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Cheng-Long Li · SciRah

Researcher profile · Semantic Scholar

Cheng-Long Li

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Cheng-Long Li — researcher profile on SciRah

h-index: 52
Works: 154
Citations: 7,432

Most-cited papers

The zinc transporter SLC39A8 is a negative feedback regulator of NF-κB through zinc-mediated inhibition of IKK
Ming-Jie Liu, Sheng-Ying Bao, Marina Gálvez-Peralta, C. Pyle +7 more
2013Cell Reports345 citations Open access
Semantic Scholar
JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells.
P. Kroon, P. Berry, M. Stower, Greta Rodrigues +8 more
2013Cancer Research177 citations Open access
Semantic Scholar
Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury.
Ji-Ping Zhao, Hao Yu, Yu-Dong Liu, S. Gibson +8 more
2016American Journal of Physiology - Lung cellular and Molecular Physiology161 citations Open access
Semantic Scholar
The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation
Somayeh S. Tarighat, R. Santhanam, D. Frankhouser, H. Radomska +13 more
2015Leukemia155 citations Open access
Semantic Scholar
Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface.
Huameng Li, Hui Xiao, Li Lin, David Jou +3 more
2014Journal of Medicinal Chemistry155 citations Open access
Semantic Scholar
Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma
Fengting Yan, L. Alinari, Mark E. Lustberg, L. K. Martin +31 more
2014Cancer Research154 citations Open access
Semantic Scholar
HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα
Mu Zhang, Shengyan Xiang, H. Joo, Lei Wang +28 more
2014Molecules and Cells146 citations Open access
Semantic Scholar
Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth
Xue-Hong Deng, Gen-Bao Shao, Huan-Tian Zhang, Cheng-Long Li +7 more
2016Oncogene145 citations Open access
Semantic Scholar
Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.
L. Alinari, K. Mahasenan, Fengting Yan, V. Karkhanis +24 more
2015Blood141 citations Open access
Semantic Scholar
Engineering CRISPR-Cpf1 crRNAs and mRNAs to maximize genome editing efficiency
Bin Li, Wei-Yu Zhao, Xiao Luo, Xinfu Zhang +3 more
2017Nature Biomedical Engineering118 citations Open access
Semantic Scholar
Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease
Olha M. Koval, Jedidiah S. Snyder, R. M. Wolf, Ryan E. Pavlovicz +14 more
2012Circulation115 citations Open access
Semantic Scholar
Impairment of Glioma Stem Cell Survival and Growth by a Novel Inhibitor for Survivin–Ran Protein Complex
H. Guvenc, M. Pavlyukov, Kaushal Joshi, Habibe Kurt +13 more
2012Clinical Cancer Research89 citations Open access
Semantic Scholar
Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design.
Wenying Yu, Hui Xiao, Jiayuh Lin, Cheng-Long Li
2013Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines
Matthew A. Bill, C. Nicholas, T. Mace, Jonathan P. Etter +10 more
2012PLoS ONE84 citations Open access
Semantic Scholar
Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy
Xiaojuan Wu, Yang Cao, Hui Xiao, Cheng-Long Li +1 more
2016Molecular Cancer Therapeutics78 citations Open access
Semantic Scholar
CaMKII-Based Regulation of Voltage-Gated Na + Channel in Cardiac Disease Quantitative modeling
Olha M. Koval, Jedidiah S. Snyder, R. M. Wolf, E. Ryan +17 more
201273 citations
Semantic Scholar
Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24− Subpopulations of Breast Cancer Cells
Li Lin, Brian J. Hutzen, Hsiu-Fang Lee, Zhen-Gang Peng +9 more
2013PLoS ONE71 citations Open access
Semantic Scholar
Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice
G. Onimoe, Ai-Guo Liu, Li Lin, Chang-Ching Wei +9 more
2012Investigational new drugs70 citations
Semantic Scholar
Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction
Wei Rao, Wujie Zhang, I. Poventud-Fuentes, Yong-Chen Wang +7 more
2014Acta Biomaterialia68 citations Open access
Semantic Scholar
Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.
Tae-Dong Kim, J. Fuchs, Eric B. Schwartz, D. Abdelhamid +6 more
2014American journal of translational research65 citations
Semantic Scholar
Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene
Shengqi Huo, Wei Shi, Haiyan Ma, Dan Yan +8 more
2021Oxidative Medicine and Cellular Longevity64 citations Open access
Semantic Scholar
Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma.
Tianshu Liu, Haiyan Ma, Wei Shi, Jialin Duan +7 more
2017International Journal of Oncology64 citations Open access
Semantic Scholar
STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells
Li Lin, David Jou, Yina Wang, Haiyan Ma +6 more
2016International Journal of Oncology64 citations Open access
Semantic Scholar
A Novel Small Molecular STAT3 Inhibitor, LY5, Inhibits Cell Viability, Cell Migration, and Angiogenesis in Medulloblastoma Cells*
Hui Xiao, H. Bid, David Jou, Xiaojuan Wu +4 more
2014Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy
Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang +3 more
2019Journal of experimental & clinical cancer research : CR60 citations Open access
