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G. Umapathy · SciRah

Researcher profile · Semantic Scholar

G. Umapathy

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G. Umapathy — researcher profile on SciRah

h-index: 16
Works: 38
Citations: 835

Most-cited papers

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase
J. Guan, G. Umapathy, Y. Yamazaki, G. Wolfstetter +9 more
2015eLife133 citations Open access
Semantic Scholar
The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma
G. Umapathy, A. El Wakil, B. Witek, L. Chesler +9 more
2014Science Signaling87 citations
Semantic Scholar
The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN
J. Guan, E. Tucker, H. Wan, D. Chand +13 more
2016Disease Models & Mechanisms76 citations Open access
Semantic Scholar
Targeting anaplastic lymphoma kinase in neuroblastoma
G. Umapathy, P. Mendoza-García, B. Hallberg, R. Palmer
2019Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)63 citations Open access
Semantic Scholar
MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)–addicted neuroblastomas
G. Umapathy, J. Guan, D. Gustafsson, Niloufar Javanmardi +5 more
2017Science Signaling48 citations
Semantic Scholar
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation
Marcus Borenäs, G. Umapathy, Wei-Yun Lai, D. Lind +15 more
2021EMBO Journal47 citations Open access
Semantic Scholar
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib
J. Guan, S. Fransson, J. Siaw, D. Treis +17 more
2018Cold Spring Harbor molecular case studies47 citations Open access
Semantic Scholar
Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells
Kamaraj Sattu, F. Hochgräfe, Jian-Min Wu, G. Umapathy +10 more
2013The FEBS Journal45 citations Open access
Semantic Scholar
ATR inhibition enables complete tumour regression in ALK-driven NB mouse models
Joanna Szydzik, D. Lind, B. Arefin, Yeshwant Kurhe +7 more
2021Nature Communications41 citations Open access
Semantic Scholar
Alectinib, an Anaplastic Lymphoma Kinase Inhibitor, Abolishes ALK Activity and Growth in ALK-Positive Neuroblastoma Cells
Muhammad Wasi Alam, Marcus Borenäs, D. Lind, Diana Cervantes-Madrid +3 more
2019Frontiers in Oncology40 citations Open access
Semantic Scholar
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways
J. Van den Eynden, G. Umapathy, A. Ashouri, Diana Cervantes-Madrid +7 more
2018Science Signaling34 citations Open access
Semantic Scholar
Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUGα) in neuroblastoma patient samples with chromosome arm 2p rearrangements
Niloufar Javanmardi, S. Fransson, A. Djos, G. Umapathy +7 more
2020Genes, Chromosomes and Cancer27 citations
Semantic Scholar
ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
Marcus Borenäs, G. Umapathy, D. Lind, Wei-Yun Lai +13 more
2023Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
Semantic Scholar
ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression
Tzu-Po Chuang, Wei-Yun Lai, J. Gabre, D. Lind +10 more
2023Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness
Liselot M. Mus, I. Lambertz, Shana Claeys, C. Kumps +16 more
2020Scientific Reports21 citations Open access
Semantic Scholar
In vivo profiling of the Alk proximitome in the developing Drosophila brain.
E. Uçkun, G. Wolfstetter, V. Anthonydhason, Sanjay Kumar Sukumar +4 more
2021Journal of Molecular Biology20 citations Open access
Semantic Scholar
Mapping the phospho-dependent ALK interactome to identify novel components in ALK signaling.
F. Aboualizadeh, Zhong Yao, J. Guan, Luka Drecun +7 more
2021Journal of Molecular Biology13 citations Open access
Semantic Scholar
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation
D. Treis, G. Umapathy, S. Fransson, J. Guan +12 more
2022JCO Precision Oncology12 citations Open access
Semantic Scholar
Loss of Chromosome Y in Neuroblastoma Is Associated With High‐Risk Disease, 11q‐Deletion, and Telomere Maintenance
A. Djos, Johanna Svensson, Jennie Gaarder, G. Umapathy +9 more
2024Genes, Chromosomes and Cancer11 citations Open access
Semantic Scholar
