantic Scholar
Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies
M. Xia, Ruili Huang, Q. Shi, Windy A. Boyd +20 more
2018Environmental Health Perspectives55 citations Open access
Semantic Scholar
Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development
J. Wagner, Andrew M. Dahlem, Lynn D. Hudson, S. Terry +4 more
2017Clinical and Translational Science49 citations Open access
Semantic Scholar
The Foundation for the National Institutes of Health Biomarkers Consortium: Past Accomplishments and New Strategic Direction
J. Menetski, S. Hoffmann, Stephanie S. Cush, Tania Nayak Kamphaus +3 more
2019Clinical pharmacology and therapy48 citations Open access
Semantic Scholar
Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
N. Coussens, G. Sittampalam, R. Guha, K. Brimacombe +41 more
2018Clinical and Translational Science44 citations Open access
Semantic Scholar
A call for global action for rare diseases in Africa
Gareth S. Baynam, S. Groft, F. H. van der Westhuizen, Safiyya D. Gassman +46 more
2019Nature Genetics43 citations Open access
Semantic Scholar
Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles
Ruili Huang, M. Xia, S. Sakamuru, Jing-Hua Zhao +5 more
2018Scientific Reports43 citations Open access
Semantic Scholar
International collaborative actions and transparency to understand, diagnose, and develop therapies for rare diseases
K. Boycott, L. Lau, Christine M. Cutillo, C. Austin
2019EMBO Molecular Medicine41 citations Open access
Semantic Scholar
Biological activity-based modeling identifies antiviral leads against SARS-CoV-2
Ruili Huang, Miao Xu, Huahua Zhu, Catherine Z. Chen +16 more
2021Nature Biotechnology40 citations Open access
Semantic Scholar
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit
M. Hall, James M. Anderson, Annaliesa S. Anderson, D. Baker +38 more
2021Journal of Infectious Diseases35 citations Open access
Semantic Scholar
‘IRDiRC Recognized Resources': a new mechanism to support scientists to conduct efficient, high-quality research for rare diseases
Hanns Lochmüller, Y. le Cam, A. Jonker, L. Lau +6 more
2016European Journal of Human Genetics35 citations Open access
Semantic Scholar
The Platform Vector Gene Therapies Project: Increasing the Efficiency of Adeno-Associated Virus Gene Therapy Clinical Trial Startup
P. Brooks, E. Ottinger, D. Portero, Richa Madan Lomash +35 more
2020Human Gene Therapy33 citations Open access
Semantic Scholar
Recommendations toward a human pathway-based approach to disease research.
L. Marshall, C. Austin, W. Casey, S. Fitzpatrick +1 more
2018Drug Discovery Today29 citations Open access
Semantic Scholar
Improved Diagnosis and Care for Rare Diseases through Implementation of Precision Public Health Framework.
G. Baynam, Faye L. Bowman, Karla J. Lister, C. E. Walker +55 more
2017Advances in Experimental Medicine and Biology27 citations Open access
Semantic Scholar
A Global Approach to Rare Diseases Research and Orphan Products Development: The International Rare Diseases Research Consortium (IRDiRC).
Christine M. Cutillo, C. Austin, S. Groft
2017Advances in Experimental Medicine and Biology26 citations
Semantic Scholar
A dynamic map for learning, communicating, navigating and improving therapeutic development
J. Wagner, Andrew M. Dahlem, Lynn D. Hudson, S. Terry +4 more
2017Nature reviews. Drug discovery26 citations Open access
Semantic Scholar
Synergistic combination of flavopiridol and carfilzomib targets commonly dysregulated pathways in adrenocortical carcinoma and has biomarkers of response
N. Nilubol, M. Boufraqech, Lisa Zhang, K. Gaskins +5 more
2018OncoTarget25 citations Open access
Semantic Scholar
Genome-Wide Interactions of Mouse-Plasmodium yoelii Parasite and Identification of Regulators of Type I Interferon Response
Jian Wu, Baowei Cai, Wenxian Sun, Ruili Huang +13 more
2015Cell Reports24 citations Open access
Semantic Scholar
Defining clinical outcome pathways.
D. Korn, Andrew Thieme, Vinicius M. Alves, Michael Yeakey +11 more
2022Drug Discovery Today23 citations Open access
Semantic Scholar
Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays
Jonathan A. Lee, P. Shinn, S. Jaken, S. Oliver +21 more
2015PLoS ONE23 citations Open access
Semantic Scholar
Deconstructing the Translational Tower of Babel
C. Austin, C. Colvis, Noel Southall
2018Clinical and Translational Science22 citations Open access
Semantic Scholar
Mapping biologically active chemical space to accelerate drug discovery
G. Sittampalam, Dobrila D. Rudnicki, D. Tagle, A. Simeonov +1 more
2018Nature reviews. Drug discovery17 citations Open access
Semantic Scholar

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