Semantic Scholar
Protein Arginine Methyltransferase 5 (PRMT5) selective inhibitors suppress inflammatory T cell responses and Experimental Autoimmune Encephalomyelitis
Lindsay M Webb, S. Amici, K. Jablonski, Himanshu Savardekar +11 more
2017Journal of Immunology60 citations Open access
Semantic Scholar
Anti-Angiogenic Activity of a Small Molecule STAT3 Inhibitor LLL12
H. Bid, Duane Oswald, Cheng-Long Li, C. London +2 more
2012PLoS ONE59 citations Open access
Semantic Scholar
Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells
Cheng-Guang Zhao, Hui Xiao, Xiaojuan Wu, Cheng-Long Li +3 more
2015OncoTarget56 citations Open access
Semantic Scholar
Alkaloids from Microcos paniculata with Cytotoxic and Nicotinic Receptor Antagonistic Activities
Patrick C. Still, B. Yi, Tatiana F. González-Cestari, L. Pan +7 more
2013Journal of Natural Products51 citations Open access
Semantic Scholar
Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy
Hui Xiao, H. Bid, Xiang Chen, Xiaojuan Wu +6 more
2017PLoS ONE42 citations Open access
Semantic Scholar
Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking.
Wenying Yu, Cheng-Long Li, Wenda Zhang, Yuan‐zheng Xia +9 more
2017Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy
M. Zuo, Cheng-Long Li, Jiayuh Lin, M. Javle
2015OncoTarget41 citations Open access
Semantic Scholar
Bazedoxifene exhibits growth suppressive activity by targeting interleukin‐6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma
Haiyan Ma, Dan Yan, Yina Wang, Wei Shi +17 more
2019Cancer Science40 citations Open access
Semantic Scholar
A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells
Chong-Qiang Zhao, Wen-long Wang, Wenying Yu, David Jou +10 more
2016OncoTarget36 citations Open access
Semantic Scholar
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.
Y. Sugimoto, Dwitiya Sawant, H. Fisk, L. Mao +5 more
2017Bioorganic & Medicinal Chemistry35 citations Open access
Semantic Scholar
Bazedoxifene exhibits anti-inflammation and anti-atherosclerotic effects via inhibition of IL-6/IL-6R/STAT3 signaling.
P. Luo, Yina Wang, Chong-Qiang Zhao, Junyi Guo +12 more
2020European Journal of Pharmacology33 citations
Semantic Scholar
Feedback activation of EGFR is the main cause for STAT3 inhibition-irresponsiveness in pancreatic cancer cells
Cheng-Guang Zhao, Le-He Yang, Feng Zhou, Yun Yu +10 more
2020Oncogene33 citations
Semantic Scholar
Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells
Xiang Chen, Jia Wei, Cheng-Long Li, C. Pierson +2 more
2017International Journal of Oncology33 citations Open access
Semantic Scholar
A STAT3 inhibitor ameliorates CNS autoimmunity by restoring Teff:Treg balance
S. Aqel, Xiaozhi Yang, E. Kraus, Jinhua Song +7 more
2021JCI Insight32 citations Open access
Semantic Scholar
Indole-based Allosteric Inhibitors of HIV-1 Integrase
Pratiq A. Patel, Nina Kvaratskhelia, Y. Mansour, Janet Antwi +9 more
2016Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista.
Wei Shi, Dan Yan, Chong-Qiang Zhao, Miao Xiao +10 more
2017Biochemical and Biophysical Research Communications - BBRC31 citations
Semantic Scholar
XZH-5 Inhibits STAT3 Phosphorylation and Enhances the Cytotoxicity of Chemotherapeutic Drugs in Human Breast and Pancreatic Cancer Cells
Ai-Guo Liu, Yan Liu, Zhigang Jin, Qun Hu +7 more
2012PLoS ONE30 citations Open access
Semantic Scholar
Raloxifene inhibits IL-6/STAT3 signaling pathway and protects against high-fat-induced atherosclerosis in ApoE-/- mice.
P. Luo, Wei Shi, Yina Wang, Haiyan Ma +11 more
2020Life Science27 citations
Semantic Scholar
Persistent GP130/STAT3 Signaling Contributes to the Resistance of Doxorubicin, Cisplatin, and MEK Inhibitor in Human Rhabdomyosarcoma Cells
Xiaojuan Wu, Hui Xiao, Ruoning Wang, Lingling Liu +2 more
2016Current Cancer Drug Targets26 citations Open access
Semantic Scholar
Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.
E. Gaudio, F. Paduano, Apollinaire Ngankeu, Francesca Lovat +14 more
2013Blood22 citations Open access
Semantic Scholar
Conformational Changes in the Lower Palm Domain of ASIC1a Contribute to Desensitization and RFamide Modulation
Erin Frey, Ryan E. Pavlovicz, Clem John Wegman, Cheng-Long Li +1 more
2013PLoS ONE22 citations Open access
Semantic Scholar
Inhibition of Interleukin‐6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice
Wei Shi, Haiyan Ma, Tianshu Liu, Dan Yan +11 more
2020Journal of Cellular and Molecular Medicine21 citations Open access
Semantic Scholar
Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.
Maocai Zhai, Junyi Guo, Haiyan Ma, Wei Shi +12 more
2018Atherosclerosis21 citations
Semantic Scholar
Decoding F508del Misfolding in Cystic Fibrosis
Xiaodong Wang, Cheng-Long Li
2014Biomolecules20 citations Open access
Semantic Scholar
Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling
Yina Wang, Haiyan Ma, Chong-Qiang Zhao, Tianshu Liu +9 more
2017OncoTarget19 citations Open access
Semantic Scholar

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