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Pui-Kai Li · SciRah

Researcher profile · Semantic Scholar

Pui-Kai Li

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Pui-Kai Li — researcher profile on SciRah

h-index: 45
Works: 156
Citations: 6,483

Most-cited papers

Multi-targeted therapy of cancer by niclosamide: a new application for an old drug
Yong-He Li, Pui-Kai Li, Michael J. Roberts, R. Arend +2 more
2014Cancer Letters351 citations Open access
Semantic Scholar
Curcumin is a potent DNA hypomethylation agent.
Zhongfa Liu, Zhiliang Xie, W. Jones, Ryan E. Pavlovicz +8 more
2009Bioorganic & Medicinal Chemistry Letters323 citations Open access
Semantic Scholar
First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy
Malabika Sen, S. Thomas, Seungwon Kim, Joanne I. Yeh +22 more
2012Cancer Discovery297 citations Open access
Semantic Scholar
STAT3 Is Necessary for Proliferation and Survival in Colon Cancer–Initiating Cells
Li Lin, Ai-Guo Liu, Zhen-Gang Peng, Huey-Jen Lin +3 more
2011Cancer Research287 citations Open access
Semantic Scholar
Novel STAT3 phosphorylation inhibitors exhibit potent growth suppressive activity in pancreatic and breast cancer cells
Li Lin, Brian J. Hutzen, M. Zuo, Sarah Ball +10 more
2010Cancer Research236 citations Open access
Semantic Scholar
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
Li Lin, Brian J. Hutzen, Pui-Kai Li, Sarah Ball +9 more
2010Neoplasia197 citations Open access
Semantic Scholar
JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells.
P. Kroon, P. Berry, M. Stower, Greta Rodrigues +8 more
2013Cancer Research177 citations Open access
Semantic Scholar
Sorafenib Overcomes TRAIL Resistance of Hepatocellular Carcinoma Cells through the Inhibition of STAT3
Kuen-Feng Chen, W. Tai, Tsung-Hao Liu, Hsiang-Po Huang +5 more
2010Clinical Cancer Research174 citations Open access
Semantic Scholar
Inhibition of STAT3 Signaling Blocks the Anti-apoptotic Activity of IL-6 in Human Liver Cancer Cells*
Yan Liu, Pui-Kai Li, Cheng-Long Li, Jiayuh Lin
2010Journal of Biological Chemistry169 citations Open access
Semantic Scholar
Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030
Li Lin, Yan Liu, H. Li, Pui-Kai Li +4 more
2011British Journal of Cancer164 citations Open access
Semantic Scholar
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
Li Lin, Stephanie Deangelis, Elizabeth Foust, J. Fuchs +8 more
2010Molecular Cancer144 citations Open access
Semantic Scholar
Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide
Zhongfa Liu, Shu-Jun Liu, Zhiliang Xie, Ryan E. Pavlovicz +17 more
2009Journal of Pharmacology and Experimental Therapeutics144 citations Open access
Semantic Scholar
Characterization of STAT3 activation and expression in canine and human osteosarcoma
S. Fossey, A. Liao, Jennifer K. McCleese, Misty D. Bear +4 more
2009BMC Cancer129 citations Open access
Semantic Scholar
Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling.
P. Agudelo-Garcia, J. D. de Jesus, Shante P. Williams, M. Nowicki +7 more
2011Neoplasia127 citations Open access
Semantic Scholar
Structure-activity relationship studies of curcumin analogues.
J. Fuchs, Bulbul Pandit, Deepak Bhasin, Jonathan P. Etter +5 more
2009Bioorganic & Medicinal Chemistry Letters122 citations
Semantic Scholar
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
B. Fuh, M. Sobo, L. Cen, D. Josiah +11 more
2009British Journal of Cancer101 citations Open access
Semantic Scholar
Design, synthesis, and studies of small molecule STAT3 inhibitors.
Deepak Bhasin, Katryna Cisek, T. Pandharkar, Nicholas Regan +4 more
2008Bioorganic & Medicinal Chemistry Letters94 citations
Semantic Scholar
New curcumin analogues exhibit enhanced growth‐suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells
Li Lin, Brian J. Hutzen, Sarah Ball, Elizabeth Foust +8 more
2009Cancer Science91 citations
Semantic Scholar
BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
K. To, En-Ming Xing, Ross C. Larue, Pui-Kai Li
2023Molecules90 citations Open access
Semantic Scholar
The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines
S. Fossey, Misty D. Bear, Jiayuh Lin, Cheng-Long Li +6 more
2011BMC Cancer90 citations Open access
Semantic Scholar
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones
Deepak Bhasin, Somsundaram N. Chettiar, Jonathan P. Etter, M. Mok +1 more
2013Bioorganic & Medicinal Chemistry86 citations Open access
Semantic Scholar
Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2
Ross C. Larue, En-Ming Xing, A. Kenney, Yue-Xiu Zhang +5 more
2020Bioconjugate chemistry85 citations Open access
Semantic Scholar
New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells
L. Cen, Brian J. Hutzen, Sarah Ball, Stephanie Deangelis +5 more
2009BMC Cancer85 citations Open access
Semantic Scholar
Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines
Matthew A. Bill, C. Nicholas, T. Mace, Jonathan P. Etter +10 more
2012PLoS ONE84 citations Open access
Semantic Scholar
Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer
R. Arend, Angelina I. Londoño-Joshi, Abhishek Gangrade, A. Katre +11 more
2016OncoTarget81 citations Open access
Semantic Scholar
Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells
L. Friedman, Li Lin, Sarah Ball, T. Bekaii-Saab +4 more
2009Anti-Cancer Drugs74 citations Open access
Semantic Scholar
A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells
Li Lin, D. Benson, Stephanie Deangelis, C. Bakan +3 more
2011International Journal of Cancer73 citations Open access
Semantic Scholar
The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells
Sarah Ball, Cheng-Long Li, Pui-Kai Li, Jiayuh Lin
2011PLoS ONE72 citations Open access
Semantic Scholar
Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24− Subpopulations of Breast Cancer Cells
Li Lin, Brian J. Hutzen, Hsiu-Fang Lee, Zhen-Gang Peng +9 more
2013PLoS ONE71 citations Open access
Semantic Scholar
Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice
G. Onimoe, Ai-Guo Liu, Li Lin, Chang-Ching Wei +9 more
2012Investigational new drugs70 citations
Semantic Scholar
Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.
Tae-Dong Kim, J. Fuchs, Eric B. Schwartz, D. Abdelhamid +6 more
2014American journal of translational research65 citations
Semantic Scholar
STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells
Li Lin, David Jou, Yina Wang, Haiyan Ma +6 more
2016International Journal of Oncology64 citations Open access
Semantic Scholar
Tumor-Induced STAT3 Signaling in Myeloid Cells Impairs Dendritic Cell Generation by Decreasing PKCβII Abundance
M. Farren, L. Carlson, Colleen S Netherby, Inna Lindner +4 more
2014Science Signaling55 citations Open access
Semantic Scholar
Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.
Bulbul Pandit, Yanjun Sun, Ping Chen, D. Sackett +6 more
2006Bioorganic & Medicinal Chemistry49 citations
Semantic Scholar
Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells.
Chang-Ching Wei, Sarah Ball, Li Lin, Ai-Guo Liu +4 more
2010International Journal of Oncology46 citations Open access
Semantic Scholar
Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells
Kamaraj Sattu, F. Hochgräfe, Jian-Min Wu, G. Umapathy +10 more
2013The FEBS Journal45 citations Open access
Semantic Scholar
Synthesis of 4′‐Hydroxy‐3′‐piperidinomethylchalcone Derivatives and Their Cytotoxicity Against PC‐3 Cell Lines
H. Gul, K. Ö. Yerdelen, M. Gul, U. Das +4 more
2007Archiv der Pharmazie44 citations
Semantic Scholar
Anti‐angiogenic and vascular disrupting effects of C9, a new microtubule‐depolymerizing agent
Xuan Ren, Mei Dai, Li-Ping Lin, Pui-Kai Li +1 more
2009British Journal of Pharmacology38 citations Open access
Semantic Scholar
Inhibition of human gamma-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors
S. Wickham, Nicholas Regan, Matthew B. West, J. Thai +4 more
2013Biochemical Journal36 citations Open access
Semantic Scholar
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.
Y. Sugimoto, Dwitiya Sawant, H. Fisk, L. Mao +5 more
2017Bioorganic & Medicinal Chemistry35 citations Open access
Semantic Scholar
A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities
Pui-Kai Li, Bulbul Pandit, D. Sackett, Zhigen Hu +7 more
2006Molecular Cancer Therapeutics34 citations
Semantic Scholar
Synthesis and cytotoxicity of novel 3-aryl-1-(3'-dibenzylaminomethyl-4'-hydroxyphenyl)-propenones and related compounds.
H. Gul, K. Ö. Yerdelen, U. Das, M. Gul +3 more
2008Chemical and pharmaceutical bulletin32 citations Open access
Semantic Scholar
Design, synthesis and biological studies of survivin dimerization modulators that prolong mitotic cycle.
Somsundaram N. Chettiar, James V. Cooley, I. Park, Deepak Bhasin +4 more
2013Bioorganic & Medicinal Chemistry Letters31 citations
Semantic Scholar
Creating Diverse Target-Binding Surfaces on FKBP12: Synthesis and Evaluation of a Rapamycin Analogue Library
Xianghong Wu, Li-Sheng Wang, Yaohua Han, Nicholas Regan +5 more
2011ACS Combinatorial Science31 citations Open access
Semantic Scholar
LLL12 Inhibits Endogenous and Exogenous Interleukin-6-induced STAT3 Phosphorylation in Human Pancreatic Cancer Cells
Ai-Guo Liu, Yan Liu, Pui-Kai Li, Cheng-Long Li +1 more
2011Anticancer Research31 citations
Semantic Scholar
Immunohistochemical analysis of steroid sulfatase in human tissues.
K. Selcer, Heidi DiFrancesca, A. Chandra, Pui-Kai Li
2007Journal of Steroid Biochemistry and Molecular Biology31 citations
Semantic Scholar
A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models
H. Ishida, T. Nakata, Masayo Suzuki, Y. Shiotsu +9 more
2007Breast Cancer Research and Treatment29 citations
Semantic Scholar
Antiproliferative activities and SAR studies of substituted anthraquinones and 1,4-naphthoquinones.
Deepak Bhasin, Jonathan P. Etter, Somsundaram N. Chettiar, M. Mok +1 more
2013Bioorganic & Medicinal Chemistry Letters26 citations
Semantic Scholar
Niclosamide Analogs for Treatment of Ovarian Cancer
C. Walters-Haygood, R. Arend, Abhishek Gangrade, Somsundaram N. Chettiar +6 more
2015International Journal of Gynecologic Cancer23 citations Open access
Semantic Scholar
Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo
H. Ishida, T. Nakata, Natsuko Sato, Pui-Kai Li +2 more
2007Breast Cancer Research and Treatment22 citations
Semantic Scholar

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Cheng-Long Li×27
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Cheng-Long Li — researcher profile on SciRah
Jiayuh Lin×23
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Jiayuh Lin — researcher profile on SciRah
J. Fuchs×16
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Li Lin×11
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Li Lin — researcher profile on SciRah

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Deepak Bhasin — researcher profile on SciRah

Bulbul Pandit×8

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Bulbul Pandit — researcher profile on SciRah

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Sarah Ball — researcher profile on SciRah

Stephanie Deangelis×7

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Stephanie Deangelis — researcher profile on SciRah

Jonathan P. Etter×6

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Jonathan P. Etter — researcher profile on SciRah

Brian J. Hutzen×6

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Brian J. Hutzen — researcher profile on SciRah

Somsundaram N. Chettiar×6

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Somsundaram N. Chettiar — researcher profile on SciRah

Nicholas Regan×6

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Nicholas Regan — researcher profile on SciRah