Telomere Maintenance Mechanisms in a Cohort of High-Risk Neuroblastoma Tumors and Its Relation to Genomic Variants in the TERT and ATRX Genes
A. Djos, Ketan Thombare, Roshan Vaid, Jennie Gaarder +10 more
2023Cancers9 citations Open access
Semantic Scholar
Erastin-induced ferroptosis enhances natural killer cell anti-tumor activity and offers therapeutic potential in neuroblastoma
V. Anthonydhason, Erna Islamagic, Nikki Leijon, Jennie Gaarder +4 more
2026Frontiers in Immunology3 citations Open access
Semantic Scholar
Comparative analysis of whole-genome sequencing of tumor and cfDNA in a neuroblastoma patient: a case report
S. Fransson, Kleopatra Georgantzi, A. Djos, Jennie Gaarder +5 more
2025Frontiers in Oncology2 citations Open access
Semantic Scholar
The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system
S. K. Sukumar, Vimala Antonydhason, Linnea Molander, Jawdat Sandakly +9 more
2024eLife2 citations Open access
Semantic Scholar
Laboratory Evaluation of Some Botanicals against the Honey Bee Ectoparasitic Mite Varroa Destructor (Acari: Varroidae) and its Impact on Honey Bees (Apis cerana indica)
M. Vijayan, G. Umapathy, M. Srinivasan, D. Uma +2 more
2023Agricultural Science Digest - A Research Journal2 citations Open access
Semantic Scholar
Abstract A36: Targeting anaplastic lymphoma kinase in neuroblastoma
J. Guan, Diana Cervantes-Madrid, J. Siaw, Wasi Alam +8 more
20202 citations
Semantic Scholar
The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila CNS
S. K. Sukumar, Vimala Antonydhason, Linnea Molander, Jawdat Sandakly +9 more
2024bioRxiv1 citations Open access
Semantic Scholar
ALK signalling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
Marcus Borenäs, G. Umapathy, D. Lind, Wei-Yun Lai +13 more
2023bioRxiv1 citations Open access
Semantic Scholar
13PPhosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways.
G. Umapathy, J. Van den Eynden, Diana Cervantes-Madrid, Joanna Szydzik +3 more
2019Annals of Oncology1 citations Open access
Semantic Scholar
Author response: FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase
J. Guan, G. Umapathy, Y. Yamazaki, G. Wolfstetter +9 more
20151 citations Open access
Semantic Scholar
Abstract B002: ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
R. Palmer, B. Hallberg, Marcus Borenäs, G. Umapathy +5 more
2024Cancer Research0 citations
Semantic Scholar
Abstract C159: ALK signaling primes the DNA damage response allowing exploitation of ATR inhibition in ALK-driven Neuroblastoma
Marcus Borenäs, G. Umapathy, D. Lind, Wei-Yun Lai +10 more
2023Molecular Cancer Therapeutics0 citations
Semantic Scholar
Abstract 3936: ALK fusion oncogene driven SERPINB4 expression enhances tumor survival in NSCLC
Tzu-Po Chuang, Wei-Yun Lai, J. Gabre, D. Lind +10 more
2023Cancer Research0 citations
Semantic Scholar
Abstract B038: Anaplastic lymphoma kinase addicted neuroblastoma cell lines are associated with growth upon treatment with MEK inhibitor trametinib
B. Hallberg, G. Umapathy, Diana Cervantes-Madrid, J. Guan +2 more
20180 citations
Semantic Scholar
Abstract 5785: EML4-ALK variant E6a/b;A20 positive NSCLC cell lines are associated with growth upon blocking MEK-ERK pathway
B. Hallberg, R. Palmer, G. Umapathy, D. Gustafsson +6 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
PO-121 ALK dependant phosphoproteome and gene expression profiling of neuroblastoma cells
Joanna Szydzik, J. Van den Eynden, G. Umapathy, A. Ashouri +5 more
2018ESMO Open0 citations Open access
Semantic Scholar
PO-181 Anaplastic lymphoma kinase addictive neuroblastoma cell lines are associated with growth upon treatment with MEK inhibitor trametinib
G. Umapathy, J. Guan, D. Gustafsson, R. Palmer +1 more
2018ESMO Open0 citations Open access
Semantic Scholar
Oncogenic ALK signaling in neuroblastoma
G. Umapathy
20170 citations
Semantic Scholar
Abstract B12: The ALK inhibitor PF-06463922 shows significant response as a single agent in ALK/MYCN driven models of neuroblastoma
J. Guan, L. Danielson, D. Chand, Y. Jamin +10 more
20160 citations
Semantic Scholar

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